TMEM41B

Summary

TMEM41B (transmembrane protein 41B, HGNC:28948) is a protein-coding gene on chromosome 11p15.4, encoding Transmembrane protein 41B (Q5BJD5). Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes. It is a selective cancer dependency (DepMap: 22.4% of cell lines).

Enables phospholipid scramblase activity. Involved in autophagosome assembly and intracellular lipid transport. Located in mitochondria-associated endoplasmic reticulum membrane contact site. Is active in endoplasmic reticulum membrane.

Source: NCBI Gene 440026 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 50 total
• Druggable target: yes
• Cancer dependency (DepMap): dependent in 22.4% of screened cell lines
• MANE Select transcript: NM_015012

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28948
Approved symbol	TMEM41B
Name	transmembrane protein 41B
Location	11p15.4
Locus type	gene with protein product
Status	Approved
Aliases	KIAA0033
Ensembl gene	ENSG00000166471
Ensembl biotype	protein_coding
OMIM	620271
Entrez	440026

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 6 protein_coding, 2 nonsense_mediated_decay, 1 retained_intron

ENST00000299596, ENST00000524543, ENST00000527813, ENST00000528080, ENST00000533723, ENST00000533867, ENST00000611268, ENST00000931712, ENST00000931713

RefSeq mRNA: 2 — MANE Select: NM_015012 NM_001165030, NM_015012

CCDS: CCDS31424, CCDS53600

Canonical transcript exons

ENST00000528080 — 7 exons

Exon	Start	End
ENSE00001123125	9288442	9288535
ENSE00001123130	9295259	9295387
ENSE00001123136	9299584	9299701
ENSE00002176576	9280654	9283593
ENSE00002201942	9314321	9314593
ENSE00003564015	9286455	9286593
ENSE00003575570	9287702	9287806

Expression profiles

Bgee: expression breadth ubiquitous, 296 present calls, max score 96.88.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 39.1103 / max 381.8517, expressed in 1826 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
118567	35.0236	1825
118565	2.4234	1130
118564	0.7636	319
118566	0.5682	347
118568	0.3316	167

Top tissues by expression

300 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
middle temporal gyrus	UBERON:0002771	96.88	gold quality
endothelial cell	CL:0000115	96.12	gold quality
visceral pleura	UBERON:0002401	95.47	gold quality
ileal mucosa	UBERON:0000331	95.07	gold quality
pancreatic ductal cell	CL:0002079	95.00	gold quality
Brodmann (1909) area 23	UBERON:0013554	95.00	gold quality
jejunal mucosa	UBERON:0000399	94.74	gold quality
esophagus squamous epithelium	UBERON:0006920	94.71	gold quality
choroid plexus epithelium	UBERON:0003911	94.60	gold quality
buccal mucosa cell	CL:0002336	94.40	silver quality
adrenal tissue	UBERON:0018303	93.99	gold quality
upper leg skin	UBERON:0004262	93.51	gold quality
tibia	UBERON:0000979	93.48	gold quality
cartilage tissue	UBERON:0002418	93.40	gold quality
nephron tubule	UBERON:0001231	93.00	gold quality
mucosa of sigmoid colon	UBERON:0004993	92.96	gold quality
colonic mucosa	UBERON:0000317	92.82	gold quality
epithelium of esophagus	UBERON:0001976	92.72	gold quality
pleura	UBERON:0000977	92.69	gold quality
squamous epithelium	UBERON:0006914	92.45	gold quality
gingival epithelium	UBERON:0001949	92.07	gold quality
lower lobe of lung	UBERON:0008949	91.58	gold quality
corpus epididymis	UBERON:0004359	91.50	gold quality
epithelial cell of pancreas	CL:0000083	91.47	gold quality
palpebral conjunctiva	UBERON:0001812	91.45	gold quality
renal glomerulus	UBERON:0000074	91.19	gold quality
duodenum	UBERON:0002114	91.17	gold quality
parietal pleura	UBERON:0002400	91.16	gold quality
gingiva	UBERON:0001828	91.15	gold quality
pigmented layer of retina	UBERON:0001782	90.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	21.97

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

17 targeting TMEM41B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-568	99.98	69.86	2084
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-7-1-3P	99.91	71.53	4384
HSA-MIR-7-2-3P	99.91	71.40	4394
HSA-MIR-1252-3P	99.55	67.71	2862
HSA-MIR-3609	99.52	69.89	2587
HSA-MIR-548AH-5P	99.52	69.73	2626
HSA-MIR-5701	98.97	69.54	1502
HSA-MIR-4635	98.74	67.63	1339
HSA-MIR-101-5P	96.84	65.66	649

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 22.4% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 6)

• These results suggest that TMEM41B and VMP1 function together at an early step of autophagosome formation. (PMID:30093494)
• TMEM41B is a novel ER-localized regulator of autophagosome biogenesis and lipid mobilization. (PMID:30126924)
• TMEM41B is an integral endoplasmic reticulum (ER) membrane protein distantly related to the established autophagy factor vacuole membrane protein 1 (VMP1), and the data show that these two factors play related, albeit not fully overlapping, roles in autophagosome biogenesis. (PMID:30933966)
• TMEM41B Is a Pan-flavivirus Host Factor. (PMID:33338421)
• TMEM41B is a host factor required for the replication of diverse coronaviruses including SARS-CoV-2. (PMID:34043740)
• VMP1 and TMEM41B are essential for DMV formation during beta-coronavirus infection. (PMID:35536318)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	tmem41b	ENSDARG00000080006
mus_musculus	Tmem41b	ENSMUSG00000047554
rattus_norvegicus	Tmem41b	ENSRNOG00000010752
drosophila_melanogaster	stas	FBGN0030850
caenorhabditis_elegans		WBGENE00006520

Paralogs (2): TMEM41A (ENSG00000163900), TMEM64 (ENSG00000180694)

Protein

Protein identifiers

Transmembrane protein 41B — Q5BJD5 (reviewed: Q5BJD5)

Alternative names: Protein stasimon

All UniProt accessions (2): E9PJ42, Q5BJD5

UniProt curated annotations — full annotation on UniProt →

Function. Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes. Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine. Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly. In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required. Required for normal motor neuron development. (Microbial infection) Critical host factor required for infection by human coronaviruses SARS-CoV-2, HCoV-OC43, HCoV-NL63, and HCoV-229E, as well as all flaviviruses tested such as Zika virus and Yellow fever virus. Required post-entry of the virus to facilitate the ER membrane remodeling necessary to form replication organelles.

Subunit / interactions. Interacts with VMP1. Interacts with COPA, COPB1, VDAC1 and ERLIN2. Interacts with ATG2A. Interacts with SURF4. (Microbial infection) Interacts with Zika virus NS4A protein and Yellow fever virus NS4B protein.

Subcellular location. Endoplasmic reticulum membrane. Endomembrane system Cytoplasm.

Domain organisation. The VTT domain was previously called the SNARE-assoc domain. As there is no evidence that this domain associates with SNARE proteins, it was renamed as VMP1, TMEM41, and TVP38 (VTT) domain. (Microbial infection) VTT domain is required for flavivirus infection.

Similarity. Belongs to the TMEM41 family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q5BJD5-1	1	yes
Q5BJD5-2	2
Q5BJD5-3	3

RefSeq proteins (2): NP_001158502, NP_055827* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR032816	VTT_dom	Domain
IPR045014	TM41A/B	Family

Pfam: PF09335

Catalyzed reactions (Rhea), 4 shown:

• a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out) (RHEA:38571)
• a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) (RHEA:38663)
• a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) (RHEA:38895)
• cholesterol(in) = cholesterol(out) (RHEA:39747)

UniProt features (17 total): transmembrane region 6, splice variant 4, modified residue 2, sequence variant 2, region of interest 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5BJD5-F1	82.76	0.48

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 35, 18

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 206 (showing top): FARMER_BREAST_CANCER_CLUSTER_7, GOBP_VACUOLE_ORGANIZATION, GOBP_PLASMA_MEMBRANE_ORGANIZATION, GOBP_MODULATION_OF_PROCESS_OF_ANOTHER_ORGANISM, GOBP_HOST_MEDIATED_PERTURBATION_OF_VIRAL_PROCESS, GOBP_REGULATION_OF_MEMBRANE_LIPID_DISTRIBUTION, GOBP_MACROAUTOPHAGY, GOBP_ORGANOPHOSPHATE_ESTER_TRANSPORT, SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM1, GOBP_VIRAL_GENOME_REPLICATION, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_5, GOBP_ORGANELLE_ASSEMBLY, GOBP_VIRAL_LIFE_CYCLE, GOBP_ENDOMEMBRANE_SYSTEM_ORGANIZATION, HOEBEKE_LYMPHOID_STEM_CELL_UP

GO Biological Process (7): autophagosome assembly (GO:0000045), nervous system development (GO:0007399), intracellular lipid transport (GO:0032365), host-mediated perturbation of viral RNA genome replication (GO:0044830), lipid transport (GO:0006869), autophagy (GO:0006914), plasma membrane phospholipid scrambling (GO:0017121)

GO Molecular Function (2): phospholipid scramblase activity (GO:0017128), protein binding (GO:0005515)

GO Cellular Component (6): endoplasmic reticulum membrane (GO:0005789), mitochondria-associated endoplasmic reticulum membrane contact site (GO:0044233), cytoplasm (GO:0005737), endoplasmic reticulum (GO:0005783), endomembrane system (GO:0012505), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
Atg12 activating enzyme activity	1
protein-phosphatidylethanolamide deconjugating activity	1
Atg12 conjugating enzyme activity	1
Atg12 ligase activity	1
organelle assembly	1
Atg1/ULK1 kinase complex assembly	1
autophagosome organization	1
system development	1
lipid transport	1
intracellular transport	1
viral RNA genome replication	1
host-mediated perturbation of viral process	1
transport	1
lipid localization	1
catabolic process	1
transmembrane transport	1
process utilizing autophagic mechanism	1
plasma membrane organization	1
phospholipid translocation	1
plasma membrane phospholipid scrambling	1
intramembrane lipid carrier activity	1
binding	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
organelle membrane contact site	1
intracellular anatomical structure	1
cytoplasm	1
endomembrane system	1
intracellular membrane-bounded organelle	1
vacuole	1
plasma membrane	1

Protein interactions and networks

STRING

1340 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TMEM41B	VMP1	Q96GC9	817
TMEM41B	ACTMAP	Q5BKX5	592
TMEM41B	ATG2A	Q2TAZ0	539
TMEM41B	CHODL	Q9H9P2	523
TMEM41B	SMN1	Q16637	518
TMEM41B	TMEM106B	Q9NUM4	506
TMEM41B	LYSET	Q8N6I4	474
TMEM41B	HNRNPR	O43390	455
TMEM41B	MINAR1	Q9UPX6	439
TMEM41B	PLS3	P13797	431
TMEM41B	RUSC2	Q8N2Y8	426
TMEM41B	EPG5	Q9HCE0	423
TMEM41B	STRAP	Q9Y3F4	421
TMEM41B	ANKLE2	Q86XL3	402
TMEM41B	ATG2B	Q96BY7	402

IntAct

35 interactions, top by confidence:

A	B	Type	Score
IFT70B	IFT56	psi-mi:“MI:0914”(association)	0.790
ASPH	STXBP3	psi-mi:“MI:0914”(association)	0.640
TMEM184A	SLC33A1	psi-mi:“MI:0914”(association)	0.530
TMEM63A	AP3D1	psi-mi:“MI:0914”(association)	0.530
	TMEM41B	psi-mi:“MI:0915”(physical association)	0.500
	RBFOX2	psi-mi:“MI:0914”(association)	0.500
TMEM41B	APOB	psi-mi:“MI:0915”(physical association)	0.400
PPP2CB	DKFZP586J0619	psi-mi:“MI:0914”(association)	0.350
	TSPO	psi-mi:“MI:0914”(association)	0.350
STYK1	XPO1	psi-mi:“MI:0914”(association)	0.350
MFSD4A	UBXN8	psi-mi:“MI:0914”(association)	0.350
SLC1A1	UBXN8	psi-mi:“MI:0914”(association)	0.350
SPPL2B	HAS3	psi-mi:“MI:0914”(association)	0.350
VIPR1	SLC33A1	psi-mi:“MI:0914”(association)	0.350
FPR2	SCAMP3	psi-mi:“MI:0914”(association)	0.350
TMEM72	MGST3	psi-mi:“MI:0914”(association)	0.350
SLC2A8	AGPAT2	psi-mi:“MI:0914”(association)	0.350
MFSD11	AGPAT2	psi-mi:“MI:0914”(association)	0.350
ACKR3	PDE2A	psi-mi:“MI:0914”(association)	0.350
APLNR	TTI1	psi-mi:“MI:0914”(association)	0.350
LY86	MAP2K7	psi-mi:“MI:0914”(association)	0.350
RAMP3	TMEM223	psi-mi:“MI:0914”(association)	0.350
SCN3B	NBAS	psi-mi:“MI:0914”(association)	0.350
SLC15A1	LCMT2	psi-mi:“MI:0914”(association)	0.350
SPPL2B	POC1B-GALNT4	psi-mi:“MI:0914”(association)	0.350
SLC19A2	TMEM223	psi-mi:“MI:0914”(association)	0.350
SLC22A5	TMEM131L	psi-mi:“MI:0914”(association)	0.350
SLC35C2	PGRMC1	psi-mi:“MI:0914”(association)	0.350
SLC39A14	ESYT2	psi-mi:“MI:0914”(association)	0.350
SLC6A15	EI24	psi-mi:“MI:0914”(association)	0.350

BioGRID (191): TMEM41B (Affinity Capture-MS), DPYS (Affinity Capture-MS), APOB (Affinity Capture-MS), TMEM41B (Proximity Label-MS), TMEM41B (Affinity Capture-MS), APOB (Affinity Capture-MS), TMEM41B (Affinity Capture-MS), TMEM41B (Affinity Capture-MS), TMEM41B (Affinity Capture-MS), TMEM41B (Affinity Capture-MS), LRPPRC (Affinity Capture-MS), TRAP1 (Affinity Capture-MS), IPO8 (Affinity Capture-MS), IPO7 (Affinity Capture-MS), ARL6IP5 (Affinity Capture-MS)

ESM2 similar proteins: A0A0G2KQY6, A1A5V7, A4II98, A8I499, A8NX72, B3TP03, B5D5N9, F4I8Q7, G5ECB2, O01840, O62126, O64759, P18581, P30823, P30825, P52569, P91679, P92942, Q10046, Q10320, Q17320, Q25479, Q2UVJ5, Q41745, Q42093, Q4QQU5, Q502G2, Q5BJD5, Q5FVN2, Q5N808, Q5PR34, Q5RBZ8, Q5REV9, Q5RFF0, Q5U4K5, Q5ZIL6, Q6IWY1, Q6NV38, Q6ZQN7, Q759P7

Diamond homologs: A1A5V7, A4II98, O62126, Q08D99, Q502G2, Q5BJD5, Q5FVN2, Q5RBZ8, Q5U4K5, Q5ZIL6, Q6NV38, Q8K1A5, Q8L586, Q8MXN7, Q96HV5, Q9D8U2, Q9VX39

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 55 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
SLC-mediated transmembrane transport	6	9.3×	7e-03
Transport of small molecules	8	5.3×	1e-02

Disease & clinical

Clinical variants and AI predictions

ClinVar

50 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	37
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

984 predictions. Top by Δscore:

Variant	Effect	Δscore
11:9285634:T:TA	donor_gain	1.0000
11:9287807:C:CC	acceptor_gain	1.0000
11:9295289:A:AC	donor_gain	1.0000
11:9295290:C:CC	donor_gain	1.0000
11:9295292:TGA:T	donor_gain	1.0000
11:9295307:T:TA	donor_gain	1.0000
11:9314317:TCA:T	donor_loss	1.0000
11:9314318:CAC:C	donor_loss	1.0000
11:9314319:AC:A	donor_gain	1.0000
11:9314320:CC:C	donor_gain	1.0000
11:9314320:CCCTT:C	donor_gain	1.0000
11:9283431:A:C	donor_gain	0.9900
11:9283591:CAC:C	acceptor_gain	0.9900
11:9285631:ATTT:A	donor_gain	0.9900
11:9287697:TTTAC:T	donor_loss	0.9900
11:9287698:TTA:T	donor_loss	0.9900
11:9287699:TA:T	donor_loss	0.9900
11:9287700:A:G	donor_loss	0.9900
11:9287701:CCT:C	donor_loss	0.9900
11:9287701:CCTG:C	donor_gain	0.9900
11:9287702:C:A	donor_loss	0.9900
11:9287802:GAACA:G	acceptor_gain	0.9900
11:9287805:CA:C	acceptor_gain	0.9900
11:9295281:C:CT	donor_gain	0.9900
11:9295282:T:TT	donor_gain	0.9900
11:9295330:T:A	donor_gain	0.9900
11:9295334:AGAG:A	donor_gain	0.9900
11:9295386:CT:C	acceptor_gain	0.9900
11:9299582:A:AC	donor_gain	0.9900
11:9299583:C:CC	donor_gain	0.9900

AlphaMissense

1880 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:9283482:G:T	A273D	1.000
11:9283557:C:T	G248E	1.000
11:9283558:C:G	G248R	1.000
11:9283558:C:T	G248R	1.000
11:9283593:C:T	G236D	1.000
11:9286455:C:G	G236R	1.000
11:9286466:C:T	G232D	1.000
11:9286467:C:G	G232R	1.000
11:9286513:A:C	N216K	1.000
11:9286513:A:T	N216K	1.000
11:9286524:A:G	W213R	1.000
11:9286524:A:T	W213R	1.000
11:9286525:A:C	N212K	1.000
11:9286525:A:T	N212K	1.000
11:9286529:G:T	P211H	1.000
11:9286547:C:A	R205I	1.000
11:9286547:C:G	R205T	1.000
11:9287780:A:C	C163W	1.000
11:9287781:C:T	C163Y	1.000
11:9287793:C:A	G159V	1.000
11:9287793:C:T	G159D	1.000
11:9287794:C:A	G159C	1.000
11:9287794:C:G	G159R	1.000
11:9288447:A:G	C153R	1.000
11:9288485:C:T	G140E	1.000
11:9288486:C:A	G140W	1.000
11:9288496:A:C	S136R	1.000
11:9288496:A:T	S136R	1.000
11:9288498:T:G	S136R	1.000
11:9288518:A:T	I129N	1.000

dbSNP variants (sampled 300 via entrez): RS1000018050 (11:9297523 C>G), RS1000066226 (11:9292663 G>A), RS1000075938 (11:9304239 G>C), RS1000149059 (11:9303915 A>G), RS1000209680 (11:9316206 C>A), RS1000235406 (11:9298363 G>A), RS1000370490 (11:9309649 G>A), RS1000421042 (11:9314798 C>A,G,T), RS1000501200 (11:9286867 G>A), RS1000548408 (11:9314891 C>T), RS1000578188 (11:9314741 C>A,G,T), RS1000764729 (11:9308901 G>A,C), RS1000887619 (11:9281053 A>G), RS1000888347 (11:9309377 C>G,T), RS1000898033 (11:9287544 C>G)

Disease associations

OMIM: gene MIM:620271 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST005024_102	Pursuit maintenance gain	6.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0008433	pursuit maintenance gain measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067187 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
5.70	Kd	2009	nM	CHEMBL5653589
5.70	ED50	2009	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149614: Binding affinity to human TMEM41B incubated for 45 mins by Kinobead based pull down assay	kd	2.0095	uM

CTD chemical–gene interactions

36 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, affects cotreatment, increases abundance, increases expression	3
Air Pollutants	decreases expression, increases abundance, increases expression	3
Cyclosporine	increases expression	3
bisphenol A	decreases methylation, affects expression, affects cotreatment, increases methylation	2
Quercetin	decreases expression, decreases phosphorylation	2
Smoke	decreases expression, increases abundance	2
Tobacco Smoke Pollution	increases expression	2
Valproic Acid	affects expression, increases expression	2
Particulate Matter	decreases expression, increases abundance, increases expression	2
aristolochic acid I	decreases expression	1
triphenyl phosphate	affects expression	1
manganese chloride	affects cotreatment, increases abundance, increases expression	1
(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	decreases expression	1
bisphenol S	affects cotreatment, increases expression	1
Bortezomib	increases expression	1
Irinotecan	decreases expression	1
Sunitinib	increases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Leflunomide	decreases expression	1
Acetylcysteine	affects cotreatment, decreases expression	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Benzo(a)pyrene	affects methylation	1
Caffeine	decreases phosphorylation	1
Carbamazepine	affects expression	1
Chloroquine	affects cotreatment, decreases expression	1
Dexamethasone	affects cotreatment, increases expression	1
Indomethacin	affects cotreatment, increases expression	1
Ivermectin	decreases expression	1
Manganese	increases expression, affects cotreatment, increases abundance	1
Nicotine	increases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652656	Binding	Binding affinity to human TMEM41B incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.