TMEM63C

Summary

TMEM63C (transmembrane protein 63C, HGNC:23787) is a protein-coding gene on chromosome 14q24.3, encoding Osmosensitive cation channel TMEM63C (Q9P1W3). Acts as an osmosensitive cation channel preferentially activated upon hypotonic stress.

Enables calcium-activated cation channel activity. Involved in monoatomic cation transport. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in plasma membrane. Implicated in hereditary spastic paraplegia 87. Biomarker of focal segmental glomerulosclerosis.

Source: NCBI Gene 57156 — RefSeq curated summary.

At a glance

• Gene–disease (curated): spastic paraplegia 87, autosomal recessive (Strong, GenCC)
• GWAS associations: 4
• Clinical variants (ClinVar): 118 total — 4 pathogenic
• Phenotypes (HPO): 18
• MANE Select transcript: NM_020431

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23787
Approved symbol	TMEM63C
Name	transmembrane protein 63C
Location	14q24.3
Locus type	gene with protein product
Status	Approved
Aliases	DKFZp434P0111, CSC1, hsCSC1
Ensembl gene	ENSG00000165548
Ensembl biotype	protein_coding
OMIM	619953
Entrez	57156

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 12 protein_coding, 2 retained_intron

ENST00000298351, ENST00000554346, ENST00000554766, ENST00000555338, ENST00000555588, ENST00000556514, ENST00000557408, ENST00000557504, ENST00000890513, ENST00000890514, ENST00000890515, ENST00000890516, ENST00000890517, ENST00000957931

RefSeq mRNA: 1 — MANE Select: NM_020431 NM_020431

CCDS: CCDS45141

Canonical transcript exons

ENST00000298351 — 24 exons

Exon	Start	End
ENSE00001094004	77238694	77238767
ENSE00001094010	77249291	77249458
ENSE00001094015	77246609	77246674
ENSE00001094018	77248767	77248872
ENSE00001094019	77225424	77225461
ENSE00001094024	77245940	77246026
ENSE00001094025	77244349	77244455
ENSE00001094026	77242347	77242469
ENSE00001094027	77239603	77239726
ENSE00001094028	77236624	77236732
ENSE00001094029	77240475	77240608
ENSE00001094030	77248347	77248509
ENSE00001094034	77242903	77243056
ENSE00001094035	77239412	77239492
ENSE00001094037	77233452	77233500
ENSE00001094039	77251789	77251898
ENSE00001158680	77256526	77259495
ENSE00001421702	77213446	77213508
ENSE00002525404	77181798	77181894
ENSE00003612103	77220006	77220087
ENSE00003638414	77253305	77253376
ENSE00003645562	77219498	77219577
ENSE00003785084	77218801	77218963
ENSE00003790788	77231588	77231730

Expression profiles

Bgee: expression breadth ubiquitous, 186 present calls, max score 94.14.

FANTOM5 (CAGE): breadth broad, TPM avg 1.7467 / max 294.7520, expressed in 454 samples.

FANTOM5 promoters (10 alternative TSS)

Promoter ID	TPM avg	Samples expressed
140767	0.7671	312
140768	0.2339	119
140766	0.2095	113
140769	0.1335	73
140761	0.1290	5
140762	0.0785	4
140758	0.0760	6
140759	0.0608	6
140760	0.0473	4
140764	0.0111	3

Top tissues by expression

248 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cerebellar cortex	UBERON:0002129	94.14	gold quality
cerebellar hemisphere	UBERON:0002245	94.11	gold quality
right hemisphere of cerebellum	UBERON:0014890	93.96	gold quality
cerebellum	UBERON:0002037	93.69	gold quality
cerebellar vermis	UBERON:0004720	92.00	gold quality
pituitary gland	UBERON:0000007	91.46	gold quality
adenohypophysis	UBERON:0002196	91.23	gold quality
islet of Langerhans	UBERON:0000006	88.36	gold quality
dorsal root ganglion	UBERON:0000044	86.18	gold quality
lateral nuclear group of thalamus	UBERON:0002736	85.01	gold quality
pancreatic ductal cell	CL:0002079	84.56	silver quality
hypothalamus	UBERON:0001898	84.52	gold quality
cortical plate	UBERON:0005343	84.24	gold quality
right frontal lobe	UBERON:0002810	84.18	gold quality
prefrontal cortex	UBERON:0000451	83.91	gold quality
substantia nigra pars compacta	UBERON:0001965	83.80	gold quality
frontal cortex	UBERON:0001870	83.02	gold quality
substantia nigra pars reticulata	UBERON:0001966	82.33	silver quality
lateral globus pallidus	UBERON:0002476	82.13	silver quality
superior vestibular nucleus	UBERON:0007227	82.00	gold quality
neocortex	UBERON:0001950	81.96	gold quality
brain	UBERON:0000955	81.79	gold quality
Brodmann (1909) area 9	UBERON:0013540	81.60	gold quality
ventral tegmental area	UBERON:0002691	81.41	silver quality
dorsolateral prefrontal cortex	UBERON:0009834	80.83	gold quality
nucleus accumbens	UBERON:0001882	80.77	gold quality
dorsal plus ventral thalamus	UBERON:0001897	80.41	silver quality
forebrain	UBERON:0001890	80.38	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.35	gold quality
endothelial cell	CL:0000115	80.08	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.35
E-CURD-10	no	0.67

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

112 targeting TMEM63C, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3689D	100.00	66.14	1181
HSA-MIR-6851-5P	100.00	65.63	1294
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-4481	100.00	66.42	1669
HSA-MIR-8075	99.97	67.20	962
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-185-3P	99.95	67.01	1743
HSA-MIR-6809-3P	99.91	71.45	3814
HSA-MIR-4753-3P	99.90	71.03	3786
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-9902	99.89	69.15	2250
HSA-MIR-6780A-5P	99.88	66.69	2776
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-1273H-5P	99.77	66.32	2471
HSA-MIR-6763-5P	99.76	64.68	1767
HSA-MIR-3150A-3P	99.76	64.44	1640
HSA-MIR-149-3P	99.72	68.22	3963
HSA-MIR-1296-3P	99.72	64.04	636
HSA-MIR-1179	99.71	68.70	1040
HSA-MIR-30B-3P	99.70	65.76	2325
HSA-MIR-3689A-3P	99.70	65.73	2306
HSA-MIR-3689B-3P	99.70	65.71	2311
HSA-MIR-3689C	99.70	65.71	2311
HSA-MIR-6779-5P	99.70	65.76	2363
HSA-MIR-6883-5P	99.69	68.05	3785
HSA-MIR-7157-5P	99.66	69.33	1829
HSA-MIR-10394-5P	99.65	66.83	1852

Literature-anchored findings (GeneRIF, showing 3)

• Tmem63c is a potential pro-survival factor in angiotensin II-treated human podocytes. (PMID:32750436)
• TMEM63C, a Potential Novel Target for Albuminuria Development, Is Regulated by MicroRNA-564 and Transforming Growth Factor beta in Human Renal Cells. (PMID:33080601)
• TMEM63C mutations cause mitochondrial morphology defects and underlie hereditary spastic paraplegia. (PMID:35718349)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	tmem63c	ENSDARG00000004158
mus_musculus	Tmem63c	ENSMUSG00000034145
rattus_norvegicus	Tmem63c	ENSRNOG00000011334

Paralogs (2): TMEM63B (ENSG00000137216), TMEM63A (ENSG00000196187)

Protein

Protein identifiers

Osmosensitive cation channel TMEM63C — Q9P1W3 (reviewed: Q9P1W3)

Alternative names: Calcium permeable stress-gated cation channel 1, Transmembrane protein 63C

All UniProt accessions (6): Q9P1W3, G3V2V1, G3V3H0, G3V3S4, G3V3S9, G3V4J5

UniProt curated annotations — full annotation on UniProt →

Function. Acts as an osmosensitive cation channel preferentially activated upon hypotonic stress. In contrast to TMEM63B, does not show phospholipid scramblase activity. Enriched in mitochondria-ER contact sites where it may regulate the metabolite flux and organelles’ morphologies in response to osmotic changes. In particular may regulate mitochondrial motility and function in motor neuron axons. Required for the functional integrity of the kidney glomerular filtration barrier.

Subunit / interactions. Monomer.

Subcellular location. Endoplasmic reticulum membrane. Cell membrane.

Tissue specificity. Expressed in podocytes of kidney glomeruli. Significantly reduced expression in patients with focal segmental glomerulosclerosis.

Disease relevance. Spastic paraplegia 87, autosomal recessive (SPG87) [MIM:619966] A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG87 is characterized by onset of lower limb spasticity in infancy or early childhood, and lack of upper limbs and bulbar regions involvement. Affected individuals have mildly delayed walking, spastic gait, and hyperreflexia. Some patients may also have mild intellectual disability or speech problems. The disease is caused by variants affecting the gene represented in this entry.

Activity regulation. Activated by hyperosmotic shock after mannitol treatment.

Similarity. Belongs to the CSC1 (TC 1.A.17) family.

RefSeq proteins (1): NP_065164* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003864	CSC1/OSCA1-like_7TM	Domain
IPR027815	CSC1/OSCA1-like_cyt	Domain
IPR032880	CSC1/OSCA1-like_N	Domain
IPR045122	Csc1-like	Family

Pfam: PF02714, PF13967, PF14703

Catalyzed reactions (Rhea), 1 shown:

• Ca(2+)(in) = Ca(2+)(out) (RHEA:29671)

UniProt features (31 total): topological domain 12, transmembrane region 11, modified residue 2, sequence variant 2, sequence conflict 2, chain 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9P1W3-F1	74.76	0.31

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 77, 80

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 110 (showing top): GSE45365_NK_CELL_VS_CD11B_DC_UP, GOCC_VACUOLAR_MEMBRANE, GOBP_MONOATOMIC_CATION_TRANSPORT, GTGCCTT_MIR506, chr14q24, GOBP_RENAL_FILTRATION, GOBP_TRANSMEMBRANE_TRANSPORT, GOBP_RENAL_SYSTEM_PROCESS, GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK, GOCC_ORGANELLE_SUBCOMPARTMENT, GOMF_LIPID_TRANSPORTER_ACTIVITY, GOMF_GATED_CHANNEL_ACTIVITY, GOMF_PASSIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY, GOMF_MONOATOMIC_CATION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY

GO Biological Process (5): glomerular filtration (GO:0003094), monoatomic cation transport (GO:0006812), monoatomic ion transport (GO:0006811), monoatomic ion transmembrane transport (GO:0034220), monoatomic cation transmembrane transport (GO:0098655)

GO Molecular Function (2): calcium-activated cation channel activity (GO:0005227), osmolarity-sensing monoatomic cation channel activity (GO:1990760)

GO Cellular Component (5): lysosomal membrane (GO:0005765), endoplasmic reticulum membrane (GO:0005789), plasma membrane (GO:0005886), endoplasmic reticulum (GO:0005783), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
monoatomic ion transport	2
renal filtration	1
transport	1
transmembrane transport	1
monoatomic cation transport	1
monoatomic ion transmembrane transport	1
monoatomic ion-gated channel activity	1
ligand-gated monoatomic cation channel activity	1
osmosensor activity	1
monoatomic cation channel activity	1
gated channel activity	1
lysosome	1
lytic vacuole membrane	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
membrane	1
cell periphery	1
cytoplasm	1
endomembrane system	1
intracellular membrane-bounded organelle	1
cellular anatomical structure	1

Protein interactions and networks

STRING

446 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TMEM63C	INCENP	Q9NQS7	955
TMEM63C	KCNJ6	P48051	844
TMEM63C	AURKB	Q96GD4	796
TMEM63C	STRIP1	Q5VSL9	547
TMEM63C	OTULINL	Q9NUU6	521
TMEM63C	EFS	O43281	520
TMEM63C	CCDC106	Q9BWC9	495
TMEM63C	STRN	O43815	480
TMEM63C	SNX15	Q9NRS6	463
TMEM63C	VWA5A	O00534	459
TMEM63C	RNF150	Q9ULK6	457
TMEM63C	TMEM234	Q8WY98	453
TMEM63C	PPP2R1A	P30153	444
TMEM63C	TMEM120A	Q9BXJ8	444
TMEM63C	CDCA8	Q53HL2	434
TMEM63C	RNPC3	Q96LT9	434

IntAct

3 interactions, top by confidence:

A	B	Type	Score
NPPA	A2ML1	psi-mi:“MI:0914”(association)	0.530
TMEM63C	GPR89A	psi-mi:“MI:0914”(association)	0.350

BioGRID (41): TMEM63C (Affinity Capture-RNA), TMEM63C (Proximity Label-MS), TMEM199 (Affinity Capture-MS), DNAJC18 (Affinity Capture-MS), RNFT1 (Affinity Capture-MS), PIGH (Affinity Capture-MS), OSBP (Affinity Capture-MS), RAB10 (Affinity Capture-MS), FAM63A (Affinity Capture-MS), TMEM63A (Affinity Capture-MS), TMEM63B (Affinity Capture-MS), PLD1 (Affinity Capture-MS), GPR89A (Affinity Capture-MS), SLC30A6 (Affinity Capture-MS), C4orf32 (Affinity Capture-MS)

ESM2 similar proteins: A0A452G813, A0A8V0ZB02, A1L3G9, A2AWR3, A9LIW2, B6HTR9, D3ZNF5, F4I248, F4JCY2, O35379, O57428, O94886, O94911, P08983, Q059Y8, Q06538, Q09427, Q09428, Q09429, Q17JQ7, Q3KTM2, Q3TWI9, Q4R7U0, Q4V8U5, Q5GH22, Q5GH60, Q5GH68, Q5R826, Q5R9A7, Q5T3F8, Q5YCC5, Q6NP91, Q6PP77, Q6UR05, Q7Q5R7, Q7Z3F1, Q7Z402, Q8C428, Q8CBX0, Q8CG09

Diamond homologs: A0A452G813, A0A8V0ZB02, D3ZNF5, O94886, Q3TWI9, Q5R826, Q5T3F8, Q6NP91, Q8CBX0, Q91YT8, Q9P1W3, X1WEM4, Q9SZT4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

118 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	4
Likely pathogenic	0
Uncertain significance	92
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (4)

Variant ID	HGVS	Classification
1698436	NM_020431.4(TMEM63C):c.1641_1656delinsGGC (p.Asn547fs)	Pathogenic
1698437	NM_020431.4(TMEM63C):c.1216del (p.Trp406fs)	Pathogenic
1698438	NM_020431.4(TMEM63C):c.585C>G (p.Tyr195Ter)	Pathogenic
1698439	NM_020431.4(TMEM63C):c.1572dup (p.Tyr525fs)	Pathogenic

SpliceAI

6003 predictions. Top by Δscore:

Variant	Effect	Δscore
14:77141598:CTCA:C	donor_loss	1.0000
14:77141599:TCA:T	donor_loss	1.0000
14:77141600:CAC:C	donor_loss	1.0000
14:77141601:A:AC	donor_gain	1.0000
14:77141602:C:CC	donor_gain	1.0000
14:77141602:C:CT	donor_loss	1.0000
14:77141602:CCGAG:C	donor_gain	1.0000
14:77219978:A:AG	acceptor_gain	1.0000
14:77219979:C:G	acceptor_gain	1.0000
14:77219985:T:TA	acceptor_gain	1.0000
14:77219996:T:A	acceptor_gain	1.0000
14:77219997:G:A	acceptor_gain	1.0000
14:77220000:T:A	acceptor_gain	1.0000
14:77220002:GCA:G	acceptor_loss	1.0000
14:77220002:GCAGC:G	acceptor_loss	1.0000
14:77220003:CAGCC:C	acceptor_loss	1.0000
14:77220004:A:AC	acceptor_loss	1.0000
14:77220004:A:AG	acceptor_gain	1.0000
14:77220004:AGCCT:A	acceptor_gain	1.0000
14:77220005:G:GT	acceptor_gain	1.0000
14:77220005:GC:G	acceptor_gain	1.0000
14:77220005:GCC:G	acceptor_gain	1.0000
14:77220005:GCCT:G	acceptor_gain	1.0000
14:77220005:GCCTG:G	acceptor_gain	1.0000
14:77220085:AAGG:A	donor_loss	1.0000
14:77220085:AAGGT:A	donor_loss	1.0000
14:77220086:AGG:A	donor_loss	1.0000
14:77220086:AGGTG:A	donor_loss	1.0000
14:77220087:GGT:G	donor_loss	1.0000
14:77220087:GGTG:G	donor_loss	1.0000

AlphaMissense

5363 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
14:77240578:T:A	V345D	0.999
14:77248842:A:C	S614R	0.999
14:77248844:C:A	S614R	0.999
14:77248844:C:G	S614R	0.999
14:77249327:G:C	R636P	0.999
14:77239603:G:C	R269S	0.998
14:77239603:G:T	R269S	0.998
14:77239623:G:C	R276P	0.998
14:77242429:T:A	W383R	0.998
14:77242429:T:C	W383R	0.998
14:77242468:T:A	W396R	0.998
14:77242468:T:C	W396R	0.998
14:77242903:G:C	W396C	0.998
14:77242903:G:T	W396C	0.998
14:77240515:T:C	L324P	0.997
14:77248355:T:G	F537C	0.997
14:77248872:G:A	G624R	0.997
14:77248872:G:C	G624R	0.997
14:77248872:G:T	G624W	0.997
14:77249291:G:A	G624E	0.997
14:77233467:T:G	F170C	0.996
14:77238707:T:C	L222P	0.996
14:77239454:C:G	C256W	0.996
14:77239471:T:C	L262P	0.996
14:77239492:G:C	R269T	0.996
14:77240575:T:C	F344S	0.996
14:77248354:T:C	F537L	0.996
14:77248356:C:A	F537L	0.996
14:77248356:C:G	F537L	0.996
14:77248824:A:C	S608R	0.996

dbSNP variants (sampled 300 via entrez): RS1000007630 (14:77227635 C>T), RS1000062954 (14:77181258 G>T), RS1000075375 (14:77186749 G>C), RS1000185666 (14:77210515 A>G), RS1000188495 (14:77215763 A>C,G), RS1000199368 (14:77259927 T>C), RS1000239985 (14:77222024 G>A), RS1000249727 (14:77255362 G>A,C), RS1000281501 (14:77181460 G>A,T), RS1000389790 (14:77216357 A>C,T), RS1000407496 (14:77216036 C>T), RS1000442512 (14:77257634 C>T), RS1000494513 (14:77203259 G>A), RS1000538982 (14:77250515 C>T), RS1000539527 (14:77198602 A>G)

Disease associations

OMIM: gene MIM:619953 | disease phenotypes: MIM:619966

GenCC curated gene-disease

Disease	Classification	Inheritance
spastic paraplegia 87, autosomal recessive	Strong	Autosomal recessive

Mondo (1): spastic paraplegia 87, autosomal recessive (MONDO:0031019)

Orphanet (1): Autosomal recessive spastic paraplegia type 87 (Orphanet:631088)

HPO phenotypes

18 total (18 of 18 shown, HPO-id order):

HPO	Term
HP:0000007	Autosomal recessive inheritance
HP:0000486	Strabismus
HP:0000639	Nystagmus
HP:0000750	Delayed speech and language development
HP:0001256	Mild intellectual disability
HP:0001260	Dysarthria
HP:0001332	Dystonia
HP:0001347	Hyperreflexia
HP:0002061	Lower limb spasticity
HP:0002064	Spastic gait
HP:0002194	Delayed gross motor development
HP:0002395	Lower limb hyperreflexia
HP:0002938	Lumbar hyperlordosis
HP:0003487	Babinski sign
HP:0003593	Infantile onset
HP:0006986	Upper limb spasticity
HP:0007350	Upper limb hyperreflexia
HP:0011463	Childhood onset

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST003434_12	Obsessive-compulsive symptoms	9.000000e-06
GCST004070_19	Cerebrospinal P-tau181p levels	4.000000e-06
GCST008155_70	Waist-hip ratio	1.000000e-06
GCST010572_6	Sweet taste preference	2.000000e-06

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0007802	obsessive-compulsive symptom measurement
EFO:0004763	p-tau measurement
EFO:0004343	waist-hip ratio
EFO:0010156	sweet liking measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

21 total (human), top 21 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, increases expression, increases methylation	4
Benzo(a)pyrene	affects methylation, decreases methylation, increases methylation	2
Cadmium Chloride	decreases expression	2
aminomethylphosphonic acid (AMPA)	decreases expression	1
propionaldehyde	increases expression	1
bisphenol A	decreases methylation	1
sodium arsenite	increases expression	1
butyraldehyde	increases expression	1
aflatoxin B2	increases methylation	1
pentanal	increases expression	1
abrine	decreases expression	1
Sunitinib	increases expression	1
Aldehydes	increases expression	1
Arsenic	affects methylation	1
Estradiol	increases expression	1
Niclosamide	increases expression	1
Tobacco Smoke Pollution	decreases expression	1
Triclosan	increases expression	1
2,4-Dichlorophenoxyacetic Acid	decreases expression	1
Aflatoxin B1	decreases methylation	1
Okadaic Acid	increases expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_YA84	IDG-HEK293T-TMEM63C-V5-OE	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.