TMEM234

Summary

TMEM234 (transmembrane protein 234, HGNC:28837) is a protein-coding gene on chromosome 1p35.2, encoding Transmembrane protein 234 (Q8WY98).

Predicted to be located in membrane.

Source: NCBI Gene 56063 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 14 total
• MANE Select transcript: NM_019118

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28837
Approved symbol	TMEM234
Name	transmembrane protein 234
Location	1p35.2
Locus type	gene with protein product
Status	Approved
Aliases	RP4-622L5, dJ622L5.7, FLJ90779
Ensembl gene	ENSG00000160055
Ensembl biotype	protein_coding
OMIM	620289
Entrez	56063

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 4 protein_coding, 3 nonsense_mediated_decay, 3 protein_coding_CDS_not_defined, 2 retained_intron

ENST00000309777, ENST00000344461, ENST00000373593, ENST00000461402, ENST00000466796, ENST00000483001, ENST00000484490, ENST00000485689, ENST00000487174, ENST00000489170, ENST00000491434, ENST00000495091

RefSeq mRNA: 2 — MANE Select: NM_019118 NM_001366191, NM_019118

CCDS: CCDS356, CCDS90906

Canonical transcript exons

ENST00000309777 — 5 exons

Exon	Start	End
ENSE00001460982	32216200	32216947
ENSE00001675237	32222307	32222353
ENSE00001780757	32221867	32222018
ENSE00003651654	32221131	32221197
ENSE00003683763	32217259	32217351

Expression profiles

Bgee: expression breadth ubiquitous, 220 present calls, max score 97.05.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.9889 / max 104.1237, expressed in 1789 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
11517	7.6744	1789
11516	0.3145	148

Top tissues by expression

247 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	97.05	gold quality
buccal mucosa cell	CL:0002336	93.05	gold quality
tendon of biceps brachii	UBERON:0008188	92.71	gold quality
right lobe of thyroid gland	UBERON:0001119	92.47	gold quality
left lobe of thyroid gland	UBERON:0001120	91.98	gold quality
adenohypophysis	UBERON:0002196	91.80	gold quality
thyroid gland	UBERON:0002046	90.86	gold quality
pituitary gland	UBERON:0000007	90.60	gold quality
left testis	UBERON:0004533	89.22	gold quality
right testis	UBERON:0004534	88.74	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.34	gold quality
metanephros cortex	UBERON:0010533	88.14	gold quality
mucosa of transverse colon	UBERON:0004991	87.38	gold quality
testis	UBERON:0000473	86.97	gold quality
body of uterus	UBERON:0009853	86.43	gold quality
endocervix	UBERON:0000458	86.30	gold quality
right adrenal gland	UBERON:0001233	86.28	gold quality
right adrenal gland cortex	UBERON:0035827	85.99	gold quality
left ovary	UBERON:0002119	85.97	gold quality
tibialis anterior	UBERON:0001385	85.59	gold quality
right ovary	UBERON:0002118	85.59	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.54	gold quality
left uterine tube	UBERON:0001303	85.53	gold quality
ileal mucosa	UBERON:0000331	85.37	gold quality
granulocyte	CL:0000094	85.17	gold quality
left adrenal gland	UBERON:0001234	85.07	gold quality
lower esophagus mucosa	UBERON:0035834	85.07	gold quality
left adrenal gland cortex	UBERON:0035825	85.04	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	84.84	gold quality
left coronary artery	UBERON:0001626	84.81	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.53

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

36 targeting TMEM234, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-34A-5P	99.99	71.21	1784
HSA-MIR-449A	99.99	71.05	1776
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-MIR-98-5P	99.98	72.33	1787
HSA-MIR-4650-5P	99.98	64.69	999
HSA-LET-7D-5P	99.96	71.76	1632
HSA-MIR-4458	99.96	71.64	1650
HSA-MIR-4487	99.96	64.58	1252
HSA-MIR-6809-3P	99.91	71.45	3814
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-383-3P	99.85	65.84	1359
HSA-MIR-202-3P	99.84	71.41	1290
HSA-MIR-7156-5P	99.64	68.81	1369
HSA-MIR-486-3P	99.51	66.82	1901
HSA-MIR-4273	99.45	67.93	1206
HSA-MIR-6165	99.44	67.12	1389
HSA-MIR-4505	99.27	67.81	2678
HSA-MIR-149-5P	99.25	67.16	1315
HSA-MIR-5787	99.22	67.86	2628
HSA-MIR-5001-3P	98.91	67.28	1394
HSA-MIR-3074-5P	98.82	66.56	1414
HSA-MIR-3135B	98.61	65.33	1470

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Tmem234	ENSMUSG00000028797
rattus_norvegicus	Tmem234	ENSRNOG00000049326

Protein

Protein identifiers

Transmembrane protein 234 — Q8WY98 (reviewed: Q8WY98)

All UniProt accessions (2): Q8WY98, E9PNU5

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

Miscellaneous. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Similarity. Belongs to the TMEM234 family.

Isoforms (4)

UniProt ID	Names	Canonical?
Q8WY98-1	1	yes
Q8WY98-2	2
Q8WY98-3	3
Q8WY98-4	4

RefSeq proteins (2): NP_001353120, NP_061991* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR018908	TMEM234	Family
IPR037185	EmrE-like	Homologous_superfamily

Pfam: PF10639

UniProt features (10 total): splice variant 5, transmembrane region 3, chain 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8WY98-F1	84.59	0.49

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 65 (showing top): MARTINEZ_RB1_TARGETS_UP, LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN, MARTINEZ_RB1_AND_TP53_TARGETS_UP, chr1p35, DODD_NASOPHARYNGEAL_CARCINOMA_DN, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, GSE13522_CTRL_VS_T_CRUZI_BRAZIL_STRAIN_INF_SKIN_UP, GSE5503_PLN_DC_VS_SPLEEN_DC_ACTIVATED_ALLOGENIC_TCELL_DN, ELF2_TARGET_GENES, FOXN3_TARGET_GENES, FOXR2_TARGET_GENES, NKX2_2_TARGET_GENES, ZNF664_TARGET_GENES, MIR4500, LET_7B_5P

GO Biological Process (0):

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (1): membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	1
cellular anatomical structure	1

Protein interactions and networks

STRING

302 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TMEM234	TMEM144	Q7Z5S9	507
TMEM234	TCP11L2	Q8N4U5	462
TMEM234	CCDC28B	Q9BUN5	460
TMEM234	ZNF185	O15231	459
TMEM234	XKRX	Q6PP77	455
TMEM234	TMEM63C	Q9P1W3	453
TMEM234	TMEM63B	Q5T3F8	436
TMEM234	EFCC1	Q9HA90	431
TMEM234	TMEM63A	O94886	426
TMEM234	SPMIP5	Q8WW14	418
TMEM234	MMADHC	Q9H3L0	396
TMEM234	RPP21	Q9H633	392
TMEM234	TCEAL8	Q8IYN2	370
TMEM234	TXLNA	P40222	357
TMEM234	LRRC49	Q8IUZ0	354

IntAct

50 interactions, top by confidence:

A	B	Type	Score
CREB3L1	TMEM234	psi-mi:“MI:0915”(physical association)	0.560
TMEM234	CREB3L1	psi-mi:“MI:0915”(physical association)	0.560
FAM241B	TMEM234	psi-mi:“MI:0915”(physical association)	0.560
CXCL9	TMEM234	psi-mi:“MI:0915”(physical association)	0.560
TMEM203	TMEM234	psi-mi:“MI:0915”(physical association)	0.560
TMEM218	TMEM234	psi-mi:“MI:0915”(physical association)	0.560
VTI1B	TMEM234	psi-mi:“MI:0915”(physical association)	0.560
BRICD5	TMEM234	psi-mi:“MI:0915”(physical association)	0.560
TMEM107	TMEM234	psi-mi:“MI:0915”(physical association)	0.560
TMEM234	VTI1B	psi-mi:“MI:0915”(physical association)	0.560
SLC10A6	TMEM234	psi-mi:“MI:0915”(physical association)	0.560
SLC10A1	TMEM234	psi-mi:“MI:0915”(physical association)	0.560
TMEM234	FAM241B	psi-mi:“MI:0915”(physical association)	0.560
SLC34A3	TMEM234	psi-mi:“MI:0915”(physical association)	0.560
TMEM234	TMEM203	psi-mi:“MI:0915”(physical association)	0.560
SLC35E3	TMEM234	psi-mi:“MI:0915”(physical association)	0.560
SMAGP	TMEM234	psi-mi:“MI:0915”(physical association)	0.560
UNC50	TMEM234	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (19): CREB3L1 (Two-hybrid), TMEM234 (Two-hybrid), TMEM234 (Two-hybrid), TMEM234 (Two-hybrid), TMEM234 (Two-hybrid), TMEM234 (Two-hybrid), TMEM234 (Two-hybrid), TMEM234 (Two-hybrid), TMEM234 (Two-hybrid), TMEM234 (Two-hybrid), SMAGP (Two-hybrid), C10orf35 (Two-hybrid), SLC35E3 (Two-hybrid), TMEM107 (Two-hybrid), BRICD5 (Two-hybrid)

ESM2 similar proteins: A0NGI1, A7YW81, O74750, O94654, P40004, Q00974, Q02334, Q03730, Q04083, Q09875, Q0D2K0, Q0V9U2, Q10000, Q29Q28, Q3E6T0, Q3SWX0, Q54V96, Q54ZG7, Q550W6, Q55FV8, Q5R7Q3, Q5T1Q4, Q6CR04, Q6FSF8, Q7RTP0, Q7TML3, Q8BGK5, Q8BHK1, Q8BLX4, Q8BMW7, Q8BZF2, Q8IXU6, Q8MXJ9, Q8N8Q9, Q8R1E7, Q8WY98, Q94EI9, Q968A5, Q9C8M1, Q9JJC8

Diamond homologs: A0NGI1, A7YW81, Q54ZG7, Q5RBQ9, Q8R1E7, Q8WY98

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

14 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	9
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1537 predictions. Top by Δscore:

Variant	Effect	Δscore
1:32215435:TTTA:T	acceptor_loss	1.0000
1:32215437:TA:T	acceptor_loss	1.0000
1:32215438:A:AC	acceptor_loss	1.0000
1:32215438:A:AG	acceptor_gain	1.0000
1:32215439:G:GG	acceptor_gain	1.0000
1:32221198:C:CC	acceptor_gain	1.0000
1:32222115:T:TA	donor_gain	1.0000
1:32215438:AG:A	acceptor_gain	0.9900
1:32215439:GG:G	acceptor_gain	0.9900
1:32215439:GGA:G	acceptor_gain	0.9900
1:32215439:GGAGT:G	acceptor_gain	0.9900
1:32217361:C:CT	acceptor_gain	0.9900
1:32221126:CCCA:C	donor_loss	0.9900
1:32221127:CCA:C	donor_loss	0.9900
1:32221128:CA:C	donor_loss	0.9900
1:32221129:A:AT	donor_loss	0.9900
1:32221195:GTA:G	acceptor_gain	0.9900
1:32221196:TA:T	acceptor_gain	0.9900
1:32221196:TACTG:T	acceptor_loss	0.9900
1:32221197:ACT:A	acceptor_loss	0.9900
1:32221198:CT:C	acceptor_loss	0.9900
1:32221862:CGCA:C	donor_loss	0.9900
1:32221863:GCA:G	donor_loss	0.9900
1:32221864:CAC:C	donor_loss	0.9900
1:32221865:A:C	donor_loss	0.9900
1:32222119:T:TA	donor_gain	0.9900
1:32215436:TTAGG:T	acceptor_gain	0.9800
1:32215437:TAGG:T	acceptor_gain	0.9800
1:32215438:AGGA:A	acceptor_gain	0.9800
1:32215439:GGAG:G	acceptor_gain	0.9800

AlphaMissense

871 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:32221983:A:G	W18R	0.976
1:32221983:A:T	W18R	0.976
1:32221991:G:T	A15D	0.974
1:32221981:C:A	W18C	0.971
1:32221981:C:G	W18C	0.971
1:32217323:G:C	N88K	0.970
1:32217323:G:T	N88K	0.970
1:32217326:A:C	C87W	0.966
1:32221166:C:T	G67E	0.966
1:32217328:A:G	C87R	0.960
1:32221174:G:C	N64K	0.959
1:32221174:G:T	N64K	0.959
1:32221957:C:A	K26N	0.958
1:32221957:C:G	K26N	0.958
1:32216914:C:T	G121E	0.956
1:32217327:C:T	C87Y	0.954
1:32221980:C:G	G19R	0.954
1:32221170:A:G	C66R	0.953
1:32217339:G:T	A83D	0.951
1:32221988:G:T	A16D	0.951
1:32217294:A:T	V98D	0.944
1:32221176:T:C	N64D	0.944
1:32221155:A:C	Y71D	0.942
1:32221197:A:G	Y57H	0.941
1:32216935:C:T	G114D	0.938
1:32221979:C:T	G19D	0.937
1:32221142:A:G	L75S	0.935
1:32221183:A:C	F61L	0.932
1:32221183:A:T	F61L	0.932
1:32221185:A:G	F61L	0.932

dbSNP variants (sampled 300 via entrez): RS1000559671 (1:32222834 C>A,G), RS1000621551 (1:32221435 A>T), RS1000713531 (1:32216362 T>C), RS1000940977 (1:32220165 T>C,G), RS1001605814 (1:32223102 C>T), RS1002415761 (1:32217620 C>A), RS1002479267 (1:32215275 G>A,C), RS1003082877 (1:32218130 G>C), RS1003162909 (1:32219325 T>C), RS1004169343 (1:32215158 GC>G,GCC), RS1004436057 (1:32220733 T>A,C), RS1004657952 (1:32215164 G>A), RS1005013841 (1:32219427 C>G), RS1005249336 (1:32216282 C>G,T), RS1005260110 (1:32216537 G>C,T)

Disease associations

OMIM: gene MIM:620289 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

25 total (human), top 25 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects cotreatment, decreases expression, increases abundance, increases expression	2
Methyl Methanesulfonate	increases expression	2
aristolochic acid I	decreases expression	1
triphenyl phosphate	affects expression	1
manganese chloride	decreases expression, increases abundance, affects cotreatment	1
1-hydroxypyrene	decreases expression	1
2-palmitoylglycerol	increases expression	1
abrine	increases expression	1
jinfukang	affects cotreatment, increases expression	1
Air Pollutants	affects expression, increases abundance	1
Air Pollutants, Occupational	decreases expression	1
Arsenic	increases abundance, affects cotreatment, decreases expression	1
Cisplatin	affects cotreatment, increases expression	1
Doxorubicin	decreases expression	1
Manganese	decreases expression, increases abundance, affects cotreatment	1
Ozone	increases abundance, affects expression	1
Smoke	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Tretinoin	increases expression	1
Valproic Acid	increases methylation	1
Aflatoxin B1	increases methylation	1
Cadmium Chloride	increases expression	1
Copper Sulfate	decreases expression	1
Acrylamide	decreases expression	1
Particulate Matter	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.