TOB1-AS1

Summary

TOB1-AS1 (TOB1 antisense RNA 1, HGNC:44340) is a long non-coding RNA gene on chromosome 17q21.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44340
Approved symbol	TOB1-AS1
Name	TOB1 antisense RNA 1
Location	17q21.33
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000229980
Ensembl biotype	lncRNA
Entrez	400604
RNAcentral	URS000075F043 — lncRNA, 1420 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 22 — 21 lncRNA, 1 retained_intron

ENST00000416263, ENST00000514358, ENST00000519432, ENST00000523470, ENST00000671267, ENST00000803427, ENST00000803428, ENST00000803429, ENST00000803430, ENST00000803431, ENST00000803432, ENST00000803433, ENST00000803434, ENST00000803435, ENST00000803436, ENST00000803437, ENST00000803438, ENST00000803439, ENST00000803440, ENST00000803441, ENST00000803442, ENST00000803443

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000416263 — 2 exons

Exon	Start	End
ENSE00004193843	50866605	50867217
ENSE00004193879	50867496	50868383

Expression profiles

Bgee: expression breadth ubiquitous, 185 present calls, max score 82.32.

Top tissues by expression

239 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
hindlimb stylopod muscle	UBERON:0004252	82.32	gold quality
muscle of leg	UBERON:0001383	79.00	gold quality
gastrocnemius	UBERON:0001388	78.79	gold quality
apex of heart	UBERON:0002098	78.68	gold quality
right lobe of liver	UBERON:0001114	75.43	gold quality
right hemisphere of cerebellum	UBERON:0014890	75.06	gold quality
cerebellar hemisphere	UBERON:0002245	74.87	gold quality
cerebellar cortex	UBERON:0002129	74.82	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	74.70	gold quality
popliteal artery	UBERON:0002250	74.46	gold quality
tibial artery	UBERON:0007610	74.43	gold quality
prefrontal cortex	UBERON:0000451	74.03	gold quality
cerebellum	UBERON:0002037	73.94	gold quality
right coronary artery	UBERON:0001625	73.89	gold quality
Brodmann (1909) area 9	UBERON:0013540	73.75	gold quality
body of stomach	UBERON:0001161	73.68	gold quality
right frontal lobe	UBERON:0002810	73.55	gold quality
anterior cingulate cortex	UBERON:0009835	73.01	gold quality
skeletal muscle tissue	UBERON:0001134	72.99	gold quality
nucleus accumbens	UBERON:0001882	72.70	gold quality
aorta	UBERON:0000947	72.43	gold quality
cortical plate	UBERON:0005343	72.24	gold quality
lower esophagus mucosa	UBERON:0035834	72.21	gold quality
muscle tissue	UBERON:0002385	72.20	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	72.19	gold quality
left testis	UBERON:0004533	72.08	gold quality
lower esophagus muscularis layer	UBERON:0035833	71.89	gold quality
lower esophagus	UBERON:0013473	71.88	gold quality
vastus lateralis	UBERON:0001379	71.83	silver quality
heart left ventricle	UBERON:0002084	71.81	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.76

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• The Putative Association of TOB1-AS1 Long Non-coding RNA with Immune Tolerance: A Study on Multiple Sclerosis Patients. (PMID:31482275)
• Long non-coding RNA TOB1-AS1 modulates cell proliferation, apoptosis, migration and invasion through miR-23a/NEU1 axis via Wnt/b-catenin pathway in gastric cancer. (PMID:31799657)
• Methylation Mediated Downregulation of TOB1-AS1 and TOB1 Correlates with Malignant Progression and Poor Prognosis of Esophageal Squamous Cell Carcinoma. (PMID:36002674)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.