TNFRSF10A-DT

Summary

TNFRSF10A-DT (TNFRSF10A divergent transcript, HGNC:52647) is a long non-coding RNA gene on chromosome 8p21.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52647
Approved symbol	TNFRSF10A-DT
Name	TNFRSF10A divergent transcript
Location	8p21.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	LOC389641, PLACT1
Ensembl gene	ENSG00000246582
Ensembl biotype	lncRNA
Entrez	389641
RNAcentral	URS000075E1EA — lncRNA, 1970 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 13 lncRNA, 1 retained_intron

ENST00000500853, ENST00000517774, ENST00000522600, ENST00000670072, ENST00000840436, ENST00000840437, ENST00000840438, ENST00000840439, ENST00000840440, ENST00000840441, ENST00000840442, ENST00000840443, ENST00000840444, ENST00000840445

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000500853 — 3 exons

Exon	Start	End
ENSE00001983380	23228066	23228153
ENSE00004263795	23225209	23226123
ENSE00004263807	23229948	23230926

Expression profiles

Bgee: expression breadth ubiquitous, 151 present calls, max score 85.65.

FANTOM5 (CAGE): breadth broad, TPM avg 4.0677 / max 65.7214, expressed in 831 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
87884	4.0677	831

Top tissues by expression

240 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	85.65	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.60	gold quality
mucosa of transverse colon	UBERON:0004991	75.48	gold quality
lower esophagus mucosa	UBERON:0035834	73.57	gold quality
leukocyte	CL:0000738	73.28	gold quality
monocyte	CL:0000576	73.12	gold quality
lymph node	UBERON:0000029	72.78	gold quality
vermiform appendix	UBERON:0001154	72.75	gold quality
granulocyte	CL:0000094	72.70	gold quality
spleen	UBERON:0002106	72.69	gold quality
bone marrow cell	CL:0002092	71.54	silver quality
esophagus mucosa	UBERON:0002469	69.81	gold quality
small intestine Peyer’s patch	UBERON:0003454	67.09	gold quality
blood	UBERON:0000178	66.50	gold quality
small intestine	UBERON:0002108	66.32	gold quality
ventricular zone	UBERON:0003053	66.04	gold quality
caecum	UBERON:0001153	65.75	gold quality
colonic epithelium	UBERON:0000397	65.37	silver quality
gall bladder	UBERON:0002110	65.34	gold quality
transverse colon	UBERON:0001157	65.04	gold quality
rectum	UBERON:0001052	65.00	gold quality
tonsil	UBERON:0002372	64.94	gold quality
oviduct epithelium	UBERON:0004804	64.87	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	64.66	gold quality
right lobe of liver	UBERON:0001114	64.59	gold quality
duodenum	UBERON:0002114	64.20	gold quality
vagina	UBERON:0000996	63.92	gold quality
minor salivary gland	UBERON:0001830	63.27	gold quality
skin of abdomen	UBERON:0001416	63.06	gold quality
hindlimb stylopod muscle	UBERON:0004252	63.06	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.90

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LOC389641 promotes pancreatic ductal adenocarcinoma progression and increases cell invasion by regulating E-cadherin with the possible involvement of TNFRSF10A. (PMID:26708505)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.