TMEM246-AS1

Summary

TMEM246-AS1 (TMEM246 antisense RNA 1, HGNC:51191) is a long non-coding RNA gene on chromosome 9q31.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51191
Approved symbol	TMEM246-AS1
Name	TMEM246 antisense RNA 1
Location	9q31.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000225376
Ensembl biotype	lncRNA
Entrez	101928470
RNAcentral	URS000075EE24 — lncRNA, 565 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 8 lncRNA

ENST00000424154, ENST00000425734, ENST00000431507, ENST00000450109, ENST00000666720, ENST00000749559, ENST00000749560, ENST00000749561

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000424154 — 3 exons

Exon	Start	End
ENSE00001631559	101468398	101468608
ENSE00001703907	101479840	101479923
ENSE00003858404	101481363	101482199

Expression profiles

Bgee: expression breadth ubiquitous, 124 present calls, max score 87.95.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0903 / max 9.5369, expressed in 50 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
97758	0.0614	38
205585	0.0190	9
97760	0.0080	4
97759	0.0021	2

Top tissues by expression

128 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
quadriceps femoris	UBERON:0001377	87.95	gold quality
cerebellar vermis	UBERON:0004720	85.99	gold quality
corpus callosum	UBERON:0002336	84.37	gold quality
adult mammalian kidney	UBERON:0000082	80.91	gold quality
kidney	UBERON:0002113	78.72	gold quality
bone marrow cell	CL:0002092	73.03	gold quality
bone marrow	UBERON:0002371	73.03	silver quality
skeletal muscle tissue	UBERON:0001134	72.06	silver quality
cortex of kidney	UBERON:0001225	71.17	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	69.14	gold quality
spinal cord	UBERON:0002240	69.12	gold quality
cortical plate	UBERON:0005343	68.86	gold quality
right uterine tube	UBERON:0001302	68.26	gold quality
primary visual cortex	UBERON:0002436	65.76	gold quality
thymus	UBERON:0002370	65.75	silver quality
substantia nigra	UBERON:0002038	65.58	gold quality
hindlimb stylopod muscle	UBERON:0004252	65.40	gold quality
cerebellar hemisphere	UBERON:0002245	64.76	gold quality
right hemisphere of cerebellum	UBERON:0014890	64.75	gold quality
cerebellar cortex	UBERON:0002129	64.71	gold quality
cerebellum	UBERON:0002037	64.63	gold quality
prefrontal cortex	UBERON:0000451	64.10	gold quality
Ammon’s horn	UBERON:0001954	63.47	gold quality
apex of heart	UBERON:0002098	63.47	gold quality
metanephros cortex	UBERON:0010533	63.35	gold quality
adrenal tissue	UBERON:0018303	63.23	gold quality
Brodmann (1909) area 9	UBERON:0013540	61.73	gold quality
frontal cortex	UBERON:0001870	61.24	gold quality
cerebral cortex	UBERON:0000956	60.75	gold quality
ventricular zone	UBERON:0003053	60.36	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.11

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.