TMEM267

Summary

TMEM267 (transmembrane protein 267, HGNC:26139) is a protein-coding gene on chromosome 5p12, encoding Transmembrane protein 267 (Q0VDI3).

Predicted to be located in membrane.

Source: NCBI Gene 64417 — RefSeq curated summary.

At a glance

• GWAS associations: 6
• Clinical variants (ClinVar): 1 total
• MANE Select transcript: NM_022483

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26139
Approved symbol	TMEM267
Name	transmembrane protein 267
Location	5p12
Locus type	gene with protein product
Status	Approved
Aliases	FLJ21657
Ensembl gene	ENSG00000151881
Ensembl biotype	protein_coding
Entrez	64417

Gene structure

Transcript identifiers

Ensembl transcripts: 42 — 41 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000397080, ENST00000500337, ENST00000506860, ENST00000510130, ENST00000511525, ENST00000512085, ENST00000890975, ENST00000890976, ENST00000890977, ENST00000890978, ENST00000890979, ENST00000890980, ENST00000890981, ENST00000890982, ENST00000890983, ENST00000890984, ENST00000890985, ENST00000890986, ENST00000890987, ENST00000890988, ENST00000890989, ENST00000890990, ENST00000890991, ENST00000890992, ENST00000890993, ENST00000890994, ENST00000916718, ENST00000916719, ENST00000916720, ENST00000916721, ENST00000916722, ENST00000961962, ENST00000961963, ENST00000961964, ENST00000961965, ENST00000961966, ENST00000961967, ENST00000961968, ENST00000961969, ENST00000961970, ENST00000961971, ENST00000961972

RefSeq mRNA: 11 — MANE Select: NM_022483 NM_001377394, NM_001377395, NM_001377396, NM_001377397, NM_001377398, NM_001377399, NM_001377400, NM_001377401, NM_001377402, NM_001377403, NM_022483

CCDS: CCDS3945

Canonical transcript exons

ENST00000397080 — 3 exons

Exon	Start	End
ENSE00001307550	43453658	43454043
ENSE00001971576	43444252	43446557
ENSE00002071042	43483822	43483865

Expression profiles

Bgee: expression breadth ubiquitous, 239 present calls, max score 87.74.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 12.1035 / max 92.0208, expressed in 1775 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
61564	10.0510	1746
61565	2.0525	964

Top tissues by expression

276 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
islet of Langerhans	UBERON:0000006	87.74	gold quality
thyroid gland	UBERON:0002046	86.77	gold quality
left lobe of thyroid gland	UBERON:0001120	86.71	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.57	gold quality
right lobe of thyroid gland	UBERON:0001119	85.93	gold quality
choroid plexus epithelium	UBERON:0003911	83.86	gold quality
stromal cell of endometrium	CL:0002255	83.72	gold quality
rectum	UBERON:0001052	82.33	gold quality
calcaneal tendon	UBERON:0003701	82.16	gold quality
tibial artery	UBERON:0007610	82.16	gold quality
popliteal artery	UBERON:0002250	82.15	gold quality
cauda epididymis	UBERON:0004360	82.05	gold quality
palpebral conjunctiva	UBERON:0001812	81.79	gold quality
pancreas	UBERON:0001264	81.68	gold quality
corpus epididymis	UBERON:0004359	81.65	gold quality
right coronary artery	UBERON:0001625	81.44	gold quality
caput epididymis	UBERON:0004358	80.99	gold quality
mucosa of sigmoid colon	UBERON:0004993	80.91	gold quality
aorta	UBERON:0000947	80.88	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.87	gold quality
bronchial epithelial cell	CL:0002328	80.74	gold quality
monocyte	CL:0000576	80.32	gold quality
leukocyte	CL:0000738	80.19	gold quality
mononuclear cell	CL:0000842	80.17	gold quality
left coronary artery	UBERON:0001626	80.11	gold quality
minor salivary gland	UBERON:0001830	79.99	gold quality
ventricular zone	UBERON:0003053	79.93	gold quality
endometrium	UBERON:0001295	79.86	gold quality
body of pancreas	UBERON:0001150	79.79	gold quality
pigmented layer of retina	UBERON:0001782	79.76	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.78

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

103 targeting TMEM267, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-3163	100.00	77.23	8605
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-4425	100.00	67.59	1049
HSA-MIR-3064-3P	100.00	70.09	1254
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-32-5P	99.98	75.21	1964
HSA-MIR-92A-3P	99.98	75.21	1960
HSA-MIR-92B-3P	99.98	75.25	1955
HSA-MIR-25-3P	99.98	74.60	1817
HSA-MIR-363-3P	99.98	74.72	1821
HSA-MIR-367-3P	99.98	74.83	1819
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-4666A-3P	99.96	71.71	3434

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	tmem267	ENSDARG00000000142
mus_musculus	Tmem267	ENSMUSG00000074634
rattus_norvegicus	Tmem267	ENSRNOG00000064070
drosophila_melanogaster	CG10866	FBGN0035475

Protein

Protein identifiers

Transmembrane protein 267 — Q0VDI3 (reviewed: Q0VDI3)

All UniProt accessions (3): Q0VDI3, D6RAV6, E9PBX6

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

RefSeq proteins (11): NP_001364323, NP_001364324, NP_001364325, NP_001364326, NP_001364327, NP_001364328, NP_001364329, NP_001364330, NP_001364331, NP_001364332, NP_071928* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR026572	TMEM267	Family

UniProt features (5 total): transmembrane region 3, chain 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q0VDI3-F1	89.78	0.74

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 88 (showing top): MODULE_205, CADWELL_ATG16L1_TARGETS_DN, COATES_MACROPHAGE_M1_VS_M2_DN, MOREAUX_MULTIPLE_MYELOMA_BY_TACI_DN, KIM_WT1_TARGETS_DN, LU_EZH2_TARGETS_DN, JOHNSTONE_PARVB_TARGETS_3_DN, TERAO_AOX4_TARGETS_SKIN_DN, SNF5_DN.V1_UP, CHAF1B_TARGET_GENES, CREB3L4_TARGET_GENES, DLX4_TARGET_GENES, DLX6_TARGET_GENES, DMRT1_TARGET_GENES, HHEX_TARGET_GENES

GO Biological Process (0):

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (1): membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	1
cellular anatomical structure	1

Protein interactions and networks

STRING

474 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TMEM267	PAIP1	Q9H074	608
TMEM267	WDR70	Q9NW82	570
TMEM267	PRXL2C	Q7RTV5	517
TMEM267	LMBRD2	Q68DH5	470
TMEM267	HDHD2	Q9H0R4	457
TMEM267	C5orf34	Q96MH7	430
TMEM267	BRIX1	Q8TDN6	411
TMEM267	C5orf22	Q49AR2	397
TMEM267	NADK2	Q4G0N4	385
TMEM267	LRRC24	Q50LG9	381
TMEM267	SPATC1	Q76KD6	375
TMEM267	SLC15A5	A6NIM6	371
TMEM267	LRRC14	Q15048	363
TMEM267	SLC33A2	Q96ES6	363
TMEM267	ADCK5	Q3MIX3	349

IntAct

23 interactions, top by confidence:

A	B	Type	Score
TMEM267	CPLX4	psi-mi:“MI:0915”(physical association)	0.560
TMEM267	TMEM52B	psi-mi:“MI:0915”(physical association)	0.560
TMEM267	TMEM14B	psi-mi:“MI:0915”(physical association)	0.560
TMEM267	RTP2	psi-mi:“MI:0915”(physical association)	0.560
STX7	TMEM267	psi-mi:“MI:0915”(physical association)	0.560
TMEM267	SAR1A	psi-mi:“MI:0915”(physical association)	0.560
TMEM267	ECPAS	psi-mi:“MI:0914”(association)	0.530
ATG16L1	ESYT2	psi-mi:“MI:0914”(association)	0.350
TMEM267	ACTA2	psi-mi:“MI:0914”(association)	0.350
TMEM267	TMEM52B	psi-mi:“MI:0915”(physical association)	0.000
TMEM267	TMEM14B	psi-mi:“MI:0915”(physical association)	0.000
RTP2	TMEM267	psi-mi:“MI:0915”(physical association)	0.000
STX7	TMEM267	psi-mi:“MI:0915”(physical association)	0.000
TMEM267	SAR1A	psi-mi:“MI:0915”(physical association)	0.000
TMEM267	CPLX4	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (17): C5orf28 (Affinity Capture-MS), LNPEP (Affinity Capture-MS), KIAA0368 (Affinity Capture-MS), PTGES2 (Affinity Capture-MS), C5orf28 (Two-hybrid), C5orf28 (Two-hybrid), C5orf28 (Two-hybrid), C5orf28 (Two-hybrid), TMEM52B (Two-hybrid), CPLX4 (Two-hybrid), RTP2 (Two-hybrid), C5orf28 (Affinity Capture-RNA), KIAA0368 (Affinity Capture-MS), LNPEP (Affinity Capture-MS), ACTA2 (Affinity Capture-MS)

ESM2 similar proteins: A0A1B0GVZ9, A4IFN5, A5PK40, A6NH52, A6NI61, B2LYG4, B2RZC9, B6ID01, D2HKB0, D3ZG27, P86229, Q0VDI3, Q15012, Q15546, Q17QJ2, Q1RLT2, Q2TA01, Q4R4I5, Q4R6E8, Q5H8A4, Q5R7Q1, Q5RAH0, Q5RL79, Q5U3C3, Q5VTY9, Q5ZML7, Q64232, Q6PHN7, Q6QRN8, Q719N3, Q71SV0, Q8BWB6, Q8IY49, Q8N6M3, Q8NFT2, Q8R189, Q8VD53, Q8VDI9, Q8VDR5, Q9CQC4

Diamond homologs: Q0VDI3, Q17QJ2, Q6DC75, Q6DED9, Q8VDR5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

1 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

938 predictions. Top by Δscore:

Variant	Effect	Δscore
5:43454493:T:C	donor_gain	0.9900
5:43454531:T:TA	donor_gain	0.9900
5:43454536:T:A	donor_gain	0.9800
5:43457001:A:C	acceptor_gain	0.9700
5:43483438:CAA:C	donor_gain	0.9700
5:43479864:C:CT	acceptor_gain	0.9500
5:43483436:TACA:T	donor_gain	0.9500
5:43483437:ACAA:A	donor_gain	0.9500
5:43483438:CAAC:C	donor_gain	0.9500
5:43481807:C:T	acceptor_gain	0.9400
5:43483439:A:AT	donor_gain	0.9400
5:43446554:CAGC:C	acceptor_gain	0.9300
5:43446558:C:CC	acceptor_gain	0.9200
5:43483820:ACC:A	donor_gain	0.9100
5:43483821:CCC:C	donor_gain	0.9100
5:43483736:T:TA	donor_gain	0.9000
5:43483820:AC:A	donor_gain	0.8900
5:43483821:CC:C	donor_gain	0.8900
5:43481807:C:CT	acceptor_gain	0.8600
5:43483787:C:A	donor_gain	0.8600
5:43480091:G:C	donor_gain	0.8400
5:43483814:ATAC:A	donor_loss	0.8300
5:43483816:ACCC:A	donor_loss	0.8300
5:43483818:CCACC:C	donor_loss	0.8300
5:43483819:CA:C	donor_loss	0.8300
5:43483820:A:AG	donor_loss	0.8300
5:43483821:C:CG	donor_loss	0.8300
5:43483815:TAC:T	donor_loss	0.8200
5:43457001:A:AC	acceptor_gain	0.8000
5:43483304:T:TA	donor_gain	0.8000

AlphaMissense

1392 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:43446397:C:G	R158P	0.990
5:43453783:A:G	W63R	0.990
5:43453783:A:T	W63R	0.990
5:43446407:G:C	H155D	0.989
5:43453777:A:G	W65R	0.987
5:43453777:A:T	W65R	0.987
5:43446524:G:C	H116D	0.986
5:43446394:T:A	D159V	0.985
5:43453698:T:A	D91V	0.982
5:43446393:A:C	D159E	0.981
5:43446393:A:T	D159E	0.981
5:43446395:C:G	D159H	0.981
5:43446405:A:C	H155Q	0.981
5:43446405:A:T	H155Q	0.981
5:43453719:C:T	G84E	0.981
5:43446394:T:G	D159A	0.980
5:43453697:A:C	D91E	0.980
5:43453697:A:T	D91E	0.980
5:43453720:C:G	G84R	0.980
5:43453720:C:T	G84R	0.980
5:43446416:A:G	W152R	0.979
5:43446416:A:T	W152R	0.979
5:43453692:T:A	D93V	0.979
5:43453788:C:T	G61D	0.978
5:43453801:G:C	H57D	0.976
5:43453808:A:C	N54K	0.976
5:43453808:A:T	N54K	0.976
5:43453688:G:C	H94Q	0.975
5:43453688:G:T	H94Q	0.975
5:43453698:T:G	D91A	0.975

dbSNP variants (sampled 300 via entrez): RS1000004093 (5:43447999 T>G), RS1000066304 (5:43486038 C>G), RS1000131860 (5:43444850 T>C), RS1000159651 (5:43454359 G>A), RS1000201060 (5:43456755 G>T), RS1000263726 (5:43447622 C>T), RS1000311257 (5:43460354 C>T), RS1000377674 (5:43478753 T>C,G), RS1000414316 (5:43463316 A>G), RS1000550329 (5:43463082 T>C,G), RS1000663867 (5:43457590 A>G), RS1000750983 (5:43474113 C>A,T), RS1000795894 (5:43486232 G>A), RS1000845432 (5:43481680 C>T), RS1000867403 (5:43454031 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

6 associations (top):

Study	Trait	p-value
GCST003265_377	Post bronchodilator FEV1/FVC ratio in COPD	2.000000e-06
GCST003265_378	Post bronchodilator FEV1/FVC ratio in COPD	2.000000e-06
GCST003265_379	Post bronchodilator FEV1/FVC ratio in COPD	2.000000e-06
GCST003265_394	Post bronchodilator FEV1/FVC ratio in COPD	2.000000e-06
GCST003265_395	Post bronchodilator FEV1/FVC ratio in COPD	2.000000e-06
GCST003265_396	Post bronchodilator FEV1/FVC ratio in COPD	2.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004713	FEV/FVC ratio

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

33 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression, affects expression	7
Cyclosporine	increases expression	3
sodium arsenite	affects cotreatment, increases abundance, increases expression, decreases expression	2
methylmercuric chloride	decreases expression	1
cobaltous chloride	decreases expression	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
aflatoxin B2	increases methylation	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluoro-n-nonanoic acid	increases expression	1
entinostat	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
jinfukang	decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Irinotecan	decreases expression	1
Sunitinib	increases expression	1
Zoledronic Acid	increases expression	1
Arsenic Trioxide	increases expression	1
Acetaminophen	decreases expression	1
Arsenic	affects cotreatment, increases abundance, increases expression, decreases expression	1
Hexachlorocyclohexane	increases expression	1
Benzo(a)pyrene	decreases expression	1
Cyclophosphamide	decreases expression	1
Formaldehyde	increases expression	1
Tobacco Smoke Pollution	increases expression	1
Tretinoin	decreases expression	1
Vincristine	increases expression	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.