TNFRSF10B-AS1

Summary

TNFRSF10B-AS1 (TNFRSF10B antisense RNA 1, HGNC:27809) is a long non-coding RNA gene on chromosome 8p21.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27809
Approved symbol	TNFRSF10B-AS1
Name	TNFRSF10B antisense RNA 1
Location	8p21.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	DR5-AS
Ensembl gene	ENSG00000246130
Ensembl biotype	lncRNA
Entrez	286059
RNAcentral	URS00002AB361 — lncRNA, 2636 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000501897, ENST00000809992

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000501897 — 3 exons

Exon	Start	End
ENSE00001741266	23068229	23068420
ENSE00001981544	23080985	23081056
ENSE00001990253	23081248	23083619

Expression profiles

Bgee: expression breadth broad, 42 present calls, max score 87.04.

Top tissues by expression

177 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	87.04	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.19	gold quality
secondary oocyte	CL:0000655	75.18	gold quality
pancreatic ductal cell	CL:0002079	73.66	silver quality
epithelial cell of pancreas	CL:0000083	73.42	gold quality
ileal mucosa	UBERON:0000331	65.13	silver quality
oocyte	CL:0000023	60.38	gold quality
tibialis anterior	UBERON:0001385	58.12	silver quality
nasal cavity epithelium	UBERON:0005384	57.54	gold quality
ventricular zone	UBERON:0003053	57.26	silver quality
granulocyte	CL:0000094	56.88	gold quality
left ventricle myocardium	UBERON:0006566	56.27	gold quality
cartilage tissue	UBERON:0002418	55.80	gold quality
skin of hip	UBERON:0001554	55.13	silver quality
blood	UBERON:0000178	55.04	gold quality
leukocyte	CL:0000738	54.97	gold quality
cardiac muscle of right atrium	UBERON:0003379	54.88	gold quality
bone marrow	UBERON:0002371	54.83	gold quality
monocyte	CL:0000576	54.72	gold quality
kidney epithelium	UBERON:0004819	53.93	gold quality
lower lobe of lung	UBERON:0008949	53.78	silver quality
right lobe of liver	UBERON:0001114	53.54	gold quality
upper arm skin	UBERON:0004263	53.52	gold quality
oviduct epithelium	UBERON:0004804	53.50	silver quality
deltoid	UBERON:0001476	53.14	gold quality
fallopian tube	UBERON:0003889	50.90	gold quality
myocardium	UBERON:0002349	50.70	gold quality
hindlimb stylopod muscle	UBERON:0004252	49.34	gold quality
thyroid gland	UBERON:0002046	48.91	gold quality
quadriceps femoris	UBERON:0001377	48.23	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.94

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Death receptor 5 antisense long non-coding RNA (DR5-AS)(ENSG00000246130) is a cisplatin-inducible lncRNA and DR5-AS silencing caused reduction in proliferation without affecting cell death. Cellular analyses showed that DR5-AS knockdown impaired cell cycle and caused arrest at S and metaphase phases. Moreover, DR5-AS knockdown reduced the invasive capacity of HeLa cells in zebrafish xenograft model. (PMID:34497804)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.