TMEM87A

Summary

TMEM87A (transmembrane protein 87A, HGNC:24522) is a protein-coding gene on chromosome 15q15.1, encoding Transmembrane protein 87A (Q8NBN3). Potential monoatomic ion channel gated by mechanical force, implicated in normal touch sensitivity through the generation of mechanically activated currents.

Involved in cellular response to mechanical stimulus and detection of mechanical stimulus involved in sensory perception of touch. Acts upstream of or within retrograde transport, endosome to Golgi. Located in Golgi cisterna membrane; plasma membrane; and ruffle.

Source: NCBI Gene 25963 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 76 total
• MANE Select transcript: NM_015497

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24522
Approved symbol	TMEM87A
Name	transmembrane protein 87A
Location	15q15.1
Locus type	gene with protein product
Status	Approved
Aliases	DKFZP564G2022, ELKIN1
Ensembl gene	ENSG00000103978
Ensembl biotype	protein_coding
OMIM	621342
Entrez	25963

Gene structure

Transcript identifiers

Ensembl transcripts: 26 — 21 protein_coding, 3 retained_intron, 2 nonsense_mediated_decay

ENST00000307216, ENST00000389834, ENST00000448392, ENST00000561578, ENST00000562946, ENST00000563371, ENST00000564329, ENST00000566014, ENST00000566474, ENST00000568067, ENST00000568400, ENST00000568432, ENST00000569075, ENST00000704760, ENST00000704761, ENST00000876966, ENST00000876967, ENST00000876968, ENST00000876969, ENST00000876970, ENST00000922064, ENST00000922065, ENST00000953451, ENST00000953452, ENST00000953453, ENST00000953454

RefSeq mRNA: 3 — MANE Select: NM_015497 NM_001110503, NM_001286487, NM_015497

CCDS: CCDS32205, CCDS45243

Canonical transcript exons

ENST00000389834 — 20 exons

Exon	Start	End
ENSE00000678369	42219581	42219642
ENSE00000678408	42220062	42220135
ENSE00000884117	42226806	42226909
ENSE00000931124	42273255	42273433
ENSE00001107516	42218323	42218378
ENSE00001107521	42217803	42217833
ENSE00001107533	42210447	42211749
ENSE00003462071	42267947	42268032
ENSE00003470800	42228712	42228820
ENSE00003479116	42227711	42227769
ENSE00003562384	42272063	42272123
ENSE00003573224	42264090	42264203
ENSE00003594699	42233213	42233306
ENSE00003629839	42231192	42231260
ENSE00003632590	42239670	42239731
ENSE00003642938	42260958	42261002
ENSE00003645378	42237432	42237615
ENSE00003663804	42244050	42244167
ENSE00003665550	42261196	42261249
ENSE00003680487	42236320	42236419

Expression profiles

Bgee: expression breadth ubiquitous, 300 present calls, max score 99.00.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 43.4256 / max 387.1359, expressed in 1816 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
149550	40.3520	1815
149549	1.5289	782
149551	1.5020	1016
149548	0.0427	17

Top tissues by expression

300 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	99.00	gold quality
oocyte	CL:0000023	98.61	gold quality
corpus callosum	UBERON:0002336	97.46	gold quality
adrenal tissue	UBERON:0018303	97.41	gold quality
calcaneal tendon	UBERON:0003701	97.20	gold quality
rectum	UBERON:0001052	96.90	gold quality
periodontal ligament	UBERON:0008266	96.83	gold quality
mammary duct	UBERON:0001765	96.72	gold quality
inferior vagus X ganglion	UBERON:0005363	96.69	gold quality
minor salivary gland	UBERON:0001830	96.65	gold quality
lower lobe of lung	UBERON:0008949	96.51	gold quality
epithelium of mammary gland	UBERON:0003244	96.42	gold quality
urethra	UBERON:0000057	96.39	gold quality
mouth mucosa	UBERON:0003729	96.34	gold quality
upper leg skin	UBERON:0004262	96.27	gold quality
bronchus	UBERON:0002185	96.14	gold quality
epithelium of bronchus	UBERON:0002031	96.13	gold quality
saliva-secreting gland	UBERON:0001044	96.11	gold quality
bronchial epithelial cell	CL:0002328	96.09	gold quality
visceral pleura	UBERON:0002401	96.05	gold quality
right lung	UBERON:0002167	96.03	gold quality
nipple	UBERON:0002030	95.91	gold quality
lung	UBERON:0002048	95.89	gold quality
skin of abdomen	UBERON:0001416	95.84	gold quality
pharyngeal mucosa	UBERON:0000355	95.83	gold quality
mammalian vulva	UBERON:0000997	95.81	gold quality
trigeminal ganglion	UBERON:0001675	95.79	gold quality
mammary gland	UBERON:0001911	95.78	gold quality
thoracic mammary gland	UBERON:0005200	95.77	gold quality
germinal epithelium of ovary	UBERON:0001304	95.75	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	23.37
E-GEOD-130148	yes	8.89

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

113 targeting TMEM87A, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-MIR-25-3P	99.98	74.60	1817
HSA-MIR-32-5P	99.98	75.21	1964
HSA-MIR-363-3P	99.98	74.72	1821
HSA-MIR-367-3P	99.98	74.83	1819
HSA-MIR-92A-3P	99.98	75.21	1960
HSA-MIR-92B-3P	99.98	75.25	1955
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-548AN	99.97	70.91	2817
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-767-5P	99.95	70.85	993
HSA-MIR-1236-3P	99.94	68.04	1695
HSA-MIR-335-3P	99.93	73.36	4958

Literature-anchored findings (GeneRIF, showing 3)

• TMEM87a/Elkin1, a component of a novel mechanoelectrical transduction pathway, modulates melanoma adhesion and migration. (PMID:32228863)
• Touch sensation requires the mechanically gated ion channel ELKIN1. (PMID:38422143)
• GolpHCat (TMEM87A), a unique voltage-dependent cation channel in Golgi apparatus, contributes to Golgi-pH maintenance and hippocampus-dependent memory. (PMID:38992057)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
mus_musculus	Tmem87a	ENSMUSG00000033808
rattus_norvegicus	Tmem87a	ENSRNOG00000008455
drosophila_melanogaster	CG12121	FBGN0030109
drosophila_melanogaster	CG17660	FBGN0031356
caenorhabditis_elegans		WBGENE00015801
caenorhabditis_elegans		WBGENE00016867

Paralogs (3): GPR108 (ENSG00000125734), GPR107 (ENSG00000148358), TMEM87B (ENSG00000153214)

Protein

Protein identifiers

Transmembrane protein 87A — Q8NBN3 (reviewed: Q8NBN3)

Alternative names: Elkin1

All UniProt accessions (10): A0A994J4W5, A0A994J7M5, Q8NBN3, H3BM87, H3BMU0, H3BPJ4, H3BRG0, H3BSZ0, H3BTS6, H3BUZ1

UniProt curated annotations — full annotation on UniProt →

Function. Potential monoatomic ion channel gated by mechanical force, implicated in normal touch sensitivity through the generation of mechanically activated currents. However, a direct channel activity is debated and an alternative could be that it functions as a chaperone for an unidentified mechanosensitive ion channel. Could also be involved in cell mechanosensitivity regulating cell adhesion and migration. May also be involved in retrograde transport from endosomes to the trans-Golgi network (TGN).

Subunit / interactions. May interact with STOML3; STOML3 potentiates the mechanosensitive ion channel activity associated with TMEM87A.

Subcellular location. Cell membrane. Golgi apparatus membrane Cell membrane. Cell projection. Ruffle.

Miscellaneous. Named Elkin, from the Greek word Elko, meaning ’to pull'.

Similarity. Belongs to the LU7TM family. TMEM87 subfamily.

Isoforms (3)

UniProt ID	Names	Canonical?
Q8NBN3-1	1	yes
Q8NBN3-2	2
Q8NBN3-3	3

RefSeq proteins (3): NP_001103973, NP_001273416, NP_056312* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR009637	GPR107/GPR108-like	Family
IPR053937	GOST_TM	Domain
IPR054101	TMEM87A/B_GOLD	Domain

Pfam: PF06814, PF21901

UniProt features (69 total): helix 13, strand 11, topological domain 8, turn 8, transmembrane region 7, sequence conflict 5, glycosylation site 4, splice variant 3, compositionally biased region 2, disulfide bond 2, mutagenesis site 2, signal peptide 1, chain 1, region of interest 1, modified residue 1

Structure

Experimental structures (PDB)

4 structures.

PDB	Method	Resolution (Å)
8HSI	ELECTRON MICROSCOPY	3.1
8KB4	ELECTRON MICROSCOPY	3.1
8HTT	ELECTRON MICROSCOPY	3.6
8CTJ	ELECTRON MICROSCOPY	4.74

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NBN3-F1	72.52	0.22

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 540

Disulfide bonds (2): 74–128, 89–431

Glycosylation sites (4): 79, 127, 157, 160

Mutagenesis-validated functional residues (2):

Position	Phenotype
271	reduced mechanosensitive channel activity in tmem87a-expressing cells.
292	reduced mechanosensitive channel activity in tmem87a-expressing cells.

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-8980692	RHOA GTPase cycle

MSigDB gene sets: 226 (showing top): TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, GOBP_SENSORY_PERCEPTION_OF_MECHANICAL_STIMULUS, GOBP_CELLULAR_RESPONSE_TO_EXTERNAL_STIMULUS, GOBP_DETECTION_OF_MECHANICAL_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, ASTON_MAJOR_DEPRESSIVE_DISORDER_DN, GOBP_VESICLE_MEDIATED_TRANSPORT, HNF1_Q6, GOCC_RUFFLE, CAGGTCC_MIR492, GOBP_DETECTION_OF_MECHANICAL_STIMULUS, ONKEN_UVEAL_MELANOMA_UP, CHARAFE_BREAST_CANCER_BASAL_VS_MESENCHYMAL_UP, GOBP_RESPONSE_TO_ABIOTIC_STIMULUS, GATA1_03, AACTTT_UNKNOWN

GO Biological Process (3): retrograde transport, endosome to Golgi (GO:0042147), detection of mechanical stimulus involved in sensory perception of touch (GO:0050976), cellular response to mechanical stimulus (GO:0071260)

GO Molecular Function (0):

GO Cellular Component (8): Golgi membrane (GO:0000139), ruffle (GO:0001726), Golgi apparatus (GO:0005794), cytosol (GO:0005829), plasma membrane (GO:0005886), Golgi cisterna membrane (GO:0032580), membrane (GO:0016020), cell projection (GO:0042995)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RHO GTPase cycle	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
cytoplasm	2
intercellular transport	1
endosomal transport	1
cytosolic transport	1
detection of mechanical stimulus involved in sensory perception	1
sensory perception of touch	1
response to mechanical stimulus	1
cellular response to abiotic stimulus	1
cellular response to external stimulus	1
Golgi apparatus	1
bounding membrane of organelle	1
cell leading edge	1
plasma membrane bounded cell projection	1
endomembrane system	1
intracellular membrane-bounded organelle	1
membrane	1
cell periphery	1
organelle membrane	1
Golgi cisterna	1

Protein interactions and networks

STRING

686 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TMEM87A	GPAA1	O43292	528
TMEM87A	TEPSIN	Q96N21	509
TMEM87A	GPR107	Q5VW38	477
TMEM87A	CENATAC	Q86UT8	475
TMEM87A	ZCCHC8	Q6NZY4	449
TMEM87A	C11orf87	Q6NUJ2	448
TMEM87A	RECQL5	O94762	443
TMEM87A	TVP23B	Q9NYZ1	429
TMEM87A	RABL2A	Q9UBK7	415
TMEM87A	TMEM150C	B9EJG8	413
TMEM87A	ZBED8L	Q8TCP9	413
TMEM87A	CLCN7	P51798	410
TMEM87A	KATNIP	O60303	403
TMEM87A	TMEM120A	Q9BXJ8	402
TMEM87A	TMEM63C	Q9P1W3	396

IntAct

115 interactions, top by confidence:

A	B	Type	Score
RINT1	NBAS	psi-mi:“MI:0914”(association)	0.830
SNX1	SNX2	psi-mi:“MI:0914”(association)	0.740
FPR2	ARL6IP5	psi-mi:“MI:0914”(association)	0.640
LPAR1	TMEM223	psi-mi:“MI:0914”(association)	0.530
IPPK	TMEM223	psi-mi:“MI:0914”(association)	0.530
SLC9A6	MAP1LC3B2	psi-mi:“MI:0914”(association)	0.530
SCN3B	ABCC5	psi-mi:“MI:0914”(association)	0.530
LPAR1	TMEM120B	psi-mi:“MI:0914”(association)	0.530
SLC22A9	GPR89A	psi-mi:“MI:0914”(association)	0.530
SYP	APBB1	psi-mi:“MI:0914”(association)	0.530
TSPAN5	SC5D	psi-mi:“MI:0914”(association)	0.530
SLC39A4	TMEM120B	psi-mi:“MI:0914”(association)	0.530
APLNR	SLC33A1	psi-mi:“MI:0914”(association)	0.530
TMEM184A	SLC33A1	psi-mi:“MI:0914”(association)	0.530
CCR6	PODXL	psi-mi:“MI:0914”(association)	0.530
TMEM63A	AP3D1	psi-mi:“MI:0914”(association)	0.530
NPTN	TNPO2	psi-mi:“MI:0914”(association)	0.530
SIGMAR1	NPC1	psi-mi:“MI:0914”(association)	0.530
GPR17	IPO8	psi-mi:“MI:0914”(association)	0.530
CMKLR1	SC5D	psi-mi:“MI:0914”(association)	0.530
NRAS	ESYT2	psi-mi:“MI:2364”(proximity)	0.480
TMEM87A	ARFGEF1	psi-mi:“MI:0915”(physical association)	0.400
	ESYT2	psi-mi:“MI:0914”(association)	0.350
UPK1A	TMEM223	psi-mi:“MI:0914”(association)	0.350
ERGIC3	TMEM223	psi-mi:“MI:0914”(association)	0.350
BTNL8	TMEM131L	psi-mi:“MI:0914”(association)	0.350

BioGRID (236): TMEM87A (Affinity Capture-MS), TMEM87A (Affinity Capture-MS), TMEM87A (Affinity Capture-MS), TMEM87A (Affinity Capture-MS), TMEM87A (Affinity Capture-MS), TMEM87A (Affinity Capture-MS), TMEM87A (Affinity Capture-MS), AGPS (Co-fractionation), TMEM87A (Co-fractionation), TMEM87A (Proximity Label-MS), TMEM87A (Proximity Label-MS), TMEM87A (Proximity Label-MS), TMEM87A (Affinity Capture-MS), TMEM87A (Affinity Capture-MS), TMEM87A (Affinity Capture-MS)

ESM2 similar proteins: A0JPH4, A3KFU9, A6H7H1, A7UA95, B9U3F2, D3ZWZ9, D4A6L0, E1BBQ2, F1M8G0, O15040, O54828, O75129, O88974, P49805, P97260, Q00M95, Q12770, Q13370, Q14432, Q15047, Q3B7M3, Q3B7T1, Q4ZIN3, Q5MNU5, Q5R9R1, Q5T848, Q5VW38, Q5ZKN3, Q61409, Q62865, Q63085, Q6A0A9, Q6F6B3, Q6GQV7, Q6L8S8, Q6P6V6, Q6PJF5, Q80WQ6, Q80Z10, Q86XL3

Diamond homologs: Q28EW0, Q8BKU8, Q8BXN9, Q8NBN3, Q96K49

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 139 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Chemokine receptors bind chemokines	6	11.7×	6e-04
Class A/1 (Rhodopsin-like receptors)	15	11.6×	9e-10
GPCR ligand binding	13	8.7×	5e-07
Signaling by GPCR	13	5.4×	6e-05
G alpha (i) signalling events	13	5.3×	6e-05
GPCR downstream signalling	11	5.0×	6e-04
G alpha (q) signalling events	8	4.8×	3e-03

GO biological processes:

GO term	Partners	Fold	FDR
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	10	17.1×	9e-08
positive regulation of cytosolic calcium ion concentration	13	11.9×	3e-08
cell chemotaxis	7	10.1×	8e-04
calcium-mediated signaling	7	10.0×	8e-04
phospholipase C-activating G protein-coupled receptor signaling pathway	7	7.2×	4e-03
G protein-coupled receptor signaling pathway	21	6.0×	3e-08

Disease & clinical

Clinical variants and AI predictions

ClinVar

76 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	53
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2676 predictions. Top by Δscore:

Variant	Effect	Δscore
15:42211748:TCCTA:T	acceptor_loss	1.0000
15:42211750:C:CC	acceptor_gain	1.0000
15:42211751:T:A	acceptor_loss	1.0000
15:42218322:CA:C	donor_gain	1.0000
15:42218322:CACAT:C	donor_gain	1.0000
15:42219575:A:AC	donor_gain	1.0000
15:42219576:C:CC	donor_gain	1.0000
15:42219576:CTTA:C	donor_gain	1.0000
15:42219577:TTACT:T	donor_loss	1.0000
15:42219578:TACTG:T	donor_loss	1.0000
15:42219579:A:AC	donor_gain	1.0000
15:42219579:ACTG:A	donor_gain	1.0000
15:42219580:C:CT	donor_gain	1.0000
15:42219580:CT:C	donor_gain	1.0000
15:42219580:CTG:C	donor_gain	1.0000
15:42219580:CTGC:C	donor_gain	1.0000
15:42219580:CTGCT:C	donor_gain	1.0000
15:42219638:TCCTT:T	acceptor_gain	1.0000
15:42219639:CCTTC:C	acceptor_gain	1.0000
15:42219640:CTT:C	acceptor_gain	1.0000
15:42219641:TT:T	acceptor_gain	1.0000
15:42219643:C:CC	acceptor_gain	1.0000
15:42219643:C:G	acceptor_loss	1.0000
15:42219645:G:C	acceptor_gain	1.0000
15:42219645:G:GC	acceptor_gain	1.0000
15:42220081:AGGCT:A	donor_gain	1.0000
15:42220131:CAAAC:C	acceptor_gain	1.0000
15:42220132:AAAC:A	acceptor_gain	1.0000
15:42220134:AC:A	acceptor_gain	1.0000
15:42220134:ACC:A	acceptor_loss	1.0000

AlphaMissense

3630 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
15:42218358:C:A	W520C	1.000
15:42218358:C:G	W520C	1.000
15:42236335:C:A	G318V	1.000
15:42236335:C:T	G318E	1.000
15:42236336:C:G	G318R	1.000
15:42236336:C:T	G318R	1.000
15:42236340:A:C	S316R	1.000
15:42236340:A:T	S316R	1.000
15:42236342:T:G	S316R	1.000
15:42237570:A:G	W244R	1.000
15:42237570:A:T	W244R	1.000
15:42218360:A:G	W520R	0.999
15:42218360:A:T	W520R	0.999
15:42220133:A:C	F469C	0.999
15:42226824:G:T	P462Q	0.999
15:42226825:G:A	P462S	0.999
15:42226831:A:G	W460R	0.999
15:42226831:A:T	W460R	0.999
15:42226833:A:G	L459P	0.999
15:42226862:G:C	F449L	0.999
15:42226862:G:T	F449L	0.999
15:42226864:A:G	F449L	0.999
15:42226892:C:A	W439C	0.999
15:42226892:C:G	W439C	0.999
15:42226894:A:G	W439R	0.999
15:42226894:A:T	W439R	0.999
15:42226904:C:A	W435C	0.999
15:42226904:C:G	W435C	0.999
15:42228729:A:G	L408P	0.999
15:42228729:A:T	L408H	0.999

dbSNP variants (sampled 300 via entrez): RS1000019196 (15:42253475 C>T), RS1000044449 (15:42243804 G>A), RS1000111738 (15:42250058 G>A), RS1000121375 (15:42237956 C>A,T), RS1000124764 (15:42249845 A>G), RS1000235423 (15:42257175 T>C), RS1000328008 (15:42231671 G>A,T), RS1000329127 (15:42229614 C>T), RS1000340122 (15:42255132 G>A,T), RS1000374153 (15:42269733 G>A), RS1000375057 (15:42270659 G>C), RS1000435560 (15:42263751 GA>G,GAA), RS1000462226 (15:42238012 T>C), RS1000490497 (15:42239082 C>T), RS1000532898 (15:42210417 G>T)

Disease associations

OMIM: gene MIM:621342 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST004122_26	Fibrinogen levels	2.000000e-09

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

51 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases expression, decreases methylation	4
sodium arsenite	increases abundance, increases expression, decreases expression, affects cotreatment	2
Air Pollutants	affects expression, increases abundance, decreases expression	2
FR900359	increases phosphorylation	1
bisphenol F	increases expression	1
dicrotophos	decreases expression	1
bisphenol A	increases expression	1
trichostatin A	affects expression	1
arsenite	affects expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
2-bromopalmitate	decreases reaction, increases abundance, increases palmitoylation	1
coumarin	decreases phosphorylation	1
beta-methylcholine	affects expression	1
pentanal	decreases expression	1
3-deazaneplanocin	increases expression	1
chloropicrin	increases expression	1
K 7174	increases expression	1
ICG 001	decreases expression	1
bisphenol B	increases expression	1
bisphenol AF	increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Resveratrol	increases expression, affects cotreatment	1
Temozolomide	increases expression	1
Acetaminophen	increases expression	1
Arsenic	increases abundance, increases expression, decreases expression, affects cotreatment	1
Benzene	increases expression	1
Bleomycin	increases expression	1
Cadmium	decreases reaction, increases abundance, increases palmitoylation	1
Coal	decreases expression, increases abundance	1
Demecolcine	increases expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D7HP	Ubigene HEK293T TMEM87A KO	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.