TP53TG3C

Summary

TP53TG3C (TP53 target 3C, HGNC:42962) is a protein-coding gene on chromosome 16p11.2, encoding TP53-target gene 3 protein (Q9ULZ0). May play a significant role in p53/TP53-mediating signaling pathway.

Located in cytoplasm and nucleus.

Source: NCBI Gene 653550 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001205259

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:42962
Approved symbol	TP53TG3C
Name	TP53 target 3C
Location	16p11.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000205457
Ensembl biotype	protein_coding
Entrez	653550

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 2 protein_coding, 2 protein_coding_CDS_not_defined, 2 nonsense_mediated_decay, 1 retained_intron

ENST00000360260, ENST00000561509, ENST00000562714, ENST00000564949, ENST00000566959, ENST00000567137, ENST00000569719

RefSeq mRNA: 1 — MANE Select: NM_001205259 NM_001205259

CCDS: CCDS58458

Canonical transcript exons

ENST00000561509 — 2 exons

Exon	Start	End
ENSE00003523103	33195827	33196858
ENSE00003978228	33194226	33194655

Expression profiles

Bgee: expression breadth broad, 63 present calls, max score 84.63.

Top tissues by expression

106 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.63	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	76.93	gold quality
stromal cell of endometrium	CL:0002255	54.62	gold quality
right testis	UBERON:0004534	52.89	gold quality
lower esophagus mucosa	UBERON:0035834	51.46	gold quality
testis	UBERON:0000473	50.91	gold quality
left testis	UBERON:0004533	47.73	gold quality
ganglionic eminence	UBERON:0004023	44.84	gold quality
ventricular zone	UBERON:0003053	43.40	gold quality
superior frontal gyrus	UBERON:0002661	42.79	gold quality
right coronary artery	UBERON:0001625	42.03	gold quality
skeletal muscle tissue	UBERON:0001134	41.50	silver quality
vermiform appendix	UBERON:0001154	41.11	gold quality
placenta	UBERON:0001987	40.35	gold quality
hindlimb stylopod muscle	UBERON:0004252	39.79	silver quality
cortical plate	UBERON:0005343	39.76	gold quality
bone marrow cell	CL:0002092	38.25	gold quality
monocyte	CL:0000576	38.19	gold quality
leukocyte	CL:0000738	38.11	gold quality
bone marrow	UBERON:0002371	37.66	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
muscle tissue	UBERON:0002385	37.03	silver quality
sural nerve	UBERON:0015488	35.76	gold quality
islet of Langerhans	UBERON:0000006	35.32	gold quality
frontal cortex	UBERON:0001870	34.39	silver quality
primary visual cortex	UBERON:0002436	33.26	gold quality
blood	UBERON:0000178	32.86	silver quality
duodenum	UBERON:0002114	32.35	gold quality
liver	UBERON:0002107	31.68	gold quality
heart left ventricle	UBERON:0002084	31.58	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

31 targeting TP53TG3C, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-6875-3P	99.82	70.26	2983
HSA-MIR-3180-5P	99.82	69.12	2422
HSA-MIR-8080	99.82	67.52	1342
HSA-MIR-3714	99.71	70.74	2671
HSA-MIR-548AV-5P	99.60	70.84	2107
HSA-MIR-548K	99.60	70.84	2107
HSA-MIR-17-3P	99.55	66.77	1311
HSA-MIR-8054	99.48	70.81	2084
HSA-MIR-520A-5P	99.35	66.72	1632
HSA-MIR-525-5P	99.35	66.85	1615
HSA-MIR-148A-5P	99.30	68.27	1141
HSA-MIR-5584-3P	99.23	68.79	1351
HSA-MIR-361-3P	99.19	66.45	1381
HSA-MIR-412-3P	98.86	66.89	712
HSA-MIR-6754-3P	98.84	66.60	889
HSA-MIR-432-5P	98.00	68.13	989
HSA-MIR-15A-3P	97.47	65.08	527
HSA-MIR-3173-5P	97.35	65.82	1282
HSA-MIR-6799-3P	97.35	65.60	1302
HSA-MIR-509-3-5P	97.21	67.74	1517
HSA-MIR-509-5P	97.21	67.90	1512
HSA-MIR-4418	97.04	67.16	1372
HSA-MIR-4433A-5P	96.79	65.01	599
HSA-MIR-6828-3P	96.06	67.61	1155

Cross-species orthologs

0 orthologs

Paralogs (7): TP53TG3 (ENSG00000183632), TP53TG3D (ENSG00000205456), TP53TG3B (ENSG00000261509), (ENSG00000274175), TP53TG3E (ENSG00000275034), (ENSG00000275869), TP53TG3F (ENSG00000278848)

Protein

Protein identifiers

TP53-target gene 3 protein — Q9ULZ0 (reviewed: Q9ULZ0)

Alternative names: TP53-inducible gene 3 protein

All UniProt accessions (1): Q9ULZ0

UniProt curated annotations — full annotation on UniProt →

Function. May play a significant role in p53/TP53-mediating signaling pathway.

Subcellular location. Cytoplasm. Nucleus.

Tissue specificity. Strongly expressed in testis. Weakly expressed in heart, placenta and skeletal muscle.

Induction. By p53/TP53.

Miscellaneous. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9ULZ0-2	2, TP53TG3a	yes
Q9ULZ0-1	1, TP53TG3b
Q9ULZ0-3	3

RefSeq proteins (1): NP_001192188* (*=MANE)

Domains & families (InterPro)

UniProt features (6 total): splice variant 3, chain 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9ULZ0-F1	40.37	0.00

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 10 (showing top): chr16p11, MIR548AW, MIR548AV_5P_MIR548K, MIR8054, MIR509_5P, MIR509_3_5P, MIR17_3P, MIR432_5P, MIR6754_3P, MIR412_3P

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (2): nucleus (GO:0005634), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
cellular anatomical structure	1

Protein interactions and networks

STRING

268 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TP53TG3C	TP53I11	O14683	400
TP53TG3C	PGBD2	Q6P3X8	398
TP53TG3C	GLYATL3	Q5SZD4	393
TP53TG3C	ZNF672	Q499Z4	370
TP53TG3C	TP53TG5	Q9Y2B4	352
TP53TG3C	FAM174A	Q8TBP5	351
TP53TG3C	ZNF595	Q8IYB9	348
TP53TG3C	ZNF280A	P59817	325
TP53TG3C	HEATR5B	Q9P2D3	324
TP53TG3C	VSIG10	Q8N0Z9	323
TP53TG3C	FAM72B	Q86X60	314
TP53TG3C	DYDC2	Q96IM9	310
TP53TG3C	SLC6A8	P48029	306
TP53TG3C	TP53I13	Q8NBR0	305
TP53TG3C	SMIM3	Q9BZL3	297

IntAct

1 interactions, top by confidence:

BioGRID (5): TP53TG3C (Negative Genetic), TP53TG3C (Negative Genetic), TP53TG3B (Negative Genetic), TP53TG3 (Positive Genetic), TP53TG3 (Affinity Capture-RNA)

ESM2 similar proteins: A0A1B0GUT2, A0A3Q1LFG5, A1L4Q6, A2RUQ5, A8MQB3, A8MU10, B1ANY3, C0HM98, H3BQW9, J3KSC0, P0C092, P0DMU3, P0DPA3, P24026, P59020, P59021, P59052, P87743, Q06250, Q0IIN9, Q0VFX4, Q14695, Q4R3X9, Q4VX62, Q52M75, Q5SR53, Q6ZUF6, Q6ZWC4, Q71F78, Q7Z4H9, Q8JMY5, Q8JMZ5, Q8JN06, Q8N2C9, Q8N2X6, Q8N3U1, Q8N9X3, Q8NAA6, Q8NBC4, Q8NDY4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 49 via entrez): RS1028219820 (16:33190641 A>G), RS1161915934 (16:33196349 T>C), RS1182251225 (16:33196491 A>T), RS1182347787 (16:33190555 C>T), RS1206224496 (16:33190882 G>A), RS1241796115 (16:33190674 T>C), RS1303096183 (16:33190657 T>A), RS1310867278 (16:33190658 C>A), RS1318638792 (16:33190653 T>A), RS1343516008 (16:33195355 C>T), RS1363212079 (16:33196495 CT>C), RS1372566164 (16:33196517 A>T), RS1373412386 (16:33190654 C>A), RS1421779805 (16:33196237 TAAA>T,TA,TAA), RS1430639324 (16:33196686 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
2-palmitoylglycerol	increases expression	1
Gold Compounds	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.