TMT1A

Summary

TMT1A (thiol methyltransferase 1A, HGNC:24550) is a protein-coding gene on chromosome 12q13.12, encoding Thiol S-methyltransferase TMT1A (Q9H8H3). Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to alkyl and phenolic thiol-containing acceptor substrates. It is a selective cancer dependency (DepMap: 11.3% of cell lines).

Enables mRNA m(6)A methyltransferase activity and thiol S-methyltransferase activity. Involved in lncRNA processing; odontogenesis; and osteoblast differentiation. Located in endoplasmic reticulum and lipid droplet.

Source: NCBI Gene 25840 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 49 total
• Druggable target: yes
• Cancer dependency (DepMap): dependent in 11.3% of screened cell lines
• MANE Select transcript: NM_014033

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24550
Approved symbol	TMT1A
Name	thiol methyltransferase 1A
Location	12q13.12
Locus type	gene with protein product
Status	Approved
Aliases	DKFZP586A0522
Ensembl gene	ENSG00000185432
Ensembl biotype	protein_coding
OMIM	618338
Entrez	25840

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 6 protein_coding, 2 nonsense_mediated_decay

ENST00000332160, ENST00000547104, ENST00000548553, ENST00000550097, ENST00000550502, ENST00000949679, ENST00000949680, ENST00000949681

RefSeq mRNA: 1 — MANE Select: NM_014033 NM_014033

CCDS: CCDS8804

Canonical transcript exons

ENST00000332160 — 2 exons

Exon	Start	End
ENSE00001317034	50925015	50925536
ENSE00001388041	50929914	50932508

Expression profiles

Bgee: expression breadth ubiquitous, 291 present calls, max score 99.86.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 33.2721 / max 955.2448, expressed in 1449 samples.

FANTOM5 promoters (12 alternative TSS)

Promoter ID	TPM avg	Samples expressed
125466	22.6971	1271
125463	5.3501	921
125462	2.8180	949
125465	0.7792	364
125464	0.4102	211
125468	0.3443	181
125461	0.2036	105
125467	0.1943	85
125460	0.1854	91
125470	0.1636	48

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bronchial epithelial cell	CL:0002328	99.86	gold quality
epithelium of bronchus	UBERON:0002031	99.72	gold quality
bronchus	UBERON:0002185	99.67	gold quality
nephron tubule	UBERON:0001231	99.66	gold quality
germinal epithelium of ovary	UBERON:0001304	99.64	gold quality
adult organism	UBERON:0007023	99.54	gold quality
mucosa of paranasal sinus	UBERON:0005030	99.51	gold quality
choroid plexus epithelium	UBERON:0003911	99.43	gold quality
seminal vesicle	UBERON:0000998	99.38	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	99.30	gold quality
caput epididymis	UBERON:0004358	99.26	gold quality
renal medulla	UBERON:0000362	99.23	gold quality
medial globus pallidus	UBERON:0002477	99.21	gold quality
dorsal motor nucleus of vagus nerve	UBERON:0002870	99.20	gold quality
cardia of stomach	UBERON:0001162	99.19	gold quality
globus pallidus	UBERON:0001875	99.18	gold quality
parietal pleura	UBERON:0002400	99.17	gold quality
lower lobe of lung	UBERON:0008949	99.17	gold quality
lateral globus pallidus	UBERON:0002476	99.13	gold quality
kidney epithelium	UBERON:0004819	99.12	gold quality
jejunal mucosa	UBERON:0000399	99.07	gold quality
trabecular bone tissue	UBERON:0002483	99.07	gold quality
epithelium of nasopharynx	UBERON:0001951	98.99	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	98.98	gold quality
synovial joint	UBERON:0002217	98.97	gold quality
pericardium	UBERON:0002407	98.97	gold quality
diaphragm	UBERON:0001103	98.93	gold quality
superficial temporal artery	UBERON:0001614	98.90	gold quality
skin of hip	UBERON:0001554	98.85	gold quality
pleura	UBERON:0000977	98.84	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	29.32

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

126 targeting TMT1A, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-6851-5P	100.00	65.63	1294
HSA-MIR-3689D	100.00	66.14	1181
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-499A-5P	99.98	70.79	1323
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-146A-5P	99.96	68.93	988
HSA-MIR-146B-5P	99.96	69.13	977
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-7153-5P	99.94	68.89	1006
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-7-1-3P	99.91	71.53	4384
HSA-MIR-7-2-3P	99.91	71.40	4394
HSA-MIR-4753-3P	99.90	71.03	3786
HSA-MIR-3529-3P	99.90	73.55	3045
HSA-MIR-548E-5P	99.89	72.73	4486
HSA-MIR-95-5P	99.89	72.17	3973
HSA-MIR-6780A-5P	99.88	66.69	2776
HSA-MIR-6857-5P	99.87	65.32	985

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 11.3% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 6)

• AAM-B is predominantly localized in lipid droplets and may be involved in recruitment of NS4B protein in the proximity of lipid droplets. (PMID:26185986)
• Results revealed that the methylation level of METTL7A was downregulated in thyroid cancer, and determined the methylation level of one CpG site at the exon of the METTL7A gene body impacted the transcriptional activity. (PMID:28416772)
• Quantitative proteomic analysis identifies novel regulators of methotrexate resistance in choriocarcinoma. (PMID:31955862)
• A Novel Localization of METTL7A in Bergmann Glial Cells in Human Cerebellum. (PMID:37176112)
• Transcriptomic characterization revealed that METTL7A inhibits melanoma progression via the p53 signaling pathway and immunomodulatory pathway. (PMID:37547717)
• The Methyltransferases METTL7A and METTL7B Confer Resistance to Thiol-Based Histone Deacetylase Inhibitors. (PMID:38151817)

Cross-species orthologs

11 orthologs

Organism	Symbol	Gene ID
danio_rerio	tmt1a.2	ENSDARG00000028478
danio_rerio	tmt1a.1	ENSDARG00000056726
danio_rerio	tmt1a.3	ENSDARG00000060889
mus_musculus	Tmt1a	ENSMUSG00000054619
mus_musculus	Tmt1a2	ENSMUSG00000056487
mus_musculus	Tmt1a3	ENSMUSG00000058057
rattus_norvegicus	Tmt1a	ENSRNOG00000001376
caenorhabditis_elegans		WBGENE00019675
caenorhabditis_elegans		WBGENE00019961
caenorhabditis_elegans		WBGENE00019963
caenorhabditis_elegans		WBGENE00019968

Paralogs (4): COQ5 (ENSG00000110871), METTL27 (ENSG00000165171), TMT1B (ENSG00000170439), AS3MT (ENSG00000214435)

Protein

Protein identifiers

Thiol S-methyltransferase TMT1A — Q9H8H3 (reviewed: Q9H8H3)

Alternative names: Methyltransferase-like protein 7A, N6-adenosine-methyltransferase TMT1A, Protein AAM-B, Thiol methyltransferase 1A

All UniProt accessions (3): F8VQX6, Q9H8H3, H0YI09

UniProt curated annotations — full annotation on UniProt →

Function. Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to alkyl and phenolic thiol-containing acceptor substrates. Together with TMT1B accounts for most of S-thiol methylation activity in the endoplasmic reticulum of hepatocytes. Able to methylate the N6 position of adenosine residues in long non-coding RNAs (lncRNAs). May facilitate lncRNAs transfer into exosomes at the tumor-stroma interface. Promotes osteogenic and odontogenic differentiation by regulating the expression of genes involved in stem cell differentiation and survival. Targeted from the endoplasmic reticulum to lipid droplets, where it recruits cellular proteins to form functional organelles. (Microbial infection) May be involved in the assembly and release stages of hepatitis C virus (HCV) life cycle and thus play a crucial role in HCV propagation.

Subunit / interactions. (Microbial infection) Interacts with HCV non-structural protein 4B/NS4B (via C-terminal region); this interaction may promote the recruitment of NS4B in the proximity of lipid droplet. Self-associates. Interacts with SNRNP200; this interaction may promote the odontogenic differentiation.

Subcellular location. Lipid droplet. Endoplasmic reticulum. Membrane. Microsome. Cytoplasm. Cytosol.

Tissue specificity. Expressed in the liver.

Post-translational modifications. Methylated at lysine residues most likely by EZH2.

Activity regulation. Inhibited by 2,3-dichloro-alpha-methylbenzylamine (DCMB).

Induction. Silenced by miR-6807-5p.

Miscellaneous. Selectively methylates drugs containing thiol-moieties such as 7alpha-thiospironolactone and mertansine.

Similarity. Belongs to the methyltransferase superfamily.

RefSeq proteins (1): NP_054752* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013216	Methyltransf_11	Domain
IPR029063	SAM-dependent_MTases_sf	Homologous_superfamily
IPR052356	Thiol_S-MT	Family

Pfam: PF08241

Catalyzed reactions (Rhea), 2 shown:

• a thiol + S-adenosyl-L-methionine = a methyl thioether + S-adenosyl-L-homocysteine + H(+) (RHEA:18277)
• an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H(+) (RHEA:55584)

UniProt features (5 total): signal peptide 1, chain 1, region of interest 1, sequence variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H8H3-F1	96.16	0.96

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-6798695	Neutrophil degranulation

MSigDB gene sets: 298 (showing top): GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN, MULLIGHAN_NPM1_SIGNATURE_3_UP, KOBAYASHI_EGFR_SIGNALING_24HR_UP, REACTOME_INNATE_IMMUNE_SYSTEM, MODULE_255, GOCC_SECRETORY_GRANULE, LOPEZ_MESOTHELIOMA_SURVIVAL_OVERALL_UP, GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP, GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_UP, MODULE_317, GOBP_OSTEOBLAST_DIFFERENTIATION, GAUSSMANN_MLL_AF4_FUSION_TARGETS_E_UP, CHEN_LVAD_SUPPORT_OF_FAILING_HEART_UP, GOBP_ANIMAL_ORGAN_MORPHOGENESIS, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1

GO Biological Process (4): osteoblast differentiation (GO:0001649), methylation (GO:0032259), odontogenesis (GO:0042476), lncRNA processing (GO:0180035)

GO Molecular Function (7): mRNA m(6)A methyltransferase activity (GO:0001734), methyltransferase activity (GO:0008168), RNA methyltransferase activity (GO:0008173), thiol S-methyltransferase activity (GO:0018708), protein binding (GO:0005515), S-adenosylmethionine-dependent methyltransferase activity (GO:0008757), transferase activity (GO:0016740)

GO Cellular Component (7): extracellular region (GO:0005576), endoplasmic reticulum (GO:0005783), lipid droplet (GO:0005811), cytosol (GO:0005829), membrane (GO:0016020), tertiary granule lumen (GO:1904724), cytoplasm (GO:0005737)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Innate Immune System	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
methyltransferase activity	2
cytoplasm	2
ossification	1
cell differentiation	1
metabolic process	1
animal organ morphogenesis	1
RNA processing	1
mRNA methyltransferase activity	1
transferase activity, transferring one-carbon groups	1
catalytic activity, acting on RNA	1
S-methyltransferase activity	1
S-adenosylmethionine-dependent methyltransferase activity	1
binding	1
catalytic activity	1
endomembrane system	1
intracellular membrane-bounded organelle	1
intracellular membraneless organelle	1
intracellular organelle lumen	1
tertiary granule	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

1206 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TMT1A	FAF2	Q96CS3	507
TMT1A	AUP1	Q9Y679	497
TMT1A	METTL17	Q9H7H0	497
TMT1A	METTL25	Q8N6Q8	485
TMT1A	HSD17B11	Q8NBQ5	445
TMT1A	EEF1AKMT2	Q5JPI9	441
TMT1A	TMEM126A	Q9H061	440
TMT1A	METTL27	Q8N6F8	430
TMT1A	METTL8	Q9H825	425
TMT1A	K7ERJ3	K7ERJ3	411
TMT1A	CEBPZOS	A8MTT3	410
TMT1A	METTL26	Q96S19	399
TMT1A	METTL6	Q8TCB7	398
TMT1A	METTL15	A6NJ78	381
TMT1A	TMEM41A	Q96HV5	381

IntAct

60 interactions, top by confidence:

A	B	Type	Score
ELAVL4	TMT1A	psi-mi:“MI:0915”(physical association)	0.560
TMT1A	FGFR3	psi-mi:“MI:0915”(physical association)	0.560
TMT1A	GSN	psi-mi:“MI:0915”(physical association)	0.560
TMT1A	NDUFS3	psi-mi:“MI:0915”(physical association)	0.560
TMT1A	PPIA	psi-mi:“MI:0915”(physical association)	0.560
TMT1A	PRKCA	psi-mi:“MI:0915”(physical association)	0.560
TMT1A	YWHAG	psi-mi:“MI:0915”(physical association)	0.560
TMT1A	SETDB1	psi-mi:“MI:0915”(physical association)	0.560
TMT1A	KAT5	psi-mi:“MI:0915”(physical association)	0.560
LMO3	TMT1A	psi-mi:“MI:0915”(physical association)	0.560
ATXN3	TMT1A	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (382): METTL7A (Affinity Capture-MS), METTL7A (Affinity Capture-MS), METTL7A (Affinity Capture-MS), METTL7A (Affinity Capture-MS), METTL7A (Affinity Capture-MS), METTL7A (Affinity Capture-MS), METTL7A (Affinity Capture-MS), METTL7A (Affinity Capture-MS), METTL7A (Proximity Label-MS), METTL7A (Affinity Capture-MS), METTL7A (Affinity Capture-MS), METTL7A (Proximity Label-MS), METTL7A (Proximity Label-MS), METTL7A (Proximity Label-MS), METTL7A (Proximity Label-MS)

ESM2 similar proteins: A2RU49, A3KCL7, A7RDN6, A7YVH9, D3ZDM7, E9PYK3, E9Q5L8, G5E8F4, O14772, O55060, O55239, P13676, P13798, P19205, P25154, P31228, P40261, P50747, P79106, P80227, P83006, Q03426, Q06AV1, Q0V8R7, Q14CH1, Q28IN4, Q5I0K5, Q5REJ2, Q5RFM7, Q5SZD4, Q5U2W9, Q68FS6, Q6DJF8, Q6GQ33, Q6PE15, Q8C1A3, Q8CDZ2, Q8R146, Q8WU10, Q90678

Diamond homologs: A0A067XMT3, A6ZRD1, P32643, P38892, Q0CCX8, Q562C4, Q6UX53, Q9DD20, Q9H8H3, Q9TYP1, E3G327, Q6D3C1

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

49 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	37
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

482 predictions. Top by Δscore:

Variant	Effect	Δscore
12:50929913:GGGA:G	acceptor_gain	1.0000
12:50925532:GACCG:G	donor_gain	0.9900
12:50925535:CGGTG:C	donor_loss	0.9900
12:50925537:G:GA	donor_loss	0.9900
12:50925537:G:GG	donor_gain	0.9900
12:50925538:T:TC	donor_loss	0.9900
12:50925539:GAGT:G	donor_loss	0.9900
12:50929911:CAGGG:C	acceptor_gain	0.9900
12:50929912:AG:A	acceptor_gain	0.9900
12:50929912:AGGG:A	acceptor_gain	0.9900
12:50929913:GG:G	acceptor_gain	0.9900
12:50929913:GGGAG:G	acceptor_gain	0.9900
12:50925033:T:TA	acceptor_gain	0.9800
12:50925540:AGTGA:A	donor_loss	0.9800
12:50929912:A:AG	acceptor_gain	0.9800
12:50929913:G:GG	acceptor_gain	0.9800
12:50925038:A:AG	acceptor_gain	0.9700
12:50929912:AGG:A	acceptor_gain	0.9700
12:50929913:GGG:G	acceptor_gain	0.9700
12:50925038:AATG:A	acceptor_gain	0.9500
12:50925534:CCG:C	donor_gain	0.9500
12:50925038:AAT:A	acceptor_gain	0.9400
12:50925113:G:A	acceptor_gain	0.9400
12:50925161:G:GC	acceptor_gain	0.9400
12:50925103:T:A	acceptor_gain	0.9300
12:50924666:G:C	acceptor_gain	0.9200
12:50925039:A:G	acceptor_gain	0.9100
12:50925547:GGGT:G	donor_gain	0.9100
12:50925548:GGTG:G	donor_gain	0.9100
12:50925112:T:TA	acceptor_gain	0.8800

AlphaMissense

1602 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:50930134:G:A	G240E	0.971
12:50925290:C:A	N84K	0.969
12:50925290:C:G	N84K	0.969
12:50925529:T:C	L164P	0.960
12:50925324:T:C	C96R	0.959
12:50930140:C:A	A242D	0.958
12:50929940:T:A	H175Q	0.955
12:50929940:T:G	H175Q	0.955
12:50925203:G:C	K55N	0.954
12:50925203:G:T	K55N	0.954
12:50925297:T:C	F87L	0.952
12:50925299:C:A	F87L	0.952
12:50925299:C:G	F87L	0.952
12:50930139:G:C	A242P	0.950
12:50925283:G:A	G82E	0.946
12:50925326:T:G	C96W	0.946
12:50925465:T:C	C143R	0.944
12:50925480:T:C	C148R	0.943
12:50929979:A:C	Q188H	0.941
12:50929979:A:T	Q188H	0.941
12:50930037:A:C	S208R	0.941
12:50930039:C:A	S208R	0.941
12:50930039:C:G	S208R	0.941
12:50925460:T:A	V141E	0.940
12:50930064:T:C	F217L	0.939
12:50930066:C:A	F217L	0.939
12:50930066:C:G	F217L	0.939
12:50925300:T:G	Y88D	0.938
12:50929936:A:T	E174V	0.938
12:50925282:G:T	G82W	0.936

dbSNP variants (sampled 300 via entrez): RS1001066648 (12:50928516 G>A), RS1001274023 (12:50930434 C>G,T), RS1001405059 (12:50930217 C>G,T), RS1001457539 (12:50929817 T>C), RS1001503330 (12:50923837 A>G), RS1001979285 (12:50924901 A>G,T), RS1002035908 (12:50923516 T>A), RS1002554250 (12:50926034 A>G), RS1003129550 (12:50931461 G>C), RS1003615733 (12:50929026 T>A), RS1003798246 (12:50924612 C>T), RS1003954716 (12:50931443 C>T), RS1004057004 (12:50926547 G>A), RS1004082824 (12:50924833 T>A,G), RS1004102272 (12:50928947 T>TA)

Disease associations

OMIM: gene MIM:618338 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST006979_1057	Heel bone mineral density	3.000000e-12

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0009270	heel bone mineral density

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067229 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 4 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
5.60	Kd	2493	nM	CHEMBL5653589
5.53	ED50	2975	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 4 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2148745: Binding affinity to human METTL7A incubated for 45 mins by Kinobead based pull down assay	kd	2.4929	uM

CTD chemical–gene interactions

93 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression	5
Air Pollutants	decreases expression, affects expression, increases abundance	4
Benzo(a)pyrene	decreases expression, decreases methylation, increases expression, affects methylation	4
Estradiol	decreases expression, increases expression, affects cotreatment	4
Progesterone	affects cotreatment, increases expression	4
Cyclosporine	decreases expression	4
Resveratrol	affects cotreatment, increases expression	3
Cisplatin	affects expression, affects cotreatment, increases expression	3
Dexamethasone	increases expression, affects cotreatment	3
Hydrogen Peroxide	affects expression, decreases expression	3
Smoke	decreases expression, increases abundance	3
Genistein	increases expression, increases reaction, decreases expression	3
bisphenol F	increases expression	2
mercuric bromide	increases expression, affects cotreatment	2
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	increases expression, affects cotreatment, decreases expression	2
Decitabine	affects expression, increases expression	2
Acetaminophen	decreases expression, increases expression	2
Calcitriol	decreases expression, affects cotreatment	2
Formaldehyde	increases expression	2
Nickel	decreases expression	2
Phenylmercuric Acetate	affects cotreatment, increases expression	2
Silicon Dioxide	decreases expression	2
Tetrachlorodibenzodioxin	decreases expression	2
Tobacco Smoke Pollution	decreases expression	2
Tretinoin	increases expression	2
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	increases expression	2
aristolochic acid I	increases expression	1
GSK-J4	decreases expression	1
6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine	increases expression	1
bisphenol A	affects expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651787	Binding	Binding affinity to human METTL7A incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.