TMEM213

Summary

TMEM213 (transmembrane protein 213, HGNC:27220) is a protein-coding gene on chromosome 7q34, encoding Transmembrane protein 213 (A2RRL7).

Predicted to be located in membrane.

Source: NCBI Gene 155006 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 17 total — 1 pathogenic
• MANE Select transcript: NM_001085429

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27220
Approved symbol	TMEM213
Name	transmembrane protein 213
Location	7q34
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000214128
Ensembl biotype	protein_coding
Entrez	155006

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 5 protein_coding, 1 retained_intron

ENST00000397602, ENST00000413208, ENST00000442682, ENST00000458494, ENST00000472775, ENST00000869134

RefSeq mRNA: 1 — MANE Select: NM_001085429 NM_001085429

CCDS: CCDS47722

Canonical transcript exons

ENST00000442682 — 3 exons

Exon	Start	End
ENSE00001529374	138801327	138801398
ENSE00001592437	138802900	138806759
ENSE00003844193	138797994	138798186

Expression profiles

Bgee: expression breadth ubiquitous, 107 present calls, max score 99.24.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1984 / max 69.1880, expressed in 21 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
81419	0.1984	21

Top tissues by expression

209 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney epithelium	UBERON:0004819	99.24	gold quality
renal medulla	UBERON:0000362	97.98	gold quality
adult mammalian kidney	UBERON:0000082	95.18	gold quality
metanephros cortex	UBERON:0010533	93.56	gold quality
mucosa of paranasal sinus	UBERON:0005030	93.40	gold quality
buccal mucosa cell	CL:0002336	93.24	gold quality
parotid gland	UBERON:0001831	93.13	gold quality
kidney	UBERON:0002113	91.90	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	87.30	gold quality
cortex of kidney	UBERON:0001225	84.64	gold quality
metanephros	UBERON:0000081	82.40	gold quality
nasal cavity epithelium	UBERON:0005384	82.37	silver quality
nasal cavity mucosa	UBERON:0001826	79.22	gold quality
endothelial cell	CL:0000115	77.72	silver quality
saliva-secreting gland	UBERON:0001044	76.19	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	75.57	gold quality
bronchial epithelial cell	CL:0002328	74.82	gold quality
bronchus	UBERON:0002185	74.43	gold quality
trachea	UBERON:0003126	72.54	gold quality
adult organism	UBERON:0007023	72.31	gold quality
minor salivary gland	UBERON:0001830	71.63	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	69.99	gold quality
cardiac muscle of right atrium	UBERON:0003379	69.84	gold quality
left ventricle myocardium	UBERON:0006566	69.62	gold quality
skin of leg	UBERON:0001511	69.57	gold quality
upper arm skin	UBERON:0004263	68.81	gold quality
pancreatic ductal cell	CL:0002079	68.65	silver quality
zone of skin	UBERON:0000014	67.92	gold quality
mouth mucosa	UBERON:0003729	67.79	gold quality
skin of abdomen	UBERON:0001416	66.03	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-CURD-135	yes	2151.49
E-GEOD-114530	yes	1691.70
E-CURD-119	yes	30.02
E-ANND-3	yes	6.19

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

57 targeting TMEM213, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-6783-3P	99.89	67.92	2059
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-1343-3P	99.89	66.78	1815
HSA-MIR-4659A-3P	99.80	72.62	4248
HSA-MIR-4659B-3P	99.80	72.62	4248
HSA-MIR-204-5P	99.79	71.62	2439
HSA-MIR-211-5P	99.79	71.65	2440
HSA-MIR-323A-3P	99.79	70.30	1739
HSA-MIR-623	99.76	68.16	1170
HSA-MIR-3934-3P	99.76	65.51	1351
HSA-MIR-4766-5P	99.75	69.23	2662
HSA-MIR-4755-5P	99.71	70.34	2716
HSA-MIR-5006-3P	99.71	70.26	2728
HSA-MIR-1208	99.70	68.28	1533
HSA-MIR-7-5P	99.67	70.53	1809
HSA-MIR-24-3P	99.59	69.97	1934
HSA-MIR-516B-5P	99.56	66.33	1495
HSA-MIR-6832-3P	99.52	70.44	1726
HSA-MIR-4441	99.49	66.56	3216
HSA-MIR-4762-3P	99.43	69.72	2363
HSA-MIR-501-3P	99.33	66.12	651
HSA-MIR-502-3P	99.33	66.12	651
HSA-MIR-504-3P	99.30	67.18	1745
HSA-MIR-133A-3P	99.27	71.53	1270
HSA-MIR-133B	99.27	71.53	1270

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Tmem213	ENSMUSG00000029829
rattus_norvegicus	Tmem213	ENSRNOG00000085221

Protein

Protein identifiers

Transmembrane protein 213 — A2RRL7 (reviewed: A2RRL7)

All UniProt accessions (1): A2RRL7

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Endoplasmic reticulum membrane.

Isoforms (4)

UniProt ID	Names	Canonical?
A2RRL7-1	1	yes
A2RRL7-2	2
A2RRL7-3	3
A2RRL7-4	4

RefSeq proteins (1): NP_001078898* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR028121	TMEM213	Family

Pfam: PF15192

UniProt features (8 total): splice variant 3, topological domain 2, signal peptide 1, chain 1, transmembrane region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A2RRL7-F1	69.09	0.19

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 42 (showing top): SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN, GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK, GOCC_ORGANELLE_SUBCOMPARTMENT, DODD_NASOPHARYNGEAL_CARCINOMA_DN, MARTENS_TRETINOIN_RESPONSE_UP, LEE_BMP2_TARGETS_UP, GLI4_TARGET_GENES, NFKBIA_TARGET_GENES, GSE10239_MEMORY_VS_KLRG1INT_EFF_CD8_TCELL_UP, GSE10239_MEMORY_VS_KLRG1HIGH_EFF_CD8_TCELL_UP, MIR4755_5P, MIR5006_3P, MIR204_5P, MIR211_5P, GSE10239_MEMORY_VS_DAY4.5_EFF_CD8_TCELL_UP

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (2): endoplasmic reticulum membrane (GO:0005789), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
cellular anatomical structure	1

Protein interactions and networks

STRING

468 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TMEM213	TMEM207	Q6UWW9	596
TMEM213	TMEM116	Q8NCL8	584
TMEM213	TMEM25	Q86YD3	542
TMEM213	RTP3	Q9BQQ7	528
TMEM213	TMEM61	Q8N0U2	528
TMEM213	NDC1	Q9BTX1	480
TMEM213	C3orf22	Q8N5N4	479
TMEM213	PLEKHG7	Q6ZR37	478
TMEM213	TMEM72	A0PK05	447
TMEM213	TMEM45A	Q9NWC5	447
TMEM213	RNASE12	Q5GAN4	447
TMEM213	C7orf33	Q8WU49	445
TMEM213	C2orf15	Q8WU43	445
TMEM213	SMIM17	P0DL12	434
TMEM213	SLC35G2	Q8TBE7	434

IntAct

3 interactions, top by confidence:

A	B	Type	Score
TMEM213	METAP2	psi-mi:“MI:0914”(association)	0.530

BioGRID (13): TMEM213 (Two-hybrid), TMEM213 (Two-hybrid), METAP2 (Affinity Capture-MS), DCUN1D5 (Affinity Capture-MS), GLMN (Affinity Capture-MS), EFNB1 (Affinity Capture-MS), ALG11 (Affinity Capture-MS), TMEM213 (Two-hybrid), TMEM213 (Two-hybrid), EFNB1 (Affinity Capture-MS), METAP2 (Affinity Capture-MS), ALG11 (Affinity Capture-MS), GLMN (Affinity Capture-MS)

ESM2 similar proteins: A0A1B0GST9, A0A1B0GTU2, A0A1B0GV90, A0A590UK83, A2RRL7, A7S641, A8WG88, A9JTJ0, B9X187, K7EJ46, O00168, O08589, O13001, P0C2S0, P15383, P41237, P56513, P60606, P63160, P63161, Q04645, Q04646, Q04679, Q04680, Q0P467, Q28EH9, Q3SZX0, Q3UJ81, Q3URE8, Q3ZBP2, Q4LDR2, Q4R6L9, Q502I1, Q592E4, Q5XF36, Q6AXF6, Q6NWH5, Q6PBK8, Q6Q3F5, Q71RC9

Diamond homologs: A2RRL7, Q08EA8, Q58CU5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

17 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	14
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
149061	GRCh38/hg38 7q33-36.3(chr7:134666829-158591882)x1	Pathogenic

SpliceAI

619 predictions. Top by Δscore:

Variant	Effect	Δscore
7:138801399:G:GG	donor_gain	1.0000
7:138798183:GCAG:G	donor_gain	0.9900
7:138798187:GTAGC:G	donor_loss	0.9900
7:138798188:T:G	donor_loss	0.9900
7:138803044:A:G	donor_gain	0.9900
7:138803055:G:GT	donor_gain	0.9900
7:138803064:GC:G	donor_gain	0.9900
7:138803128:G:T	donor_gain	0.9900
7:138837817:T:TA	donor_gain	0.9900
7:138803066:G:GG	donor_gain	0.9800
7:138803077:GC:G	donor_gain	0.9800
7:138803126:GGGGA:G	donor_gain	0.9800
7:138803127:GGGAG:G	donor_gain	0.9800
7:138803128:G:GT	donor_gain	0.9800
7:138801325:A:AG	acceptor_gain	0.9700
7:138801326:G:GG	acceptor_gain	0.9700
7:138802898:A:AG	acceptor_gain	0.9700
7:138802899:G:GG	acceptor_gain	0.9700
7:138837846:T:A	donor_gain	0.9700
7:138798193:T:G	donor_gain	0.9600
7:138800636:TTCTC:T	donor_gain	0.9600
7:138801326:GAA:G	acceptor_gain	0.9600
7:138801487:TGTC:T	donor_gain	0.9600
7:138802899:GAC:G	acceptor_gain	0.9600
7:138801326:GA:G	acceptor_gain	0.9500
7:138837862:T:TA	donor_gain	0.9500
7:138798184:C:T	donor_gain	0.9400
7:138798187:G:GG	donor_gain	0.9400
7:138801393:GCCTC:G	donor_gain	0.9400
7:138798182:GGCAG:G	donor_gain	0.9300

AlphaMissense

691 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:138802983:A:C	S80R	0.996
7:138802985:C:A	S80R	0.996
7:138802985:C:G	S80R	0.996
7:138802980:T:A	W79R	0.995
7:138802980:T:C	W79R	0.995
7:138802961:G:C	W72C	0.991
7:138802961:G:T	W72C	0.991
7:138802959:T:A	W72R	0.988
7:138802959:T:C	W72R	0.988
7:138802992:T:C	F83L	0.985
7:138802994:C:A	F83L	0.985
7:138802994:C:G	F83L	0.985
7:138802978:G:A	G78D	0.984
7:138802977:G:C	G78R	0.982
7:138802972:C:A	A76D	0.979
7:138802975:T:A	V77D	0.978
7:138802989:T:A	W82R	0.977
7:138802989:T:C	W82R	0.977
7:138802993:T:C	F83S	0.970
7:138802971:G:C	A76P	0.969
7:138803013:T:C	C90R	0.969
7:138802982:G:C	W79C	0.968
7:138802982:G:T	W79C	0.968
7:138802929:T:C	C62R	0.966
7:138802911:T:C	C56R	0.963
7:138802956:G:T	G71C	0.963
7:138802932:T:C	C63R	0.961
7:138802911:T:A	C56S	0.960
7:138802912:G:C	C56S	0.960
7:138802969:C:A	A75E	0.960

dbSNP variants (sampled 300 via entrez): RS1000067797 (7:138801313 A>G), RS1000205377 (7:138797011 C>T), RS1000351177 (7:138796459 T>C), RS1000911349 (7:138806239 G>C), RS1001070308 (7:138799689 T>C), RS1001313258 (7:138800441 T>C), RS1001773673 (7:138797066 G>A,T), RS1001923626 (7:138802266 T>C,G), RS1002292636 (7:138802493 G>A), RS1002306485 (7:138799103 T>C), RS1002683593 (7:138799322 G>A), RS1002896846 (7:138805252 A>C), RS1003297120 (7:138804167 C>T), RS1003332623 (7:138803526 C>T), RS1003413302 (7:138803893 G>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

7 total (human), top 7 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Nickel	decreases expression	2
aflatoxin B2	decreases methylation	1
Poly(amidoamine)	decreases expression	1
Zoledronic Acid	decreases expression	1
Benzo(a)pyrene	increases methylation, decreases methylation	1
Silicon Dioxide	decreases expression	1
Tobacco Smoke Pollution	affects expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.