TNRC18

Summary

TNRC18 (trinucleotide repeat containing 18, HGNC:11962) is a protein-coding gene on chromosome 7p22.1, encoding Trinucleotide repeat-containing gene 18 protein (O15417). Chromatin reader involved in the silencing of endogenous retroviruses (ERV) class-I elements, such as LTR12.

Predicted to enable chromatin binding activity. Located in cytosol; mitochondrion; and nucleus.

Source: NCBI Gene 84629 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 964 total
• MANE Select transcript: NM_001080495

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:11962
Approved symbol	TNRC18
Name	trinucleotide repeat containing 18
Location	7p22.1
Locus type	gene with protein product
Status	Approved
Aliases	CAGL79, TNRC18A, KIAA1856
Ensembl gene	ENSG00000182095
Ensembl biotype	protein_coding
OMIM	620902
Entrez	84629

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 8 protein_coding, 2 retained_intron

ENST00000328270, ENST00000399434, ENST00000399537, ENST00000413081, ENST00000430969, ENST00000434361, ENST00000440081, ENST00000455076, ENST00000464852, ENST00000497663

RefSeq mRNA: 1 — MANE Select: NM_001080495 NM_001080495

CCDS: CCDS47534

Canonical transcript exons

ENST00000430969 — 30 exons

Exon	Start	End
ENSE00001036207	5361594	5361722
ENSE00001036210	5370375	5371364
ENSE00001036212	5359398	5359569
ENSE00001036218	5362650	5362825
ENSE00001086226	5351819	5352094
ENSE00001086228	5345562	5345810
ENSE00001243325	5361897	5362033
ENSE00001598260	5306811	5308312
ENSE00001603408	5376034	5376224
ENSE00001625690	5320532	5320607
ENSE00001636763	5325096	5325248
ENSE00001643372	5377922	5378024
ENSE00001649243	5374055	5374484
ENSE00001656592	5312503	5313863
ENSE00001665613	5376847	5376993
ENSE00001683886	5390485	5390628
ENSE00001693361	5321073	5321190
ENSE00001702441	5356916	5357276
ENSE00001734273	5332622	5333049
ENSE00001737063	5308875	5308949
ENSE00001742050	5315956	5316072
ENSE00001756091	5309132	5309368
ENSE00001763886	5324214	5324355
ENSE00001765397	5320318	5320426
ENSE00001766309	5387672	5389336
ENSE00001771332	5377371	5377576
ENSE00001777465	5314984	5315148
ENSE00002733281	5421060	5421489
ENSE00003532211	5394440	5394595
ENSE00003921945	5423441	5423834

Expression profiles

Bgee: expression breadth ubiquitous, 248 present calls, max score 98.15.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 17.7869 / max 302.5122, expressed in 1745 samples.

FANTOM5 promoters (13 alternative TSS)

Promoter ID	TPM avg	Samples expressed
82573	8.9470	1651
82570	1.8728	1031
82566	1.8166	735
82569	0.8920	483
82572	0.8749	440
82575	0.6998	388
82571	0.6254	321
82567	0.5471	339
82577	0.4545	237
82565	0.4527	119

Top tissues by expression

255 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	98.15	gold quality
cardiac muscle of right atrium	UBERON:0003379	97.71	gold quality
upper arm skin	UBERON:0004263	97.63	gold quality
ventricular zone	UBERON:0003053	97.26	gold quality
colonic epithelium	UBERON:0000397	97.06	gold quality
kidney epithelium	UBERON:0004819	96.73	gold quality
ganglionic eminence	UBERON:0004023	95.71	gold quality
cortical plate	UBERON:0005343	95.54	gold quality
nasal cavity epithelium	UBERON:0005384	95.46	gold quality
popliteal artery	UBERON:0002250	95.40	gold quality
tibial artery	UBERON:0007610	95.39	gold quality
left ventricle myocardium	UBERON:0006566	95.35	silver quality
body of uterus	UBERON:0009853	95.23	gold quality
superficial temporal artery	UBERON:0001614	95.08	gold quality
mucosa of stomach	UBERON:0001199	94.96	gold quality
lower esophagus muscularis layer	UBERON:0035833	94.93	gold quality
lower esophagus	UBERON:0013473	94.90	gold quality
aorta	UBERON:0000947	94.84	gold quality
muscle layer of sigmoid colon	UBERON:0035805	94.83	gold quality
pylorus	UBERON:0001166	94.78	gold quality
right coronary artery	UBERON:0001625	94.78	gold quality
saphenous vein	UBERON:0007318	94.78	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	94.72	gold quality
left uterine tube	UBERON:0001303	94.67	gold quality
renal medulla	UBERON:0000362	94.63	gold quality
cardia of stomach	UBERON:0001162	94.60	gold quality
cauda epididymis	UBERON:0004360	94.52	gold quality
thoracic aorta	UBERON:0001515	94.11	gold quality
descending thoracic aorta	UBERON:0002345	94.08	gold quality
ascending aorta	UBERON:0001496	94.05	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.61
E-GEOD-98556	no	40.47

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

141 targeting TNRC18, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-34A-5P	99.99	71.21	1784
HSA-MIR-449A	99.99	71.05	1776
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-4803	99.98	71.99	3117
HSA-MIR-34C-5P	99.97	70.45	1577
HSA-MIR-449B-5P	99.97	70.26	1580
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-767-5P	99.95	70.85	993
HSA-MIR-8082	99.95	67.27	1170
HSA-MIR-128-3P	99.95	71.17	2484
HSA-MIR-216A-3P	99.95	71.19	2505
HSA-MIR-185-3P	99.95	67.01	1743
HSA-MIR-101-3P	99.94	75.03	2230
HSA-MIR-144-3P	99.94	73.98	2698
HSA-MIR-6721-5P	99.93	68.92	2981

Literature-anchored findings (GeneRIF, showing 1)

• Disruption of PCDH10 and TNRC18 Genes due to a Balanced Translocation. (PMID:32535594)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	tnrc18	ENSDARG00000077052
mus_musculus	Tnrc18	ENSMUSG00000039477
rattus_norvegicus	Tnrc18	ENSRNOG00000024482
drosophila_melanogaster	wge	FBGN0051151

Paralogs (2): BAHD1 (ENSG00000140320), BAHCC1 (ENSG00000266074)

Protein

Protein identifiers

Trinucleotide repeat-containing gene 18 protein — O15417 (reviewed: O15417)

Alternative names: Long CAG trinucleotide repeat-containing gene 79 protein

All UniProt accessions (8): O15417, A8MTZ4, C9J9K1, H7BXS9, H7C0N9, H7C177, H7C3U5, H9KVB4

UniProt curated annotations — full annotation on UniProt →

Function. Chromatin reader involved in the silencing of endogenous retroviruses (ERV) class-I elements, such as LTR12. Specifically binds histone H3 trimethylated at ‘Lys-9’ (H3K9me3) deposited by SETB1 at class-I ERV and directly mediates recruitment of corepressor complexes, such as Sin3-type and N-Cor complexes, leading to ERV silencing.

Subcellular location. Nucleus. Chromosome.

Domain organisation. The BAH domain specifically binds histone H3 trimethylated at ‘Lys-9’ (H3K9me3).

Miscellaneous. Dubious isoform produced through aberrant splice sites.

Isoforms (3)

UniProt ID	Names	Canonical?
O15417-1	1	yes
O15417-2	2
O15417-4	4

RefSeq proteins (1): NP_001073964* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001025	BAH_dom	Domain
IPR043151	BAH_sf	Homologous_superfamily
IPR048924	BAHCC1-like_Tudor	Domain
IPR052429	BAH_domain_protein	Family
IPR056841	TNRC18_BAHCC1-like_SH3	Domain

Pfam: PF01426, PF21744, PF24912

UniProt features (104 total): compositionally biased region 38, region of interest 14, strand 10, modified residue 9, mutagenesis site 8, sequence conflict 6, helix 5, splice variant 5, turn 3, coiled-coil region 2, chain 1, domain 1, cross-link 1, sequence variant 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
8DS8	X-RAY DIFFRACTION	1.84

Predicted structure (AlphaFold)

No AlphaFold model available for O15417 — AlphaFold DB does not currently provide models for proteins above ~3000 aa.

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (10): 263, 611, 1127, 1136, 1540, 1857, 1863, 2146, 2771, 620

Mutagenesis-validated functional residues (8):

Position	Phenotype
760	abolished interactiomn with sin3 (sin3a or sin3b), leading to endogenous retroviruses (erv) derepression.
2837	abolished ability to bind histone h3 trimethylated at ’lys-9’ (h3k9me3).
2858	abolished ability to bind histone h3 trimethylated at ’lys-9’ (h3k9me3), leading to endogenous retroviruses (erv) derepr
2860	abolished ability to bind histone h3 trimethylated at ’lys-9’ (h3k9me3).
2864	abolished ability to bind histone h3 trimethylated at ’lys-9’ (h3k9me3).
2908	abolished ability to bind histone h3 trimethylated at ’lys-9’ (h3k9me3).
2910	abolished ability to bind histone h3 trimethylated at ’lys-9’ (h3k9me3).
2912	abolished ability to bind histone h3 trimethylated at ’lys-9’ (h3k9me3).

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 190 (showing top): chr7p22, GOBP_NEGATIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC, GOBP_PROTEIN_LOCALIZATION_TO_CHROMATIN, GOBP_PROTEIN_LOCALIZATION_TO_CHROMOSOME, GOBP_PROTEIN_LOCALIZATION_TO_ORGANELLE, GOBP_CHROMATIN_REMODELING, GOBP_HETEROCHROMATIN_ORGANIZATION, NIKOLSKY_BREAST_CANCER_7P22_AMPLICON, GOBP_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION, GOCC_NUCLEAR_ENVELOPE, GOMF_CHROMATIN_BINDING, GOCC_NUCLEAR_MEMBRANE, VECCHI_GASTRIC_CANCER_EARLY_UP, DODD_NASOPHARYNGEAL_CARCINOMA_DN, GOCC_ORGANELLE_ENVELOPE

GO Biological Process (2): protein localization to chromatin (GO:0071168), transposable element silencing by heterochromatin formation (GO:0141005)

GO Molecular Function (3): chromatin binding (GO:0003682), histone H3K9me2/3 reader activity (GO:0062072), chromatin-protein adaptor activity (GO:0140463)

GO Cellular Component (6): chromatin (GO:0000785), nucleus (GO:0005634), nucleoplasm (GO:0005654), mitochondrion (GO:0005739), cytosol (GO:0005829), nuclear membrane (GO:0031965)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
intracellular membrane-bounded organelle	2
cytoplasm	2
protein localization to chromosome	1
transposable element silencing	1
constitutive heterochromatin formation	1
binding	1
histone H3 reader activity	1
chromatin binding	1
chromatin organization	1
protein-macromolecule adaptor activity	1
chromosome	1
nuclear lumen	1
nucleus	1
nuclear envelope	1
organelle membrane	1

Protein interactions and networks

STRING

1108 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TNRC18	MRPL54	Q6P161	474
TNRC18	OSBPL6	Q9BZF3	461
TNRC18	NCAPH2	Q6IBW4	455
TNRC18	DNPEP	Q9ULA0	446
TNRC18	SIN3A	Q96ST3	444
TNRC18	GALNT18	Q6P9A2	442
TNRC18	SEZ6L	Q9BYH1	440
TNRC18	RMND1	Q9NWS8	372
TNRC18	FAM193A	P78311	359
TNRC18	SLC66A1	Q6ZP29	358
TNRC18	ZNF20	P17024	354
TNRC18	RUNDC3B	Q96NL0	354
TNRC18	MLLT11	Q13015	335
TNRC18	BTBD18	B2RXH4	331
TNRC18	GRHL2	Q6ISB3	326

IntAct

76 interactions, top by confidence:

A	B	Type	Score
HDAC1	CDK2AP1	psi-mi:“MI:0914”(association)	0.840
HDAC1	TNRC18	psi-mi:“MI:0914”(association)	0.790
RBBP4	CDK2AP1	psi-mi:“MI:0914”(association)	0.790
HDAC1	ZNF609	psi-mi:“MI:0914”(association)	0.730
RBBP7	HAT1	psi-mi:“MI:0914”(association)	0.730
SINHCAF	TNRC18	psi-mi:“MI:0914”(association)	0.640
CAMKV	AP3B1	psi-mi:“MI:0914”(association)	0.640
SIN3B	TNRC18	psi-mi:“MI:0914”(association)	0.530
PES1	AP3B1	psi-mi:“MI:0914”(association)	0.530
MDK	SETD1A	psi-mi:“MI:0914”(association)	0.530
FHL2	CNOT1	psi-mi:“MI:0914”(association)	0.530
EPB41L1	AP3B1	psi-mi:“MI:0914”(association)	0.530
EDA	AP3B1	psi-mi:“MI:0914”(association)	0.530
EPB41L3	AP3B1	psi-mi:“MI:0914”(association)	0.530
RBBP4	TNRC18	psi-mi:“MI:0914”(association)	0.530
RBBP7	EPOP	psi-mi:“MI:0914”(association)	0.530
SAP30	TNRC18	psi-mi:“MI:0914”(association)	0.530
EPB41L1	TNRC18	psi-mi:“MI:0914”(association)	0.530
DAXX	TNRC18	psi-mi:“MI:0914”(association)	0.530

BioGRID (110): TNRC18 (Affinity Capture-MS), TNRC18 (Synthetic Lethality), TNRC18 (Affinity Capture-MS), TNRC18 (Affinity Capture-MS), TNRC18 (Affinity Capture-MS), TNRC18 (Affinity Capture-MS), TNRC18 (Affinity Capture-MS), TNRC18 (Affinity Capture-MS), TNRC18 (Affinity Capture-MS), TNRC18 (Affinity Capture-MS), TNRC18 (Affinity Capture-MS), TNRC18 (Affinity Capture-MS), TNRC18 (Affinity Capture-MS), TNRC18 (Affinity Capture-MS), TNRC18 (Affinity Capture-MS)

ESM2 similar proteins: A1YFU7, A2AJK6, A2BH40, A3RK75, D3YWE6, E9PYL2, E9Q4N7, O00512, O14497, O15417, O35126, O35740, O43365, P02831, P09026, P09027, P14651, P25822, P31249, P48634, P54258, P54259, P78414, P81068, P91613, P91716, P92203, Q06A37, Q08DG7, Q0VCT9, Q10571, Q24248, Q3UHR0, Q5IS70, Q5TM26, Q67FY3, Q7TQ40, Q80WC3, Q8CFT2, Q8NFD5

Diamond homologs: O15417, Q3LHL9, Q80WC3, Q9P281, Q497V6, Q8TBE0, F4JGB7, F4JL28, Q3UHR0, Q9FEN9

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 71 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
HDACs deacetylate histones	5	12.5×	6e-03
Potential therapeutics for SARS	5	11.9×	6e-03

GO biological processes:

GO term	Partners	Fold	FDR
negative regulation of stem cell population maintenance	8	97.3×	4e-12
positive regulation of stem cell population maintenance	9	49.1×	4e-11
negative regulation of transforming growth factor beta receptor signaling pathway	8	22.1×	4e-07
negative regulation of cell migration	9	15.9×	5e-07
brain development	7	8.8×	1e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

964 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	714
Likely benign	69
Benign	113

Top pathogenic / likely-pathogenic (0)

SpliceAI

5725 predictions. Top by Δscore:

Variant	Effect	Δscore
7:5308309:CGCG:C	acceptor_gain	1.0000
7:5308311:CG:C	acceptor_gain	1.0000
7:5308312:GC:G	acceptor_loss	1.0000
7:5308313:C:CC	acceptor_gain	1.0000
7:5308313:CT:C	acceptor_loss	1.0000
7:5308871:CTA:C	donor_loss	1.0000
7:5308873:A:AC	donor_gain	1.0000
7:5308873:ACC:A	donor_loss	1.0000
7:5308873:ACCT:A	donor_gain	1.0000
7:5308873:ACCTC:A	donor_gain	1.0000
7:5308874:C:CC	donor_gain	1.0000
7:5308874:CCT:C	donor_gain	1.0000
7:5308874:CCTC:C	donor_gain	1.0000
7:5308874:CCTCC:C	donor_gain	1.0000
7:5308889:T:TA	donor_gain	1.0000
7:5308945:CAGTG:C	acceptor_gain	1.0000
7:5308946:AGTG:A	acceptor_gain	1.0000
7:5308947:GTG:G	acceptor_gain	1.0000
7:5308947:GTGC:G	acceptor_loss	1.0000
7:5308948:TG:T	acceptor_gain	1.0000
7:5308948:TGC:T	acceptor_loss	1.0000
7:5308949:GC:G	acceptor_loss	1.0000
7:5308950:C:CC	acceptor_gain	1.0000
7:5308951:T:A	acceptor_loss	1.0000
7:5308952:G:C	acceptor_gain	1.0000
7:5308952:G:GC	acceptor_gain	1.0000
7:5308954:G:C	acceptor_gain	1.0000
7:5308954:G:GC	acceptor_gain	1.0000
7:5309131:CCTGG:C	donor_gain	1.0000
7:5309153:G:A	donor_gain	1.0000

AlphaMissense

19029 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:5308250:G:C	C2921W	1.000
7:5308252:A:G	C2921R	1.000
7:5309183:C:A	W2858C	1.000
7:5309183:C:G	W2858C	1.000
7:5309185:A:G	W2858R	1.000
7:5309185:A:T	W2858R	1.000
7:5309190:A:T	V2856D	1.000
7:5309196:A:T	V2854D	1.000
7:5309222:C:A	W2845C	1.000
7:5309222:C:G	W2845C	1.000
7:5309224:A:G	W2845R	1.000
7:5309224:A:T	W2845R	1.000
7:5309241:C:T	G2839D	1.000
7:5309242:C:G	G2839R	1.000
7:5309274:A:G	L2828P	1.000
7:5309276:G:C	F2827L	1.000
7:5309276:G:T	F2827L	1.000
7:5309277:A:C	F2827C	1.000
7:5309277:A:G	F2827S	1.000
7:5309278:A:G	F2827L	1.000
7:5309283:G:T	A2825D	1.000
7:5309322:A:T	I2812N	1.000
7:5309326:C:G	A2811P	1.000
7:5309332:A:C	Y2809D	1.000
7:5309333:G:C	F2808L	1.000
7:5309333:G:T	F2808L	1.000
7:5309335:A:G	F2808L	1.000
7:5312521:C:A	W2790C	1.000
7:5312521:C:G	W2790C	1.000
7:5312523:A:G	W2790R	1.000

dbSNP variants (sampled 300 via entrez): RS1000024928 (7:5368894 C>G), RS1000028499 (7:5401649 G>A,C), RS1000031084 (7:5382094 C>A), RS1000047387 (7:5413799 G>A,C), RS1000064178 (7:5408905 G>A,T), RS1000073269 (7:5309553 C>T), RS1000081921 (7:5401868 G>A,T), RS1000116035 (7:5349779 A>C), RS1000122137 (7:5329736 G>A,C,T), RS1000128101 (7:5340007 T>C), RS1000146322 (7:5356473 G>A,C,T), RS1000162905 (7:5339868 C>A,T), RS1000183029 (7:5340790 A>T), RS1000203307 (7:5318914 G>T), RS1000224058 (7:5412174 G>A,C,T)

Disease associations

OMIM: gene MIM:620902 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST002183_6	Relative hand skill in reading disability	4.000000e-06
GCST006284_14	Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease	2.000000e-06
GCST006284_5	Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease	7.000000e-09
GCST011741_36	LDL cholesterol levels in HIV infection	3.000000e-07

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0009902	handedness
EFO:0006899	PCSK9 protein measurement
EFO:0004611	low density lipoprotein cholesterol measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB variants

1 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs10234709	TNRC18		0.00	0

CTD chemical–gene interactions

59 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
methylmercuric chloride	increases expression, affects cotreatment	3
Air Pollutants	decreases expression, increases abundance, affects expression, increases expression, affects cotreatment	3
Ozone	decreases expression, increases abundance, affects expression, affects cotreatment	3
sodium arsenite	increases expression	2
methacrylaldehyde	decreases expression, increases abundance, affects cotreatment	2
Acrolein	affects cotreatment, decreases expression, increases abundance	2
Benzo(a)pyrene	decreases expression, affects methylation	2
Tetrachlorodibenzodioxin	decreases methylation, increases abundance, affects expression	2
Tobacco Smoke Pollution	decreases expression, decreases methylation	2
Valproic Acid	decreases expression, increases methylation	2
aristolochic acid I	increases expression	1
FR900359	affects phosphorylation	1
TAK-243	increases sumoylation	1
dicrotophos	increases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, decreases expression, increases abundance	1
bisphenol A	affects cotreatment, increases methylation	1
trichostatin A	affects expression	1
arsenite	affects binding, decreases reaction	1
11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid	affects methylation, increases abundance	1
butyraldehyde	decreases expression	1
benzo(e)pyrene	affects methylation	1
pentanal	decreases expression	1
pentabromodiphenyl ether	decreases expression	1
tebuconazole	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	decreases expression	1
dorsomorphin	affects cotreatment, increases expression	1
bisphenol S	decreases methylation	1
MT19c compound	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.