TMEM265

Summary

TMEM265 (transmembrane protein 265, HGNC:51241) is a protein-coding gene on chromosome 16p11.2, encoding Transmembrane protein 265 (A0A087WTH1).

Predicted to be located in membrane.

Source: NCBI Gene 100862671 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 2 total
• MANE Select transcript: NM_001256829

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51241
Approved symbol	TMEM265
Name	transmembrane protein 265
Location	16p11.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000281991
Ensembl biotype	protein_coding
Entrez	100862671

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000615541

RefSeq mRNA: 1 — MANE Select: NM_001256829 NM_001256829

CCDS: CCDS73870

Canonical transcript exons

ENST00000615541 — 3 exons

Exon	Start	End
ENSE00003741658	30743782	30745196
ENSE00003743789	30741741	30741908
ENSE00003751453	30740642	30740707

Expression profiles

Bgee: expression breadth ubiquitous, 112 present calls, max score 85.68.

FANTOM5 (CAGE): breadth broad, TPM avg 3.4122 / max 121.2574, expressed in 569 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
153718	3.0485	547
153717	0.2048	125
153716	0.1589	98

Top tissues by expression

130 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	85.68	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.57	gold quality
skin of abdomen	UBERON:0001416	79.76	gold quality
esophagus mucosa	UBERON:0002469	79.53	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	78.61	gold quality
zone of skin	UBERON:0000014	78.34	gold quality
skin of leg	UBERON:0001511	77.80	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.58	gold quality
right lung	UBERON:0002167	75.88	gold quality
minor salivary gland	UBERON:0001830	67.75	gold quality
upper lobe of left lung	UBERON:0008952	67.38	gold quality
mucosa of transverse colon	UBERON:0004991	66.64	gold quality
metanephros cortex	UBERON:0010533	66.35	gold quality
saliva-secreting gland	UBERON:0001044	65.35	gold quality
lung	UBERON:0002048	62.70	gold quality
left lobe of thyroid gland	UBERON:0001120	61.47	gold quality
thyroid gland	UBERON:0002046	60.27	gold quality
vagina	UBERON:0000996	58.92	gold quality
esophagus	UBERON:0001043	56.65	gold quality
cerebellar hemisphere	UBERON:0002245	56.26	gold quality
gall bladder	UBERON:0002110	56.18	gold quality
cerebellum	UBERON:0002037	55.25	gold quality
cerebellar cortex	UBERON:0002129	55.13	gold quality
right hemisphere of cerebellum	UBERON:0014890	53.38	gold quality
right lobe of thyroid gland	UBERON:0001119	53.32	gold quality
transverse colon	UBERON:0001157	49.61	gold quality
adenohypophysis	UBERON:0002196	48.71	gold quality
adult mammalian kidney	UBERON:0000082	47.25	gold quality
right uterine tube	UBERON:0001302	47.06	gold quality
islet of Langerhans	UBERON:0000006	46.82	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

78 targeting TMEM265, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3134	100.00	66.43	777
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-3185	99.99	68.12	1959
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-1297	99.91	73.41	3162
HSA-MIR-106A-5P	99.90	73.94	2683
HSA-MIR-17-5P	99.89	73.83	2665
HSA-MIR-106B-5P	99.88	74.72	2795
HSA-MIR-20A-5P	99.88	74.76	2769
HSA-MIR-6780A-5P	99.88	66.69	2776
HSA-MIR-20B-5P	99.88	74.01	2621
HSA-MIR-519D-3P	99.88	73.97	2607
HSA-MIR-526B-3P	99.88	74.06	2587
HSA-MIR-93-5P	99.88	73.98	2606
HSA-MIR-10395-5P	99.86	67.35	676
HSA-MIR-765	99.84	68.24	2442
HSA-MIR-6875-3P	99.82	70.26	2983
HSA-MIR-26A-5P	99.78	73.52	2303
HSA-MIR-26B-5P	99.78	73.51	2305
HSA-MIR-577	99.78	69.13	2479
HSA-MIR-1273H-5P	99.77	66.32	2471
HSA-MIR-11181-3P	99.75	66.38	2205
HSA-MIR-556-3P	99.74	68.75	1203
HSA-MIR-4465	99.71	72.56	2096
HSA-MIR-30B-3P	99.70	65.76	2325
HSA-MIR-3689A-3P	99.70	65.73	2306
HSA-MIR-3689B-3P	99.70	65.71	2311
HSA-MIR-3689C	99.70	65.71	2311

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Transmembrane protein 265 — A0A087WTH1 (reviewed: A0A087WTH1)

All UniProt accessions (1): A0A087WTH1

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

Similarity. Belongs to the CD225/Dispanin family.

RefSeq proteins (1): NP_001243758* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR007593	CD225/Dispanin_fam	Family

Pfam: PF04505

UniProt features (3 total): transmembrane region 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A0A087WTH1-F1	71.12	0.06

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 57 (showing top): ENK_UV_RESPONSE_KERATINOCYTE_UP, BROWNE_HCMV_INFECTION_12HR_UP, BROWNE_HCMV_INFECTION_24HR_UP, BLALOCK_ALZHEIMERS_DISEASE_UP, chr16p11, FOURNIER_ACINAR_DEVELOPMENT_EARLY_UP, ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP, PHONG_TNF_RESPONSE_NOT_VIA_P38, PBXIP1_TARGET_GENES, MIR1297, MIR106B_5P, MIR20A_5P, MIR106A_5P, MIR17_5P, MIR20B_5P

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (1): membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	1

Protein interactions and networks

STRING

64 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TMEM265	GLB1L	Q6UWU2	696
TMEM265	A0A087WTJ2	A0A087WTJ2	621
TMEM265	MLF1	P58340	506
TMEM265	CES4A	Q5XG92	477
TMEM265	SIRPB1	O00241	390
TMEM265	NUP160	Q12769	360
TMEM265	TCN2	P20062	349
TMEM265	U2AF1	Q01081	348
TMEM265	MTHFD1L	Q6UB35	348
TMEM265	MYL11	Q96A32	336
TMEM265	DTL	Q9NZJ0	314
TMEM265	PSMA2	P25787	160
TMEM265	CASP6	P55212	0
TMEM265	MALL	Q13021	0
TMEM265	OVOL2	Q9BRP0	0
TMEM265	DTX3L	Q8TDB6	0
TMEM265	SCEL	O95171	0
TMEM265	SH3D19	Q5HYK7	0

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A087WTH1, A0A125YWU9, A0PK84, A6PVL3, C9JQL5, F1QHM7, F1QX91, O15503, O41933, O70418, O88728, P0DI73, P13164, P26376, Q01628, Q01629, Q08755, Q0II74, Q21642, Q32L65, Q3UNB8, Q3YBM2, Q5FVR1, Q5FWL7, Q5I0I2, Q5R8D6, Q5RF75, Q5Y5T3, Q6DHI1, Q76IC6, Q7M734, Q7TQJ1, Q8BGI3, Q8CES1, Q8CFA6, Q8IYP9, Q8N6L7, Q8WVZ1, Q91WU6, Q921C1

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

2 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

173 predictions. Top by Δscore:

Variant	Effect	Δscore
16:30741736:CACAG:C	acceptor_loss	1.0000
16:30741739:A:AG	acceptor_gain	1.0000
16:30741739:AGGT:A	acceptor_gain	1.0000
16:30741740:G:GG	acceptor_gain	1.0000
16:30741740:GGT:G	acceptor_gain	1.0000
16:30741740:GGTG:G	acceptor_gain	1.0000
16:30741905:CAAGG:C	donor_loss	1.0000
16:30741906:AAGG:A	donor_loss	1.0000
16:30741907:AGGTG:A	donor_loss	1.0000
16:30741908:GGTG:G	donor_loss	1.0000
16:30741909:G:T	donor_loss	1.0000
16:30744317:T:A	acceptor_gain	1.0000
16:30744318:G:A	acceptor_gain	1.0000
16:30741732:C:A	acceptor_gain	0.9900
16:30741739:AG:A	acceptor_gain	0.9900
16:30741740:G:GT	acceptor_gain	0.9900
16:30741740:GG:G	acceptor_gain	0.9900
16:30741740:GGTGA:G	acceptor_gain	0.9900
16:30741786:G:GT	donor_gain	0.9900
16:30741879:G:GT	donor_gain	0.9900
16:30741909:G:GG	donor_gain	0.9900
16:30743776:CCACA:C	acceptor_loss	0.9900
16:30743777:CACAG:C	acceptor_loss	0.9900
16:30743779:CAGGC:C	acceptor_loss	0.9900
16:30743780:A:AC	acceptor_loss	0.9900
16:30743780:A:AG	acceptor_gain	0.9900
16:30743780:AGGC:A	acceptor_gain	0.9900
16:30743781:G:GC	acceptor_loss	0.9900
16:30743781:G:GG	acceptor_gain	0.9900
16:30743781:G:GT	acceptor_loss	0.9900

AlphaMissense

682 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:30741852:A:C	S37R	0.986
16:30741854:C:A	S37R	0.986
16:30741854:C:G	S37R	0.986
16:30743860:A:C	S82R	0.986
16:30743862:C:A	S82R	0.986
16:30743862:C:G	S82R	0.986
16:30743872:T:A	W86R	0.963
16:30743872:T:C	W86R	0.963
16:30741867:T:C	C42R	0.942
16:30741879:G:A	G46R	0.936
16:30741879:G:C	G46R	0.936
16:30741908:G:C	K55N	0.934
16:30741908:G:T	K55N	0.934
16:30741865:G:A	G41D	0.929
16:30741873:T:C	C44R	0.925
16:30741900:G:C	A53P	0.925
16:30743782:G:C	A56P	0.924
16:30741897:T:C	F52L	0.918
16:30741899:T:A	F52L	0.918
16:30741899:T:G	F52L	0.918
16:30741861:T:C	C40R	0.916
16:30741859:T:A	I39N	0.913
16:30741880:G:A	G46E	0.911
16:30743861:G:A	S82N	0.910
16:30741853:G:A	S37N	0.908
16:30741864:G:C	G41R	0.901
16:30743893:G:C	G93R	0.878
16:30741889:C:A	A49D	0.876
16:30743792:G:C	R59P	0.875
16:30741844:C:A	A34E	0.871

dbSNP variants (sampled 300 via entrez): RS1000934588 (16:30743812 G>A), RS1000965796 (16:30744080 G>A,C), RS1001305949 (16:30740134 C>T), RS1002214469 (16:30745069 C>G,T), RS1002355551 (16:30739004 T>C), RS1002948620 (16:30741180 T>G), RS1003132125 (16:30739097 C>T), RS1003426032 (16:30738861 C>T), RS1003588420 (16:30740029 A>C,G), RS1004191675 (16:30741876 C>G), RS1005868765 (16:30743129 G>A), RS1006251562 (16:30741973 T>A), RS1007028839 (16:30743450 T>G), RS1007182750 (16:30740938 G>A), RS1007871939 (16:30740552 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
dicrotophos	increases expression	1
abrine	increases expression	1
Cadmium	decreases expression, increases abundance	1
Urethane	increases expression	1
Cadmium Chloride	decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.