TMF1

Summary

TMF1 (TATA element modulatory factor 1, HGNC:11870) is a protein-coding gene on chromosome 3p14.1, encoding TATA element modulatory factor (P82094). Potential coactivator of the androgen receptor.

Enables nuclear androgen receptor binding activity and transcription coactivator activity. Involved in androgen receptor signaling pathway and positive regulation of transcription by RNA polymerase II. Located in Golgi apparatus.

Source: NCBI Gene 7110 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 156 total — 1 pathogenic
• MANE Select transcript: NM_007114

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:11870
Approved symbol	TMF1
Name	TATA element modulatory factor 1
Location	3p14.1
Locus type	gene with protein product
Status	Approved
Aliases	ARA160, TMF
Ensembl gene	ENSG00000144747
Ensembl biotype	protein_coding
OMIM	601126
Entrez	7110

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 10 protein_coding, 2 retained_intron, 1 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000398559, ENST00000477872, ENST00000488010, ENST00000489370, ENST00000645406, ENST00000646304, ENST00000646708, ENST00000936590, ENST00000948162, ENST00000948163, ENST00000948164, ENST00000948165, ENST00000948166, ENST00000948167

RefSeq mRNA: 2 — MANE Select: NM_007114 NM_001363879, NM_007114

CCDS: CCDS43105, CCDS87105

Canonical transcript exons

ENST00000398559 — 17 exons

Exon	Start	End
ENSE00000966895	69047358	69048562
ENSE00000966896	69044492	69044595
ENSE00000966897	69043750	69043876
ENSE00000966898	69042807	69042912
ENSE00000966899	69039551	69039693
ENSE00000966900	69038843	69039009
ENSE00000966901	69038564	69038720
ENSE00000966902	69035023	69035115
ENSE00000966903	69033548	69033704
ENSE00000966904	69029815	69030007
ENSE00001909854	69019827	69023320
ENSE00003479250	69028226	69028295
ENSE00003625724	69027900	69027992
ENSE00003651633	69025560	69025712
ENSE00003659887	69024055	69024180
ENSE00003687972	69025996	69026097
ENSE00003828424	69051945	69052333

Expression profiles

Bgee: expression breadth ubiquitous, 279 present calls, max score 96.45.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 28.9931 / max 259.0913, expressed in 1818 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
42952	19.5806	1813
42953	5.2416	1660
42951	2.9322	1462
42954	0.7183	441
42949	0.2788	92
42950	0.2417	79

Top tissues by expression

294 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	96.45	gold quality
stromal cell of endometrium	CL:0002255	93.55	gold quality
mucosa of paranasal sinus	UBERON:0005030	92.92	gold quality
caput epididymis	UBERON:0004358	92.87	gold quality
adrenal tissue	UBERON:0018303	91.95	gold quality
islet of Langerhans	UBERON:0000006	91.89	gold quality
bronchial epithelial cell	CL:0002328	91.51	gold quality
right uterine tube	UBERON:0001302	91.13	gold quality
corpus epididymis	UBERON:0004359	90.98	gold quality
rectum	UBERON:0001052	90.93	gold quality
body of pancreas	UBERON:0001150	90.80	gold quality
left testis	UBERON:0004533	90.74	gold quality
minor salivary gland	UBERON:0001830	90.45	gold quality
pancreas	UBERON:0001264	90.37	gold quality
endometrium	UBERON:0001295	89.83	gold quality
monocyte	CL:0000576	89.61	gold quality
right testis	UBERON:0004534	89.61	gold quality
cauda epididymis	UBERON:0004360	89.21	gold quality
testis	UBERON:0000473	89.19	gold quality
mononuclear cell	CL:0000842	89.17	gold quality
leukocyte	CL:0000738	89.06	gold quality
right lung	UBERON:0002167	89.04	gold quality
tibia	UBERON:0000979	89.01	gold quality
gall bladder	UBERON:0002110	89.01	gold quality
saliva-secreting gland	UBERON:0001044	88.95	gold quality
mucosa of sigmoid colon	UBERON:0004993	88.72	gold quality
left ovary	UBERON:0002119	88.61	gold quality
right ovary	UBERON:0002118	88.43	gold quality
mouth mucosa	UBERON:0003729	88.43	gold quality
adenohypophysis	UBERON:0002196	88.41	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

1 targets.

Target	Regulation
AR	Activation

miRNA regulators (miRDB)

230 targeting TMF1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-32-5P	99.98	75.21	1964
HSA-MIR-92A-3P	99.98	75.21	1960
HSA-MIR-92B-3P	99.98	75.25	1955
HSA-MIR-25-3P	99.98	74.60	1817
HSA-MIR-363-3P	99.98	74.72	1821

Literature-anchored findings (GeneRIF, showing 5)

• These observations suggest critical roles for TMF in two Rab6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the endoplasmic reticulum. (PMID:17698061)
• Overexpression of TMF/ARA160 downregulates proangiogenic genes and attenuates the progression of prostate cancer xenografts. (PMID:19330832)
• COG complex interacts with two different Rabs in addition to each end of the golgin “TATA element modulatory factor” (TMF). (PMID:23239882)
• In patient with chronic granulomatous disease, a 5.8-kb, incomplete and partly exonized TMF1 transcript was identified in intron 1 of CYBB, in opposite orientation to the host gene. (PMID:24478191)
• In the nucleus, PDGFRbeta formed ligand-inducible complexes with the tyrosine kinase Fer and its substrate, TATA element-modifying factor 1 (TMF-1). (PMID:29545370)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	tmf1	ENSDARG00000057997
mus_musculus	Tmf1	ENSMUSG00000030059
rattus_norvegicus	Tmf1	ENSRNOG00000056462

Paralogs (44): MYH13 (ENSG00000006788), MYO16 (ENSG00000041515), MYO9A (ENSG00000066933), MYO3B (ENSG00000071909), MYH7B (ENSG00000078814), MYO15A (ENSG00000091536), MYH7 (ENSG00000092054), MYO3A (ENSG00000095777), MYO9B (ENSG00000099331), MYH9 (ENSG00000100345), MYH14 (ENSG00000105357), MYH1 (ENSG00000109061), MYH3 (ENSG00000109063), MYH2 (ENSG00000125414), MYO1B (ENSG00000128641), MYO5C (ENSG00000128833), CGNL1 (ENSG00000128849), MYH8 (ENSG00000133020), MYH10 (ENSG00000133026), MYH11 (ENSG00000133392), MYO18B (ENSG00000133454), CCDC102A (ENSG00000135736), MYO1G (ENSG00000136286), MYO7A (ENSG00000137474), MYO1F (ENSG00000142347), CGN (ENSG00000143375), MYH15 (ENSG00000144821), MYO10 (ENSG00000145555), CCDC102B (ENSG00000150636), MYO1E (ENSG00000157483), CCDC158 (ENSG00000163749), MYO1A (ENSG00000166866), MYO5B (ENSG00000167306), MYO7B (ENSG00000169994), MYO1H (ENSG00000174527), MYO1D (ENSG00000176658), MYO18A (ENSG00000196535), MYO6 (ENSG00000196586), MYO5A (ENSG00000197535), MYH6 (ENSG00000197616)

Protein

Protein identifiers

TATA element modulatory factor — P82094 (reviewed: P82094)

Alternative names: Androgen receptor coactivator 160 kDa protein, Androgen receptor-associated protein of 160 kDa

All UniProt accessions (3): P82094, A0A2R8Y7M0, F8WF45

UniProt curated annotations — full annotation on UniProt →

Function. Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP).

Subunit / interactions. Interacts with TRNP1; may regulate TRNP1 proteasomal degradation. Component of the SNF/SWI transcription factor complexes. Interacts with RAB6A. Interacts with STAT3 and FER. Interacts with TCEB1.

Subcellular location. Cytoplasm. Nucleus. Golgi apparatus membrane.

Post-translational modifications. Phosphorylated by FER.

Domain organisation. The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].

Induction. Down-regulated in malignant brain tumors.

Isoforms (2)

UniProt ID	Names	Canonical?
P82094-1	1	yes
P82094-2	2

RefSeq proteins (2): NP_001350808, NP_009045* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR022091	TMF_TATA-bd	Domain
IPR022092	TMF_DNA-bd	Family
IPR052602	Growth_transcription_reg	Family

Pfam: PF12325, PF12329

UniProt features (39 total): modified residue 17, compositionally biased region 7, region of interest 6, sequence variant 4, coiled-coil region 2, chain 1, splice variant 1, mutagenesis site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P82094-F1	66.05	0.38

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (17): 72, 77, 112, 136, 199, 217, 328, 330, 333, 338, 344, 413, 542, 925, 928, 929, 933

Mutagenesis-validated functional residues (1):

Position	Phenotype
333–335	strongly reduced the ubiquitination directing activity of the protein.

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-6811440	Retrograde transport at the Trans-Golgi-Network

MSigDB gene sets: 258 (showing top): MODULE_416, GOBP_CELLULAR_RESPONSE_TO_LIPID, GOBP_VESICLE_ORGANIZATION, ENK_UV_RESPONSE_KERATINOCYTE_UP, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, GOBP_REGULATION_OF_HORMONE_LEVELS, GOBP_HORMONE_TRANSPORT, GOBP_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION, BROWNE_HCMV_INFECTION_16HR_UP, GOBP_MALE_GAMETE_GENERATION, REACTOME_MEMBRANE_TRAFFICKING, CAGCTG_AP4_Q5, GOBP_POSITIVE_REGULATION_OF_LIPID_TRANSPORT, GOBP_CELL_CELL_SIGNALING, GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT

GO Biological Process (17): acrosome assembly (GO:0001675), positive regulation of cytokine production (GO:0001819), spermatid nucleus differentiation (GO:0007289), negative regulation of gene expression (GO:0010629), flagellated sperm motility (GO:0030317), androgen receptor signaling pathway (GO:0030521), luteinizing hormone secretion (GO:0032275), Leydig cell differentiation (GO:0033327), defense response to bacterium (GO:0042742), positive regulation of transcription by RNA polymerase II (GO:0045944), regulation of proteasomal protein catabolic process (GO:0061136), epithelial cell apoptotic process (GO:1904019), negative regulation of epithelial cell apoptotic process (GO:1904036), positive regulation of testosterone secretion (GO:2000845), apoptotic process (GO:0006915), spermatid development (GO:0007286), male gonad development (GO:0008584)

GO Molecular Function (4): DNA binding (GO:0003677), transcription coactivator activity (GO:0003713), nuclear androgen receptor binding (GO:0050681), protein binding (GO:0005515)

GO Cellular Component (7): Golgi membrane (GO:0000139), nucleus (GO:0005634), endoplasmic reticulum (GO:0005783), Golgi apparatus (GO:0005794), cytosol (GO:0005829), cytoplasm (GO:0005737), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Intra-Golgi and retrograde Golgi-to-ER traffic	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
intracellular membrane-bounded organelle	3
cytoplasm	3
cellular anatomical structure	3
developmental process involved in reproduction	2
spermatid development	2
positive regulation of DNA-templated transcription	2
endomembrane system	2
cellular component assembly involved in morphogenesis	1
cellular process involved in reproduction in multicellular organism	1
secretory granule organization	1
organelle assembly	1
cytokine production	1
regulation of cytokine production	1
positive regulation of gene expression	1
positive regulation of multicellular organismal process	1
nucleus organization	1
gene expression	1
regulation of gene expression	1
negative regulation of macromolecule biosynthetic process	1
cilium-dependent cell motility	1
cilium movement involved in cell motility	1
sperm motility	1
nuclear receptor-mediated steroid hormone signaling pathway	1
gonadotropin secretion	1
male gonad development	1
cell differentiation	1
defense response	1
response to bacterium	1
regulation of transcription by RNA polymerase II	1
transcription by RNA polymerase II	1
proteasomal protein catabolic process	1
regulation of protein catabolic process	1
apoptotic process	1
negative regulation of apoptotic process	1
epithelial cell apoptotic process	1
regulation of epithelial cell apoptotic process	1
positive regulation of lipid transport	1
testosterone secretion	1
positive regulation of hormone secretion	1
regulation of testosterone secretion	1

Protein interactions and networks

STRING

1232 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TMF1	RAB6A	P20340	846
TMF1	ANKAR	Q7Z5J8	820
TMF1	OSGEPL1	Q9H4B0	669
TMF1	RAB6B	Q9NRW1	657
TMF1	GOLGA5	Q8TBA6	546
TMF1	ZFPL1	O95159	538
TMF1	USO1	O60763	532
TMF1	RNF14	Q9UBS8	506
TMF1	TBP	P20226	482
TMF1	STT3A	P46977	478
TMF1	GCC1	Q96CN9	473
TMF1	NFATC2	Q13469	470
TMF1	RUNDC1	Q96C34	451
TMF1	GCC2	Q8IWJ2	447
TMF1	BLZF1	Q9H2G9	444

IntAct

51 interactions, top by confidence:

A	B	Type	Score
PLK1	SPAG9	psi-mi:“MI:0914”(association)	0.790
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
FOXK2	DVL2	psi-mi:“MI:0914”(association)	0.640
TMF1	CMTM5	psi-mi:“MI:0915”(physical association)	0.560
PLK1	C1orf226	psi-mi:“MI:0914”(association)	0.560
KXD1	HIP1	psi-mi:“MI:0914”(association)	0.530
BAG2	HGS	psi-mi:“MI:0914”(association)	0.530
CBFA2T3	CBFA2T2	psi-mi:“MI:0914”(association)	0.530
KXD1	TRAK2	psi-mi:“MI:0914”(association)	0.530
TMF1	NR3C1	psi-mi:“MI:0915”(physical association)	0.520
NR3C1	TMF1	psi-mi:“MI:0915”(physical association)	0.520
TMF1	CEBPZ	psi-mi:“MI:0915”(physical association)	0.400
TMF1	E2	psi-mi:“MI:0915”(physical association)	0.370
TMF1		psi-mi:“MI:0915”(physical association)	0.370
	TMF1	psi-mi:“MI:0915”(physical association)	0.370
TFAP2C	TMF1	psi-mi:“MI:0915”(physical association)	0.370
USP7	STIL	psi-mi:“MI:0914”(association)	0.350
PDHA1		psi-mi:“MI:0914”(association)	0.350
ESR1	ESYT2	psi-mi:“MI:0914”(association)	0.350
PLK1	ERCC6L	psi-mi:“MI:0914”(association)	0.350
	TNFRSF10A	psi-mi:“MI:0914”(association)	0.350
ATG16L1	ESYT2	psi-mi:“MI:0914”(association)	0.350
AP1M2	AP1G1	psi-mi:“MI:0914”(association)	0.350
BSPRY	SRGAP2	psi-mi:“MI:0914”(association)	0.350
CCDC183	PCNT	psi-mi:“MI:0914”(association)	0.350

BioGRID (132): TMF1 (Affinity Capture-MS), TMF1 (Affinity Capture-MS), TMF1 (Affinity Capture-MS), TMF1 (Two-hybrid), TMF1 (Proximity Label-MS), TMF1 (Affinity Capture-MS), TMF1 (Affinity Capture-MS), TMF1 (Proximity Label-MS), TMF1 (Affinity Capture-MS), TMF1 (Affinity Capture-MS), TMF1 (Affinity Capture-MS), TMF1 (Affinity Capture-MS), TMF1 (Affinity Capture-MS), TMF1 (Affinity Capture-MS), TMF1 (Affinity Capture-MS)

ESM2 similar proteins: A0MZ66, A0MZ67, A6PWD2, A7MD70, B3DLE8, B9EKI3, F7DP49, O35550, O35551, O45420, P82094, Q05D60, Q08DR9, Q15276, Q28IH8, Q3KR99, Q3UIJ9, Q4L180, Q4R7H3, Q4V7C8, Q53EZ4, Q5BIX7, Q5R923, Q5RA03, Q5RI56, Q5U3Z6, Q6NRC9, Q6NRW2, Q6P0R8, Q6P402, Q6P6L0, Q7YS99, Q7Z7B0, Q861Q8, Q8BT07, Q8BVC4, Q8K2Q9, Q8K3K8, Q8K4T4, Q8R5M4

Diamond homologs: B9EKI3, P82094

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

156 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	121
Likely benign	10
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
1064533	Single allele	Pathogenic

SpliceAI

2591 predictions. Top by Δscore:

Variant	Effect	Δscore
3:69023321:CTGAA:C	acceptor_loss	1.0000
3:69024053:A:AC	donor_gain	1.0000
3:69024054:C:CC	donor_gain	1.0000
3:69025583:C:A	donor_gain	1.0000
3:69025589:G:C	donor_gain	1.0000
3:69025595:G:C	donor_gain	1.0000
3:69027894:CAATA:C	donor_loss	1.0000
3:69027895:AATAC:A	donor_loss	1.0000
3:69027896:ATACC:A	donor_loss	1.0000
3:69027897:TA:T	donor_loss	1.0000
3:69027898:A:AT	donor_loss	1.0000
3:69027899:C:CA	donor_loss	1.0000
3:69027990:TGT:T	acceptor_gain	1.0000
3:69027991:GT:G	acceptor_gain	1.0000
3:69027993:C:CC	acceptor_gain	1.0000
3:69028221:AATAC:A	donor_loss	1.0000
3:69028222:ATAC:A	donor_loss	1.0000
3:69028223:TA:T	donor_loss	1.0000
3:69028224:ACCTT:A	donor_loss	1.0000
3:69028225:C:T	donor_loss	1.0000
3:69028234:T:A	donor_gain	1.0000
3:69035021:ACCT:A	donor_loss	1.0000
3:69035022:CCTG:C	donor_gain	1.0000
3:69035111:CCCAC:C	acceptor_gain	1.0000
3:69035112:CCAC:C	acceptor_gain	1.0000
3:69035112:CCACC:C	acceptor_gain	1.0000
3:69035113:CAC:C	acceptor_gain	1.0000
3:69035113:CACC:C	acceptor_gain	1.0000
3:69035114:AC:A	acceptor_gain	1.0000
3:69035115:CC:C	acceptor_gain	1.0000

AlphaMissense

7208 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:69023292:A:G	L1056P	1.000
3:69052049:G:T	A13D	1.000
3:69023241:A:G	L1073P	0.999
3:69023253:A:G	L1069P	0.999
3:69023272:C:G	A1063P	0.999
3:69024131:A:G	L1021P	0.999
3:69025594:A:G	L993P	0.999
3:69025606:A:G	L989P	0.999
3:69033562:A:G	L796P	0.999
3:69033611:C:G	A780P	0.999
3:69033628:T:G	Q774P	0.999
3:69033631:C:G	R773P	0.999
3:69033634:A:G	L772P	0.999
3:69033682:C:G	R756P	0.999
3:69033692:C:G	A753P	0.999
3:69033700:A:G	L750P	0.999
3:69035030:A:G	L746P	0.999
3:69035105:A:G	L721P	0.999
3:69052004:A:G	L28P	0.999
3:69052016:A:T	I24N	0.999
3:69052028:G:T	A20D	0.999
3:69023263:C:G	A1066P	0.998
3:69024059:A:G	L1045P	0.998
3:69024141:C:G	A1018P	0.998
3:69024152:C:G	R1014P	0.998
3:69024164:A:G	L1010P	0.998
3:69033670:A:G	L760P	0.998
3:69038858:A:G	L660P	0.998
3:69039684:A:G	L565P	0.998
3:69052016:A:C	I24S	0.998

dbSNP variants (sampled 300 via entrez): RS1000072943 (3:69051602 G>A,C,T), RS1000073728 (3:69046871 T>C), RS1000091140 (3:69029091 T>G), RS1000126432 (3:69051972 C>A,T), RS1000298310 (3:69039120 A>C,G), RS1000304409 (3:69029116 C>G,T), RS1000518845 (3:69035461 T>G), RS1000532619 (3:69041691 T>C), RS1000572378 (3:69021684 TG>T), RS1000704217 (3:69027589 A>T), RS1000950227 (3:69044046 T>C), RS1001132029 (3:69050572 T>C), RS1001163345 (3:69021045 C>A,T), RS1001301128 (3:69037919 G>A), RS1001360199 (3:69044391 A>C,G)

Disease associations

OMIM: gene MIM:601126 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST009391_1084	Metabolite levels	2.000000e-06
GCST010143_29	Meat-related diet	5.000000e-09

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0010543	uridine diphosphate galactose measurement
EFO:0010544	uridine diphosphate glucose measurement
EFO:0008111	diet measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

47 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
trichostatin A	increases expression	2
aristolochic acid I	decreases expression	1
FR900359	affects phosphorylation	1
dicrotophos	decreases expression	1
testosterone enanthate	affects expression	1
methylmercuric chloride	decreases expression, increases expression	1
bisphenol A	increases methylation	1
beta-lapachone	increases expression	1
arsenite	affects binding, decreases reaction	1
sodium bichromate	increases expression	1
sodium arsenite	increases expression	1
butyraldehyde	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	decreases expression	1
CGP 52608	affects binding, increases reaction	1
jinfukang	decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Sunitinib	increases expression	1
Acetaminophen	decreases expression	1
Atrazine	increases expression	1
Benzo(a)pyrene	increases methylation	1
Caffeine	affects phosphorylation	1
Clorgyline	increases expression	1
Demecolcine	increases expression	1
Enzyme Inhibitors	increases O-linked glycosylation, decreases activity	1
Ethyl Methanesulfonate	increases expression	1
Lead	affects expression	1
Mercury	decreases expression	1
Methyl Methanesulfonate	increases expression	1
Phenobarbital	affects expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.