TNNI1

Summary

TNNI1 (troponin I1, slow skeletal type, HGNC:11945) is a protein-coding gene on chromosome 1q32.1, encoding Troponin I, slow skeletal muscle (P19237). Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes.

Source: NCBI Gene 7135 — RefSeq curated summary.

At a glance

• Gene–disease (curated): arthrogryposis (Moderate, GenCC) — +2 more curated relationships
• Clinical variants (ClinVar): 32 total
• MANE Select transcript: NM_003281

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:11945
Approved symbol	TNNI1
Name	troponin I1, slow skeletal type
Location	1q32.1
Locus type	gene with protein product
Status	Approved
Aliases	ssTnI
Ensembl gene	ENSG00000159173
Ensembl biotype	protein_coding
OMIM	191042
Entrez	7135

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 protein_coding

ENST00000336092, ENST00000361379, ENST00000367312, ENST00000555340, ENST00000555948, ENST00000556362

RefSeq mRNA: 1 — MANE Select: NM_003281 NM_003281

CCDS: CCDS1411

Canonical transcript exons

ENST00000361379 — 9 exons

Exon	Start	End
ENSE00001074229	201410326	201410435
ENSE00001074235	201413032	201413121
ENSE00001350131	201417783	201417812
ENSE00001957519	201403784	201409250
ENSE00003526310	201415213	201415254
ENSE00003535850	201417116	201417119
ENSE00003561878	201414518	201414649
ENSE00003787328	201411357	201411533
ENSE00003843411	201421673	201421730

Expression profiles

Bgee: expression breadth ubiquitous, 183 present calls, max score 99.93.

FANTOM5 (CAGE): breadth broad, TPM avg 15.7471 / max 3108.0544, expressed in 247 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
16648	15.4919	246
16650	0.1741	47
16651	0.0382	22
16649	0.0279	16
16652	0.0150	7

Top tissues by expression

293 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	99.93	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	99.91	gold quality
diaphragm	UBERON:0001103	99.89	gold quality
triceps brachii	UBERON:0001509	99.89	gold quality
hindlimb stylopod muscle	UBERON:0004252	99.89	gold quality
gluteal muscle	UBERON:0002000	99.88	gold quality
biceps brachii	UBERON:0001507	99.84	gold quality
vastus lateralis	UBERON:0001379	99.77	gold quality
skeletal muscle tissue	UBERON:0001134	99.71	gold quality
quadriceps femoris	UBERON:0001377	99.61	gold quality
gastrocnemius	UBERON:0001388	99.54	gold quality
body of tongue	UBERON:0011876	99.27	gold quality
deltoid	UBERON:0001476	98.96	gold quality
tibialis anterior	UBERON:0001385	98.74	gold quality
muscle organ	UBERON:0001630	98.24	gold quality
muscle of leg	UBERON:0001383	97.66	gold quality
muscle tissue	UBERON:0002385	94.55	gold quality
right atrium auricular region	UBERON:0006631	93.08	gold quality
tongue	UBERON:0001723	92.04	gold quality
cardiac atrium	UBERON:0002081	92.04	gold quality
superior surface of tongue	UBERON:0007371	86.72	gold quality
apex of heart	UBERON:0002098	86.00	gold quality
cardiac muscle of right atrium	UBERON:0003379	83.69	gold quality
pharyngeal mucosa	UBERON:0000355	83.47	gold quality
heart	UBERON:0000948	82.52	gold quality
heart left ventricle	UBERON:0002084	81.11	gold quality
cardiac ventricle	UBERON:0002082	80.82	gold quality
myocardium	UBERON:0002349	77.46	gold quality
trabecular bone tissue	UBERON:0002483	77.27	gold quality
heart right ventricle	UBERON:0002080	76.91	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-HCAD-56	yes	3139.36
E-GEOD-114530	yes	1834.54
E-HCAD-10	yes	18.94
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): NVL

miRNA regulators (miRDB)

203 targeting TNNI1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-3925-3P	100.00	69.95	1237
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-5193	100.00	67.26	1744
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4481	100.00	66.42	1669
HSA-MIR-574-5P	100.00	66.01	989
HSA-MIR-6758-5P	100.00	66.21	1470
HSA-MIR-6856-5P	100.00	65.47	1298
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-3185	99.99	68.12	1959
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-4715-3P	99.98	66.03	670
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-4487	99.96	64.58	1252
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-495-3P	99.96	72.81	4197

Literature-anchored findings (GeneRIF, showing 21)

• troponin I phosphorylation has a role in protein kinase C-mediated enhanced contractile performance of myocytes (PMID:12815045)
• MEF2 activation of the troponin I slow enhancer is repressed by hMusTRD1alpha1 (PMID:12857748)
• Low expression of ssTnI was found in 60% of patients in sinus rhythm or paroxysmal AF and in 8% of patients with chronic AF. Relative ssTnI mRNA expression was significantly lower in patients with AF than in those in sinus rhythm. (PMID:15289369)
• These results suggest that this R21C mutation in TnI affects the Ca(2+)-sensitizing effect of Tn, the ability of TnI to be readily phosphorylated by PKA and the stability of TnI to calpain. (PMID:16005017)
• A revised method of troponin exchange in pemeabilized cardiac trabeculae using vanadate: functional consequences of a HCM-causing mutation in troponin I. (PMID:17051347)
• a localized N-terminal region of TnI comprised of amino acids 33-80, which interacts with C-terminal regions of cTnC and cTnT, is of particular significance in transducing signaling of thin filament activation by strong cross-bridges (PMID:17099250)
• Elevated post-operative troponin 1 levels predict long-term mortality in older patients undergoing emergency orthpedic surgery. (PMID:19811558)
• Evaluated the prevalence of TNN13 gene mutations in sudden death caused by cardiomyopathy (CM); in dilated CM cases, a new missense mutation Pro16Thr was detected. A single nucleotide polymorphism at -8 position of intron 3 was identified. (PMID:20817590)
• sTnI as a sensitive marker of skeletal muscle injury. (PMID:22323298)
• Elevations of troponin I and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are common in patients with atrial fibrillation and independently related to increased risks of stroke and mortality. (PMID:22374183)
• Data suggest that mutation A162H in switch region of troponin I induces transitory curved conformation and promotes contraction of troponin I bound to regulatory domain of troponin C; this is countered by residue E164 to ensure proper relaxation. (PMID:25996354)
• CT-1 was found to be associated with Tn-I, which is used to detect myocardial damage after OPCAB surgery. CT-1 may also be used to detect myocardial damage. (PMID:26334851)
• GDF-15, sST2, and hs-TnI are associated with incident cardiovascular disease and heart failure (PMID:26972631)
• Measuring mean platelet volume in conjunction with troponin I levels improves the diagnostic value of troponin I in acute coronary syndrome. (PMID:27524214)
• Ultrasensitive troponin I was detectable in almost all individuals of a study sample reflecting middle-aged to elderly European general population. Ultrasensitive troponin concentrations exhibit an independent, graded, positive relation with incident CHD [coronary heart disease]. (PMID:28585121)
• Studied use of serum levels of Troponin I as a predictive biomarker for diagnosis of left ventricular systolic dysfunction after anthracycline treatment in breast cancer. (PMID:28718245)
• Troponin I levels at intensive care unit admission are a strong independent predictor of dialysis needs in sepsis. (PMID:30453890)
• Cardiac Troponin I Is an Independent Predictor for Mortality in Hospitalized Patients With COVID-19. (PMID:32539541)
• Postoperative troponin increases after noncardiac surgery are associated with raised neurofilament light: a prospective observational cohort study. (PMID:33158499)
• Elevation of fast but not slow troponin I in the circulation of patients with Becker and Duchenne muscular dystrophy. (PMID:33683712)
• Pathogenic TNNI1 variants disrupt sarcomere contractility resulting in hypo- and hypercontractile muscle disease. (PMID:38569017)

Cross-species orthologs

9 orthologs

Organism	Symbol	Gene ID
danio_rerio	tnni1a	ENSDARG00000000474
danio_rerio	tnni1b	ENSDARG00000052708
mus_musculus	Tnni1	ENSMUSG00000026418
rattus_norvegicus	Tnni1	ENSRNOG00000009073
drosophila_melanogaster	wupA	FBGN0283471
caenorhabditis_elegans		WBGENE00006584
caenorhabditis_elegans		WBGENE00006585
caenorhabditis_elegans		WBGENE00006586
caenorhabditis_elegans		WBGENE00006764

Paralogs (2): TNNI3 (ENSG00000129991), TNNI2 (ENSG00000130598)

Protein

Protein identifiers

Troponin I, slow skeletal muscle — P19237 (reviewed: P19237)

Alternative names: Troponin I, slow-twitch isoform

All UniProt accessions (4): P19237, G3V3L5, G3V489, G3V4F8

UniProt curated annotations — full annotation on UniProt →

Function. Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Subunit / interactions. Binds to actin and tropomyosin.

Tissue specificity. Highest levels observed in human skeletal muscle (e.g. gastrocnemious muscle), differentiated cultures of primary human muscle cells and rhabdomyosarcoma cells cultured in low serum medium. Expressed in C2 muscle cell myoblasts and myotubes.

Similarity. Belongs to the troponin I family.

RefSeq proteins (1): NP_003272* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001978	Troponin	Family
IPR038077	Troponin_sf	Homologous_superfamily
IPR050875	Troponin_I	Family

Pfam: PF00992

UniProt features (13 total): sequence conflict 6, region of interest 2, modified residue 2, initiator methionine 1, chain 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P19237-F1	78.44	0.47

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 2, 58

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-390522	Striated Muscle Contraction

MSigDB gene sets: 180 (showing top): GOBP_CARDIAC_CHAMBER_DEVELOPMENT, GGGACCA_MIR133A_MIR133B, GOBP_MUSCLE_TISSUE_DEVELOPMENT, GOBP_CIRCULATORY_SYSTEM_PROCESS, GOBP_CARDIAC_CHAMBER_MORPHOGENESIS, GOBP_SKELETAL_MUSCLE_ADAPTATION, GCANCTGNY_MYOD_Q6, AREB6_03, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP, TGACCTY_ERR1_Q2, GOBP_MULTICELLULAR_ORGANISMAL_MOVEMENT, MEF2_02, GOBP_SKELETAL_MUSCLE_CONTRACTION, COUP_01

GO Biological Process (5): skeletal muscle contraction (GO:0003009), regulation of striated muscle contraction (GO:0006942), transition between fast and slow fiber (GO:0014883), ventricular cardiac muscle tissue morphogenesis (GO:0055010), cardiac muscle contraction (GO:0060048)

GO Molecular Function (2): actin binding (GO:0003779), protein binding (GO:0005515)

GO Cellular Component (2): cytosol (GO:0005829), troponin complex (GO:0005861)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Muscle contraction	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
striated muscle contraction	3
musculoskeletal movement	1
regulation of muscle contraction	1
regulation of skeletal muscle adaptation	1
cardiac ventricle morphogenesis	1
ventricular cardiac muscle tissue development	1
cardiac muscle tissue morphogenesis	1
heart contraction	1
cytoskeletal protein binding	1
binding	1
cytoplasm	1
cellular anatomical structure	1
striated muscle thin filament	1
protein-containing complex	1

Protein interactions and networks

STRING

1170 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TNNI1	TNNT1	P13805	967
TNNI1	TNNT3	P45378	935
TNNI1	TNNT2	P45379	909
TNNI1	TNNC1	P02590	868
TNNI1	MYH7	P12883	817
TNNI1	TPM3	P06753	749
TNNI1	MYL3	P08590	717
TNNI1	MYL7	Q01449	707
TNNI1	TNNC2	P02585	697
TNNI1	MYL2	P10916	682
TNNI1	MYH7B	A7E2Y1	655
TNNI1	MYBPC3	Q14896	653
TNNI1	MYH6	P13533	651
TNNI1	ACTN3	Q08043	631
TNNI1	MYL11	Q96A32	629

IntAct

138 interactions, top by confidence:

A	B	Type	Score
PNMA1	TNNI1	psi-mi:“MI:0915”(physical association)	0.720
TNNI1	PNMA1	psi-mi:“MI:0915”(physical association)	0.720
TNNI1	TNNC1	psi-mi:“MI:0915”(physical association)	0.700
TNNI1	MDFI	psi-mi:“MI:0915”(physical association)	0.560
MDFI	TNNI1	psi-mi:“MI:0915”(physical association)	0.560
MFAP1	TNNI1	psi-mi:“MI:0915”(physical association)	0.560
EAF1	TNNI1	psi-mi:“MI:0915”(physical association)	0.560
	TNNI1	psi-mi:“MI:0915”(physical association)	0.560
TNNT1	TNNI1	psi-mi:“MI:0915”(physical association)	0.560
TRIM41	TNNI1	psi-mi:“MI:0915”(physical association)	0.560
MCRS1	TNNI1	psi-mi:“MI:0915”(physical association)	0.560
PIK3R3	TNNI1	psi-mi:“MI:0915”(physical association)	0.560
POLR1C	TNNI1	psi-mi:“MI:0915”(physical association)	0.560
EFCAB2	TNNI1	psi-mi:“MI:0915”(physical association)	0.560
KIFC3	TNNI1	psi-mi:“MI:0915”(physical association)	0.560
ANKRD11	TNNI1	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (59): TNNI1 (Two-hybrid), TNNI1 (Two-hybrid), TNNI1 (Two-hybrid), PNMA1 (Two-hybrid), CCDC85B (Two-hybrid), MYH3 (Co-fractionation), MYH6 (Co-fractionation), MYH7 (Co-fractionation), TNNI1 (Co-fractionation), TPM1 (Co-fractionation), TPM2 (Co-fractionation), TNNI1 (Reconstituted Complex), TNNI1 (Affinity Capture-MS), TNNI1 (Two-hybrid), TNNI1 (Two-hybrid)

ESM2 similar proteins: A2AQ19, B5G1C4, B5XE27, O43395, O43768, O75391, O95983, P19237, P56211, P56212, P60840, P60841, P68210, P68211, Q0MUU2, Q13123, Q13435, Q1L8X2, Q28055, Q28GU6, Q2KI76, Q2KIA6, Q3UJB0, Q3ZBD4, Q5NVI3, Q5R5F1, Q5R5J3, Q5RAD5, Q5RB90, Q5ZIF8, Q5ZJ85, Q5ZLY8, Q66HG8, Q6DEB4, Q6GQG3, Q6NVR1, Q712U5, Q712U6, Q7TNE3, Q7ZXH9

Diamond homologs: O44572, P02643, P02645, P02646, P08057, P13412, P13413, P19237, P19429, P23693, P27672, P27673, P27768, P36188, P48787, P48788, P50754, P68246, P68247, Q20334, Q5PYI0, Q7M3Y3, Q863B6, Q8MKD5, Q969A1, Q9GYF1, Q9WUZ5, P05547, Q9XUN9

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
TRIM63	“down-regulates quantity by destabilization”	TNNI1	polyubiquitination

Disease & clinical

Clinical variants and AI predictions

ClinVar

32 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	24
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1103 predictions. Top by Δscore:

Variant	Effect	Δscore
1:201410321:GGTAC:G	donor_loss	1.0000
1:201410322:GTACC:G	donor_loss	1.0000
1:201410323:TA:T	donor_loss	1.0000
1:201410324:A:C	donor_loss	1.0000
1:201410325:C:A	donor_loss	1.0000
1:201410325:CCT:C	donor_gain	1.0000
1:201410327:T:TA	donor_gain	1.0000
1:201410431:CGCTC:C	acceptor_gain	1.0000
1:201410433:CTC:C	acceptor_gain	1.0000
1:201410434:TCC:T	acceptor_loss	1.0000
1:201410435:CCTG:C	acceptor_loss	1.0000
1:201410436:C:CC	acceptor_gain	1.0000
1:201410436:CTGTA:C	acceptor_loss	1.0000
1:201410437:T:G	acceptor_loss	1.0000
1:201411351:CCTCA:C	donor_loss	1.0000
1:201411352:CTCA:C	donor_loss	1.0000
1:201411353:TCAC:T	donor_loss	1.0000
1:201411354:CACC:C	donor_loss	1.0000
1:201411355:A:AC	donor_gain	1.0000
1:201411355:A:AT	donor_loss	1.0000
1:201411355:AC:A	donor_gain	1.0000
1:201411356:C:CC	donor_gain	1.0000
1:201411356:CC:C	donor_gain	1.0000
1:201411356:CCTT:C	donor_gain	1.0000
1:201411370:T:TA	donor_gain	1.0000
1:201411533:TC:T	acceptor_loss	1.0000
1:201411534:C:CC	acceptor_gain	1.0000
1:201411534:CT:C	acceptor_loss	1.0000
1:201413027:CTCA:C	donor_loss	1.0000
1:201413028:TCACC:T	donor_loss	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000088279 (1:201406510 G>C), RS1000149941 (1:201409460 C>T), RS1000222182 (1:201410890 A>G), RS1000380388 (1:201423156 T>C), RS1000411672 (1:201420736 T>G), RS1000502463 (1:201409245 G>A,T), RS1000750348 (1:201419790 G>A,T), RS1000867065 (1:201420985 C>G,T), RS1001298673 (1:201420676 G>A), RS1001757375 (1:201405248 G>C,T), RS1002099324 (1:201422232 C>T), RS1002233342 (1:201408868 G>C), RS1002455982 (1:201421903 G>A,T), RS1002566866 (1:201407581 C>A,T), RS1002583056 (1:201414331 A>G)

Disease associations

OMIM: gene MIM:191042 | disease phenotypes:

GenCC curated gene-disease

Disease	Classification	Inheritance
arthrogryposis	Moderate	Autosomal dominant

ClinGen Gene-Disease Validity (2)

Expert-panel classifications — Definitive > Strong > Moderate > Limited > Disputed > Refuted.

Disease	Classification	Inheritance
childhood-onset nemaline myopathy	Limited	AR
nemaline myopathy	Limited	AD

Mondo (1): arthrogryposis (MONDO:0008779)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
D001176	Arthrogryposis	C05.550.150; C05.651.102; C05.660.077; C16.131.621.077

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

17 total (human), top 17 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases methylation, increases expression	2
methylmercuric chloride	increases expression	1
pirinixic acid	affects binding, decreases expression, increases activity, increases expression	1
tebuconazole	decreases expression	1
CGP 52608	affects binding, increases reaction	1
incobotulinumtoxinA	decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Sunitinib	decreases expression	1
Benzo(a)pyrene	affects methylation, increases methylation	1
Doxorubicin	increases expression	1
Plant Extracts	affects cotreatment, decreases expression	1
Dronabinol	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Urethane	decreases expression	1
Valproic Acid	affects expression	1
1-Methyl-4-phenylpyridinium	increases expression	1
Aflatoxin B1	increases methylation	1

Clinical trials (associated diseases)

9 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT01028833	PHASE2	COMPLETED	Effects of Power Mobility on Young Children With Severe Motor Impairments
NCT01144741	Not specified	TERMINATED	Survey Study and Records Review of Treatment Outcomes in Freeman-Sheldon Syndrome
NCT01306994	Not specified	WITHDRAWN	Study of Resting and Exercising Body Functioning in Freeman-Sheldon Syndrome and Related Conditions
NCT01307475	Not specified	TERMINATED	Study of Quality of Life in Freeman-Sheldon Syndrome and Related Conditions
NCT02218593	Not specified	COMPLETED	WREX Outcome Study
NCT04789746	Not specified	UNKNOWN	Ready, Set, Go! A Physical Fitness Intervention for Children With Mobility Challenges
NCT04798378	Not specified	ACTIVE_NOT_RECRUITING	NuroSleeve Powered Brace & Stimulation System to Restore Arm Function
NCT06192134	Not specified	NOT_YET_RECRUITING	Continuous Passive Motion Device for Children With Arthrogryposis
NCT07429188	Not specified	RECRUITING	Impact Study on Users of Upper Limb Assistive Devices