TOMM7

Summary

TOMM7 (translocase of outer mitochondrial membrane 7, HGNC:21648) is a protein-coding gene on chromosome 7p15.3, encoding Mitochondrial import receptor subunit TOM7 homolog (Q9P0U1). Component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins.

This gene encodes a subunit of the translocase of the outer mitochondrial membrane. The encoded protein regulates the assembly and stability of the translocase complex.

Source: NCBI Gene 54543 — RefSeq curated summary.

At a glance

• Gene–disease (curated): Garg-Mishra progeroid syndrome (Moderate, GenCC)
• GWAS associations: 11
• Clinical variants (ClinVar): 23 total — 2 pathogenic
• Phenotypes (HPO): 30
• MANE Select transcript: NM_019059

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21648
Approved symbol	TOMM7
Name	translocase of outer mitochondrial membrane 7
Location	7p15.3
Locus type	gene with protein product
Status	Approved
Aliases	Tom7
Ensembl gene	ENSG00000196683
Ensembl biotype	protein_coding
OMIM	607980
Entrez	54543

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 3 protein_coding, 2 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000358435, ENST00000372879, ENST00000405021, ENST00000463284, ENST00000483581, ENST00000496129

RefSeq mRNA: 1 — MANE Select: NM_019059 NM_019059

CCDS: CCDS5376

Canonical transcript exons

ENST00000358435 — 3 exons

Exon	Start	End
ENSE00001410211	22818000	22818048
ENSE00001864098	22822677	22822849
ENSE00003638113	22812974	22813185

Expression profiles

Bgee: expression breadth ubiquitous, 295 present calls, max score 99.76.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 169.8676 / max 1507.4884, expressed in 1826 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
83092	136.8223	1825
83091	33.0453	1812

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	99.76	gold quality
medial globus pallidus	UBERON:0002477	99.72	gold quality
tendon of biceps brachii	UBERON:0008188	99.72	gold quality
nucleus accumbens	UBERON:0001882	99.71	gold quality
diaphragm	UBERON:0001103	99.68	gold quality
left ovary	UBERON:0002119	99.68	gold quality
pituitary gland	UBERON:0000007	99.67	gold quality
adenohypophysis	UBERON:0002196	99.67	gold quality
amygdala	UBERON:0001876	99.66	gold quality
cerebellar cortex	UBERON:0002129	99.65	gold quality
cerebellar hemisphere	UBERON:0002245	99.65	gold quality
hindlimb stylopod muscle	UBERON:0004252	99.65	gold quality
right hemisphere of cerebellum	UBERON:0014890	99.65	gold quality
granulocyte	CL:0000094	99.64	gold quality
caudate nucleus	UBERON:0001873	99.64	gold quality
right frontal lobe	UBERON:0002810	99.64	gold quality
muscle of leg	UBERON:0001383	99.63	gold quality
gastrocnemius	UBERON:0001388	99.63	gold quality
cingulate cortex	UBERON:0003027	99.63	gold quality
anterior cingulate cortex	UBERON:0009835	99.63	gold quality
muscle layer of sigmoid colon	UBERON:0035805	99.63	gold quality
globus pallidus	UBERON:0001875	99.62	gold quality
apex of heart	UBERON:0002098	99.62	gold quality
tendon	UBERON:0000043	99.61	gold quality
endocervix	UBERON:0000458	99.61	gold quality
body of pancreas	UBERON:0001150	99.61	gold quality
right ovary	UBERON:0002118	99.61	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	99.61	gold quality
muscle organ	UBERON:0001630	99.60	gold quality
right lung	UBERON:0002167	99.60	gold quality

Single-cell (SCXA)

Detected in 17 experiment(s), a significant marker in 10.

Experiment	Marker?	Max mean expression
E-HCAD-4	yes	1502.96
E-MTAB-6701	yes	101.20
E-CURD-122	yes	81.39
E-CURD-88	yes	55.24
E-MTAB-9221	yes	53.30
E-CURD-46	yes	37.54
E-GEOD-135922	yes	28.59
E-GEOD-84465	yes	24.37
E-ANND-3	yes	16.15
E-MTAB-10042	yes	10.51
E-MTAB-10662	no	1515.61
E-MTAB-10018	no	1331.31
E-MTAB-8271	no	854.15
E-HCAD-1	no	92.05
E-HCAD-8	no	58.58

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

36 targeting TOMM7, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-141-3P	99.94	72.79	2421
HSA-MIR-200A-3P	99.94	72.68	2420
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-2052	99.79	69.37	2031
HSA-MIR-2681-5P	99.75	67.64	1655
HSA-MIR-1208	99.70	68.28	1533
HSA-MIR-4729	99.69	72.18	4233
HSA-MIR-7161-5P	99.68	68.92	1592
HSA-MIR-548U	99.65	67.78	1463
HSA-MIR-6083	99.47	68.73	2393
HSA-MIR-548V	99.29	69.47	1157
HSA-MIR-7151-3P	99.04	69.72	2370
HSA-MIR-2467-3P	98.65	67.18	1969
HSA-MIR-6728-3P	98.63	67.63	1534
HSA-MIR-5581-3P	98.55	70.31	1161
HSA-MIR-3136-5P	98.53	67.68	793
HSA-MIR-4439	98.53	67.53	793
HSA-MIR-4438	97.96	63.70	947
HSA-MIR-4432	97.80	67.87	705
HSA-MIR-630	97.50	66.38	921
HSA-MIR-890	97.47	68.67	982
HSA-MIR-6791-3P	97.45	64.31	1123
HSA-MIR-6829-3P	97.45	64.31	1137
HSA-MIR-134-5P	97.11	66.52	976
HSA-MIR-3118	97.11	66.58	984
HSA-MIR-6836-3P	97.08	64.99	712
HSA-MIR-6857-3P	96.70	65.43	915

Literature-anchored findings (GeneRIF, showing 4)

• Levels of Tom22 in mitochondria accelerate the rate of Tom7 assembly into the mature TOM complex. (PMID:12198123)
• The human counterparts of Tom5 and Tom6, together with the other components including Tom7, were identified in the preprotein translocase complex. (PMID:18331822)
• Mitochondrial membrane potential loss-dependent PINK1 import arrest does not result solely from Tim23 inactivation but also through an actively regulated “tug of war” between Tom7 and OMA1. (PMID:30733118)
• The receptor subunit Tom20 is dynamically associated with the TOM complex in mitochondria of human cells. (PMID:34347503)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Tomm7	ENSMUSG00000028998
rattus_norvegicus	Tomm7	ENSRNOG00000043114

Protein

Protein identifiers

Mitochondrial import receptor subunit TOM7 homolog — Q9P0U1 (reviewed: Q9P0U1)

Alternative names: Translocase of outer membrane 7 kDa subunit homolog

All UniProt accessions (4): A6NIV2, B5MD00, Q9P0U1, Q75MR5

UniProt curated annotations — full annotation on UniProt →

Function. Component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN.

Subunit / interactions. Part of the translocase of the outer mitochondrial membrane (TOM complex) consisting of at least TOMM5, TOMM6, TOMM7, TOMM20, TOMM22 and TOMM40. TOMM70 may also be found in the TOM complex. The TOM complex interacts with the VDAC2 homodimer. Upon mitochondrial depolarization, the TOM-VDAC assembly interacts with PINK1; the interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy.

Subcellular location. Mitochondrion outer membrane.

Disease relevance. Garg-Mishra progeroid syndrome (GMPGS) [MIM:620601] An autosomal recessive syndrome characterized by a progeroid appearance, severe dwarfism, mandibular hypoplasia, hyperopia, and partial lipodystrophy. The disease is caused by variants affecting the gene represented in this entry.

Similarity. Belongs to the Tom7 family.

RefSeq proteins (1): NP_061932* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR012621	Tom7	Family

Pfam: PF08038

UniProt features (10 total): topological domain 2, sequence variant 2, helix 2, chain 1, transmembrane region 1, sequence conflict 1, strand 1

Structure

Experimental structures (PDB)

12 structures.

PDB	Method	Resolution (Å)
7VD2	ELECTRON MICROSCOPY	2.53
7VBY	ELECTRON MICROSCOPY	2.54
9EII	ELECTRON MICROSCOPY	2.75
9JXV	ELECTRON MICROSCOPY	2.89
8XDN	ELECTRON MICROSCOPY	2.93
7CP9	ELECTRON MICROSCOPY	3
9EIH	ELECTRON MICROSCOPY	3.1
9EIJ	ELECTRON MICROSCOPY	3.3
7CK6	ELECTRON MICROSCOPY	3.4
7VC4	ELECTRON MICROSCOPY	3.74
7VDD	ELECTRON MICROSCOPY	3.74
8XVA	ELECTRON MICROSCOPY	5.92

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9P0U1-F1	93.03	0.87

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-1268020	Mitochondrial protein import
R-HSA-5205685	PINK1-PRKN Mediated Mitophagy

MSigDB gene sets: 250 (showing top): GOBP_REGULATION_OF_AUTOPHAGY, TGCGCANK_UNKNOWN, GOBP_PROTEIN_TARGETING, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE, ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_UP, GOBP_MACROAUTOPHAGY, GOBP_REGULATION_OF_CATABOLIC_PROCESS, GOBP_POSITIVE_REGULATION_OF_CATABOLIC_PROCESS, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE, GOCC_MITOCHONDRIAL_ENVELOPE, GOBP_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MITOCHONDRION, GOBP_REGULATION_OF_PROTEIN_STABILITY, SCHLOSSER_SERUM_RESPONSE_DN, GOBP_PROTEIN_LOCALIZATION_TO_ORGANELLE, GOBP_PROTEIN_TRANSMEMBRANE_TRANSPORT

GO Biological Process (6): protein import into mitochondrial matrix (GO:0030150), regulation of protein stability (GO:0031647), protein insertion into mitochondrial outer membrane (GO:0045040), obsolete positive regulation of protein targeting to mitochondrion (GO:1903955), positive regulation of type 2 mitophagy (GO:1905091), protein transport (GO:0015031)

GO Molecular Function (2): transmembrane protein transporter activity (GO:0008320), protein binding (GO:0005515)

GO Cellular Component (5): mitochondrion (GO:0005739), mitochondrial outer membrane (GO:0005741), mitochondrial outer membrane translocase complex (GO:0005742), TOM complex (GO:0140596), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Protein localization	1
Mitophagy	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
protein transmembrane import into intracellular organelle	1
protein localization to mitochondrion	1
import into the mitochondrion	1
mitochondrial protein import pathway	1
regulation of biological quality	1
outer mitochondrial membrane organization	1
protein insertion into mitochondrial membrane	1
type 2 mitophagy	1
positive regulation of mitophagy	1
regulation of type 2 mitophagy	1
transport	1
intracellular protein localization	1
establishment of protein localization	1
macromolecule transmembrane transporter activity	1
protein transmembrane transport	1
protein transporter activity	1
binding	1
cytoplasm	1
intracellular membrane-bounded organelle	1
mitochondrial membrane	1
organelle outer membrane	1
outer mitochondrial membrane protein complex	1
mitochondrial outer membrane translocase complex	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1668 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TOMM7	TOMM22	Q9NS69	999
TOMM7	TOMM6	Q96B49	998
TOMM7	TOMM70	O94826	997
TOMM7	TOMM40	O96008	997
TOMM7	TOMM5	Q8N4H5	997
TOMM7	TOMM20	Q15388	996
TOMM7	SAMM50	Q9Y512	745
TOMM7	TIMM17A	Q99595	724
TOMM7	TIMM9	Q9Y5J7	724
TOMM7	TIMM10	P62072	719
TOMM7	TIMM21	Q9BVV7	716
TOMM7	TIMM44	O43615	715
TOMM7	TIMM50	Q3ZCQ8	715
TOMM7	PINK1	Q9BXM7	639
TOMM7	TIMM13	P62206	637

IntAct

13 interactions, top by confidence:

A	B	Type	Score
TOMM22	TOMM40	psi-mi:“MI:0915”(physical association)	0.740
TOMM7	TOMM20	psi-mi:“MI:0915”(physical association)	0.560
TOMM7	TOMM22	psi-mi:“MI:0915”(physical association)	0.400
TOMM22	TOMM7	psi-mi:“MI:0915”(physical association)	0.400
TOMM7	Tomm22	psi-mi:“MI:0915”(physical association)	0.400
TOMM7	Tomm40	psi-mi:“MI:0915”(physical association)	0.400
TOMM7	TOMM40	psi-mi:“MI:0915”(physical association)	0.400
SHLD3		psi-mi:“MI:0914”(association)	0.350
RYBP	FAM186A	psi-mi:“MI:0914”(association)	0.350
TOMM20	TIMM44	psi-mi:“MI:0914”(association)	0.350
TOMM6	TOMM40	psi-mi:“MI:0914”(association)	0.350
TOMM7	AMY2A	psi-mi:“MI:0914”(association)	0.350

BioGRID (31): TOMM7 (Two-hybrid), TOMM7 (Proximity Label-MS), TOMM7 (Proximity Label-MS), TOMM7 (Affinity Capture-MS), TOMM7 (Affinity Capture-MS), AMY2A (Affinity Capture-MS), TOMM40L (Affinity Capture-MS), TOMM7 (Affinity Capture-MS), TPP2 (Cross-Linking-MS (XL-MS)), TOMM7 (Cross-Linking-MS (XL-MS)), TOMM7 (Cross-Linking-MS (XL-MS)), TOMM7 (Cross-Linking-MS (XL-MS)), TOMM7 (Cross-Linking-MS (XL-MS)), TOMM7 (Affinity Capture-MS), TOMM7 (Co-fractionation)

ESM2 similar proteins: A1XQS2, D3Z9R8, E2R4X3, E9PQ53, O14548, O60397, O82067, P14790, P34660, P46269, P46270, P56378, P56379, Q02827, Q1RMH3, Q29259, Q2KI08, Q3SZ13, Q3T061, Q3ZBI7, Q4V8S3, Q56JY4, Q5R987, Q5RDZ8, Q5XFV8, Q5ZML6, Q61387, Q63ZZ0, Q69YU5, Q78IK2, Q7SXI1, Q8BH51, Q8BTC1, Q8C1Q6, Q8N0X7, Q96B49, Q96I36, Q96IX5, Q96KF7, Q99KD6

Diamond homologs: A1XQS2, P34660, Q2KI08, Q9D173, Q9P0U1, O42999

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
TOMM7	“form complex”	“TOM40 complex”	binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

23 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	2
Likely pathogenic	0
Uncertain significance	8
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (2)

Variant ID	HGVS	Classification
2628316	NM_019059.5(TOMM7):c.86C>T (p.Pro29Leu)	Pathogenic
3809502	NM_019059.5(TOMM7):c.26_29del (p.Lys9fs)	Pathogenic

SpliceAI

448 predictions. Top by Δscore:

Variant	Effect	Δscore
7:22813195:T:TC	acceptor_gain	1.0000
7:22818056:A:T	acceptor_gain	1.0000
7:22822641:C:A	donor_gain	1.0000
7:22822655:T:A	donor_gain	1.0000
7:22822726:C:CA	donor_gain	1.0000
7:22813195:T:C	acceptor_gain	0.9900
7:22818055:C:CT	acceptor_gain	0.9900
7:22822640:T:TA	donor_gain	0.9900
7:22822719:A:AC	donor_gain	0.9900
7:22822720:C:CC	donor_gain	0.9900
7:22822770:G:C	donor_gain	0.9900
7:22813186:C:CC	acceptor_gain	0.9800
7:22813197:G:C	acceptor_gain	0.9800
7:22822727:C:A	donor_gain	0.9800
7:22813191:A:AC	acceptor_gain	0.9700
7:22813191:A:C	acceptor_gain	0.9700
7:22822675:AC:A	donor_gain	0.9700
7:22822676:CC:C	donor_gain	0.9700
7:22822685:A:C	donor_gain	0.9700
7:22813181:GTAGG:G	acceptor_gain	0.9600
7:22813182:TAGG:T	acceptor_gain	0.9600
7:22813184:GG:G	acceptor_gain	0.9600
7:22813194:T:C	acceptor_gain	0.9600
7:22813197:G:GC	acceptor_gain	0.9600
7:22818045:AATCC:A	acceptor_loss	0.9600
7:22818048:CCTGA:C	acceptor_loss	0.9600
7:22818049:C:A	acceptor_loss	0.9600
7:22818050:T:C	acceptor_loss	0.9600
7:22822627:TCCGC:T	donor_gain	0.9600
7:22822628:CCGCC:C	donor_gain	0.9600

AlphaMissense

353 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:22822704:C:G	G26R	0.995
7:22822707:A:G	W25R	0.994
7:22822707:A:T	W25R	0.994
7:22822715:G:T	A22D	0.994
7:22822677:C:G	G35R	0.991
7:22822677:C:T	G35R	0.991
7:22818048:C:T	G35E	0.990
7:22822703:C:T	G26D	0.990
7:22822700:A:G	F27S	0.989
7:22822699:A:C	F27L	0.987
7:22822699:A:T	F27L	0.987
7:22822701:A:G	F27L	0.987
7:22822694:G:C	P29R	0.986
7:22822694:G:T	P29H	0.985
7:22822723:G:C	S19R	0.984
7:22822723:G:T	S19R	0.984
7:22822725:T:G	S19R	0.984
7:22818045:A:G	F36S	0.976
7:22822753:C:A	K9N	0.976
7:22822753:C:G	K9N	0.976
7:22822679:A:G	L34P	0.974
7:22813175:C:G	G55R	0.973
7:22813175:C:T	G55R	0.973
7:22822695:G:A	P29S	0.971
7:22822745:A:G	L12P	0.971
7:22813180:A:T	L53H	0.969
7:22822683:A:C	Y33D	0.968
7:22822685:A:T	I32N	0.968
7:22822697:A:T	I28N	0.967
7:22818006:A:T	V49D	0.966

dbSNP variants (sampled 300 via entrez): RS1000007337 (7:22813669 T>C), RS1000033766 (7:22818146 G>A,C,T), RS1000059989 (7:22813263 A>C), RS1000145124 (7:22823949 C>A), RS1000322421 (7:22823439 T>G), RS1000438390 (7:22823686 G>A), RS1000516642 (7:22824253 C>A), RS1001058061 (7:22819408 G>A), RS1001487029 (7:22818664 T>C,G), RS1001534710 (7:22824770 C>G,T), RS1001610101 (7:22824329 A>C,G), RS1001855623 (7:22818983 A>G), RS1002062431 (7:22815823 TAAAAAA>T,TAAAAA,TAAAAAAA,TAAAAAAAA), RS1002170844 (7:22821285 C>A,G), RS1002381369 (7:22814095 G>A)

Disease associations

OMIM: gene MIM:607980 | disease phenotypes: MIM:620601

GenCC curated gene-disease

Disease	Classification	Inheritance
Garg-Mishra progeroid syndrome	Moderate	Autosomal recessive

Mondo (1): Garg-Mishra progeroid syndrome (MONDO:0957953)

Orphanet (0):

HPO phenotypes

30 total (30 of 30 shown, HPO-id order):

HPO	Term
HP:0000007	Autosomal recessive inheritance
HP:0000325	Triangular face
HP:0000337	Broad forehead
HP:0000347	Micrognathia
HP:0000414	Bulbous nose
HP:0000426	Prominent nasal bridge
HP:0000568	Microphthalmia
HP:0000639	Nystagmus
HP:0000678	Dental crowding
HP:0000774	Narrow chest
HP:0000883	Thin ribs
HP:0000926	Platyspondyly
HP:0000957	Cafe-au-lait spot
HP:0001169	Broad palm
HP:0001252	Hypotonia
HP:0001414	Microvesicular hepatic steatosis
HP:0001792	Small nail
HP:0002673	Coxa valga
HP:0003100	Slender long bone
HP:0003300	Ovoid vertebral bodies
HP:0003593	Infantile onset
HP:0004322	Short stature
HP:0004474	Persistent open anterior fontanelle
HP:0005484	Secondary microcephaly
HP:0006236	Slender metacarpals
HP:0007663	Reduced visual acuity
HP:0008070	Sparse hair
HP:0008499	High hypermetropia
HP:0008897	Postnatal growth retardation
HP:0025435	Increased circulating lactate dehydrogenase concentration

GWAS associations

11 associations (top):

Study	Trait	p-value
GCST002147_24	Fibrinogen	7.000000e-09
GCST003194_20	Fibrinogen levels	5.000000e-09
GCST004121_30	Fibrinogen levels	3.000000e-08
GCST004122_4	Fibrinogen levels	3.000000e-07
GCST007798_82	Asthma	3.000000e-06
GCST007800_90	Asthma (childhood onset)	3.000000e-08
GCST007994_18	Asthma (age of onset)	8.000000e-06
GCST007995_51	Asthma (childhood onset)	5.000000e-10
GCST009391_1109	Metabolite levels	6.000000e-06
GCST009798_59	Asthma	3.000000e-10
GCST90014325_33	Asthma	2.000000e-09

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0010448	3-hydroxyphenylacetic acid measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects expression, decreases expression	2
sodium arsenite	decreases expression, decreases methylation, increases expression	2
Valproic Acid	affects cotreatment, increases expression	2
Particulate Matter	affects cotreatment, decreases expression, increases abundance	2
dicrotophos	decreases expression	1
beauvericin	affects cotreatment, decreases expression	1
arsenite	affects binding, increases reaction	1
isobutyl alcohol	decreases expression, increases abundance, affects cotreatment	1
perfluorooctane sulfonic acid	increases expression	1
CD 437	decreases expression	1
chloropicrin	increases expression	1
enniatins	affects cotreatment, decreases expression	1
3-(4’-hydroxy-3’-adamantylbiphenyl-4-yl)acrylic acid	decreases expression	1
Arsenic Trioxide	affects cotreatment, decreases expression	1
Ethanol	decreases expression, increases abundance, affects cotreatment	1
Ascorbic Acid	decreases expression, affects cotreatment	1
Atrazine	decreases expression	1
Diuron	decreases expression	1
Doxorubicin	increases expression	1
Gasoline	affects cotreatment, decreases expression, increases abundance	1
Hydralazine	affects cotreatment, increases expression	1
Lead	affects expression	1
Polycyclic Aromatic Hydrocarbons	decreases expression, increases abundance, affects cotreatment	1
Rotenone	increases expression	1
Selenium	decreases expression	1
Aflatoxin B1	decreases methylation	1
Antirheumatic Agents	increases expression	1
Copper Sulfate	decreases expression	1

Cellosaurus cell lines

3 cell lines: 2 cancer cell line, 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B3JU	Abcam HEK293T TOMM7 KO	Transformed cell line	Female
CVCL_TT26	HAP1 TOMM7 (-) 1	Cancer cell line	Male
CVCL_TT27	HAP1 TOMM7 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.