TMSB15C

Summary

TMSB15C (thymosin beta 15C, HGNC:55173) is a protein-coding gene on chromosome Xq22.2, encoding Thymosin beta-15C (P0DX04). Plays an important role in the organization of the cytoskeleton.

Predicted to enable actin monomer binding activity. Involved in positive regulation of cell migration. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm.

Source: NCBI Gene 122394733 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001395930

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55173
Approved symbol	TMSB15C
Name	thymosin beta 15C
Location	Xq22.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000269226
Ensembl biotype	protein_coding
Entrez	122394733

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 protein_coding

ENST00000598087, ENST00000620307, ENST00000881651, ENST00000913430, ENST00000913431, ENST00000913432

RefSeq mRNA: 1 — MANE Select: NM_001395930 NM_001395930

CCDS: CCDS94644

Canonical transcript exons

ENST00000598087 — 3 exons

Exon	Start	End
ENSE00003006043	104074241	104074357
ENSE00003978335	104076140	104076236
ENSE00003978336	104072887	104073324

Expression profiles

Bgee: expression breadth ubiquitous, 154 present calls, max score 85.89.

Top tissues by expression

244 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ganglionic eminence	UBERON:0004023	85.89	gold quality
cortical plate	UBERON:0005343	85.10	gold quality
ventricular zone	UBERON:0003053	79.91	gold quality
right ovary	UBERON:0002118	79.30	gold quality
left ovary	UBERON:0002119	78.78	gold quality
right hemisphere of cerebellum	UBERON:0014890	78.58	gold quality
cerebellar hemisphere	UBERON:0002245	78.53	gold quality
cerebellar cortex	UBERON:0002129	78.34	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	75.97	gold quality
cerebellum	UBERON:0002037	75.65	gold quality
stromal cell of endometrium	CL:0002255	74.27	gold quality
right coronary artery	UBERON:0001625	74.01	gold quality
body of uterus	UBERON:0009853	73.82	gold quality
descending thoracic aorta	UBERON:0002345	73.00	gold quality
tibial artery	UBERON:0007610	72.98	gold quality
popliteal artery	UBERON:0002250	72.97	gold quality
ovary	UBERON:0000992	72.55	gold quality
aorta	UBERON:0000947	72.48	gold quality
thoracic aorta	UBERON:0001515	72.27	gold quality
ascending aorta	UBERON:0001496	72.23	gold quality
mucosa of stomach	UBERON:0001199	71.91	gold quality
endocervix	UBERON:0000458	71.42	gold quality
left coronary artery	UBERON:0001626	70.57	gold quality
smooth muscle tissue	UBERON:0001135	70.45	gold quality
left uterine tube	UBERON:0001303	70.27	gold quality
islet of Langerhans	UBERON:0000006	69.55	gold quality
coronary artery	UBERON:0001621	69.20	gold quality
ectocervix	UBERON:0012249	69.00	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.28	gold quality
calcaneal tendon	UBERON:0003701	67.95	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-GEOD-109979	yes	104.44
E-MTAB-7606	no	26.60
E-HCAD-5	no	14.20
E-ANND-3	no	1.21

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (2): TMSB15A (ENSG00000158164), TMSB15B (ENSG00000158427)

Protein

Protein identifiers

Thymosin beta-15C — P0DX04 (reviewed: P0DX04)

All UniProt accessions (2): A0A087X1C1, P0DX04

UniProt curated annotations — full annotation on UniProt →

Function. Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G-actin) and therefore inhibits actin polymerization.

Subcellular location. Cytoplasm. Cytoskeleton.

Similarity. Belongs to the thymosin beta family.

RefSeq proteins (2): NP_001337142, NP_001382859* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001152	Beta-thymosin	Family
IPR038386	Beta-thymosin_sf	Homologous_superfamily

Pfam: PF01290

UniProt features (5 total): compositionally biased region 2, initiator methionine 1, chain 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0DX04-F1	72.00	0.00

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 21 (showing top): GOBP_ACTIN_FILAMENT_ORGANIZATION, GOMF_ACTIN_BINDING, GOCC_FILAMENTOUS_ACTIN, GOMF_CYTOSKELETAL_PROTEIN_BINDING, GOMF_ACTIN_MONOMER_BINDING, chrXq22, GOBP_SUPRAMOLECULAR_FIBER_ORGANIZATION, GOCC_SUPRAMOLECULAR_COMPLEX, GOCC_POLYMERIC_CYTOSKELETAL_FIBER, GOCC_SUPRAMOLECULAR_POLYMER, GOBP_LOCOMOTION, GOBP_POSITIVE_REGULATION_OF_LOCOMOTION, GOMF_PROTEIN_SEQUESTERING_ACTIVITY, GOMF_MOLECULAR_SEQUESTERING_ACTIVITY, GOBP_REGULATION_OF_LOCOMOTION

GO Biological Process (2): actin filament organization (GO:0007015), regulation of cell migration (GO:0030334)

GO Molecular Function (2): actin monomer binding (GO:0003785), protein sequestering activity (GO:0140311)

GO Cellular Component (3): cytoskeleton (GO:0005856), cytoplasm (GO:0005737), filamentous actin (GO:0031941)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
actin cytoskeleton organization	1
supramolecular fiber organization	1
cell migration	1
regulation of cell motility	1
actin binding	1
protein binding	1
molecular sequestering activity	1
intracellular membraneless organelle	1
intracellular anatomical structure	1
cellular anatomical structure	1
actin filament	1
protein-containing complex	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A097SRV6, A0A0J1BDH3, O41801, P04605, P0C1K3, P0C766, P0CG34, P0CG35, P0DX04, P12692, P15633, P15835, P18758, P20065, P21113, P21117, P21752, P21753, P26351, P26352, P33248, P33735, P33736, P33737, P34338, P34493, P53768, P60743, P75605, Q12026, Q4UKT5, Q54CC7, Q55GR5, Q5MJ07, Q5MJ08, Q5VSR9, Q66H17, Q6I7R5, Q6SJ84, Q6SJ91

Diamond homologs: O14604, P0CG34, P0CG35, P0DX04, P18758, P20065, P21752, P21753, P26351, P26352, P33248, P34032, P62326, P62327, P62328, P62329, P63312, P63313, P63314, Q5R7H8, Q6S9C5, Q6ZWY8, Q7YRC3, Q8T697, Q95274, Q9DET5, Q9DFJ9, Q9I954, Q9I955, Q9I980, Q9W7M8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

291 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
X:104074302:A:C	F13L	0.971
X:104074302:A:T	F13L	0.971
X:104074304:A:G	F13L	0.971
X:104073315:T:G	Q37P	0.912
X:104073321:A:T	I35N	0.901
X:104074284:C:A	K19N	0.899
X:104074284:C:G	K19N	0.899
X:104073321:A:C	I35S	0.892
X:104073311:C:A	E38D	0.864
X:104073311:C:G	E38D	0.864
X:104073321:A:G	I35T	0.860
X:104073318:T:G	Q36P	0.845
X:104074288:A:G	L18P	0.836
X:104073312:T:A	E38V	0.815
X:104073313:C:T	E38K	0.805
X:104074303:A:G	F13S	0.784
X:104073312:T:G	E38A	0.776
X:104074263:T:A	K26N	0.769
X:104074263:T:G	K26N	0.769
X:104074303:A:C	F13C	0.767
X:104073308:T:A	K39N	0.756
X:104073308:T:G	K39N	0.756
X:104073312:T:C	E38G	0.742
X:104074288:A:T	L18Q	0.692
X:104074285:T:G	K19T	0.672
X:104074264:T:A	K26I	0.659
X:104074312:A:T	V10E	0.659
X:104074273:G:A	T23I	0.658
X:104074286:T:C	K19E	0.635
X:104074281:T:A	K20N	0.623

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.