TMEM92-AS1

Summary

TMEM92-AS1 (TMEM92 antisense RNA 1, HGNC:50442) is a long non-coding RNA gene on chromosome 17q21.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50442
Approved symbol	TMEM92-AS1
Name	TMEM92 antisense RNA 1
Location	17q21.33
Locus type	RNA, long non-coding
Status	Approved
Aliases	RP11-893F2.9, lncRNA-508851, TCONS_00025237
Ensembl gene	ENSG00000251179
Ensembl biotype	lncRNA
Entrez	103752589
RNAcentral	URS00007E4094 — lncRNA, 748 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000508851, ENST00000784388, ENST00000784389

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000508851 — 4 exons

Exon	Start	End
ENSE00002039508	50281577	50281876
ENSE00002058299	50287740	50287855
ENSE00002063049	50282468	50282551
ENSE00002084891	50283958	50284207

Expression profiles

Bgee: expression breadth ubiquitous, 122 present calls, max score 86.40.

Top tissues by expression

122 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.40	gold quality
ascending aorta	UBERON:0001496	75.07	gold quality
thoracic aorta	UBERON:0001515	74.75	gold quality
descending thoracic aorta	UBERON:0002345	73.34	gold quality
endocervix	UBERON:0000458	73.18	gold quality
sural nerve	UBERON:0015488	72.03	silver quality
right coronary artery	UBERON:0001625	71.17	gold quality
ectocervix	UBERON:0012249	71.08	gold quality
uterine cervix	UBERON:0000002	71.04	gold quality
stromal cell of endometrium	CL:0002255	70.77	gold quality
popliteal artery	UBERON:0002250	70.50	gold quality
tibial artery	UBERON:0007610	70.47	gold quality
body of stomach	UBERON:0001161	70.39	gold quality
fundus of stomach	UBERON:0001160	69.47	gold quality
vagina	UBERON:0000996	69.21	gold quality
stomach	UBERON:0000945	69.15	gold quality
left coronary artery	UBERON:0001626	68.99	gold quality
urinary bladder	UBERON:0001255	67.99	gold quality
prostate gland	UBERON:0002367	67.03	gold quality
body of uterus	UBERON:0009853	65.82	gold quality
blood	UBERON:0000178	65.54	gold quality
myometrium	UBERON:0001296	65.21	gold quality
saliva-secreting gland	UBERON:0001044	64.37	gold quality
minor salivary gland	UBERON:0001830	64.32	gold quality
small intestine	UBERON:0002108	64.14	gold quality
gall bladder	UBERON:0002110	64.09	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.09	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.76	gold quality
endometrium	UBERON:0001295	63.08	gold quality
calcaneal tendon	UBERON:0003701	62.99	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.44

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• A novel long noncoding RNA, TMEM92-AS1, promotes gastric cancer progression by binding to YBX1 to mediate CCL5. (PMID:33247987)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.