TMEM72-AS1

Summary

TMEM72-AS1 (TMEM72 antisense RNA 1, HGNC:27349) is a long non-coding RNA gene on chromosome 10q11.21.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27349
Approved symbol	TMEM72-AS1
Name	TMEM72 antisense RNA 1
Location	10q11.21
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000224812
Ensembl biotype	lncRNA
Entrez	220980
RNAcentral	URS00000952F1 — lncRNA, 3300 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 45 — 45 lncRNA

ENST00000450287, ENST00000609898, ENST00000653578, ENST00000656140, ENST00000657040, ENST00000657941, ENST00000659046, ENST00000659078, ENST00000659160, ENST00000659185, ENST00000659737, ENST00000659915, ENST00000659921, ENST00000660870, ENST00000662041, ENST00000663109, ENST00000663870, ENST00000666306, ENST00000667765, ENST00000668436, ENST00000668942, ENST00000669460, ENST00000670212, ENST00000670425, ENST00000670791, ENST00000670801, ENST00000685555, ENST00000689847, ENST00000717482, ENST00000717483, ENST00000813785, ENST00000813786, ENST00000813787, ENST00000813788, ENST00000813789, ENST00000813790, ENST00000813791, ENST00000813792, ENST00000813793, ENST00000813794, ENST00000813795, ENST00000813796, ENST00000813797, ENST00000813798, ENST00000813799

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000450287 — 8 exons

Exon	Start	End
ENSE00000999700	44831000	44831245
ENSE00001592536	44826152	44826368
ENSE00001611226	44923081	44923226
ENSE00001621964	44834066	44835319
ENSE00001633509	44823190	44823288
ENSE00001688238	44825502	44825581
ENSE00001770888	44811024	44812183
ENSE00001799867	44959592	44959689

Expression profiles

Bgee: expression breadth ubiquitous, 154 present calls, max score 76.76.

FANTOM5 (CAGE): breadth broad, TPM avg 0.5893 / max 23.3062, expressed in 234 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
109212	0.3497	181
109214	0.1858	81
109213	0.0539	27

Top tissues by expression

242 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	76.76	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	75.94	silver quality
ganglionic eminence	UBERON:0004023	73.48	gold quality
cortical plate	UBERON:0005343	72.56	gold quality
right frontal lobe	UBERON:0002810	72.22	gold quality
Brodmann (1909) area 9	UBERON:0013540	71.51	gold quality
mucosa of stomach	UBERON:0001199	70.73	gold quality
right hemisphere of cerebellum	UBERON:0014890	70.45	gold quality
cerebellar hemisphere	UBERON:0002245	70.37	gold quality
cerebellar cortex	UBERON:0002129	70.30	gold quality
prefrontal cortex	UBERON:0000451	69.55	gold quality
anterior cingulate cortex	UBERON:0009835	69.19	gold quality
sural nerve	UBERON:0015488	68.92	gold quality
cerebellum	UBERON:0002037	68.47	gold quality
mucosa of paranasal sinus	UBERON:0005030	67.94	gold quality
metanephros cortex	UBERON:0010533	67.73	gold quality
tibial nerve	UBERON:0001323	67.30	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.12	gold quality
amygdala	UBERON:0001876	66.84	gold quality
hypothalamus	UBERON:0001898	66.32	gold quality
neocortex	UBERON:0001950	65.87	gold quality
frontal cortex	UBERON:0001870	65.52	gold quality
cortex of kidney	UBERON:0001225	64.32	gold quality
right coronary artery	UBERON:0001625	64.15	gold quality
nucleus accumbens	UBERON:0001882	63.72	gold quality
cerebral cortex	UBERON:0000956	63.34	gold quality
adult mammalian kidney	UBERON:0000082	63.27	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	63.13	gold quality
right ovary	UBERON:0002118	62.49	gold quality
spinal cord	UBERON:0002240	62.35	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.90

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.