TMEM82

Summary

TMEM82 (transmembrane protein 82, HGNC:32350) is a protein-coding gene on chromosome 1p36.21, encoding Transmembrane protein 82 (A0PJX8).

Predicted to be located in membrane.

Source: NCBI Gene 388595 — RefSeq curated summary.

At a glance

• GWAS associations: 6
• MANE Select transcript: NM_001013641

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32350
Approved symbol	TMEM82
Name	transmembrane protein 82
Location	1p36.21
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000162460
Ensembl biotype	protein_coding
Entrez	388595

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 2 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000375782, ENST00000465575, ENST00000853368

RefSeq mRNA: 1 — MANE Select: NM_001013641 NM_001013641

CCDS: CCDS30608

Canonical transcript exons

ENST00000375782 — 6 exons

Exon	Start	End
ENSE00001065415	15742835	15742907
ENSE00001065417	15746867	15747054
ENSE00001468363	15747546	15747982
ENSE00001468365	15742499	15742647
ENSE00003502888	15743020	15743194
ENSE00003668792	15744160	15744580

Expression profiles

Bgee: expression breadth broad, 50 present calls, max score 92.56.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2198 / max 50.8453, expressed in 56 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
905	0.1938	44
906	0.0260	13

Top tissues by expression

118 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of liver	UBERON:0001114	92.56	gold quality
duodenum	UBERON:0002114	88.55	gold quality
liver	UBERON:0002107	88.23	gold quality
mucosa of transverse colon	UBERON:0004991	87.93	gold quality
adult mammalian kidney	UBERON:0000082	79.02	gold quality
small intestine	UBERON:0002108	74.55	gold quality
small intestine Peyer’s patch	UBERON:0003454	74.34	gold quality
transverse colon	UBERON:0001157	70.39	gold quality
kidney	UBERON:0002113	70.24	gold quality
ascending aorta	UBERON:0001496	65.90	gold quality
thoracic aorta	UBERON:0001515	65.89	gold quality
descending thoracic aorta	UBERON:0002345	64.97	gold quality
right coronary artery	UBERON:0001625	61.55	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	60.99	gold quality
intestine	UBERON:0000160	59.31	gold quality
cortex of kidney	UBERON:0001225	58.51	gold quality
rectum	UBERON:0001052	58.04	gold quality
left coronary artery	UBERON:0001626	57.58	gold quality
metanephros cortex	UBERON:0010533	56.82	gold quality
colon	UBERON:0001155	53.96	gold quality
popliteal artery	UBERON:0002250	51.13	gold quality
tibial artery	UBERON:0007610	51.03	gold quality
colonic epithelium	UBERON:0000397	49.46	gold quality
vermiform appendix	UBERON:0001154	47.23	gold quality
body of stomach	UBERON:0001161	45.85	gold quality
stomach	UBERON:0000945	44.55	gold quality
fundus of stomach	UBERON:0001160	43.59	gold quality
granulocyte	CL:0000094	42.80	silver quality
gall bladder	UBERON:0002110	39.33	gold quality
smooth muscle tissue	UBERON:0001135	37.07	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.96

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

4 targeting TMEM82, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4524A-3P	99.72	66.85	2406
HSA-MIR-4663	99.62	65.33	957
HSA-MIR-3922-5P	98.77	66.53	1059
HSA-MIR-4297	98.77	66.95	2013

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	tmem82	ENSDARG00000097606
mus_musculus	Tmem82	ENSMUSG00000043085
rattus_norvegicus		ENSRNOG00000071385

Protein

Protein identifiers

Transmembrane protein 82 — A0PJX8 (reviewed: A0PJX8)

All UniProt accessions (1): A0PJX8

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

Similarity. Belongs to the TMEM82 family.

RefSeq proteins (1): NP_001013663* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR031648	TMEM82	Domain

Pfam: PF15816

UniProt features (14 total): transmembrane region 8, compositionally biased region 2, chain 1, sequence variant 1, sequence conflict 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A0PJX8-F1	77.61	0.30

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 27 (showing top): GSE45365_NK_CELL_VS_BCELL_DN, ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN, RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN, chr1p36, MIKKELSEN_ES_ICP_WITH_H3K4ME3, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, ZNF146_TARGET_GENES, ZNF85_TARGET_GENES, GSE7568_CTRL_VS_3H_TGFB_TREATED_MACROPHAGES_WITH_IL4_AND_DEXAMETHASONE_UP, GSE17580_UNINFECTED_VS_S_MANSONI_INF_TEFF_DN, DESCARTES_MAIN_FETAL_HEPATOBLASTS, DESCARTES_FETAL_LIVER_HEPATOBLASTS, ZC3H11A_TARGET_GENES, CC2D1A_TARGET_GENES, GSE9946_IMMATURE_VS_MATURE_STIMULATORY_DC_DN

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (1): membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	1

Protein interactions and networks

STRING

340 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TMEM82	FAM131C	Q96AQ9	578
TMEM82	SPATA3	Q8NHX4	561
TMEM82	SLC25A34	Q6PIV7	559
TMEM82	FBLIM1	Q8WUP2	533
TMEM82	CCDC163	A0A0D9SF12	530
TMEM82	CEP78	Q5JTW2	521
TMEM82	CEP41	Q9BYV8	492
TMEM82	SH3BP4	Q9P0V3	492
TMEM82	CEP250	Q9BV73	477
TMEM82	SNPH	O15079	471
TMEM82	OTOP2	Q7RTS6	465
TMEM82	BEST4	Q8NFU0	451
TMEM82	ZNF638	Q14966	450
TMEM82	NTAN1	Q96AB6	441
TMEM82	Q6GMV1	Q6GMV1	434

IntAct

2 interactions, top by confidence:

A	B	Type	Score
TMEM82	H2BC12L	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (4): TMEM82 (Two-hybrid), TMEM82 (Two-hybrid), CYP4F2 (Two-hybrid), LOC102724334 (Proximity Label-MS)

ESM2 similar proteins: A0JN53, A0PJX8, A1L1L2, A1L3T7, A4FV45, B0BMG8, E2JF22, G3HQ82, O15360, O43299, O70491, P60330, Q0KL00, Q0V8E7, Q17Q97, Q24JP3, Q3U829, Q49LS3, Q4QR83, Q562E7, Q5ND34, Q5R7B4, Q5T1A1, Q5XG04, Q6NUQ4, Q6PH58, Q6UX68, Q7L4E1, Q7Z412, Q8BGI5, Q8BM55, Q8BSD4, Q8BXV2, Q8C3R1, Q8C7B8, Q8IXR5, Q8K0R6, Q8N6S5, Q8R115, Q8VCA6

Diamond homologs: A0PJX8, B0BMG8, Q5XG04, Q8R115

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

673 predictions. Top by Δscore:

Variant	Effect	Δscore
1:15744576:GCAGG:G	donor_gain	1.0000
1:15744579:GG:G	donor_gain	1.0000
1:15744580:GG:G	donor_gain	1.0000
1:15744581:G:GG	donor_gain	1.0000
1:15744581:GTGA:G	donor_loss	1.0000
1:15746865:A:AG	acceptor_gain	1.0000
1:15746866:G:GA	acceptor_gain	1.0000
1:15746866:GA:G	acceptor_gain	1.0000
1:15746866:GAGGA:G	acceptor_gain	1.0000
1:15742908:G:GG	donor_gain	0.9900
1:15743018:A:AG	acceptor_gain	0.9900
1:15743019:G:GG	acceptor_gain	0.9900
1:15743019:GT:G	acceptor_gain	0.9900
1:15743191:CAAG:C	donor_loss	0.9900
1:15743192:AAGGT:A	donor_loss	0.9900
1:15743193:AGGT:A	donor_loss	0.9900
1:15743194:GG:G	donor_loss	0.9900
1:15743195:GTG:G	donor_loss	0.9900
1:15743196:T:A	donor_loss	0.9900
1:15744578:AGG:A	donor_gain	0.9900
1:15744579:GGG:G	donor_gain	0.9900
1:15746865:A:AC	acceptor_loss	0.9900
1:15746865:AGAG:A	acceptor_gain	0.9900
1:15746866:GAGG:G	acceptor_gain	0.9900
1:15742903:GCCAA:G	donor_gain	0.9800
1:15743016:A:AG	acceptor_gain	0.9800
1:15743016:AAAGT:A	acceptor_gain	0.9800
1:15743017:A:G	acceptor_gain	0.9800
1:15744577:CAGG:C	donor_gain	0.9800
1:15744581:G:T	donor_gain	0.9800

AlphaMissense

2134 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:15743153:T:C	F99L	0.993
1:15743155:C:A	F99L	0.993
1:15743155:C:G	F99L	0.993
1:15744532:T:A	W237R	0.982
1:15744532:T:C	W237R	0.982
1:15744502:T:C	F227L	0.981
1:15744504:C:A	F227L	0.981
1:15744504:C:G	F227L	0.981
1:15744479:C:A	A219D	0.968
1:15742647:G:C	G30R	0.966
1:15744542:T:A	L240H	0.966
1:15744550:T:C	C243R	0.966
1:15744548:T:A	I242N	0.964
1:15744457:T:C	F212L	0.963
1:15744459:T:A	F212L	0.963
1:15744459:T:G	F212L	0.963
1:15744530:T:C	F236S	0.963
1:15743154:T:C	F99S	0.961
1:15743150:G:A	E98K	0.960
1:15744289:A:C	S156R	0.959
1:15744291:C:A	S156R	0.959
1:15744291:C:G	S156R	0.959
1:15744529:T:C	F236L	0.957
1:15744531:C:A	F236L	0.957
1:15744531:C:G	F236L	0.957
1:15744217:G:C	G132R	0.953
1:15744503:T:G	F227C	0.953
1:15744552:C:G	C243W	0.950
1:15743151:A:T	E98V	0.949
1:15742852:G:A	G36R	0.947

dbSNP variants (sampled 300 via entrez): RS1000512368 (1:15742729 C>T), RS1000915865 (1:15740775 C>T), RS1002016956 (1:15742473 C>A), RS1002573247 (1:15745618 C>T), RS1002757512 (1:15741075 T>A,G), RS1002763163 (1:15745963 A>C,G), RS1002789745 (1:15745696 C>T), RS1003000983 (1:15741429 C>T), RS1003119108 (1:15746257 G>A), RS1003158082 (1:15741193 T>C), RS1003749981 (1:15742367 G>A), RS1003860316 (1:15741552 G>C), RS1004373841 (1:15746203 G>A), RS1004413266 (1:15746004 C>T), RS1005391388 (1:15742151 A>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

6 associations (top):

Study	Trait	p-value
GCST001762_33	Obesity-related traits	2.000000e-06
GCST004027_2	Alcohol consumption (heavy vs. light/non-drinkers)	2.000000e-07
GCST004860_1	Alcoholic chronic pancreatitis	7.000000e-07
GCST004860_107	Alcoholic chronic pancreatitis	2.000000e-06
GCST004860_109	Alcoholic chronic pancreatitis	6.000000e-06
GCST004860_134	Alcoholic chronic pancreatitis	1.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004626	IGFBP-3 measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

6 total (human), top 6 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	decreases expression, increases methylation	2
methyleugenol	decreases expression	1
N-Nitrosopyrrolidine	decreases expression	1
Valproic Acid	increases methylation	1
Palmitic Acid	decreases expression	1
Okadaic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.