TMPO-AS1

Summary

TMPO-AS1 (TMPO antisense RNA 1, HGNC:44158) is a long non-coding RNA gene on chromosome 12q23.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44158
Approved symbol	TMPO-AS1
Name	TMPO antisense RNA 1
Location	12q23.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000257167
Ensembl biotype	lncRNA
Entrez	100128191
RNAcentral	URS000075B992 — lncRNA, 3161 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

ENST00000546421, ENST00000548760, ENST00000733960, ENST00000733961, ENST00000733962

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000546421 — 3 exons

Exon	Start	End
ENSE00002359707	98515477	98515897
ENSE00002373951	98515991	98516210
ENSE00002387340	98514400	98515390

Expression profiles

Bgee: expression breadth ubiquitous, 157 present calls, max score 80.65.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.8794 / max 107.3582, expressed in 1284 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
132831	1.7832	845
132829	0.7682	373
132832	0.7465	450
132827	0.7241	354
132828	0.6483	367
132830	0.2090	113

Top tissues by expression

255 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.65	silver quality
left testis	UBERON:0004533	79.74	gold quality
right testis	UBERON:0004534	78.91	gold quality
testis	UBERON:0000473	78.14	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	77.95	gold quality
ventricular zone	UBERON:0003053	73.83	gold quality
ganglionic eminence	UBERON:0004023	72.17	gold quality
bone marrow cell	CL:0002092	72.06	gold quality
monocyte	CL:0000576	70.25	gold quality
leukocyte	CL:0000738	70.13	gold quality
adult organism	UBERON:0007023	69.68	gold quality
stromal cell of endometrium	CL:0002255	67.65	gold quality
sperm	CL:0000019	67.32	silver quality
cortical plate	UBERON:0005343	66.69	gold quality
granulocyte	CL:0000094	66.38	gold quality
colonic epithelium	UBERON:0000397	65.54	silver quality
vermiform appendix	UBERON:0001154	63.32	gold quality
right uterine tube	UBERON:0001302	62.68	gold quality
left ovary	UBERON:0002119	60.44	gold quality
lymph node	UBERON:0000029	60.37	gold quality
mucosa of transverse colon	UBERON:0004991	60.11	gold quality
ovary	UBERON:0000992	59.50	gold quality
spleen	UBERON:0002106	58.93	gold quality
caecum	UBERON:0001153	58.28	gold quality
right ovary	UBERON:0002118	58.25	gold quality
smooth muscle tissue	UBERON:0001135	58.21	gold quality
rectum	UBERON:0001052	57.46	gold quality
ileal mucosa	UBERON:0000331	57.27	silver quality
corpus epididymis	UBERON:0004359	56.57	gold quality
blood	UBERON:0000178	56.24	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.17

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 18)

• TMPO-AS1 contributes to lung carcinogenesis, which may be partially through upregulation TMPO. (PMID:31230752)
• TMPO-AS1 is closely associated with the estrogen signaling pathway. TMPO-AS1 could positively regulate estrogen receptor 1 (ESR1) mRNA expression by stabilizing ESR1 mRNA through interaction with ESR1 mRNA. (PMID:31501276)
• LncRNA TMPO-AS1 serves as a ceRNA to promote osteosarcoma tumorigenesis by regulating miR-199a-5p/WNT7B axis. (PMID:31680323)
• Overexpression and Clinicopathological Correlation of Long Noncoding RNA TMPO-AS1 in Colorectal Cancer Patients. (PMID:31768869)
• LncRNA TMPO-AS1 up-regulates the expression of HIF-1alpha and promotes the malignant phenotypes of retinoblastoma cells via sponging miR-199a-5p. (PMID:32139259)
• Roles of a TMPO-AS1/microRNA-200c/TMEFF2 ceRNA network in the malignant behaviors and 5-FU resistance of ovarian cancer cells. (PMID:32497621)
• LncRNA TMPO-AS1 promotes LCN2 transcriptional activity and exerts oncogenic functions in ovarian cancer. (PMID:32692467)
• Inhibition of lncRNA TMPOAS1 suppresses proliferation, migration and invasion of colorectal cancer cells by targeting miR1433p. (PMID:32945436)
• LncRNA TMPO-AS1 promotes proliferation and migration in bladder cancer. (PMID:32964962)
• LncRNA TMPO-AS1 facilitates the proliferation and metastasis of NSCLC cells by up-regulating ERBB2 via sponging miR-204-3p. (PMID:32969763)
• LncRNA-TMPO-AS1 promotes apoptosis of osteosarcoma cells by targeting miR-329 and regulating E2F1. (PMID:33215415)
• Down-Regulation of TMPO-AS1 Induces Apoptosis in Lung Carcinoma Cells by Regulating miR-143-3p/CDK1 Axis. (PMID:33685293)
• The Emerging Role of Thymopoietin-Antisense RNA 1 as Long Noncoding RNA in the Pathogenesis of Human Cancers. (PMID:34096793)
• LncRNA TMPO-AS1 suppresses the maturation of miR-335-5p to participate in polycystic ovary syndrome. (PMID:34330309)
• lncRNA TMPO antisense RNA 1 promotes the malignancy of cholangiocarcinoma cells by regulating let-7g-5p/ high-mobility group A1 axis. (PMID:35040749)
• LncRNA TMPO-AS1 promotes esophageal squamous cell carcinoma progression by forming biomolecular condensates with FUS and p300 to regulate TMPO transcription. (PMID:35760875)
• Long noncoding RNA TMPO-AS1 accelerates glycolysis by regulating the miR-1270/PKM2 axis in colorectal cancer. (PMID:38383342)
• LncRNA TMPO-AS1 Promotes Triple-Negative Breast Cancer by Sponging miR-383-5p to Trigger the LDHA Axis. (PMID:39205592)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.