TP53TG3E

Summary

TP53TG3E (TP53 target 3 family member E, HGNC:51816) is a protein-coding gene on chromosome 16p11.2, encoding TP53-target gene 3 protein (Q9ULZ0). May play a significant role in p53/TP53-mediating signaling pathway.

Located in cytoplasm and nucleus.

Source: NCBI Gene 102724101 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001330061

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51816
Approved symbol	TP53TG3E
Name	TP53 target 3 family member E
Location	16p11.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000275034
Ensembl biotype	protein_coding
Entrez	102724101

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000611321, ENST00000623491

RefSeq mRNA: 1 — MANE Select: NM_001330061 NM_001330061

CCDS: CCDS81974

Canonical transcript exons

ENST00000623491 — 2 exons

Exon	Start	End
ENSE00003978231	33305907	33306945
ENSE00003978232	33304306	33304735

Expression profiles

Bgee: expression breadth broad, 42 present calls, max score 87.92.

Top tissues by expression

111 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.92	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.77	gold quality
ganglionic eminence	UBERON:0004023	45.66	gold quality
ventricular zone	UBERON:0003053	45.01	gold quality
stromal cell of endometrium	CL:0002255	42.74	silver quality
bone marrow cell	CL:0002092	42.48	gold quality
placenta	UBERON:0001987	40.71	gold quality
monocyte	CL:0000576	40.30	gold quality
prefrontal cortex	UBERON:0000451	39.97	gold quality
leukocyte	CL:0000738	39.76	gold quality
skeletal muscle tissue	UBERON:0001134	39.03	gold quality
bone marrow	UBERON:0002371	38.75	gold quality
hindlimb stylopod muscle	UBERON:0004252	38.71	gold quality
sural nerve	UBERON:0015488	37.82	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
superior frontal gyrus	UBERON:0002661	35.26	gold quality
vermiform appendix	UBERON:0001154	35.22	gold quality
muscle tissue	UBERON:0002385	35.22	gold quality
frontal cortex	UBERON:0001870	33.12	gold quality
duodenum	UBERON:0002114	32.45	gold quality
blood	UBERON:0000178	32.26	silver quality
islet of Langerhans	UBERON:0000006	31.29	gold quality
liver	UBERON:0002107	29.79	gold quality
urinary bladder	UBERON:0001255	29.76	gold quality
tonsil	UBERON:0002372	28.80	gold quality
lymph node	UBERON:0000029	28.75	gold quality
cerebral cortex	UBERON:0000956	28.46	gold quality
primary visual cortex	UBERON:0002436	28.03	gold quality
muscle of leg	UBERON:0001383	27.91	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (7): TP53TG3 (ENSG00000183632), TP53TG3D (ENSG00000205456), TP53TG3C (ENSG00000205457), TP53TG3B (ENSG00000261509), (ENSG00000274175), (ENSG00000275869), TP53TG3F (ENSG00000278848)

Protein

Protein identifiers

TP53-target gene 3 protein — Q9ULZ0 (reviewed: Q9ULZ0)

Alternative names: TP53-inducible gene 3 protein

All UniProt accessions (1): Q9ULZ0

UniProt curated annotations — full annotation on UniProt →

Function. May play a significant role in p53/TP53-mediating signaling pathway.

Subcellular location. Cytoplasm. Nucleus.

Tissue specificity. Strongly expressed in testis. Weakly expressed in heart, placenta and skeletal muscle.

Induction. By p53/TP53.

Miscellaneous. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9ULZ0-2	2, TP53TG3a	yes
Q9ULZ0-1	1, TP53TG3b
Q9ULZ0-3	3

RefSeq proteins (1): NP_001316990* (*=MANE)

Domains & families (InterPro)

UniProt features (6 total): splice variant 3, chain 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9ULZ0-F1	40.37	0.00

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 1 (showing top): chr16p11

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (2): nucleus (GO:0005634), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
cellular anatomical structure	1

Protein interactions and networks

STRING

268 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TP53TG3E	TP53I11	O14683	400
TP53TG3E	PGBD2	Q6P3X8	398
TP53TG3E	GLYATL3	Q5SZD4	393
TP53TG3E	ZNF672	Q499Z4	370
TP53TG3E	TP53TG5	Q9Y2B4	352
TP53TG3E	FAM174A	Q8TBP5	351
TP53TG3E	ZNF595	Q8IYB9	348
TP53TG3E	ZNF280A	P59817	325
TP53TG3E	HEATR5B	Q9P2D3	324
TP53TG3E	VSIG10	Q8N0Z9	323
TP53TG3E	FAM72B	Q86X60	314
TP53TG3E	DYDC2	Q96IM9	310
TP53TG3E	SLC6A8	P48029	306
TP53TG3E	TP53I13	Q8NBR0	305
TP53TG3E	SMIM3	Q9BZL3	297

IntAct

1 interactions, top by confidence:

BioGRID (5): TP53TG3C (Negative Genetic), TP53TG3C (Negative Genetic), TP53TG3B (Negative Genetic), TP53TG3 (Positive Genetic), TP53TG3 (Affinity Capture-RNA)

ESM2 similar proteins: A0A1B0GUT2, A0A3Q1LFG5, A1L4Q6, A2RUQ5, A8MQB3, A8MU10, B1ANY3, C0HM98, H3BQW9, J3KSC0, P0C092, P0DMU3, P0DPA3, P24026, P59020, P59021, P59052, P87743, Q06250, Q0IIN9, Q0VFX4, Q14695, Q4R3X9, Q4VX62, Q52M75, Q5SR53, Q6ZUF6, Q6ZWC4, Q71F78, Q7Z4H9, Q8JMY5, Q8JMZ5, Q8JN06, Q8N2C9, Q8N2X6, Q8N3U1, Q8N9X3, Q8NAA6, Q8NBC4, Q8NDY4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

363 predictions. Top by Δscore:

Variant	Effect	Δscore
16:33305567:G:GT	donor_gain	0.9900
16:33305574:C:G	donor_gain	0.9900
16:33305658:GGTC:G	donor_gain	0.9800
16:33305568:A:T	donor_gain	0.9700
16:33305562:C:CG	donor_gain	0.9500
16:33304731:TCAAG:T	donor_loss	0.9400
16:33304732:CAAG:C	donor_loss	0.9400
16:33304733:AAG:A	donor_loss	0.9400
16:33304734:AG:A	donor_loss	0.9400
16:33304735:G:GT	donor_loss	0.9400
16:33304736:GTAA:G	donor_loss	0.9400
16:33304737:T:G	donor_loss	0.9400
16:33305025:G:GT	donor_gain	0.9300
16:33305537:G:GT	donor_gain	0.9000
16:33304728:TTGTC:T	donor_gain	0.8900
16:33304483:TTG:T	donor_gain	0.8800
16:33305007:G:GA	donor_gain	0.8800
16:33304730:GTCAA:G	donor_loss	0.8700
16:33304738:A:C	donor_loss	0.8700
16:33305741:T:TA	donor_gain	0.8600
16:33305742:A:AA	donor_gain	0.8600
16:33305581:G:T	donor_gain	0.8300
16:33305905:A:G	acceptor_gain	0.8300
16:33304590:C:G	donor_gain	0.8100
16:33305120:T:TA	donor_gain	0.7900
16:33305121:A:AA	donor_gain	0.7900
16:33305906:G:GA	acceptor_loss	0.7900
16:33305902:TTAAG:T	acceptor_gain	0.7700
16:33305903:TAAG:T	acceptor_gain	0.7700
16:33305904:AAG:A	acceptor_gain	0.7700

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 2 via entrez): RS1567317809 (16:33300699 A>G), RS1567317812 (16:33306409 T>TC)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.