TP53TG1

Summary

TP53TG1 (TP53 target 1, HGNC:17026) is a long non-coding RNA gene on chromosome 7q21.12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17026
Approved symbol	TP53TG1
Name	TP53 target 1
Location	7q21.12
Locus type	RNA, long non-coding
Status	Approved
Aliases	H_RG012D21.9, LINC00096, TP53LC12
Ensembl gene	ENSG00000182165
Ensembl biotype	lncRNA
OMIM	616403
Entrez	11257
RNAcentral	URS000075D314 — lncRNA, 751 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 63 — 63 lncRNA

ENST00000359941, ENST00000416560, ENST00000421293, ENST00000432193, ENST00000542586, ENST00000610086, ENST00000616845, ENST00000653182, ENST00000654969, ENST00000661943, ENST00000685527, ENST00000685636, ENST00000685707, ENST00000685722, ENST00000686297, ENST00000686728, ENST00000687819, ENST00000688353, ENST00000689667, ENST00000690980, ENST00000701419, ENST00000702094, ENST00000702749, ENST00000766307, ENST00000766308, ENST00000766309, ENST00000766310, ENST00000766311, ENST00000766312, ENST00000766313, ENST00000766314, ENST00000766315, ENST00000766316, ENST00000766317, ENST00000766318, ENST00000766319, ENST00000766320, ENST00000766321, ENST00000766322, ENST00000766323, ENST00000766324, ENST00000766325, ENST00000766326, ENST00000766327, ENST00000766328, ENST00000766329, ENST00000766330, ENST00000766331, ENST00000766332, ENST00000766333, ENST00000766334, ENST00000766335, ENST00000766336, ENST00000766337, ENST00000766338, ENST00000766339, ENST00000766340, ENST00000766341, ENST00000766342, ENST00000766343, ENST00000766344, ENST00000766345, ENST00000766346

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000359941 — 4 exons

Exon	Start	End
ENSE00001302559	87341523	87341684
ENSE00003856441	87329935	87330094
ENSE00004124954	87345043	87345540
ENSE00004124968	87325115	87325444

Expression profiles

Bgee: expression breadth ubiquitous, 283 present calls, max score 93.59.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 16.9039 / max 175.2569, expressed in 1760 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
84718	14.8555	1755
84717	1.3685	671
84715	0.3671	175
84716	0.2059	94
84714	0.1068	28

Top tissues by expression

293 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mucosa of transverse colon	UBERON:0004991	93.59	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	93.16	gold quality
right lobe of liver	UBERON:0001114	91.08	gold quality
right uterine tube	UBERON:0001302	90.19	gold quality
transverse colon	UBERON:0001157	90.13	gold quality
hindlimb stylopod muscle	UBERON:0004252	89.90	gold quality
right adrenal gland	UBERON:0001233	89.87	gold quality
right adrenal gland cortex	UBERON:0035827	89.83	gold quality
skin of abdomen	UBERON:0001416	89.40	gold quality
lower esophagus	UBERON:0013473	89.17	gold quality
lower esophagus muscularis layer	UBERON:0035833	89.16	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	89.08	gold quality
epithelium of bronchus	UBERON:0002031	88.96	gold quality
skin of leg	UBERON:0001511	88.91	gold quality
left adrenal gland cortex	UBERON:0035825	88.83	gold quality
left adrenal gland	UBERON:0001234	88.77	gold quality
left coronary artery	UBERON:0001626	88.74	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	88.64	gold quality
bronchus	UBERON:0002185	88.59	gold quality
pancreatic ductal cell	CL:0002079	88.56	gold quality
bronchial epithelial cell	CL:0002328	88.44	gold quality
muscle layer of sigmoid colon	UBERON:0035805	88.40	gold quality
lower esophagus mucosa	UBERON:0035834	88.40	gold quality
esophagus	UBERON:0001043	88.31	gold quality
popliteal artery	UBERON:0002250	88.25	gold quality
tibial artery	UBERON:0007610	88.23	gold quality
descending thoracic aorta	UBERON:0002345	88.22	gold quality
adrenal cortex	UBERON:0001235	88.20	gold quality
ascending aorta	UBERON:0001496	88.19	gold quality
thoracic aorta	UBERON:0001515	88.18	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• From our analysis, variants in the genes ABCB4, TP53AIP1, ARHGAP32 and TMEM88B were identified linked to the alexithymia phenotype. (PMID:25882097)
• Study reports that TP53TG1 is an lncRNA that is critical for the correct response of p53 to DNA damage. The cancer growth suppressor features of TP53TG1 are linked to its ability to block the tumorigenic activity of the RNA binding protein YBX1. The DNA methylation-associated silencing of TP53TG1 produces aggressive tumors that are resistant to cellular death when DNAdamaging agents and small targeted molecules are used. (PMID:27821766)
• data showed that TP53TG1 under glucose deprivation may promote cell proliferation and migration by influencing the expression of glucose metabolism related genes in glioma. (PMID:28569381)
• TP53TG1 could directly bind to miR-96 and effectively function as a sponge for miR-96, antagonizing the functions of miR-96 and leading to derepression of KRAS, which is a core oncogene in the initiation and maintenance of pancreatic ductal adenocarcinoma (PDAC). TP53TG1 contributes to the growth and progression of PDAC by acting as a competing endogenous RNA to competitively bind to miR-96 and regulate KRAS expression. (PMID:31325400)
• Survival analysis for long noncoding RNAs identifies TP53TG1 as an antioncogenic target for the breast cancer. (PMID:32020607)
• Long Noncoding RNA TP53TG1 Contributes to Radioresistance of Glioma Cells Via miR-524-5p/RAB5A Axis. (PMID:32762546)
• Long non-coding RNA tumor protein 53 target gene 1 promotes cervical cancer development via regulating microRNA-33a-5p to target forkhead box K2. (PMID:35090377)
• Comprehensive analysis of DRAIC and TP53TG1 in breast cancer luminal subtypes through the construction of lncRNAs regulatory model. (PMID:35871431)
• m6A modification-mediated lncRNA TP53TG1 inhibits gastric cancer progression by regulating CIP2A stability. (PMID:36114757)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.