TP53I11

Summary

TP53I11 (tumor protein p53 inducible protein 11, HGNC:16842) is a protein-coding gene on chromosome 11p11.2, encoding Tumor protein p53-inducible protein 11 (O14683).

Predicted to be involved in negative regulation of cell population proliferation. Predicted to be located in membrane.

Source: NCBI Gene 9537 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 9 total
• MANE Select transcript: NM_006034

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16842
Approved symbol	TP53I11
Name	tumor protein p53 inducible protein 11
Location	11p11.2
Locus type	gene with protein product
Status	Approved
Aliases	PIG11
Ensembl gene	ENSG00000175274
Ensembl biotype	protein_coding
OMIM	617867
Entrez	9537

Gene structure

Transcript identifiers

Ensembl transcripts: 49 — 41 protein_coding, 3 nonsense_mediated_decay, 3 retained_intron, 2 protein_coding_CDS_not_defined

ENST00000308212, ENST00000354556, ENST00000395648, ENST00000524774, ENST00000525138, ENST00000525145, ENST00000525667, ENST00000525680, ENST00000525683, ENST00000527685, ENST00000528290, ENST00000528473, ENST00000530035, ENST00000531130, ENST00000531928, ENST00000532253, ENST00000532921, ENST00000533443, ENST00000533937, ENST00000533940, ENST00000533955, ENST00000616990, ENST00000627720, ENST00000860867, ENST00000860868, ENST00000860869, ENST00000860870, ENST00000860871, ENST00000860872, ENST00000860873, ENST00000860874, ENST00000860875, ENST00000860876, ENST00000860877, ENST00000860878, ENST00000860879, ENST00000860880, ENST00000860881, ENST00000860882, ENST00000924475, ENST00000924476, ENST00000924477, ENST00000924478, ENST00000924479, ENST00000924480, ENST00000924481, ENST00000924482, ENST00000924483, ENST00000956183

RefSeq mRNA: 13 — MANE Select: NM_006034 NM_001258320, NM_001258321, NM_001258322, NM_001258323, NM_001258324, NM_001318384, NM_001318385, NM_001318386, NM_001318387, NM_001318388, NM_001318389, NM_001318390, NM_006034

CCDS: CCDS7911

Canonical transcript exons

ENST00000525680 — 7 exons

Exon	Start	End
ENSE00001372147	44932348	44935017
ENSE00003620504	44935561	44935662
ENSE00003626084	44938207	44938366
ENSE00003697553	44936803	44936899
ENSE00003786209	44937555	44937613
ENSE00003786941	44937304	44937352
ENSE00003904042	44950677	44950883

Expression profiles

Bgee: expression breadth ubiquitous, 231 present calls, max score 98.90.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 33.5719 / max 976.9348, expressed in 1691 samples.

FANTOM5 promoters (17 alternative TSS)

Promoter ID	TPM avg	Samples expressed
119464	14.1413	1641
119463	6.2543	1329
119451	5.1104	1204
119452	3.7834	1161
119453	0.5984	331
119462	0.5636	322
119465	0.4783	250
119457	0.4450	241
119458	0.3593	190
119460	0.3366	168

Top tissues by expression

283 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	98.90	gold quality
right hemisphere of cerebellum	UBERON:0014890	95.96	gold quality
omental fat pad	UBERON:0010414	95.80	gold quality
peritoneum	UBERON:0002358	95.73	gold quality
right atrium auricular region	UBERON:0006631	95.64	gold quality
cerebellar hemisphere	UBERON:0002245	95.36	gold quality
right uterine tube	UBERON:0001302	95.23	gold quality
cerebellar cortex	UBERON:0002129	95.23	gold quality
left uterine tube	UBERON:0001303	95.15	gold quality
ganglionic eminence	UBERON:0004023	94.60	gold quality
apex of heart	UBERON:0002098	94.53	gold quality
mucosa of transverse colon	UBERON:0004991	94.14	gold quality
cardiac atrium	UBERON:0002081	94.00	gold quality
adipose tissue of abdominal region	UBERON:0007808	93.96	gold quality
popliteal artery	UBERON:0002250	93.72	gold quality
tibial artery	UBERON:0007610	93.70	gold quality
upper lobe of left lung	UBERON:0008952	93.69	gold quality
transverse colon	UBERON:0001157	93.63	gold quality
minor salivary gland	UBERON:0001830	93.61	gold quality
right lobe of thyroid gland	UBERON:0001119	93.59	gold quality
left coronary artery	UBERON:0001626	93.27	gold quality
cerebellum	UBERON:0002037	93.03	gold quality
sural nerve	UBERON:0015488	92.91	gold quality
right lung	UBERON:0002167	92.90	gold quality
endometrium epithelium	UBERON:0004811	92.90	gold quality
spleen	UBERON:0002106	92.88	gold quality
left lobe of thyroid gland	UBERON:0001120	92.76	gold quality
mucosa of stomach	UBERON:0001199	92.60	gold quality
small intestine Peyer’s patch	UBERON:0003454	92.57	gold quality
lower esophagus	UBERON:0013473	92.56	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	15.99
E-GEOD-93593	yes	9.56
E-MTAB-6678	no	3.52

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): CTNNB1, TP53

miRNA regulators (miRDB)

101 targeting TP53I11, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-6127	100.00	66.76	2188
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-6133	100.00	66.48	2064
HSA-MIR-574-5P	100.00	66.01	989
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-4650-5P	99.98	64.69	999
HSA-MIR-4645-5P	99.98	65.81	1284
HSA-MIR-507	99.97	70.11	1915
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-185-3P	99.95	67.01	1743
HSA-MIR-6772-5P	99.94	67.01	577
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-6857-5P	99.87	65.32	985
HSA-MIR-221-5P	99.86	65.45	1052
HSA-MIR-8073	99.86	65.21	1118
HSA-MIR-4739	99.84	65.25	1832
HSA-MIR-1321	99.84	65.30	1811
HSA-MIR-4756-5P	99.84	64.98	1809
HSA-MIR-6752-3P	99.72	66.71	1587
HSA-MIR-1827	99.63	68.57	3265
HSA-MIR-4516	99.61	67.78	3390
HSA-MIR-6132	99.60	65.83	1554
HSA-MIR-6836-5P	99.60	65.62	1538
HSA-MIR-24-3P	99.59	69.97	1934
HSA-MIR-6733-3P	99.54	67.80	1281
HSA-MIR-671-5P	99.52	67.11	1277
HSA-MIR-1207-5P	99.49	69.11	2983
HSA-MIR-4441	99.49	66.56	3216

Literature-anchored findings (GeneRIF, showing 9)

• PIG11, as a downstream target of p53, is involved in apoptosis of gastric cancer cells (PMID:12883691)
• Overexpression of PIG11 could induce cell apoptosis in the low levels and enhanced the apoptotic effects of arsenic trioxide (PMID:15225615)
• Jasmonates can circumvent drug resistance induced by p53 mutations. (PMID:16170329)
• PIG11 protein may play an important role by interaction with other biological molecules in the regulation of apoptosis and provided us a novel angel of view to explore the possible function of PIG11 in vivo. (PMID:17482569)
• PIG11 is considered to be a new candidate liver tumour suppressor gene. (PMID:19096915)
• TP53I11 functions as a mediator to balance activation of AKT and AMPK to adapt cells to different cellular contexts such as extracellular matrix-attachment and -detachment. (PMID:30376610)
• Findings showed that hypoxic treatment upregulated the expression of HIF1alpha, but reduced TP53I11 protein levels and TP53I11 overexpression reduced HIF1alpha expression under normal culture and hypoxicconditions, and in xenografts of MDA-MB-231 cells. (PMID:30940320)
• MiR-645 promotes proliferation and migration of non-small cell lung cancer cells by targeting TP53I11. (PMID:32572880)
• Overexpression of hsa_circ_0006470 inhibits the malignant behavior of gastric cancer cells via regulation of miR-1234/TP53I11 axis. (PMID:36190397)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	tp53i11b	ENSDARG00000006025
danio_rerio	tp53i11a	ENSDARG00000069430
mus_musculus	Trp53i11	ENSMUSG00000068735
rattus_norvegicus	Tp53i11	ENSRNOG00000008738
caenorhabditis_elegans		WBGENE00021185

Protein

Protein identifiers

Tumor protein p53-inducible protein 11 — O14683 (reviewed: O14683)

Alternative names: p53-induced gene 11 protein

All UniProt accessions (13): E9PIK4, E9PIN5, E9PKN9, E9PKZ4, E9PMW4, E9PMY0, E9PN66, E9PNB3, E9PPM1, E9PQ46, E9PS55, O14683, U3KQ32

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

Induction. By p53/TP53.

RefSeq proteins (13): NP_001245249, NP_001245250, NP_001245251, NP_001245252, NP_001245253, NP_001305313, NP_001305314, NP_001305315, NP_001305316, NP_001305317, NP_001305318, NP_001305319, NP_006025* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR028266	TP53I11	Family

Pfam: PF14936

UniProt features (11 total): topological domain 5, transmembrane region 4, chain 1, modified residue 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O14683-F1	75.77	0.25

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 14

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 137 (showing top): GSE45365_NK_CELL_VS_CD8A_DC_MCMV_INFECTION_UP, CHIBA_RESPONSE_TO_TSA_UP, TGCGCANK_UNKNOWN, MODULE_45, KYNG_DNA_DAMAGE_DN, KYNG_ENVIRONMENTAL_STRESS_RESPONSE_NOT_BY_GAMMA_IN_WS, SASSON_RESPONSE_TO_FORSKOLIN_DN, OCT1_03, JAZAG_TGFB1_SIGNALING_VIA_SMAD4_UP, KYNG_ENVIRONMENTAL_STRESS_RESPONSE_UP, LIU_CMYB_TARGETS_UP, DOUGLAS_BMI1_TARGETS_UP, MODULE_60, KYNG_ENVIRONMENTAL_STRESS_RESPONSE_NOT_BY_UV_IN_OLD, SASSON_RESPONSE_TO_GONADOTROPHINS_DN

GO Biological Process (1): negative regulation of cell population proliferation (GO:0008285)

GO Molecular Function (0):

GO Cellular Component (1): membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cell population proliferation	1
regulation of cell population proliferation	1
negative regulation of cellular process	1
cellular anatomical structure	1

Protein interactions and networks

STRING

388 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TP53I11	TXNL1	O43396	772
TP53I11	TP53	P04637	527
TP53I11	TP53TG5	Q9Y2B4	492
TP53I11	ZNF573	Q86YE8	476
TP53I11	PRRX2	Q99811	441
TP53I11	MCTP2	Q6DN12	426
TP53I11	PRDM15	P57071	423
TP53I11	UNC80	Q8N2C7	423
TP53I11	CMC2	Q9NRP2	418
TP53I11	MAST4	O15021	418
TP53I11	PTPN1	P18031	417
TP53I11	COL19A1	Q14993	410
TP53I11	TP53I13	Q8NBR0	402
TP53I11	TP53TG3	Q9ULZ0	400
TP53I11	ABCA13	Q86UQ4	398
TP53I11	EFCAB10	A6NFE3	398

IntAct

31 interactions, top by confidence:

A	B	Type	Score
NIPAL1	ESYT2	psi-mi:“MI:0914”(association)	0.640
MANSC1	KLRG2	psi-mi:“MI:0914”(association)	0.530
NRAS	ESYT2	psi-mi:“MI:2364”(proximity)	0.480
TP53I11	ATXN1	psi-mi:“MI:0915”(physical association)	0.370
	ESYT2	psi-mi:“MI:0914”(association)	0.350
ESR1	ESYT2	psi-mi:“MI:0914”(association)	0.350
YIPF3	TMEM223	psi-mi:“MI:0914”(association)	0.350
MAPT	SHTN1	psi-mi:“MI:0914”(association)	0.350
CHD8	IGLV4-60	psi-mi:“MI:0914”(association)	0.350
GNB1	TP53I11	psi-mi:“MI:0914”(association)	0.350
RAB11A	SCAMP1	psi-mi:“MI:0914”(association)	0.350
TSPAN8	TP53I11	psi-mi:“MI:0914”(association)	0.350
MFSD10	NDUFS8	psi-mi:“MI:0914”(association)	0.350
MFSD5	ILVBL	psi-mi:“MI:0914”(association)	0.350
NIPAL3	ILVBL	psi-mi:“MI:0914”(association)	0.350
SLC35A3	STXBP3	psi-mi:“MI:0914”(association)	0.350
SLC35E3	TP53I11	psi-mi:“MI:0914”(association)	0.350
SLC35F6	TP53I11	psi-mi:“MI:0914”(association)	0.350
SLC7A1	ESYT2	psi-mi:“MI:0914”(association)	0.350
CASP3	TMEM223	psi-mi:“MI:0914”(association)	0.350
FOS	TMEM223	psi-mi:“MI:0914”(association)	0.350
GATA2	C11orf98	psi-mi:“MI:0914”(association)	0.350
TCTN3	TMEM120B	psi-mi:“MI:2364”(proximity)	0.270
TCTN2	TMEM120B	psi-mi:“MI:2364”(proximity)	0.270
KRAS	ESYT2	psi-mi:“MI:2364”(proximity)	0.270
HRAS	ESYT2	psi-mi:“MI:2364”(proximity)	0.270

BioGRID (67): TP53I11 (Proximity Label-MS), TP53I11 (Proximity Label-MS), TP53I11 (Affinity Capture-MS), TP53I11 (Affinity Capture-MS), TP53I11 (Affinity Capture-RNA), TP53I11 (Affinity Capture-MS), TP53I11 (Affinity Capture-MS), TP53I11 (Proximity Label-MS), TP53I11 (Proximity Label-MS), TP53I11 (PCA), TP53I11 (Proximity Label-MS), TP53I11 (Proximity Label-MS), TP53I11 (Proximity Label-MS), TP53I11 (Proximity Label-MS), TP53I11 (Proximity Label-MS)

ESM2 similar proteins: A8XSV3, A9RA88, B0CMA4, B3DMA0, B3NGS7, F1RAX4, O14683, Q0V9G6, Q0VCQ8, Q19317, Q298S5, Q2NKY9, Q3UF64, Q4KM64, Q4QQM4, Q4R866, Q4X251, Q5EBF8, Q5F3W2, Q5FWM8, Q5R687, Q5REI9, Q5SPP5, Q5U4Q2, Q5XKN4, Q642F4, Q66J27, Q6C520, Q6DF80, Q6NVQ1, Q6NYE7, Q6NZ21, Q6PQZ3, Q6QAJ8, Q755Y0, Q80UA9, Q875M2, Q8AV61, Q8BGI3, Q8BH47

Diamond homologs: B3DMA0, O14683, Q0VCQ8, Q4QQM4, Q5REI9

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 36 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
Ras protein signal transduction	5	35.4×	1e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

9 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

3311 predictions. Top by Δscore:

Variant	Effect	Δscore
11:44906475:TATTT:T	donor_gain	1.0000
11:44906478:TT:T	donor_gain	1.0000
11:44906480:G:GG	donor_gain	1.0000
11:44909682:A:AG	acceptor_gain	1.0000
11:44909683:A:G	acceptor_gain	1.0000
11:44909684:C:G	acceptor_gain	1.0000
11:44909691:A:AG	acceptor_gain	1.0000
11:44909691:ACT:A	acceptor_gain	1.0000
11:44909691:ACTG:A	acceptor_gain	1.0000
11:44909692:C:G	acceptor_gain	1.0000
11:44909693:T:TA	acceptor_gain	1.0000
11:44909694:G:A	acceptor_gain	1.0000
11:44909699:GAGCA:G	acceptor_loss	1.0000
11:44909700:AGCAG:A	acceptor_loss	1.0000
11:44909702:CAGCT:C	acceptor_loss	1.0000
11:44909703:AGCTG:A	acceptor_gain	1.0000
11:44909704:GCTGG:G	acceptor_gain	1.0000
11:44909896:ATTT:A	donor_gain	1.0000
11:44909897:TTT:T	donor_gain	1.0000
11:44909897:TTTG:T	donor_loss	1.0000
11:44909898:TTG:T	donor_loss	1.0000
11:44909899:TGTG:T	donor_loss	1.0000
11:44909900:G:GG	donor_gain	1.0000
11:44909900:GTGA:G	donor_loss	1.0000
11:44909901:TGAG:T	donor_loss	1.0000
11:44909902:GAGTA:G	donor_loss	1.0000
11:44917970:A:AG	acceptor_gain	1.0000
11:44917971:G:GG	acceptor_gain	1.0000
11:44918045:AT:A	donor_gain	1.0000
11:44918046:TGT:T	donor_loss	1.0000

AlphaMissense

1221 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:44938267:C:A	K23N	0.999
11:44938267:C:G	K23N	0.999
11:44938251:C:G	G29R	0.998
11:44938263:G:T	R25S	0.998
11:44938271:A:G	L22P	0.998
11:44938276:G:C	S20R	0.998
11:44938276:G:T	S20R	0.998
11:44938278:T:G	S20R	0.998
11:44934929:G:C	S175R	0.997
11:44934929:G:T	S175R	0.997
11:44934931:T:G	S175R	0.997
11:44938269:T:C	K23E	0.997
11:44938275:G:T	R21S	0.997
11:44935661:G:C	S112R	0.996
11:44935661:G:T	S112R	0.996
11:44936803:T:G	S112R	0.996
11:44937348:A:G	W65R	0.996
11:44937348:A:T	W65R	0.996
11:44937612:A:G	I44T	0.996
11:44938207:C:A	K43N	0.996
11:44938207:C:G	K43N	0.996
11:44938211:G:A	S42F	0.996
11:44938253:A:T	L28H	0.996
11:44938262:C:G	R25P	0.996
11:44938275:G:C	R21G	0.996
11:44937600:A:G	L48S	0.995
11:44937608:G:C	S45R	0.995
11:44937608:G:T	S45R	0.995
11:44937610:T:G	S45R	0.995
11:44938250:C:T	G29D	0.995

dbSNP variants (sampled 300 via entrez): RS1000033701 (11:44940903 C>T), RS1000052830 (11:44946509 C>T), RS1000172109 (11:44947457 G>A), RS1000268244 (11:44947716 C>T), RS1000323269 (11:44942137 C>T), RS1000420294 (11:44933565 G>A), RS1000511084 (11:44948880 G>A), RS1000653774 (11:44932396 G>A), RS1000769720 (11:44932023 G>A), RS1000902370 (11:44952776 G>T), RS1001007580 (11:44943428 G>A), RS1001016399 (11:44952267 C>T), RS1001100121 (11:44938086 G>A), RS1001257954 (11:44934521 C>A), RS1001287718 (11:44946261 G>A)

Disease associations

OMIM: gene MIM:617867 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST002337_19	Amyotrophic lateral sclerosis (sporadic)	3.000000e-07
GCST003818_13	Resting heart rate	1.000000e-12
GCST005789_16	Resting heart rate	7.000000e-06

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

57 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Arsenic Trioxide	decreases expression, increases expression, decreases reaction, affects response to substance, increases response to substance	4
Tetrachlorodibenzodioxin	affects expression, affects cotreatment, decreases expression, increases expression	3
daidzein	affects cotreatment, decreases expression	2
bisphenol A	decreases expression, decreases methylation	2
glycitein	affects cotreatment, decreases expression	2
Acetaminophen	decreases expression, increases expression	2
Air Pollutants	affects expression, increases abundance, decreases expression	2
Benzo(a)pyrene	affects methylation, increases expression, increases methylation	2
Dactinomycin	affects cotreatment, increases expression, decreases reaction, decreases expression	2
Estradiol	decreases expression, increases expression	2
Genistein	affects cotreatment, decreases expression	2
Particulate Matter	decreases expression, increases abundance, increases expression	2
FR900359	decreases phosphorylation	1
triphenyl phosphate	affects expression	1
glycidyl methacrylate	decreases expression	1
terbufos	increases methylation	1
dimethylselenide	decreases expression, increases expression, increases oxidation	1
daidzin	affects cotreatment, decreases expression	1
sulforaphane	decreases expression	1
sodium arsenite	increases expression	1
3,4,3’,4’-tetrachlorobiphenyl	affects expression	1
S-(1,2-dichlorovinyl)cysteine	affects cotreatment, decreases expression	1
genistin	affects cotreatment, decreases expression	1
glycitin	affects cotreatment, decreases expression	1
nutlin 3	affects cotreatment, increases expression	1
abrine	decreases expression	1
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	decreases expression, affects cotreatment	1
jinfukang	affects cotreatment, increases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Sunitinib	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.