TMEM44-AS1

Summary

TMEM44-AS1 (TMEM44 antisense RNA 1, HGNC:44272) is a long non-coding RNA gene on chromosome 3q29.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44272
Approved symbol	TMEM44-AS1
Name	TMEM44 antisense RNA 1
Location	3q29
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000231770
Ensembl biotype	lncRNA
Entrez	100507297
RNAcentral	URS000075DE24 — lncRNA, 1433 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 9 lncRNA

ENST00000419571, ENST00000447982, ENST00000453671, ENST00000693189, ENST00000737518, ENST00000737519, ENST00000737520, ENST00000737521, ENST00000737522

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000419571 — 3 exons

Exon	Start	End
ENSE00001637884	194589855	194590249
ENSE00001778581	194584299	194584448
ENSE00002527435	194589025	194589142

Expression profiles

Bgee: expression breadth ubiquitous, 203 present calls, max score 85.96.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.5921 / max 101.1359, expressed in 1643 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
40663	6.4803	1636
40664	0.1118	44

Top tissues by expression

239 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.96	gold quality
mucosa of transverse colon	UBERON:0004991	82.09	gold quality
sural nerve	UBERON:0015488	82.09	gold quality
islet of Langerhans	UBERON:0000006	81.63	gold quality
right lobe of thyroid gland	UBERON:0001119	81.56	gold quality
right lobe of liver	UBERON:0001114	81.51	gold quality
pancreatic ductal cell	CL:0002079	81.48	gold quality
adenohypophysis	UBERON:0002196	81.34	gold quality
left lobe of thyroid gland	UBERON:0001120	80.73	gold quality
body of pancreas	UBERON:0001150	80.35	gold quality
metanephros cortex	UBERON:0010533	80.20	gold quality
thyroid gland	UBERON:0002046	80.16	gold quality
pancreas	UBERON:0001264	80.13	gold quality
right uterine tube	UBERON:0001302	80.12	gold quality
tibial nerve	UBERON:0001323	80.10	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	80.08	gold quality
calcaneal tendon	UBERON:0003701	79.76	gold quality
right adrenal gland	UBERON:0001233	79.71	gold quality
monocyte	CL:0000576	79.60	gold quality
pituitary gland	UBERON:0000007	79.46	gold quality
leukocyte	CL:0000738	79.41	gold quality
granulocyte	CL:0000094	79.15	gold quality
right adrenal gland cortex	UBERON:0035827	78.92	gold quality
left adrenal gland cortex	UBERON:0035825	78.69	gold quality
left adrenal gland	UBERON:0001234	78.56	gold quality
apex of heart	UBERON:0002098	78.13	gold quality
spinal cord	UBERON:0002240	78.04	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	77.99	gold quality
body of stomach	UBERON:0001161	77.96	gold quality
epithelial cell of pancreas	CL:0000083	77.88	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.96

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Super-enhancer-associated TMEM44-AS1 aggravated glioma progression by forming a positive feedback loop with Myc. (PMID:34696771)
• Chitosan-Gelatin-EGCG Nanoparticle-Meditated LncRNA TMEM44-AS1 Silencing to Activate the P53 Signaling Pathway for the Synergistic Reversal of 5-FU Resistance in Gastric Cancer. (PMID:35717675)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.