TMEM39A

Summary

TMEM39A (transmembrane protein 39A, HGNC:25600) is a protein-coding gene on chromosome 3q13.33, encoding Transmembrane protein 39A (Q9NV64). Regulates autophagy by controlling the spatial distribution and levels of the intracellular phosphatidylinositol 4-phosphate (PtdIns(4)P) pools.

Involved in negative regulation of autophagosome assembly; negative regulation of autophagosome maturation; and positive regulation of viral genome replication. Located in endoplasmic reticulum membrane.

Source: NCBI Gene 55254 — RefSeq curated summary.

At a glance

• GWAS associations: 5
• Clinical variants (ClinVar): 55 total
• MANE Select transcript: NM_018266

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25600
Approved symbol	TMEM39A
Name	transmembrane protein 39A
Location	3q13.33
Locus type	gene with protein product
Status	Approved
Aliases	FLJ10902, SUSR2
Ensembl gene	ENSG00000176142
Ensembl biotype	protein_coding
Entrez	55254

Gene structure

Transcript identifiers

Ensembl transcripts: 24 — 17 protein_coding, 3 nonsense_mediated_decay, 2 retained_intron, 2 protein_coding_CDS_not_defined

ENST00000319172, ENST00000438581, ENST00000461654, ENST00000468545, ENST00000468676, ENST00000473684, ENST00000482162, ENST00000486159, ENST00000486235, ENST00000490099, ENST00000491685, ENST00000497993, ENST00000884856, ENST00000884857, ENST00000884858, ENST00000884859, ENST00000884860, ENST00000924820, ENST00000924821, ENST00000924822, ENST00000924823, ENST00000955953, ENST00000955954, ENST00000955955

RefSeq mRNA: 1 — MANE Select: NM_018266 NM_018266

CCDS: CCDS2987

Canonical transcript exons

ENST00000319172 — 9 exons

Exon	Start	End
ENSE00001857038	119463336	119463615
ENSE00003472202	119436791	119436978
ENSE00003560311	119437755	119438103
ENSE00003577939	119428949	119432214
ENSE00003581208	119434762	119434882
ENSE00003630088	119461962	119462148
ENSE00003784324	119447018	119447172
ENSE00003785531	119452447	119452530
ENSE00003789003	119458018	119458240

Expression profiles

Bgee: expression breadth ubiquitous, 255 present calls, max score 96.33.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 34.5272 / max 450.1498, expressed in 1820 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
43983	32.7496	1813
43985	0.6041	276
43984	0.4368	193
43988	0.3139	99
43986	0.2554	49
43987	0.0905	30
43982	0.0769	27

Top tissues by expression

275 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stromal cell of endometrium	CL:0002255	96.33	gold quality
body of pancreas	UBERON:0001150	95.82	gold quality
tibia	UBERON:0000979	93.51	gold quality
pancreas	UBERON:0001264	92.79	gold quality
right lung	UBERON:0002167	92.10	gold quality
calcaneal tendon	UBERON:0003701	92.07	gold quality
upper lobe of left lung	UBERON:0008952	91.79	gold quality
right lobe of thyroid gland	UBERON:0001119	91.66	gold quality
left lobe of thyroid gland	UBERON:0001120	91.62	gold quality
colonic epithelium	UBERON:0000397	91.26	gold quality
cartilage tissue	UBERON:0002418	91.26	gold quality
endocervix	UBERON:0000458	91.00	gold quality
upper lobe of lung	UBERON:0008948	90.99	gold quality
thyroid gland	UBERON:0002046	90.78	gold quality
gall bladder	UBERON:0002110	90.57	gold quality
tibial nerve	UBERON:0001323	90.43	gold quality
adenohypophysis	UBERON:0002196	90.39	gold quality
minor salivary gland	UBERON:0001830	90.37	gold quality
pituitary gland	UBERON:0000007	90.31	gold quality
body of uterus	UBERON:0009853	90.19	gold quality
right ovary	UBERON:0002118	90.15	gold quality
omental fat pad	UBERON:0010414	89.78	gold quality
peritoneum	UBERON:0002358	89.76	gold quality
adrenal tissue	UBERON:0018303	89.66	gold quality
monocyte	CL:0000576	89.62	gold quality
saliva-secreting gland	UBERON:0001044	89.60	gold quality
left ovary	UBERON:0002119	89.59	gold quality
right atrium auricular region	UBERON:0006631	89.53	gold quality
islet of Langerhans	UBERON:0000006	89.42	gold quality
mononuclear cell	CL:0000842	89.40	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

112 targeting TMEM39A, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-340-5P	100.00	72.50	4437
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-12118	100.00	65.88	1270
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-4682	100.00	68.89	1258
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-513B-5P	99.99	69.96	2150
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-3173-3P	99.98	66.49	1217
HSA-MIR-6891-5P	99.98	66.53	1372
HSA-MIR-4803	99.98	71.99	3117
HSA-MIR-3692-3P	99.98	70.27	2139
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-128-3P	99.95	71.17	2484
HSA-MIR-216A-3P	99.95	71.19	2505
HSA-MIR-1236-3P	99.94	68.04	1695
HSA-MIR-4778-3P	99.93	70.40	1818
HSA-MIR-381-3P	99.93	71.87	2854
HSA-MIR-1-3P	99.93	72.35	1914

Literature-anchored findings (GeneRIF, showing 6)

• Comprehensive follow-up of the first genome-wide association study of multiple sclerosis identifies TMEM39A as susceptibility (PMID:20007504)
• Pooled analysis corroborated the effect on multiple sclerosis predisposition of three genes: TMEM39A, IL12B, and CBLB (PMID:22194214)
• Four additional susceptibility loci (IRF8, TMEM39A, IKZF3, and ZPBP2) for systemic lupus erythematosus were robustly established a multiethnic population (European, African American, Asian, Hispanic, Gullah, and Amerindian). (PMID:22464253)
• Findings identified three novel associations in SNPs located in the TMEM39A gene associated with systemic lupus erythematous susceptibility in a Chinese Han population. (PMID:28427360)
• TMEM39A mRNA expression may be associated with the development and/or course of multiple sclerosis. rs1132200 and rs17281647 were not associated with multiple sclerosis. (PMID:28444502)
• Polymorphisms of the TMEM39A gene are associated with the susceptibility to Autoimmune Thyroid diseases (AITD), especially for early-onset AITD and Hashimoto thyroiditis with hypothyroidism. (PMID:31553233)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	tmem39a	ENSDARG00000102746
mus_musculus	Tmem39a	ENSMUSG00000002845
rattus_norvegicus	Tmem39a	ENSRNOG00000003075
drosophila_melanogaster	CG13016	FBGN0033899
caenorhabditis_elegans	tmem-39	WBGENE00017003

Paralogs (1): TMEM39B (ENSG00000121775)

Protein

Protein identifiers

Transmembrane protein 39A — Q9NV64 (reviewed: Q9NV64)

All UniProt accessions (7): Q9NV64, C9IYN1, C9JUZ6, C9JYN8, C9K0C7, F8WAU1, H7C5P7

UniProt curated annotations — full annotation on UniProt →

Function. Regulates autophagy by controlling the spatial distribution and levels of the intracellular phosphatidylinositol 4-phosphate (PtdIns(4)P) pools. Modulates (PtdIns(4)P) levels by regulating the ER-to-Golgi trafficking of the phosphatidylinositide phosphatase SACM1L. (Microbial infection) Positively regulates the replication of encephalomyocarditis virus (EMCV) via autophagy-dependent pathway.

Subunit / interactions. Interacts with SACM1L, SEC23A and SEC24A. (Microbial infection) Interacts with encephalomyocarditis virus (EMCV) major capsid proteins VP1 and VP2.

Subcellular location. Endoplasmic reticulum membrane.

Tissue specificity. Up-regulated in brain tumor glioblastoma multiforme cells (at protein level).

Similarity. Belongs to the TMEM39 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9NV64-1	1	yes
Q9NV64-2	2

RefSeq proteins (1): NP_060736* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR019397	Uncharacterised_TMEM39	Family

Pfam: PF10271

UniProt features (16 total): transmembrane region 8, glycosylation site 2, splice variant 2, sequence variant 2, chain 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NV64-F1	74.80	0.30

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (2): 39, 31

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 242 (showing top): ATF_B, GOBP_REGULATION_OF_AUTOPHAGY, TGCGCANK_UNKNOWN, GOBP_VACUOLE_ORGANIZATION, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN, GOBP_POSITIVE_REGULATION_OF_VIRAL_GENOME_REPLICATION, GOBP_REGULATION_OF_VACUOLE_ORGANIZATION, GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, GOBP_NEGATIVE_REGULATION_OF_ORGANELLE_ASSEMBLY, GOBP_MACROAUTOPHAGY, GOBP_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION, CREB_Q4, GOBP_NEGATIVE_REGULATION_OF_AUTOPHAGY, GOBP_REGULATION_OF_CATABOLIC_PROCESS

GO Biological Process (4): autophagy (GO:0006914), positive regulation of viral genome replication (GO:0045070), negative regulation of autophagosome maturation (GO:1901097), negative regulation of autophagosome assembly (GO:1902902)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (3): endoplasmic reticulum membrane (GO:0005789), endoplasmic reticulum (GO:0005783), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
negative regulation of macroautophagy	2
catabolic process	1
transmembrane transport	1
process utilizing autophagic mechanism	1
viral genome replication	1
regulation of viral genome replication	1
positive regulation of viral process	1
negative regulation of protein-containing complex disassembly	1
autophagosome maturation	1
regulation of autophagosome maturation	1
autophagosome assembly	1
negative regulation of organelle assembly	1
regulation of autophagosome assembly	1
binding	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
cytoplasm	1
endomembrane system	1
intracellular membrane-bounded organelle	1
cellular anatomical structure	1

Protein interactions and networks

STRING

538 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TMEM39A	CLEC16A	Q2KHT3	527
TMEM39A	ARHGAP31	Q2M1Z3	520
TMEM39A	SEC24B	O95487	518
TMEM39A	TIMMDC1	Q9NPL8	507
TMEM39A	CHRNA9	Q9UGM1	466
TMEM39A	KIF21B	O75037	442
TMEM39A	IQCJ	Q1A5X6	419
TMEM39A	POU2AF2	Q8IXP5	400
TMEM39A	EVI5	O60447	399
TMEM39A	ZPBP2	Q6X784	399
TMEM39A	MACIR	Q96GV9	398
TMEM39A	POGLUT1	Q8NBL1	397
TMEM39A	EXOC3L4	Q17RC7	391
TMEM39A	TMEM25	Q86YD3	389
TMEM39A	CFAP263	Q9H0I3	367
TMEM39A	OR8D4	Q8NGM9	367

IntAct

64 interactions, top by confidence:

A	B	Type	Score
GABRE	FZD6	psi-mi:“MI:0914”(association)	0.530
ZNRF4	UPK3BL1	psi-mi:“MI:0914”(association)	0.530
ZACN	GPAA1	psi-mi:“MI:0914”(association)	0.530
TCTN2	TPST2	psi-mi:“MI:0914”(association)	0.530
GAA	B3GAT3	psi-mi:“MI:0914”(association)	0.530
TM2D2	TMEM97	psi-mi:“MI:0914”(association)	0.530
IL9R	RETSAT	psi-mi:“MI:0914”(association)	0.530
FBXO2	TMEM131L	psi-mi:“MI:0914”(association)	0.530
LRRTM1	UPK3BL1	psi-mi:“MI:0914”(association)	0.530
CHRNA9	CHEK1	psi-mi:“MI:0914”(association)	0.530
B4GAT1	ADCY6	psi-mi:“MI:0914”(association)	0.530
CHRND	TPST2	psi-mi:“MI:0914”(association)	0.530
ADAM21	PLXNA2	psi-mi:“MI:0914”(association)	0.530
FKBP2	TTC13	psi-mi:“MI:0914”(association)	0.530
TMEM39A	rep	psi-mi:“MI:0915”(physical association)	0.370
UPK1A	TMEM223	psi-mi:“MI:0914”(association)	0.350
LRRTM1	TMEM223	psi-mi:“MI:0914”(association)	0.350
HTR3C	TMEM223	psi-mi:“MI:0914”(association)	0.350
PCDHA4	TMEM223	psi-mi:“MI:0914”(association)	0.350
CHRNA9	TMEM120B	psi-mi:“MI:0914”(association)	0.350
TENT5A	TMEM131L	psi-mi:“MI:0914”(association)	0.350
NLGN3	TMEM131L	psi-mi:“MI:0914”(association)	0.350
SLC39A12	POM121C	psi-mi:“MI:0914”(association)	0.350
TMPRSS3	UPK3BL1	psi-mi:“MI:0914”(association)	0.350
CDH5	ARVCF	psi-mi:“MI:0914”(association)	0.350
IL17RC	C2CD2L	psi-mi:“MI:0914”(association)	0.350
MPPE1	ADAM10	psi-mi:“MI:0914”(association)	0.350
PCDHGA5	MAP2K7	psi-mi:“MI:0914”(association)	0.350

BioGRID (75): TMEM39A (Affinity Capture-MS), TMEM39A (Affinity Capture-MS), TMEM39A (Affinity Capture-MS), TMEM39A (Affinity Capture-MS), TMEM39A (Affinity Capture-MS), TMEM39A (Affinity Capture-MS), TMEM39A (Affinity Capture-MS), TMEM39A (Affinity Capture-MS), TMEM39A (Affinity Capture-MS), TMEM39A (Affinity Capture-MS), TMEM39A (Affinity Capture-MS), TMEM39A (Affinity Capture-MS), TMEM39A (Affinity Capture-MS), TMEM39A (Affinity Capture-MS), TMEM39A (Affinity Capture-MS)

ESM2 similar proteins: A0A8I3MKU8, A9RA88, B0CMA4, B3M3X7, B3NGS7, B4GZN1, B4HEB1, B4J2W3, B4L184, B4LC58, B4N5D3, B4PF15, B4QPR1, F4K2U8, I6VSD2, Q0V947, Q12016, Q1DKX4, Q28FG4, Q28FY5, Q2LZ37, Q2TA63, Q3SZR6, Q5F3W2, Q5FWK6, Q5FWM8, Q5R687, Q5R9R3, Q5T9L3, Q5U4Q2, Q5ZLR1, Q66IZ4, Q66J27, Q6DFI2, Q6DGL7, Q6DID7, Q6P689, Q6PQZ3, Q7SY10, Q80UA9

Diamond homologs: Q0IHF1, Q0VCF5, Q17QW2, Q5U2V9, Q66H44, Q6DF19, Q6GL42, Q6GNY8, Q6NRI4, Q6PH58, Q7ZW11, Q810L4, Q9CYC3, Q9GZU3, Q9NV64

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 75 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Neurotransmitter receptors and postsynaptic signal transmission	7	14.6×	4e-05
Transmission across Chemical Synapses	7	11.1×	1e-04
Neuronal System	9	8.3×	8e-05

GO biological processes:

GO term	Partners	Fold	FDR
monoatomic ion transmembrane transport	9	29.7×	8e-09

Disease & clinical

Clinical variants and AI predictions

ClinVar

55 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	44
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2193 predictions. Top by Δscore:

Variant	Effect	Δscore
3:119436789:A:AC	donor_gain	1.0000
3:119436790:C:CC	donor_gain	1.0000
3:119436977:CT:C	acceptor_gain	1.0000
3:119437750:CTTA:C	donor_loss	1.0000
3:119437751:TTA:T	donor_loss	1.0000
3:119437752:TACCT:T	donor_loss	1.0000
3:119437753:ACCT:A	donor_loss	1.0000
3:119437754:C:CA	donor_loss	1.0000
3:119437819:T:TA	donor_gain	1.0000
3:119432215:C:CC	acceptor_gain	0.9900
3:119436785:A:AC	donor_gain	0.9900
3:119436786:C:CC	donor_gain	0.9900
3:119436786:CTCA:C	donor_gain	0.9900
3:119436790:CAT:C	donor_gain	0.9900
3:119436975:TACT:T	acceptor_gain	0.9900
3:119436979:C:CC	acceptor_gain	0.9900
3:119436990:C:CT	acceptor_gain	0.9900
3:119437591:T:C	donor_gain	0.9900
3:119437753:A:AC	donor_gain	0.9900
3:119437754:C:CC	donor_gain	0.9900
3:119437754:CCTT:C	donor_gain	0.9900
3:119438002:T:A	donor_gain	0.9900
3:119438099:CAAAC:C	acceptor_gain	0.9900
3:119438101:AACC:A	acceptor_loss	0.9900
3:119438102:ACCT:A	acceptor_loss	0.9900
3:119438104:C:CC	acceptor_gain	0.9900
3:119438226:A:C	donor_gain	0.9900
3:119452529:TT:T	acceptor_gain	0.9900
3:119452531:C:CC	acceptor_gain	0.9900
3:119458013:CTTA:C	donor_loss	0.9900

AlphaMissense

3172 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:119432113:C:A	W445C	1.000
3:119432113:C:G	W445C	1.000
3:119432115:A:G	W445R	1.000
3:119432115:A:T	W445R	1.000
3:119432206:A:C	F414L	1.000
3:119432206:A:T	F414L	1.000
3:119432208:A:G	F414L	1.000
3:119434790:G:C	P402R	1.000
3:119434790:G:T	P402H	1.000
3:119434791:G:A	P402S	1.000
3:119434791:G:T	P402T	1.000
3:119434801:G:C	N398K	1.000
3:119434801:G:T	N398K	1.000
3:119434824:A:C	Y391D	1.000
3:119434861:C:A	W378C	1.000
3:119434861:C:G	W378C	1.000
3:119434863:A:G	W378R	1.000
3:119434863:A:T	W378R	1.000
3:119434879:C:A	W372C	1.000
3:119434879:C:G	W372C	1.000
3:119434881:A:G	W372R	1.000
3:119434881:A:T	W372R	1.000
3:119436835:C:A	W356C	1.000
3:119436835:C:G	W356C	1.000
3:119436836:C:G	W356S	1.000
3:119436837:A:G	W356R	1.000
3:119436837:A:T	W356R	1.000
3:119436842:C:A	G354V	1.000
3:119436842:C:T	G354D	1.000
3:119436843:C:A	G354C	1.000

dbSNP variants (sampled 300 via entrez): RS1000000439 (3:119434141 G>A), RS1000101276 (3:119455342 CAT>C), RS1000109190 (3:119461908 A>T), RS1000165201 (3:119458635 C>T), RS1000246337 (3:119458564 AG>A), RS1000359203 (3:119464749 A>G), RS1000677429 (3:119445164 C>T), RS1000696652 (3:119452272 G>C), RS1000772710 (3:119464556 C>A), RS1000825077 (3:119445802 G>A), RS1001098368 (3:119432794 T>C), RS1001195358 (3:119465132 C>G), RS1001364382 (3:119441265 A>G), RS1001542929 (3:119446651 A>G), RS1001566953 (3:119452990 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST001198_7	Multiple sclerosis	3.000000e-09
GCST002449_2	Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid)	3.000000e-08
GCST003129_25	Primary biliary cholangitis	4.000000e-15
GCST005581_44	Primary biliary cirrhosis	7.000000e-16
GCST005752_152	Systemic lupus erythematosus	1.000000e-11

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0005680	omega-6 polyunsaturated fatty acid measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

34 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cyclosporine	increases expression	4
sodium arsenite	decreases expression, increases expression	3
Valproic Acid	affects expression, decreases expression	3
Tobacco Smoke Pollution	increases expression	2
methylmercuric chloride	increases expression	1
beta-lapachone	increases expression	1
didecyldimethylammonium	increases expression	1
potassium chromate(VI)	increases expression	1
perfluorooctane sulfonic acid	increases expression	1
pentabromodiphenyl ether	increases expression	1
K 7174	increases expression	1
pinostrobin	increases phosphorylation	1
ICG 001	decreases expression	1
abrine	increases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	increases expression	1
NSC 689534	affects binding, increases expression	1
Air Pollutants	increases abundance, increases expression	1
Air Pollutants, Occupational	affects expression	1
Atrazine	increases expression	1
Benzene	increases expression	1
Copper	affects binding, increases expression	1
Dichlorodiphenyl Dichloroethylene	decreases expression	1
Diuron	decreases expression	1
Doxorubicin	decreases expression	1
Dihydrotestosterone	increases expression	1
Sulindac	increases expression	1
Testosterone	decreases expression	1
Dronabinol	decreases expression	1
Thiram	increases expression	1
Tunicamycin	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.