TMX3

Summary

TMX3 (thioredoxin related transmembrane protein 3, HGNC:24718) is a protein-coding gene on chromosome 18q22.1, encoding Protein disulfide-isomerase TMX3 (Q96JJ7). Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds.

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The canonical protein encoded by this gene has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and a C-terminal ER-retention sequence. This gene is expressed in many tissues but has its highest expression in heart and skeletal muscle. It is expressed in the retinal neuroepithelium and lens epithelium in the developing murine eye and haploinsufficiency of this gene in humans and zebrafish is associated with microphthalmia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Source: NCBI Gene 54495 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 113 total
• MANE Select transcript: NM_019022

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24718
Approved symbol	TMX3
Name	thioredoxin related transmembrane protein 3
Location	18q22.1
Locus type	gene with protein product
Status	Approved
Aliases	FLJ20793, KIAA1830, PDIA13
Ensembl gene	ENSG00000166479
Ensembl biotype	protein_coding
OMIM	616102
Entrez	54495

Gene structure

Transcript identifiers

Ensembl transcripts: 20 — 9 protein_coding, 5 nonsense_mediated_decay, 3 protein_coding_CDS_not_defined, 3 retained_intron

ENST00000299608, ENST00000443099, ENST00000544714, ENST00000562706, ENST00000564008, ENST00000564631, ENST00000565918, ENST00000566135, ENST00000566887, ENST00000569053, ENST00000569982, ENST00000578765, ENST00000578816, ENST00000580785, ENST00000903506, ENST00000903507, ENST00000915516, ENST00000915517, ENST00000961335, ENST00000961336

RefSeq mRNA: 7 — MANE Select: NM_019022 NM_001350512, NM_001350513, NM_001350514, NM_001350515, NM_001350516, NM_001350517, NM_019022

CCDS: CCDS32840, CCDS86679, CCDS86680

Canonical transcript exons

ENST00000299608 — 16 exons

Exon	Start	End
ENSE00001103356	68711364	68711403
ENSE00001103392	68710021	68710144
ENSE00001289718	68673688	68677193
ENSE00002613683	68714936	68715108
ENSE00003502953	68682925	68682981
ENSE00003512848	68679463	68679531
ENSE00003526142	68680981	68681110
ENSE00003537138	68687667	68687765
ENSE00003550256	68701745	68701790
ENSE00003577117	68700405	68700485
ENSE00003595378	68713846	68713900
ENSE00003603731	68684428	68684485
ENSE00003607676	68697226	68697303
ENSE00003620717	68684190	68684243
ENSE00003667897	68697932	68698031
ENSE00003686628	68691295	68691361

Expression profiles

Bgee: expression breadth ubiquitous, 262 present calls, max score 98.22.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 30.2893 / max 358.8404, expressed in 1808 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
172320	25.9067	1803
172319	4.3296	1470
172318	0.0529	16

Top tissues by expression

262 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	98.22	gold quality
endothelial cell	CL:0000115	96.79	gold quality
Brodmann (1909) area 23	UBERON:0013554	96.24	gold quality
stromal cell of endometrium	CL:0002255	96.06	gold quality
decidua	UBERON:0002450	95.88	gold quality
oviduct epithelium	UBERON:0004804	95.88	gold quality
vermiform appendix	UBERON:0001154	95.72	gold quality
visceral pleura	UBERON:0002401	95.61	gold quality
epithelial cell of pancreas	CL:0000083	95.30	silver quality
parietal pleura	UBERON:0002400	95.06	gold quality
cardiac muscle of right atrium	UBERON:0003379	95.05	gold quality
secondary oocyte	CL:0000655	94.72	gold quality
tibia	UBERON:0000979	94.57	gold quality
monocyte	CL:0000576	94.53	gold quality
rectum	UBERON:0001052	94.31	gold quality
lymph node	UBERON:0000029	94.30	gold quality
tendon	UBERON:0000043	94.12	gold quality
smooth muscle tissue	UBERON:0001135	94.05	gold quality
leukocyte	CL:0000738	94.03	gold quality
right uterine tube	UBERON:0001302	94.03	gold quality
oocyte	CL:0000023	93.78	gold quality
caecum	UBERON:0001153	93.67	gold quality
epithelium of nasopharynx	UBERON:0001951	93.64	gold quality
germinal epithelium of ovary	UBERON:0001304	93.57	gold quality
adrenal tissue	UBERON:0018303	93.38	gold quality
endometrium	UBERON:0001295	93.36	gold quality
small intestine Peyer’s patch	UBERON:0003454	93.17	gold quality
nerve	UBERON:0001021	93.15	gold quality
tibial nerve	UBERON:0001323	93.15	gold quality
gall bladder	UBERON:0002110	92.94	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.44
E-MTAB-2983	no	733.19

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

187 targeting TMX3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-518D-5P	100.00	67.51	979
HSA-MIR-518E-5P	100.00	67.66	954
HSA-MIR-518F-5P	100.00	67.51	979
HSA-MIR-519A-5P	100.00	67.66	954
HSA-MIR-519B-5P	100.00	67.66	954
HSA-MIR-519C-5P	100.00	67.66	954
HSA-MIR-520C-5P	100.00	67.51	979
HSA-MIR-522-5P	100.00	67.66	954
HSA-MIR-523-5P	100.00	67.66	954
HSA-MIR-526A-5P	100.00	67.51	979
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-4803	99.98	71.99	3117
HSA-MIR-433-3P	99.98	69.37	1203

Literature-anchored findings (GeneRIF, showing 4)

• TMX3 is a thioredoxin-related transmembrane protein of the endoplasmic reticulum (PMID:15623505)
• analysis of TMX3 interdomain stabilization of the N-terminal redox-active domain (PMID:17881353)
• Haploinsufficiency for TMX3 results in a small eye phenotype and represents a novel genetic cause of microphthalmia and coloboma. (PMID:20485507)
• Data show that TMX3 expression is upregulated in melanoma cell lines and patient samples. TMX knockdown altered mitochondrial organization, enhanced bioenergetics, and elevated mitochondrial- and NOX4-derived ROS. The TMX-knockdown-induced oxidative stress suppressed melanoma proliferation, migration, and xenograft tumor growth by inhibiting NFAT1. TMX1 is associated with poor disease outcome. (PMID:31304984)

Cross-species orthologs

12 orthologs

Organism	Symbol	Gene ID
danio_rerio	tmx3a	ENSDARG00000038894
danio_rerio	tmx3b	ENSDARG00000088466
mus_musculus	Tmx3	ENSMUSG00000024614
rattus_norvegicus	Tmx3	ENSRNOG00000045740
drosophila_melanogaster	ERp60	FBGN0033663
drosophila_melanogaster	Tmx3	FBGN0036579
drosophila_melanogaster	Pdi	FBGN0286818
caenorhabditis_elegans		WBGENE00003962
caenorhabditis_elegans		WBGENE00003963
caenorhabditis_elegans	pdi-3	WBGENE00003964
caenorhabditis_elegans	M04D5.1	WBGENE00014807
caenorhabditis_elegans	ZK973.11	WBGENE00022836

Paralogs (13): ERP44 (ENSG00000023318), PDIA5 (ENSG00000065485), TMX4 (ENSG00000125827), ERP27 (ENSG00000139055), TMX1 (ENSG00000139921), PDIA6 (ENSG00000143870), TXNDC11 (ENSG00000153066), PDIA4 (ENSG00000155660), PDIA3 (ENSG00000167004), PDILT (ENSG00000169340), PDIA2 (ENSG00000185615), P4HB (ENSG00000185624), TXNDC5 (ENSG00000239264)

Protein

Protein identifiers

Protein disulfide-isomerase TMX3 — Q96JJ7 (reviewed: Q96JJ7)

Alternative names: Thioredoxin domain-containing protein 10, Thioredoxin-related transmembrane protein 3

All UniProt accessions (6): B4DIE3, Q96JJ7, H3BPB3, H3BRY0, H3BT89, H3BVI1

UniProt curated annotations — full annotation on UniProt →

Function. Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals.

Subcellular location. Endoplasmic reticulum membrane.

Tissue specificity. Widely expressed. Expressed in brain, testis, lung, skin, kidney, uterus, bone, stomach, liver, prostate, placenta, eye and muscle.

Post-translational modifications. N-glycosylated.

Domain organisation. The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.

Induction. Not up-regulated by unfolded protein response (UPR).

Similarity. Belongs to the protein disulfide isomerase family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q96JJ7-1	1	yes
Q96JJ7-2	2

RefSeq proteins (7): NP_001337441, NP_001337442, NP_001337443, NP_001337444, NP_001337445, NP_001337446, NP_061895* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013766	Thioredoxin_domain	Domain
IPR017937	Thioredoxin_CS	Conserved_site
IPR036249	Thioredoxin-like_sf	Homologous_superfamily
IPR052250	PDI_TMX3	Family

Pfam: PF00085, PF13848

UniProt features (19 total): sequence variant 3, active site 2, glycosylation site 2, splice variant 2, topological domain 2, signal peptide 1, chain 1, disulfide bond 1, transmembrane region 1, domain 1, region of interest 1, short sequence motif 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96JJ7-F1	85.68	0.65

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (2): 56 (nucleophile); 53 (nucleophile)

Disulfide bonds (1): 53–56

Glycosylation sites (2): 258, 313

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-114608	Platelet degranulation

MSigDB gene sets: 122 (showing top): GOCC_SECRETORY_GRANULE, REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION, GOCC_CELL_SURFACE, chr18q22, DURCHDEWALD_SKIN_CARCINOGENESIS_DN, SENESE_HDAC3_TARGETS_DN, GOCC_PLATELET_ALPHA_GRANULE, GOCC_PLATELET_ALPHA_GRANULE_MEMBRANE, GOCC_SECRETORY_VESICLE, NUYTTEN_EZH2_TARGETS_DN, GOCC_SECRETORY_GRANULE_MEMBRANE, GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK, GOCC_ORGANELLE_SUBCOMPARTMENT, GOMF_DISULFIDE_OXIDOREDUCTASE_ACTIVITY, GOMF_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY

GO Biological Process (0):

GO Molecular Function (4): protein disulfide isomerase activity (GO:0003756), protein-disulfide reductase activity (GO:0015035), protein binding (GO:0005515), isomerase activity (GO:0016853)

GO Cellular Component (6): endoplasmic reticulum (GO:0005783), endoplasmic reticulum membrane (GO:0005789), plasma membrane (GO:0005886), cell surface (GO:0009986), platelet alpha granule membrane (GO:0031092), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Response to elevated platelet cytosolic Ca2+	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
catalytic activity, acting on a protein	2
cellular anatomical structure	2
intramolecular oxidoreductase activity, transposing S-S bonds	1
disulfide oxidoreductase activity	1
binding	1
catalytic activity	1
cytoplasm	1
endomembrane system	1
intracellular membrane-bounded organelle	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
membrane	1
cell periphery	1
secretory granule membrane	1
platelet alpha granule	1

Protein interactions and networks

STRING

1547 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TMX3	UNC50	Q53HI1	677
TMX3	TMX4	Q9H1E5	661
TMX3	TMX2	Q9Y320	634
TMX3	ERP29	P30040	578
TMX3	RIC3	Q7Z5B4	572
TMX3	ERP27	Q96DN0	568
TMX3	DSEL	Q8IZU8	542
TMX3	SCCPDH	Q8NBX0	467
TMX3	TXN	P10599	460
TMX3	EMC6	Q9BV81	455
TMX3	FAM240B	A0A1B0GVZ2	451
TMX3	AGR3	Q8TD06	450
TMX3	PCF11	O94913	423
TMX3	CCT7	Q99832	414
TMX3	RBM5	P52756	412

IntAct

81 interactions, top by confidence:

A	B	Type	Score
CFTR	ESYT2	psi-mi:“MI:0914”(association)	0.710
TMX3	FHL3	psi-mi:“MI:0915”(physical association)	0.560
FHL3	TMX3	psi-mi:“MI:0915”(physical association)	0.560
CANX	TMX3	psi-mi:“MI:0403”(colocalization)	0.530
	ZW10	psi-mi:“MI:0914”(association)	0.350
		psi-mi:“MI:0914”(association)	0.350
	ESYT2	psi-mi:“MI:0914”(association)	0.350
E5	ESYT2	psi-mi:“MI:0914”(association)	0.350
	PGRMC1	psi-mi:“MI:0914”(association)	0.350
	HAX1	psi-mi:“MI:0914”(association)	0.350
BVLF1	VWA8	psi-mi:“MI:0914”(association)	0.350
M2	IPO5	psi-mi:“MI:0914”(association)	0.350
HSCB	RBP5	psi-mi:“MI:0914”(association)	0.350
	TSPO	psi-mi:“MI:0914”(association)	0.350
EHD4	DNAJA2	psi-mi:“MI:0914”(association)	0.350
MS4A4A	MON2	psi-mi:“MI:0914”(association)	0.350
P2RY6	ESYT2	psi-mi:“MI:0914”(association)	0.350
SLC15A3		psi-mi:“MI:0914”(association)	0.350
UNC93B1		psi-mi:“MI:0914”(association)	0.350
VAMP5	ESYT2	psi-mi:“MI:0914”(association)	0.350

BioGRID (150): TMX3 (Two-hybrid), TMX3 (Affinity Capture-MS), TMX3 (Affinity Capture-MS), TMX3 (Proximity Label-MS), TMX3 (Proximity Label-MS), TMX3 (Affinity Capture-MS), TMX3 (Affinity Capture-MS), TMX3 (Affinity Capture-MS), TMX3 (Affinity Capture-MS), TMX3 (Affinity Capture-MS), TMX3 (Affinity Capture-RNA), TMX3 (Affinity Capture-MS), TMX3 (Affinity Capture-MS), TMX3 (Synthetic Lethality), TMX3 (Co-fractionation)

ESM2 similar proteins: A0A8M1N5Y4, F1R520, O09161, O09165, O14958, O18934, P07221, P08003, P12637, P13667, P14211, P15253, P18418, P19204, P19633, P20942, P27797, P28491, P30040, P30101, P31231, P31235, P31415, P38657, P38659, P51868, P52193, P52555, P57759, P81623, P81628, Q01H84, Q14554, Q29RV1, Q2HWU3, Q2KIL5, Q4R6K8, Q4VIT4, Q4VIT5, Q5I0H9

Diamond homologs: A0A8M1N5Y4, A3KPF5, D4B2L8, O13704, O13811, O22022, O22263, O48773, O83889, P05307, P07591, P07887, P08003, P09103, P0A4L1, P0A4L2, P0AGG4, P0AGG5, P0AGG6, P0AGG7, P11598, P12243, P12865, P13667, P17967, P21195, P23400, P27773, P30101, P33791, P34329, P37395, P38657, P38658, P38659, P38660, P38661, P46843, P50254, P50338

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

113 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	39
Likely benign	6
Benign	37

Top pathogenic / likely-pathogenic (0)

SpliceAI

3770 predictions. Top by Δscore:

Variant	Effect	Δscore
18:68677189:ATAGA:A	acceptor_gain	1.0000
18:68677190:TAGA:T	acceptor_gain	1.0000
18:68677191:AGA:A	acceptor_gain	1.0000
18:68677191:AGACT:A	acceptor_loss	1.0000
18:68677192:GA:G	acceptor_gain	1.0000
18:68677193:ACTG:A	acceptor_loss	1.0000
18:68677194:C:A	acceptor_loss	1.0000
18:68677194:C:CC	acceptor_gain	1.0000
18:68677195:T:G	acceptor_loss	1.0000
18:68679456:AACTT:A	donor_loss	1.0000
18:68679457:ACTTA:A	donor_loss	1.0000
18:68679458:CTTAC:C	donor_loss	1.0000
18:68679459:TTA:T	donor_loss	1.0000
18:68679460:TA:T	donor_loss	1.0000
18:68679461:A:AC	donor_gain	1.0000
18:68679462:C:A	donor_loss	1.0000
18:68679462:C:CC	donor_gain	1.0000
18:68679462:CCA:C	donor_gain	1.0000
18:68679531:CCT:C	acceptor_loss	1.0000
18:68679532:C:CA	acceptor_loss	1.0000
18:68679532:C:CC	acceptor_gain	1.0000
18:68679535:C:CT	acceptor_gain	1.0000
18:68679536:A:T	acceptor_gain	1.0000
18:68680137:A:C	donor_gain	1.0000
18:68680979:A:AC	donor_gain	1.0000
18:68680980:C:CC	donor_gain	1.0000
18:68680980:CTT:C	donor_gain	1.0000
18:68681109:CA:C	acceptor_gain	1.0000
18:68682923:A:AC	donor_gain	1.0000
18:68682923:ACT:A	donor_gain	1.0000

AlphaMissense

3002 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
18:68677128:A:C	S390R	1.000
18:68677128:A:T	S390R	1.000
18:68677130:T:G	S390R	1.000
18:68700422:A:C	F125L	1.000
18:68700422:A:T	F125L	1.000
18:68700424:A:G	F125L	1.000
18:68701757:G:T	P100Q	1.000
18:68701758:G:A	P100S	1.000
18:68677144:G:C	P385R	0.999
18:68677150:C:T	G383D	0.999
18:68697284:G:T	A171D	0.999
18:68700423:A:G	F125S	0.999
18:68700460:A:C	Y113D	0.999
18:68701745:A:G	L104P	0.999
18:68701757:G:A	P100L	0.999
18:68701757:G:C	P100R	0.999
18:68701758:G:C	P100A	0.999
18:68701758:G:T	P100T	0.999
18:68701769:A:T	V96D	0.999
18:68710056:A:T	V77D	0.999
18:68710097:C:A	W63C	0.999
18:68710097:C:G	W63C	0.999
18:68710099:A:G	W63R	0.999
18:68710099:A:T	W63R	0.999
18:68710118:A:C	C56W	0.999
18:68710119:C:A	C56F	0.999
18:68710119:C:G	C56S	0.999
18:68710119:C:T	C56Y	0.999
18:68710120:A:G	C56R	0.999
18:68710120:A:T	C56S	0.999

dbSNP variants (sampled 300 via entrez): RS1000003885 (18:68701684 T>C), RS1000096842 (18:68702108 C>A,T), RS1000129206 (18:68693333 G>A), RS1000323214 (18:68687452 T>C), RS1000326405 (18:68707669 C>T), RS1000386671 (18:68681558 G>A,C), RS1000417727 (18:68681858 C>A), RS1000455422 (18:68713028 C>T), RS1000465915 (18:68694199 CAAG>C), RS1000475483 (18:68673804 T>A,C), RS1000543499 (18:68688574 C>CTCT), RS1000611697 (18:68687080 C>A), RS1000677162 (18:68707416 T>A), RS1000832082 (18:68713792 A>G,T), RS1000884229 (18:68714035 C>T)

Disease associations

OMIM: gene MIM:616102 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST002048_1	Attention deficit hyperactivity disorder	3.000000e-06
GCST002699_4	Suicide in bipolar disorder	4.000000e-06
GCST003074_20	Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging)	8.000000e-08
GCST009391_1934	Metabolite levels	8.000000e-07

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0004321	attempted suicide
EFO:0007707	cerebral amyloid deposition measurement
EFO:0009766	asparagine measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

30 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression, decreases methylation	5
entinostat	decreases expression, affects cotreatment	2
Cyclosporine	decreases expression, increases expression	2
dicrotophos	decreases expression	1
methylmercuric chloride	increases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	increases expression	1
deoxynivalenol	increases expression	1
sodium arsenate	decreases expression	1
arsenite	affects binding, decreases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
bisphenol B	increases expression	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Benzo(a)pyrene	decreases methylation	1
Cadmium	increases abundance, increases expression	1
Ethyl Methanesulfonate	decreases expression	1
Formaldehyde	decreases expression	1
Ivermectin	decreases expression	1
Quercetin	increases expression	1
Rotenone	increases expression	1
Testosterone	decreases expression	1
Dronabinol	increases expression	1
Theophylline	increases expression	1
Aflatoxin B1	affects expression	1
Cadmium Chloride	increases abundance, increases expression	1
Copper Sulfate	increases expression	1
Lactic Acid	decreases expression	1
Particulate Matter	increases abundance, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.