TNFRSF10A-AS1

Summary

TNFRSF10A-AS1 (TNFRSF10A antisense RNA 1, HGNC:53164) is a long non-coding RNA gene on chromosome 8p21.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53164
Approved symbol	TNFRSF10A-AS1
Name	TNFRSF10A antisense RNA 1
Location	8p21.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	RP11-1149O23.2
Ensembl gene	ENSG00000253930
Ensembl biotype	lncRNA
Entrez	110806274
RNAcentral	URS0000101F1E — lncRNA, 637 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000518308

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000518308 — 2 exons

Exon	Start	End
ENSE00002122055	23190212	23190675
ENSE00002122917	23189279	23189451

Expression profiles

Bgee: expression breadth ubiquitous, 126 present calls, max score 84.32.

Top tissues by expression

126 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.32	gold quality
monocyte	CL:0000576	82.88	gold quality
leukocyte	CL:0000738	82.20	gold quality
endometrium	UBERON:0001295	78.37	gold quality
lymph node	UBERON:0000029	76.03	gold quality
gall bladder	UBERON:0002110	74.60	gold quality
colonic epithelium	UBERON:0000397	74.03	gold quality
vermiform appendix	UBERON:0001154	73.08	gold quality
rectum	UBERON:0001052	72.24	gold quality
islet of Langerhans	UBERON:0000006	72.01	gold quality
bone marrow	UBERON:0002371	71.75	gold quality
esophagus mucosa	UBERON:0002469	71.42	gold quality
bone marrow cell	CL:0002092	71.21	silver quality
granulocyte	CL:0000094	71.14	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	70.97	gold quality
smooth muscle tissue	UBERON:0001135	70.23	gold quality
placenta	UBERON:0001987	70.18	gold quality
hindlimb stylopod muscle	UBERON:0004252	69.39	gold quality
adipose tissue	UBERON:0001013	68.33	gold quality
mucosa of transverse colon	UBERON:0004991	68.28	gold quality
subcutaneous adipose tissue	UBERON:0002190	68.27	gold quality
calcaneal tendon	UBERON:0003701	68.26	gold quality
upper lobe of left lung	UBERON:0008952	68.20	gold quality
omental fat pad	UBERON:0010414	68.14	gold quality
lung	UBERON:0002048	68.11	gold quality
tonsil	UBERON:0002372	67.96	gold quality
skin of abdomen	UBERON:0001416	67.55	gold quality
zone of skin	UBERON:0000014	67.19	gold quality
blood	UBERON:0000178	67.19	gold quality
small intestine	UBERON:0002108	67.05	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.52

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• LncRNA TNFRSF10A-AS1 promotes gastric cancer by directly binding to oncogenic MPZL1 and is associated with patient outcome. (PMID:35637954)
• Long noncoding RNA TNFRSF10A-AS1 promotes colorectal cancer through upregulation of HuR. (PMID:35721888)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.