TOMM22

Summary

TOMM22 (translocase of outer mitochondrial membrane 22, HGNC:18002) is a protein-coding gene on chromosome 22q13.1, encoding Mitochondrial import receptor subunit TOM22 homolog (Q9NS69). Central receptor component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. It is a common-essential gene (DepMap: required in 99.2% of cancer cell lines).

The protein encoded by this gene is an integral membrane protein of the mitochondrial outer membrane. The encoded protein interacts with TOMM20 and TOMM40, and forms a complex with several other proteins to import cytosolic preproteins into the mitochondrion.

Source: NCBI Gene 56993 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 11 total
• Druggable target: yes
• Cancer dependency (DepMap): dependent in 99.2% of screened cell lines (common-essential)
• MANE Select transcript: NM_020243

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18002
Approved symbol	TOMM22
Name	translocase of outer mitochondrial membrane 22
Location	22q13.1
Locus type	gene with protein product
Status	Approved
Aliases	TOM22
Ensembl gene	ENSG00000100216
Ensembl biotype	protein_coding
OMIM	607046
Entrez	56993

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 4 protein_coding, 1 retained_intron

ENST00000216034, ENST00000492561, ENST00000915615, ENST00000915616, ENST00000915617

RefSeq mRNA: 1 — MANE Select: NM_020243 NM_020243

CCDS: CCDS13975

Canonical transcript exons

ENST00000216034 — 4 exons

Exon	Start	End
ENSE00000654439	38682323	38682441
ENSE00000880314	38681957	38682095
ENSE00000880315	38683767	38685421
ENSE00003637957	38682879	38682996

Expression profiles

Bgee: expression breadth ubiquitous, 274 present calls, max score 97.86.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 94.9107 / max 422.9215, expressed in 1827 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
192262	94.8676	1827
192263	0.0432	6

Top tissues by expression

286 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tendon of biceps brachii	UBERON:0008188	97.86	gold quality
mucosa of transverse colon	UBERON:0004991	96.13	gold quality
rectum	UBERON:0001052	95.73	gold quality
ganglionic eminence	UBERON:0004023	94.84	gold quality
cortical plate	UBERON:0005343	94.73	gold quality
medial globus pallidus	UBERON:0002477	94.60	gold quality
monocyte	CL:0000576	94.33	gold quality
apex of heart	UBERON:0002098	94.25	gold quality
hindlimb stylopod muscle	UBERON:0004252	94.25	gold quality
prefrontal cortex	UBERON:0000451	94.10	gold quality
granulocyte	CL:0000094	94.02	gold quality
leukocyte	CL:0000738	94.01	gold quality
mononuclear cell	CL:0000842	93.92	gold quality
islet of Langerhans	UBERON:0000006	93.85	gold quality
transverse colon	UBERON:0001157	93.45	gold quality
tendon	UBERON:0000043	93.41	gold quality
esophagus mucosa	UBERON:0002469	93.40	gold quality
buccal mucosa cell	CL:0002336	93.35	gold quality
right adrenal gland	UBERON:0001233	93.10	gold quality
right atrium auricular region	UBERON:0006631	93.04	gold quality
left adrenal gland	UBERON:0001234	93.03	gold quality
gastrocnemius	UBERON:0001388	93.02	gold quality
heart left ventricle	UBERON:0002084	92.91	gold quality
muscle of leg	UBERON:0001383	92.88	gold quality
anterior cingulate cortex	UBERON:0009835	92.88	gold quality
left adrenal gland cortex	UBERON:0035825	92.86	gold quality
right adrenal gland cortex	UBERON:0035827	92.86	gold quality
right testis	UBERON:0004534	92.77	gold quality
cardiac ventricle	UBERON:0002082	92.72	gold quality
cingulate cortex	UBERON:0003027	92.71	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

46 targeting TOMM22, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-3617-3P	99.98	67.86	918
HSA-MIR-8082	99.95	67.27	1170
HSA-MIR-4753-3P	99.90	71.03	3786
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-4524A-3P	99.72	66.85	2406
HSA-MIR-5700	99.64	69.88	2280
HSA-MIR-587	99.64	70.86	2611
HSA-MIR-4261	99.59	70.30	3415
HSA-MIR-6733-3P	99.54	67.80	1281
HSA-MIR-4672	99.50	71.58	2893
HSA-MIR-4687-3P	99.48	66.41	968
HSA-MIR-147B-5P	99.45	70.62	2432
HSA-MIR-889-5P	99.41	68.75	1025
HSA-MIR-6505-3P	99.34	67.39	1071
HSA-MIR-130A-5P	99.33	70.26	2623
HSA-MIR-3614-5P	99.30	65.25	837
HSA-MIR-593-3P	99.22	67.28	1327
HSA-MIR-4291	99.20	68.88	2969
HSA-MIR-4426	99.17	66.74	1949
HSA-MIR-491-5P	99.13	65.98	1468
HSA-MIR-371A-5P	99.08	66.51	1914
HSA-MIR-4478	99.07	65.16	2320
HSA-MIR-922	99.02	67.23	1838
HSA-MIR-3619-5P	99.00	68.87	2308
HSA-MIR-361-5P	98.95	70.16	1340
HSA-MIR-455-5P	98.74	67.31	795
HSA-MIR-214-3P	98.71	68.12	2128

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 99.2% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 10)

• Levels of Tom22 in mitochondria accelerate the rate of Tom7 assembly into the mature TOM complex. (PMID:12198123)
• the cytosolic domains of Tom20 and Tom22 function to maintain their substrate preproteins unfolded and prevent them from aggregating on the mitochondrial surface (PMID:14699115)
• We have identified TOM22, a component of the translocase of the outer mitochondrial membrane (TOM), as a mitochondrial receptor of Bax. (PMID:17096026)
• Studies indicate that PUMA and TOMM22 as potential targets for miRNA-BART viral transcripts. (PMID:22178394)
• The interaction with the cytosolic domain of Tom22 helps Bax to acquire a conformation able to interact with the outer mitochondrial membrane. (PMID:22198199)
• Blockade of mitochondrial protein import triggers the recruitment of PARK2, by PINK1, to the TOMM machinery. (PMID:24149440)
• Tom22 is essential for metabolic conversion, as its knockdown by small interfering RNA (siRNA) completely ablated progesterone conversion in both steroidogenic mouse Leydig MA-10 and human adrenal NCI cells. (PMID:26787839)
• A directed proteomic approach discovered the novel interaction of BKCa with Tom22, a component of the mitochondrion outer membrane import system, and the adenine nucleotide translocator (ANT). (PMID:27592226)
• Structural basis of Tom20 and Tom22 cytosolic domains as the human TOM complex receptors. (PMID:35733257)
• Mitochondrial Translocase TOMM22 Is Overexpressed in Pancreatic Cancer and Promotes Aggressive Growth by Modulating Mitochondrial Protein Import and Function. (PMID:37878010)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	tomm22	ENSDARG00000045146
mus_musculus	Tomm22	ENSMUSG00000022427
rattus_norvegicus	Tomm22	ENSRNOG00000014058
drosophila_melanogaster	mge	FBGN0035473
caenorhabditis_elegans		WBGENE00021133

Protein

Protein identifiers

Mitochondrial import receptor subunit TOM22 homolog — Q9NS69 (reviewed: Q9NS69)

Alternative names: 1C9-2, Translocase of outer membrane 22 kDa subunit homolog

All UniProt accessions (2): Q9NS69, Q549C5

UniProt curated annotations — full annotation on UniProt →

Function. Central receptor component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOMM20, functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore. The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN. Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases.

Subunit / interactions. Part of the translocase of the outer mitochondrial membrane (TOM complex) consisting of at least TOMM5, TOMM6, TOMM7, TOMM20, TOMM22 and TOMM40. TOMM70 may also be found in the TOM complex. The TOM complex interacts with the VDAC2 homodimer. Upon mitochondrial depolarization, the TOM-VDAC assembly interacts with PINK1; the interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy. Interacts with PPP2R2B.

Subcellular location. Mitochondrion outer membrane.

Tissue specificity. Ubiquitous.

Domain organisation. Requires the transmembrane domain (TMD), a short segment (the import sequence) in the cytoplasmic domain localizing separately from the TMD and the C-tail signal in the C-terminal domain for efficient targeting and integration into the TOM complex. The N-terminal domain (residues 1-62) is important for binding to the unfolded mature imported proteins. Residues (49-71) of the cytoplasmic domain interacts with TOMM20 while the C-terminal segment (residues 63-82) binds presequence of preproteins.

Similarity. Belongs to the Tom22 family.

RefSeq proteins (1): NP_064628* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR005683	Tom22	Family

Pfam: PF04281

UniProt features (20 total): helix 5, modified residue 4, region of interest 4, compositionally biased region 2, topological domain 2, initiator methionine 1, chain 1, transmembrane region 1

Structure

Experimental structures (PDB)

12 structures.

PDB	Method	Resolution (Å)
7VD2	ELECTRON MICROSCOPY	2.53
7VBY	ELECTRON MICROSCOPY	2.54
9EII	ELECTRON MICROSCOPY	2.75
9JXV	ELECTRON MICROSCOPY	2.89
8XDN	ELECTRON MICROSCOPY	2.93
7CP9	ELECTRON MICROSCOPY	3
9EIH	ELECTRON MICROSCOPY	3.1
9EIJ	ELECTRON MICROSCOPY	3.3
7CK6	ELECTRON MICROSCOPY	3.4
7VC4	ELECTRON MICROSCOPY	3.74
7VDD	ELECTRON MICROSCOPY	3.74
8XVA	ELECTRON MICROSCOPY	5.92

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NS69-F1	72.65	0.23

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (4): 2, 15, 43, 45

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-1268020	Mitochondrial protein import
R-HSA-5205685	PINK1-PRKN Mediated Mitophagy

MSigDB gene sets: 167 (showing top): GSE45365_NK_CELL_VS_CD8_TCELL_DN, ELVIDGE_HYPOXIA_DN, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP, GOBP_INTRACELLULAR_PROTEIN_TRANSPORT, GOBP_PROTEIN_TARGETING, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE, AMIT_SERUM_RESPONSE_40_MCF10A, TGCTGAY_UNKNOWN, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE, GOCC_MITOCHONDRIAL_ENVELOPE, AACTTT_UNKNOWN, GOBP_PROTEIN_LOCALIZATION_TO_ORGANELLE, NRF2_01, GOBP_PROTEIN_TRANSMEMBRANE_TRANSPORT, GOBP_MEMBRANE_ORGANIZATION

GO Biological Process (5): obsolete protein targeting to mitochondrion (GO:0006626), intracellular protein transport (GO:0006886), protein import into mitochondrial matrix (GO:0030150), protein insertion into mitochondrial outer membrane (GO:0045040), protein transport (GO:0015031)

GO Molecular Function (3): transmembrane protein transporter activity (GO:0008320), mitochondrion targeting sequence binding (GO:0030943), protein binding (GO:0005515)

GO Cellular Component (5): mitochondrion (GO:0005739), mitochondrial outer membrane (GO:0005741), mitochondrial outer membrane translocase complex (GO:0005742), membrane (GO:0016020), TOM complex (GO:0140596)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Protein localization	1
Mitophagy	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
intracellular protein localization	2
protein transport	1
intracellular transport	1
protein transmembrane import into intracellular organelle	1
protein localization to mitochondrion	1
import into the mitochondrion	1
mitochondrial protein import pathway	1
outer mitochondrial membrane organization	1
protein insertion into mitochondrial membrane	1
transport	1
establishment of protein localization	1
macromolecule transmembrane transporter activity	1
protein transmembrane transport	1
protein transporter activity	1
signal sequence receptor activity	1
binding	1
cytoplasm	1
intracellular membrane-bounded organelle	1
mitochondrial membrane	1
organelle outer membrane	1
outer mitochondrial membrane protein complex	1
cellular anatomical structure	1
mitochondrial outer membrane translocase complex	1

Protein interactions and networks

STRING

2740 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TOMM22	TOMM70	O94826	999
TOMM22	TOMM40	O96008	999
TOMM22	TOMM20	Q15388	999
TOMM22	TOMM7	Q9P0U1	999
TOMM22	TOMM5	Q8N4H5	996
TOMM22	TOMM6	Q96B49	996
TOMM22	SAMM50	Q9Y512	968
TOMM22	TIMM21	Q9BVV7	922
TOMM22	TIMM50	Q3ZCQ8	911
TOMM22	STAR	P49675	892
TOMM22	TIMM23	O14925	876
TOMM22	TIMM17A	Q99595	872
TOMM22	TIMM44	O43615	851
TOMM22	TIMM13	P62206	817
TOMM22	PINK1	Q9BXM7	784

IntAct

146 interactions, top by confidence:

A	B	Type	Score
TOMM22	TOMM40	psi-mi:“MI:0915”(physical association)	0.740
TOMM22	TOMM40	psi-mi:“MI:0914”(association)	0.740
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
TOMM22	XRCC3	psi-mi:“MI:0914”(association)	0.640
AQP6	TOMM22	psi-mi:“MI:0915”(physical association)	0.560
LAMP2	TOMM22	psi-mi:“MI:0915”(physical association)	0.560
SH3GLB1	TOMM22	psi-mi:“MI:0915”(physical association)	0.560
HTT	TOMM22	psi-mi:“MI:0915”(physical association)	0.560
ILK	HAX1	psi-mi:“MI:0914”(association)	0.530
TMEM184A	SLC33A1	psi-mi:“MI:0914”(association)	0.530
SFXN5	TOMM40	psi-mi:“MI:0914”(association)	0.530
M	TOMM22	psi-mi:“MI:0915”(physical association)	0.520
STOM	EI24	psi-mi:“MI:0914”(association)	0.510
NRAS	ESYT2	psi-mi:“MI:2364”(proximity)	0.480
TOMM20	TPP1	psi-mi:“MI:0914”(association)	0.480
LTK	PIK3R2	psi-mi:“MI:0914”(association)	0.420
TOMM7	TOMM22	psi-mi:“MI:0915”(physical association)	0.400
TOMM22	TOMM7	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (599): TOMM22 (Two-hybrid), TOMM22 (Affinity Capture-MS), TOMM22 (Affinity Capture-MS), TOMM22 (Affinity Capture-MS), CLTC (Co-fractionation), EHD1 (Co-fractionation), HSD17B12 (Co-fractionation), PDHA1 (Co-fractionation), SSR3 (Co-fractionation), SSR4 (Co-fractionation), TOMM22 (Co-fractionation), TOMM22 (Co-fractionation), TOMM22 (Co-fractionation), TOMM22 (Co-fractionation), TOMM22 (Co-fractionation)

ESM2 similar proteins: A0A1B0GVV1, A0M8U1, A6H6W9, A6QPI6, B1AZA5, D3ZXD8, D4ABL6, E1BWM5, E9PV86, F1QH17, G3MWR8, O43399, P01134, P01135, Q0X0A5, Q1RLU8, Q29S14, Q2PG42, Q3KNM2, Q3SZB3, Q3ZC24, Q3ZCQ8, Q4R3C7, Q5RAJ8, Q5RBB8, Q5RCT1, Q5SQY2, Q5ZJ41, Q5ZJB7, Q6AYJ2, Q6DN14, Q6GM44, Q6ZVM7, Q75Q41, Q7RTP6, Q8BR65, Q8CJ19, Q8IVP5, Q8K1Z0, Q8TF64

Diamond homologs: A6QPI6, O17287, Q4R3C7, Q75Q41, Q9CPQ3, Q9NS69, O64497, Q9FNC9

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
TOMM22	“form complex”	“TOM40 complex”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 158 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	5	24.7×	2e-04
Downstream signal transduction	5	18.1×	7e-04
PINK1-PRKN Mediated Mitophagy	5	17.0×	7e-04
RAF activation	5	16.0×	9e-04
Signaling by high-kinase activity BRAF mutants	5	15.1×	1e-03
MAP2K and MAPK activation	5	13.6×	1e-03
Signaling by RAF1 mutants	5	13.3×	1e-03
Negative regulation of MAPK pathway	5	12.7×	1e-03

GO biological processes:

GO term	Partners	Fold	FDR
obsolete protein targeting to mitochondrion	6	25.8×	6e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

11 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	8
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

319 predictions. Top by Δscore:

Variant	Effect	Δscore
22:38682092:GGAG:G	donor_gain	1.0000
22:38682093:G:GT	donor_gain	1.0000
22:38682095:GG:G	donor_loss	1.0000
22:38682096:GTACT:G	donor_loss	1.0000
22:38682097:T:A	donor_loss	1.0000
22:38682875:GCA:G	acceptor_loss	1.0000
22:38682877:A:AG	acceptor_gain	1.0000
22:38682877:A:G	acceptor_loss	1.0000
22:38682877:AG:A	acceptor_gain	1.0000
22:38682878:G:GA	acceptor_gain	1.0000
22:38682878:GG:G	acceptor_gain	1.0000
22:38682878:GGT:G	acceptor_gain	1.0000
22:38682878:GGTT:G	acceptor_gain	1.0000
22:38682878:GGTTT:G	acceptor_gain	1.0000
22:38682994:CAGG:C	donor_loss	1.0000
22:38682995:AGGTG:A	donor_loss	1.0000
22:38682996:GGTG:G	donor_loss	1.0000
22:38682997:G:T	donor_loss	1.0000
22:38682998:T:A	donor_loss	1.0000
22:38682078:G:GT	donor_gain	0.9900
22:38682081:G:GT	donor_gain	0.9900
22:38682093:G:T	donor_gain	0.9900
22:38682322:GCTA:G	acceptor_gain	0.9900
22:38682440:AG:A	donor_loss	0.9900
22:38682442:GTAAG:G	donor_loss	0.9900
22:38682874:T:TA	acceptor_gain	0.9900
22:38682874:TGCAG:T	acceptor_gain	0.9900
22:38682875:GCAGG:G	acceptor_gain	0.9900
22:38682876:CAGGT:C	acceptor_gain	0.9900
22:38682877:AGGT:A	acceptor_gain	0.9900

AlphaMissense

909 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
22:38682893:C:A	A84D	1.000
22:38682898:T:A	W86R	1.000
22:38682898:T:C	W86R	1.000
22:38682904:G:A	G88R	1.000
22:38682904:G:C	G88R	1.000
22:38682905:G:A	G88E	1.000
22:38682926:T:C	L95P	1.000
22:38682932:T:A	L97H	1.000
22:38682934:C:T	P98S	1.000
22:38682935:C:A	P98H	1.000
22:38682935:C:G	P98R	1.000
22:38683768:T:C	I119T	1.000
22:38683771:T:A	L120H	1.000
22:38683777:G:A	G122E	1.000
22:38682345:G:C	R47T	0.999
22:38682346:A:C	R47S	0.999
22:38682346:A:T	R47S	0.999
22:38682353:G:C	G50R	0.999
22:38682357:T:A	L51Q	0.999
22:38682357:T:C	L51P	0.999
22:38682366:T:C	M54T	0.999
22:38682393:C:A	A63D	0.999
22:38682426:C:A	A74D	0.999
22:38682887:G:T	R82M	0.999
22:38682892:G:C	A84P	0.999
22:38682900:G:C	W86C	0.999
22:38682900:G:T	W86C	0.999
22:38682911:C:T	T90I	0.999
22:38682913:T:C	S91P	0.999
22:38682914:C:A	S91Y	0.999

dbSNP variants (sampled 300 via entrez): RS1000228231 (22:38681947 C>A,T), RS1000917266 (22:38683468 A>C), RS1000963116 (22:38683151 G>GC,GT), RS1001231812 (22:38680933 A>G,T), RS1002417674 (22:38684629 G>A,C), RS1002750836 (22:38684290 A>G), RS1003774980 (22:38685420 T>C), RS1005333871 (22:38684379 G>A), RS1005750456 (22:38681888 G>C,T), RS1006013666 (22:38682757 G>A,C), RS1006092541 (22:38681651 T>C), RS1006506560 (22:38683073 T>C), RS1007708892 (22:38682798 G>A,C), RS1008197529 (22:38683201 T>C), RS1008603427 (22:38684965 A>G)

Disease associations

OMIM: gene MIM:607046 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST003818_40	Resting heart rate	5.000000e-16
GCST007561_72	Sleep duration	4.000000e-08
GCST007614_7	C-reactive protein levels	7.000000e-14

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004458	C-reactive protein measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067373 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

34 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases expression, decreases expression, affects cotreatment, increases abundance	3
Acetaminophen	decreases expression	2
GSK-J4	decreases expression	1
FR900359	increases phosphorylation	1
beauvericin	affects cotreatment, decreases expression	1
deoxynivalenol	decreases expression	1
O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	affects expression, affects response to substance	1
arsenite	affects binding, increases reaction	1
cobaltous chloride	decreases expression	1
manganese chloride	increases expression, affects cotreatment, increases abundance	1
coumarin	increases phosphorylation	1
2,3,5-(triglutathion-S-yl)hydroquinone	increases ADP-ribosylation, decreases ADP-ribosylation	1
enniatins	affects cotreatment, decreases expression	1
K 7174	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
LDN 193189	affects cotreatment, decreases expression	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Atrazine	decreases expression	1
Benzo(a)pyrene	decreases expression	1
Dichlorodiphenyl Dichloroethylene	increases expression	1
Ethyl Methanesulfonate	decreases expression	1
Ivermectin	decreases expression	1
Manganese	increases expression, affects cotreatment, increases abundance	1
Methyl Methanesulfonate	decreases expression	1
Quercetin	decreases expression	1
Smoke	decreases expression	1
Thiram	decreases expression	1
Tretinoin	decreases expression	1
Tunicamycin	decreases expression	1
Valproic Acid	decreases methylation	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652673	Binding	Binding affinity to human TOMM22 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.