TP53TG3B

Summary

TP53TG3B (TP53 target 3B, HGNC:37202) is a protein-coding gene on chromosome 16p11.2, encoding TP53-target gene 3 protein (Q9ULZ0). May play a significant role in p53/TP53-mediating signaling pathway.

Located in cytoplasm and nucleus.

Source: NCBI Gene 729355 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• MANE Select transcript: NM_001099687

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37202
Approved symbol	TP53TG3B
Name	TP53 target 3B
Location	16p11.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000261509
Ensembl biotype	protein_coding
Entrez	729355

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 2 protein_coding, 2 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000341305, ENST00000563564, ENST00000563809, ENST00000567724, ENST00000569741

RefSeq mRNA: 1 — MANE Select: NM_001099687 NM_001099687

CCDS: CCDS45477

Canonical transcript exons

ENST00000341305 — 2 exons

Exon	Start	End
ENSE00003603592	33362442	33363478
ENSE00003978227	33360841	33361270

Expression profiles

Bgee: expression breadth broad, 58 present calls, max score 86.13.

Top tissues by expression

109 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.13	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	80.26	gold quality
testis	UBERON:0000473	70.09	gold quality
left testis	UBERON:0004533	68.39	gold quality
right testis	UBERON:0004534	66.74	gold quality
lower esophagus mucosa	UBERON:0035834	50.58	gold quality
placenta	UBERON:0001987	48.28	gold quality
ganglionic eminence	UBERON:0004023	43.53	gold quality
ventricular zone	UBERON:0003053	43.12	gold quality
Brodmann (1909) area 9	UBERON:0013540	40.89	gold quality
skeletal muscle tissue	UBERON:0001134	39.86	gold quality
islet of Langerhans	UBERON:0000006	39.25	gold quality
stromal cell of endometrium	CL:0002255	39.15	gold quality
prefrontal cortex	UBERON:0000451	39.04	gold quality
cerebellum	UBERON:0002037	38.84	gold quality
cerebellar cortex	UBERON:0002129	38.80	gold quality
cerebellar hemisphere	UBERON:0002245	38.73	gold quality
right hemisphere of cerebellum	UBERON:0014890	38.73	gold quality
endometrium	UBERON:0001295	38.67	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	38.66	gold quality
monocyte	CL:0000576	38.33	gold quality
hindlimb stylopod muscle	UBERON:0004252	38.33	gold quality
bone marrow cell	CL:0002092	38.25	gold quality
leukocyte	CL:0000738	37.83	gold quality
superior frontal gyrus	UBERON:0002661	37.60	silver quality
vermiform appendix	UBERON:0001154	37.45	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
muscle tissue	UBERON:0002385	36.90	gold quality
frontal cortex	UBERON:0001870	36.78	gold quality
cortical plate	UBERON:0005343	36.47	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

68 targeting TP53TG3B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-539-5P	99.93	70.30	2855
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-380-3P	99.89	70.18	1978
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-12119	99.87	68.35	1653
HSA-MIR-6875-3P	99.82	70.26	2983
HSA-MIR-3180-5P	99.82	69.12	2422
HSA-MIR-8080	99.82	67.52	1342
HSA-MIR-4524A-3P	99.72	66.85	2406
HSA-MIR-3714	99.71	70.74	2671
HSA-MIR-4690-5P	99.65	66.24	813
HSA-MIR-6126	99.62	68.09	996
HSA-MIR-548AV-5P	99.60	70.84	2107
HSA-MIR-548K	99.60	70.84	2107
HSA-MIR-4649-3P	99.56	66.90	1783
HSA-MIR-1252-3P	99.55	67.71	2862
HSA-MIR-17-3P	99.55	66.77	1311
HSA-MIR-7159-5P	99.53	72.12	2472
HSA-MIR-8054	99.48	70.81	2084
HSA-MIR-5695	99.41	67.48	1047
HSA-MIR-4251	99.40	69.19	3363
HSA-MIR-148A-5P	99.30	68.27	1141

Cross-species orthologs

0 orthologs

Paralogs (7): TP53TG3 (ENSG00000183632), TP53TG3D (ENSG00000205456), TP53TG3C (ENSG00000205457), (ENSG00000274175), TP53TG3E (ENSG00000275034), (ENSG00000275869), TP53TG3F (ENSG00000278848)

Protein

Protein identifiers

TP53-target gene 3 protein — Q9ULZ0 (reviewed: Q9ULZ0)

Alternative names: TP53-inducible gene 3 protein

All UniProt accessions (2): A0A1Y8EMM2, Q9ULZ0

UniProt curated annotations — full annotation on UniProt →

Function. May play a significant role in p53/TP53-mediating signaling pathway.

Subcellular location. Cytoplasm. Nucleus.

Tissue specificity. Strongly expressed in testis. Weakly expressed in heart, placenta and skeletal muscle.

Induction. By p53/TP53.

Miscellaneous. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9ULZ0-2	2, TP53TG3a	yes
Q9ULZ0-1	1, TP53TG3b
Q9ULZ0-3	3

RefSeq proteins (1): NP_001093157* (*=MANE)

Domains & families (InterPro)

UniProt features (6 total): splice variant 3, chain 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9ULZ0-F1	40.37	0.00

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 20 (showing top): chr16p11, MIR3646, MIR548AW, MIR551B_5P, MIR3065_5P, MIR539_5P, MIR4291, MIR1252_3P, MIR4801, MIR4731_3P, MIR509_5P, MIR509_3_5P, MIR4766_3P, MIR17_3P, MIR432_5P

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (2): nucleus (GO:0005634), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
cellular anatomical structure	1

Protein interactions and networks

STRING

268 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TP53TG3B	TP53I11	O14683	400
TP53TG3B	PGBD2	Q6P3X8	398
TP53TG3B	GLYATL3	Q5SZD4	393
TP53TG3B	ZNF672	Q499Z4	370
TP53TG3B	TP53TG5	Q9Y2B4	352
TP53TG3B	FAM174A	Q8TBP5	351
TP53TG3B	ZNF595	Q8IYB9	348
TP53TG3B	ZNF280A	P59817	325
TP53TG3B	HEATR5B	Q9P2D3	324
TP53TG3B	VSIG10	Q8N0Z9	323
TP53TG3B	FAM72B	Q86X60	314
TP53TG3B	DYDC2	Q96IM9	310
TP53TG3B	SLC6A8	P48029	306
TP53TG3B	TP53I13	Q8NBR0	305
TP53TG3B	SMIM3	Q9BZL3	297

IntAct

1 interactions, top by confidence:

BioGRID (5): TP53TG3C (Negative Genetic), TP53TG3C (Negative Genetic), TP53TG3B (Negative Genetic), TP53TG3 (Positive Genetic), TP53TG3 (Affinity Capture-RNA)

ESM2 similar proteins: A0A1B0GUT2, A0A3Q1LFG5, A1L4Q6, A2RUQ5, A8MQB3, A8MU10, B1ANY3, C0HM98, H3BQW9, J3KSC0, P0C092, P0DMU3, P0DPA3, P24026, P59020, P59021, P59052, P87743, Q06250, Q0IIN9, Q0VFX4, Q14695, Q4R3X9, Q4VX62, Q52M75, Q5SR53, Q6ZUF6, Q6ZWC4, Q71F78, Q7Z4H9, Q8JMY5, Q8JMZ5, Q8JN06, Q8N2C9, Q8N2X6, Q8N3U1, Q8N9X3, Q8NAA6, Q8NBC4, Q8NDY4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

353 predictions. Top by Δscore:

Variant	Effect	Δscore
16:33362102:G:GT	donor_gain	0.9900
16:33362109:C:G	donor_gain	0.9900
16:33362103:A:T	donor_gain	0.9700
16:33362193:GGTC:G	donor_gain	0.9700
16:33361266:TCAAG:T	donor_loss	0.9400
16:33361267:CAAG:C	donor_loss	0.9400
16:33361268:AAG:A	donor_loss	0.9400
16:33361269:AG:A	donor_loss	0.9400
16:33361270:GGTAA:G	donor_loss	0.9400
16:33361271:G:A	donor_loss	0.9400
16:33361272:T:G	donor_loss	0.9400
16:33361560:G:GT	donor_gain	0.9400
16:33362097:C:CG	donor_gain	0.9300
16:33361018:TTG:T	donor_gain	0.8800
16:33361263:TTGTC:T	donor_gain	0.8800
16:33362072:G:GT	donor_gain	0.8800
16:33361542:G:GA	donor_gain	0.8700
16:33361265:GTCAA:G	donor_loss	0.8600
16:33361273:A:C	donor_loss	0.8600
16:33362276:T:TA	donor_gain	0.8500
16:33362277:A:AA	donor_gain	0.8500
16:33361125:C:G	donor_gain	0.8300
16:33362440:A:G	acceptor_gain	0.8200
16:33362116:G:T	donor_gain	0.8100
16:33361655:T:TA	donor_gain	0.7900
16:33361656:A:AA	donor_gain	0.7900
16:33362440:A:AC	acceptor_loss	0.7900
16:33362441:GTTTT:G	acceptor_loss	0.7900
16:33362441:GT:G	acceptor_gain	0.7800
16:33362436:A:AG	acceptor_loss	0.7700

AlphaMissense

764 scored. Top likely-pathogenic:

dbSNP variants (sampled 20 via entrez): RS1555487202 (16:33360912 C>T), RS1555487203 (16:33361256 G>C), RS1555487204 (16:33361301 A>G), RS1555487205 (16:33361465 C>T), RS1555487207 (16:33361492 G>A), RS1555487208 (16:33361518 T>G), RS1555487209 (16:33361570 G>C), RS1555487211 (16:33361650 A>G), RS1555487212 (16:33361692 G>T), RS1555487213 (16:33361713 G>T), RS1555487214 (16:33361970 C>T), RS1555487218 (16:33361986 G>A), RS1555487219 (16:33362137 G>A), RS1555487220 (16:33362349 A>G), RS1555487221 (16:33362410 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST001762_296	Obesity-related traits	4.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0003939	energy intake

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
2-palmitoylglycerol	increases expression	1
Valproic Acid	decreases methylation	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.