TNK2-AS1

Summary

TNK2-AS1 (TNK2 antisense RNA 1, HGNC:49093) is a long non-coding RNA gene on chromosome 3q29.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49093
Approved symbol	TNK2-AS1
Name	TNK2 antisense RNA 1
Location	3q29
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000224614
Ensembl biotype	lncRNA
Entrez	100128262
RNAcentral	URS0000ABD8BF — lncRNA, 4103 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

ENST00000424819, ENST00000448113, ENST00000458180, ENST00000653505, ENST00000727118

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000424819 — 2 exons

Exon	Start	End
ENSE00003888359	195913149	195913265
ENSE00004052326	195912022	195912181

Expression profiles

Bgee: expression breadth ubiquitous, 155 present calls, max score 79.31.

FANTOM5 (CAGE): breadth broad, TPM avg 1.1441 / max 118.6577, expressed in 265 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
40708	0.7502	226
40709	0.3939	95

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	79.31	gold quality
muscle of leg	UBERON:0001383	77.45	gold quality
right uterine tube	UBERON:0001302	75.37	gold quality
monocyte	CL:0000576	75.26	gold quality
leukocyte	CL:0000738	74.59	gold quality
bone marrow cell	CL:0002092	72.24	silver quality
hindlimb stylopod muscle	UBERON:0004252	71.38	gold quality
adenohypophysis	UBERON:0002196	68.74	gold quality
granulocyte	CL:0000094	68.72	gold quality
pituitary gland	UBERON:0000007	65.95	gold quality
colonic epithelium	UBERON:0000397	62.80	silver quality
blood	UBERON:0000178	62.70	gold quality
skin of abdomen	UBERON:0001416	62.45	gold quality
skin of leg	UBERON:0001511	62.33	gold quality
lower esophagus mucosa	UBERON:0035834	61.85	gold quality
sural nerve	UBERON:0015488	61.76	gold quality
cerebellar cortex	UBERON:0002129	61.10	gold quality
ventricular zone	UBERON:0003053	61.02	gold quality
cerebellar hemisphere	UBERON:0002245	60.97	gold quality
right hemisphere of cerebellum	UBERON:0014890	60.41	gold quality
ganglionic eminence	UBERON:0004023	60.01	gold quality
cerebellum	UBERON:0002037	59.81	gold quality
zone of skin	UBERON:0000014	59.77	gold quality
vermiform appendix	UBERON:0001154	59.63	gold quality
right lobe of liver	UBERON:0001114	59.23	gold quality
prostate gland	UBERON:0002367	58.00	gold quality
spleen	UBERON:0002106	57.88	gold quality
prefrontal cortex	UBERON:0000451	57.25	gold quality
ectocervix	UBERON:0012249	57.07	gold quality
right atrium auricular region	UBERON:0006631	56.95	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.95

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• This work has elucidated a novel mechanism of TNK2-AS1-mediated angiogenesis by enforcing STAT3/VEGFA signaling. (PMID:30454892)
• TNK2-AS1 upregulated by YY1 boosts the course of osteosarcoma through targeting miR-4319/WDR1. (PMID:33164271)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.