TMEM236

Summary

TMEM236 (transmembrane protein 236, HGNC:23473) is a protein-coding gene on chromosome 10p12.33, encoding Transmembrane protein 236 (Q5W0B7).

Predicted to be located in membrane.

Source: NCBI Gene 653567 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 6 total
• MANE Select transcript: NM_001098844

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23473
Approved symbol	TMEM236
Name	transmembrane protein 236
Location	10p12.33
Locus type	gene with protein product
Status	Approved
Aliases	bA16O1.2, bA162I21.2
Ensembl gene	ENSG00000148483
Ensembl biotype	protein_coding
Entrez	653567

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000377495

RefSeq mRNA: 1 — MANE Select: NM_001098844 NM_001098844

CCDS: CCDS41492

Canonical transcript exons

ENST00000377495 — 4 exons

Exon	Start	End
ENSE00002436408	17795921	17800868
ENSE00002437431	17776029	17776170
ENSE00002447119	17771309	17771381
ENSE00002449723	17752201	17752552

Expression profiles

Bgee: expression breadth broad, 89 present calls, max score 88.66.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.7294 / max 175.3422, expressed in 131 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
205750	0.4183	116
205744	0.2538	12
205749	0.0364	14
205745	0.0163	7
205743	0.0046	4

Top tissues by expression

113 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
duodenum	UBERON:0002114	88.66	gold quality
rectum	UBERON:0001052	84.88	gold quality
islet of Langerhans	UBERON:0000006	84.26	gold quality
mucosa of transverse colon	UBERON:0004991	82.75	gold quality
small intestine	UBERON:0002108	75.46	gold quality
transverse colon	UBERON:0001157	75.19	gold quality
small intestine Peyer’s patch	UBERON:0003454	74.74	gold quality
intestine	UBERON:0000160	68.70	gold quality
placenta	UBERON:0001987	66.12	gold quality
colon	UBERON:0001155	65.95	gold quality
colonic epithelium	UBERON:0000397	65.91	silver quality
vermiform appendix	UBERON:0001154	65.48	gold quality
smooth muscle tissue	UBERON:0001135	64.59	gold quality
pancreas	UBERON:0001264	62.77	gold quality
right lung	UBERON:0002167	57.68	gold quality
right adrenal gland cortex	UBERON:0035827	56.87	gold quality
subcutaneous adipose tissue	UBERON:0002190	56.82	gold quality
muscle tissue	UBERON:0002385	56.62	gold quality
upper lobe of left lung	UBERON:0008952	55.23	gold quality
bone marrow cell	CL:0002092	55.20	gold quality
adipose tissue	UBERON:0001013	55.03	gold quality
right adrenal gland	UBERON:0001233	54.59	gold quality
left adrenal gland	UBERON:0001234	54.41	gold quality
skeletal muscle tissue	UBERON:0001134	54.39	silver quality
left adrenal gland cortex	UBERON:0035825	53.70	gold quality
mucosa of stomach	UBERON:0001199	53.68	gold quality
adrenal gland	UBERON:0002369	53.68	gold quality
lung	UBERON:0002048	53.15	gold quality
right coronary artery	UBERON:0001625	52.99	gold quality
gastrocnemius	UBERON:0001388	52.94	gold quality

Single-cell (SCXA)

Detected in 6 experiment(s), a significant marker in 6.

Experiment	Marker?	Max mean expression
E-GEOD-83139	yes	242.13
E-GEOD-81608	yes	206.86
E-ENAD-27	yes	164.24
E-MTAB-5061	yes	32.11
E-GEOD-81547	yes	20.32
E-ANND-3	yes	4.40

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

140 targeting TMEM236, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-3064-3P	100.00	70.09	1254
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-767-5P	99.95	70.85	993
HSA-MIR-9983-3P	99.94	71.48	3631
HSA-MIR-3119	99.92	71.34	2390
HSA-MIR-652-5P	99.91	67.49	505
HSA-MIR-1297	99.91	73.41	3162
HSA-MIR-454-3P	99.91	74.01	1925

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	tmem236	ENSDARG00000075715
mus_musculus	Tmem236	ENSMUSG00000061531
rattus_norvegicus	Tmem236	ENSRNOG00000037982

Protein

Protein identifiers

Transmembrane protein 236 — Q5W0B7 (reviewed: Q5W0B7)

All UniProt accessions (1): Q5W0B7

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

Similarity. Belongs to the TMEM236 family.

RefSeq proteins (1): NP_001092314* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR020394	Uncharacterised_FAM23-like_TM	Family

UniProt features (10 total): transmembrane region 6, chain 1, region of interest 1, compositionally biased region 1, glycosylation site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5W0B7-F1	73.71	0.20

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (1): 193

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 43 (showing top): chr10p12, ZFP91_TARGET_GENES, MIR153_5P, MIR12136, MIR3646, MIR4659A_3P_MIR4659B_3P, MIR95_5P, MIR548AR_3P, MIR548F_3P, MIR548BC, MIR548AZ_3P, MIR548A_3P, MIR4495, MIR548E_3P, MIR944

GO Biological Process (0):

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (1): membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	1
cellular anatomical structure	1

Protein interactions and networks

STRING

300 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TMEM236	TXLNB	Q8N3L3	627
TMEM236	CCDC158	Q5M9N0	531
TMEM236	IQSEC3	Q9UPP2	510
TMEM236	OR13C8	Q8NGS7	504
TMEM236	LRRC14B	A6NHZ5	499
TMEM236	TMEM191B	P0C7N4	476
TMEM236	CALN1	Q9BXU9	471
TMEM236	IGSF5	Q9NSI5	469
TMEM236	RBMS3	Q6XE24	463
TMEM236	ZFYVE26	Q68DK2	459
TMEM236	PRPF6	O94906	448
TMEM236	KCTD16	Q68DU8	448
TMEM236	FAM47B	Q8NA70	444
TMEM236	TTC9	Q92623	437
TMEM236	TMEM179B	Q7Z7N9	435

IntAct

18 interactions, top by confidence:

A	B	Type	Score
OPRM1	TMEM236	psi-mi:“MI:0915”(physical association)	0.560
TMEM236	TMEM179B	psi-mi:“MI:0915”(physical association)	0.560
AQP2	TMEM236	psi-mi:“MI:0915”(physical association)	0.560
TMEM236	GPR152	psi-mi:“MI:0915”(physical association)	0.560
FAM209A	TMEM236	psi-mi:“MI:0915”(physical association)	0.560
TMEM236	SHBG	psi-mi:“MI:0915”(physical association)	0.400
TMEM236	OPRM1	psi-mi:“MI:0915”(physical association)	0.000
TMEM236	AQP2	psi-mi:“MI:0915”(physical association)	0.000
TMEM236	GPR152	psi-mi:“MI:0915”(physical association)	0.000
TMEM236	FAM209A	psi-mi:“MI:0915”(physical association)	0.000
TMEM236	TMEM179B	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (7): SHBG (Affinity Capture-MS), TMEM236 (Two-hybrid), TMEM236 (Two-hybrid), AQP2 (Two-hybrid), GPR152 (Two-hybrid), TMEM179B (Two-hybrid), SHBG (Affinity Capture-MS)

ESM2 similar proteins: A0A0R4IDX9, A0A2C9VBV6, A2ARJ3, A7T1N0, A7Y2X0, A8Y2U2, O12977, O17386, O35119, O70131, O76689, O80739, P31662, P52166, P70617, P79100, Q05005, Q08469, Q0WMJ8, Q3UP23, Q57UM0, Q5JK32, Q5R9C2, Q5W0B7, Q69RI8, Q6H4R6, Q6NPT7, Q6ZUK4, Q75G84, Q84MS3, Q84MS4, Q8BG16, Q8BJI1, Q8MPP0, Q90X07, Q92982, Q94KB1, Q94KB9, Q9FI00, Q9FY75

Diamond homologs: A2ARJ3, A5WVU6, Q05005, Q5W0B7

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

6 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	4
Likely benign	1
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

1259 predictions. Top by Δscore:

Variant	Effect	Δscore
10:17775765:G:GT	donor_gain	1.0000
10:17776166:AAAGA:A	donor_gain	1.0000
10:17776167:AAGA:A	donor_gain	1.0000
10:17776167:AAGAG:A	donor_loss	1.0000
10:17776168:AGA:A	donor_gain	1.0000
10:17776168:AGAGT:A	donor_loss	1.0000
10:17776169:GA:G	donor_gain	1.0000
10:17776169:GAG:G	donor_gain	1.0000
10:17776169:GAGTA:G	donor_loss	1.0000
10:17776171:G:C	donor_loss	1.0000
10:17776171:G:GG	donor_gain	1.0000
10:17776172:TAAG:T	donor_loss	1.0000
10:17752548:GGATG:G	donor_gain	0.9900
10:17752549:GATG:G	donor_gain	0.9900
10:17752549:GATGG:G	donor_gain	0.9900
10:17752550:ATGGT:A	donor_loss	0.9900
10:17752551:TGGTA:T	donor_loss	0.9900
10:17752553:G:C	donor_loss	0.9900
10:17752554:T:G	donor_loss	0.9900
10:17776024:AACAG:A	acceptor_loss	0.9900
10:17776025:ACAGG:A	acceptor_loss	0.9900
10:17776026:CAGG:C	acceptor_loss	0.9900
10:17776027:A:AG	acceptor_gain	0.9900
10:17776028:G:GG	acceptor_gain	0.9900
10:17776159:G:GT	donor_gain	0.9900
10:17776173:AAGT:A	donor_loss	0.9900
10:17778778:C:G	donor_gain	0.9900
10:17795920:GGTA:G	acceptor_gain	0.9900
10:17752551:TG:T	donor_gain	0.9800
10:17752552:GG:G	donor_gain	0.9800

AlphaMissense

2273 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
10:17796265:A:C	S273R	0.996
10:17796267:T:A	S273R	0.996
10:17796267:T:G	S273R	0.996
10:17796416:A:T	K323I	0.994
10:17796181:T:A	W245R	0.992
10:17796181:T:C	W245R	0.992
10:17796417:A:C	K323N	0.992
10:17796417:A:T	K323N	0.992
10:17796420:T:A	N324K	0.991
10:17796420:T:G	N324K	0.991
10:17796241:T:A	W265R	0.989
10:17796241:T:C	W265R	0.989
10:17752491:T:A	W66R	0.988
10:17752491:T:C	W66R	0.988
10:17796349:T:C	F301L	0.988
10:17796351:C:A	F301L	0.988
10:17796351:C:G	F301L	0.988
10:17752390:C:A	A32D	0.985
10:17796362:G:C	R305T	0.985
10:17796188:A:T	D247V	0.983
10:17796187:G:C	D247H	0.982
10:17796206:G:C	R253P	0.982
10:17796448:T:C	F334L	0.982
10:17796450:C:A	F334L	0.982
10:17796450:C:G	F334L	0.982
10:17796347:C:G	P300R	0.981
10:17796188:A:C	D247A	0.980
10:17796363:A:C	R305S	0.980
10:17796363:A:T	R305S	0.980
10:17796200:T:G	M251R	0.979

dbSNP variants (sampled 300 via entrez): RS1000055894 (10:17789676 T>C), RS1000066599 (10:17754347 G>A,T), RS1000114971 (10:17795114 G>A), RS1000120957 (10:17779550 A>C,G), RS1000213065 (10:17764508 A>G), RS1000233896 (10:17794883 C>G), RS1000244423 (10:17764795 C>T), RS1000296887 (10:17800369 T>G), RS1000343465 (10:17789845 C>A,T), RS1000408613 (10:17789426 A>T), RS1000486890 (10:17770063 A>G,T), RS1000541186 (10:17759840 G>T), RS1000600085 (10:17759414 C>G), RS1000610728 (10:17774975 A>G), RS1000641938 (10:17775279 T>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST000583_17	Hematological and biochemical traits	1.000000e-16
GCST007732_14	Allergic disease (asthma, hay fever or eczema)	7.000000e-07

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004736	aspartate aminotransferase measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

15 total (human), top 15 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
aristolochic acid I	increases expression	1
sotorasib	decreases expression, affects cotreatment	1
bisphenol A	decreases expression	1
butyraldehyde	increases expression	1
perfluorooctanoic acid	decreases expression	1
ferrous chloride	increases expression	1
abrine	increases expression	1
trametinib	affects cotreatment, decreases expression	1
NVP-BKM120	affects cotreatment, decreases expression	1
ortho-topolin riboside	affects cotreatment, decreases expression	1
Melatonin	affects cotreatment, decreases expression	1
Thiram	increases expression	1
Aflatoxin B1	increases methylation	1
Okadaic Acid	increases expression	1
Magnetite Nanoparticles	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.