TNKS2-DT

Summary

TNKS2-DT (TNKS2 divergent transcript, HGNC:45173) is a long non-coding RNA gene on chromosome 10q23.32.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:45173
Approved symbol	TNKS2-DT
Name	TNKS2 divergent transcript
Location	10q23.32
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000228701
Ensembl biotype	lncRNA
Entrez	100507633
RNAcentral	URS000075EAA8 — lncRNA, 706 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 15 lncRNA

ENST00000432246, ENST00000432938, ENST00000662946, ENST00000668345, ENST00000770267, ENST00000770268, ENST00000770269, ENST00000770270, ENST00000770271, ENST00000770272, ENST00000770273, ENST00000770274, ENST00000770275, ENST00000770276, ENST00000770277

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000432246 — 2 exons

Exon	Start	End
ENSE00001599096	91797813	91798196
ENSE00001642949	91782936	91783160

Expression profiles

Bgee: expression breadth ubiquitous, 131 present calls, max score 85.97.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3998 / max 16.2662, expressed in 176 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
110640	0.3998	176

Top tissues by expression

131 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.97	gold quality
right testis	UBERON:0004534	77.60	gold quality
testis	UBERON:0000473	76.26	gold quality
left testis	UBERON:0004533	75.65	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	73.41	gold quality
bone marrow cell	CL:0002092	71.80	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.65	gold quality
cortical plate	UBERON:0005343	71.18	gold quality
skeletal muscle tissue	UBERON:0001134	71.12	gold quality
ganglionic eminence	UBERON:0004023	69.93	gold quality
metanephros cortex	UBERON:0010533	69.15	gold quality
sural nerve	UBERON:0015488	68.93	gold quality
muscle tissue	UBERON:0002385	68.81	gold quality
muscle of leg	UBERON:0001383	68.19	gold quality
hindlimb stylopod muscle	UBERON:0004252	68.09	gold quality
lymph node	UBERON:0000029	68.07	gold quality
gastrocnemius	UBERON:0001388	67.81	gold quality
granulocyte	CL:0000094	67.51	gold quality
ventricular zone	UBERON:0003053	67.28	gold quality
tonsil	UBERON:0002372	66.51	gold quality
substantia nigra	UBERON:0002038	66.23	gold quality
heart left ventricle	UBERON:0002084	65.48	gold quality
duodenum	UBERON:0002114	65.23	gold quality
amygdala	UBERON:0001876	65.13	gold quality
mucosa of stomach	UBERON:0001199	65.06	gold quality
adult mammalian kidney	UBERON:0000082	64.81	gold quality
left lobe of thyroid gland	UBERON:0001120	64.79	gold quality
putamen	UBERON:0001874	64.72	gold quality
placenta	UBERON:0001987	64.32	gold quality
liver	UBERON:0002107	64.26	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.07

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.