TMEM254-AS1

Summary

TMEM254-AS1 (TMEM254 antisense RNA 1, HGNC:27340) is a long non-coding RNA gene on chromosome 10q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27340
Approved symbol	TMEM254-AS1
Name	TMEM254 antisense RNA 1
Location	10q22.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	CPHX
Ensembl gene	ENSG00000230091
Ensembl biotype	lncRNA
Entrez	219347
RNAcentral	URS000075EFB9 — lncRNA, 4059 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 26 — 26 lncRNA

ENST00000412298, ENST00000432070, ENST00000448729, ENST00000797037, ENST00000797038, ENST00000797039, ENST00000797040, ENST00000797041, ENST00000797042, ENST00000797043, ENST00000797044, ENST00000797045, ENST00000797046, ENST00000797047, ENST00000797048, ENST00000797049, ENST00000797050, ENST00000797051, ENST00000797052, ENST00000797053, ENST00000797054, ENST00000797055, ENST00000797056, ENST00000797057, ENST00000797058, ENST00000797059

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000412298 — 6 exons

Exon	Start	End
ENSE00001600604	80053396	80053586
ENSE00001602031	80060790	80060933
ENSE00001628427	80046860	80049178
ENSE00001646470	80056319	80056405
ENSE00001752341	80055916	80056126
ENSE00001764756	80078727	80078895

Expression profiles

Bgee: expression breadth ubiquitous, 159 present calls, max score 84.12.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1405 / max 5.9142, expressed in 70 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
110322	0.0726	25
110321	0.0678	31

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.12	gold quality
bone marrow cell	CL:0002092	77.18	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	75.31	gold quality
buccal mucosa cell	CL:0002336	73.21	silver quality
lower esophagus mucosa	UBERON:0035834	72.05	gold quality
skin of abdomen	UBERON:0001416	71.91	gold quality
endothelial cell	CL:0000115	71.67	gold quality
skin of leg	UBERON:0001511	71.38	gold quality
right uterine tube	UBERON:0001302	71.06	gold quality
zone of skin	UBERON:0000014	69.97	gold quality
ventricular zone	UBERON:0003053	69.46	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	68.69	gold quality
cortical plate	UBERON:0005343	68.42	gold quality
amygdala	UBERON:0001876	68.37	gold quality
nucleus accumbens	UBERON:0001882	68.19	gold quality
spinal cord	UBERON:0002240	68.00	gold quality
anterior cingulate cortex	UBERON:0009835	67.72	gold quality
caudate nucleus	UBERON:0001873	67.60	gold quality
putamen	UBERON:0001874	67.55	gold quality
right adrenal gland cortex	UBERON:0035827	67.39	gold quality
hindlimb stylopod muscle	UBERON:0004252	67.26	gold quality
ganglionic eminence	UBERON:0004023	67.16	gold quality
right testis	UBERON:0004534	66.73	gold quality
sperm	CL:0000019	66.44	gold quality
right frontal lobe	UBERON:0002810	66.26	gold quality
hypothalamus	UBERON:0001898	66.23	gold quality
left testis	UBERON:0004533	66.21	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.18	gold quality
right adrenal gland	UBERON:0001233	66.14	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	65.84	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.27

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.