TONSL-AS1

Summary

TONSL-AS1 (TONSL antisense RNA 1, HGNC:51556) is a long non-coding RNA gene on chromosome 8q24.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51556
Approved symbol	TONSL-AS1
Name	TONSL antisense RNA 1
Location	8q24.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000232600
Ensembl biotype	lncRNA
Entrez	100287098
RNAcentral	URS000075A6FB — lncRNA, 1196 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000442850

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000442850 — 4 exons

Exon	Start	End
ENSE00001594427	144438228	144438333
ENSE00001698893	144437675	144437746
ENSE00001753678	144438677	144438782
ENSE00001784579	144439828	144439971

Expression profiles

Bgee: expression breadth ubiquitous, 124 present calls, max score 91.20.

Top tissues by expression

124 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	91.20	gold quality
apex of heart	UBERON:0002098	72.51	gold quality
stromal cell of endometrium	CL:0002255	71.80	gold quality
cortical plate	UBERON:0005343	70.25	gold quality
esophagus mucosa	UBERON:0002469	69.28	gold quality
right lobe of thyroid gland	UBERON:0001119	69.15	gold quality
left lobe of thyroid gland	UBERON:0001120	69.03	gold quality
body of stomach	UBERON:0001161	68.73	gold quality
thyroid gland	UBERON:0002046	68.47	gold quality
ventricular zone	UBERON:0003053	67.67	gold quality
duodenum	UBERON:0002114	67.36	gold quality
stomach	UBERON:0000945	67.19	gold quality
mucosa of transverse colon	UBERON:0004991	66.95	gold quality
ganglionic eminence	UBERON:0004023	66.59	gold quality
right lobe of liver	UBERON:0001114	65.56	gold quality
gall bladder	UBERON:0002110	65.52	gold quality
fundus of stomach	UBERON:0001160	65.13	gold quality
right coronary artery	UBERON:0001625	64.86	gold quality
liver	UBERON:0002107	64.60	gold quality
lower esophagus mucosa	UBERON:0035834	64.56	gold quality
transverse colon	UBERON:0001157	64.49	gold quality
mucosa of stomach	UBERON:0001199	64.22	gold quality
bone marrow	UBERON:0002371	63.29	gold quality
esophagus	UBERON:0001043	63.00	gold quality
left adrenal gland	UBERON:0001234	62.70	gold quality
small intestine	UBERON:0002108	62.48	gold quality
lymph node	UBERON:0000029	62.46	gold quality
left adrenal gland cortex	UBERON:0035825	62.34	gold quality
prostate gland	UBERON:0002367	62.27	gold quality
small intestine Peyer’s patch	UBERON:0003454	62.13	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.81

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• TONSL-AS1 was downregulated in gastric cancer tissues and cell lines compared with the normal. TONSL-AS1 inhibited cell migration, invasion and proliferation in SGC-7901, MGC-803cells and suppressed cell tumorigenesis in vivo. TONSL’s promoter is activated by TONSL-AS1.TONSL-AS1 was positively associated with TONSL in cancer tissues. TONSL-AS1’s tumor-inhibiting effect in gastric cancer cells was associated with TONSL. (PMID:31158361)
• LncRNA TONSL-AS1 regulates miR-490-3p/CDK1 to affect ovarian epithelial carcinoma cell proliferation. (PMID:32414422)
• LncRNA TONSL-AS1 participates in coronary artery disease by interacting with miR-197. (PMID:33662410)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.