TP53TG3F

Summary

TP53TG3F (TP53 target 3 family member F, HGNC:51817) is a protein-coding gene on chromosome 16p11.2, encoding TP53-target gene 3 protein (Q9ULZ0). May play a significant role in p53/TP53-mediating signaling pathway.

Located in cytoplasm and nucleus.

Source: NCBI Gene 102724127 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001330066

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51817
Approved symbol	TP53TG3F
Name	TP53 target 3 family member F
Location	16p11.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000278848
Ensembl biotype	protein_coding
Entrez	102724127

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000617705, ENST00000623042

RefSeq mRNA: 1 — MANE Select: NM_001330066 NM_001330066

CCDS: CCDS81976

Canonical transcript exons

ENST00000623042 — 2 exons

Exon	Start	End
ENSE00003978343	33461213	33462249
ENSE00003978344	33459612	33460041

Expression profiles

Bgee: expression breadth broad, 46 present calls, max score 84.47.

Top tissues by expression

113 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.47	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.32	gold quality
testis	UBERON:0000473	60.91	gold quality
right testis	UBERON:0004534	60.84	gold quality
left testis	UBERON:0004533	60.50	gold quality
lower esophagus mucosa	UBERON:0035834	56.48	gold quality
placenta	UBERON:0001987	49.11	gold quality
ventricular zone	UBERON:0003053	43.71	silver quality
ganglionic eminence	UBERON:0004023	43.53	gold quality
hindlimb stylopod muscle	UBERON:0004252	38.33	gold quality
endometrium	UBERON:0001295	38.20	silver quality
monocyte	CL:0000576	38.14	gold quality
bone marrow cell	CL:0002092	37.97	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	37.92	gold quality
leukocyte	CL:0000738	37.67	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
cerebellum	UBERON:0002037	36.68	silver quality
cerebellar cortex	UBERON:0002129	36.62	silver quality
cerebellar hemisphere	UBERON:0002245	36.56	silver quality
cortical plate	UBERON:0005343	36.47	gold quality
skeletal muscle tissue	UBERON:0001134	36.02	gold quality
bone marrow	UBERON:0002371	35.81	gold quality
sural nerve	UBERON:0015488	35.11	gold quality
frontal cortex	UBERON:0001870	34.90	silver quality
smooth muscle tissue	UBERON:0001135	34.69	silver quality
superior frontal gyrus	UBERON:0002661	34.62	gold quality
vermiform appendix	UBERON:0001154	34.56	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	34.33	gold quality
islet of Langerhans	UBERON:0000006	33.81	silver quality
duodenum	UBERON:0002114	32.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (7): TP53TG3 (ENSG00000183632), TP53TG3D (ENSG00000205456), TP53TG3C (ENSG00000205457), TP53TG3B (ENSG00000261509), (ENSG00000274175), TP53TG3E (ENSG00000275034), (ENSG00000275869)

Protein

Protein identifiers

TP53-target gene 3 protein — Q9ULZ0 (reviewed: Q9ULZ0)

Alternative names: TP53-inducible gene 3 protein

All UniProt accessions (1): Q9ULZ0

UniProt curated annotations — full annotation on UniProt →

Function. May play a significant role in p53/TP53-mediating signaling pathway.

Subcellular location. Cytoplasm. Nucleus.

Tissue specificity. Strongly expressed in testis. Weakly expressed in heart, placenta and skeletal muscle.

Induction. By p53/TP53.

Miscellaneous. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9ULZ0-2	2, TP53TG3a	yes
Q9ULZ0-1	1, TP53TG3b
Q9ULZ0-3	3

RefSeq proteins (1): NP_001316995* (*=MANE)

Domains & families (InterPro)

UniProt features (6 total): splice variant 3, chain 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9ULZ0-F1	40.37	0.00

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 1 (showing top): chr16p11

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (2): nucleus (GO:0005634), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
cellular anatomical structure	1

Protein interactions and networks

STRING

268 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TP53TG3F	TP53I11	O14683	400
TP53TG3F	PGBD2	Q6P3X8	398
TP53TG3F	GLYATL3	Q5SZD4	393
TP53TG3F	ZNF672	Q499Z4	370
TP53TG3F	TP53TG5	Q9Y2B4	352
TP53TG3F	FAM174A	Q8TBP5	351
TP53TG3F	ZNF595	Q8IYB9	348
TP53TG3F	ZNF280A	P59817	325
TP53TG3F	HEATR5B	Q9P2D3	324
TP53TG3F	VSIG10	Q8N0Z9	323
TP53TG3F	FAM72B	Q86X60	314
TP53TG3F	DYDC2	Q96IM9	310
TP53TG3F	SLC6A8	P48029	306
TP53TG3F	TP53I13	Q8NBR0	305
TP53TG3F	SMIM3	Q9BZL3	297

IntAct

1 interactions, top by confidence:

BioGRID (5): TP53TG3C (Negative Genetic), TP53TG3C (Negative Genetic), TP53TG3B (Negative Genetic), TP53TG3 (Positive Genetic), TP53TG3 (Affinity Capture-RNA)

ESM2 similar proteins: A0A1B0GUT2, A0A3Q1LFG5, A1L4Q6, A2RUQ5, A8MQB3, A8MU10, B1ANY3, C0HM98, H3BQW9, J3KSC0, P0C092, P0DMU3, P0DPA3, P24026, P59020, P59021, P59052, P87743, Q06250, Q0IIN9, Q0VFX4, Q14695, Q4R3X9, Q4VX62, Q52M75, Q5SR53, Q6ZUF6, Q6ZWC4, Q71F78, Q7Z4H9, Q8JMY5, Q8JMZ5, Q8JN06, Q8N2C9, Q8N2X6, Q8N3U1, Q8N9X3, Q8NAA6, Q8NBC4, Q8NDY4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

764 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:33459953:T:C	F92L	0.941
16:33459955:T:A	F92L	0.941
16:33459955:T:G	F92L	0.941
16:33459863:T:C	F62L	0.935
16:33459865:C:A	F62L	0.935
16:33459865:C:G	F62L	0.935
16:33459818:T:C	F47L	0.924
16:33459820:T:A	F47L	0.924
16:33459820:T:G	F47L	0.924
16:33459899:G:T	G74W	0.910
16:33459899:G:A	G74R	0.899
16:33459899:G:C	G74R	0.899
16:33459900:G:T	G74V	0.894
16:33459981:T:C	I101T	0.887
16:33459923:T:A	C82S	0.883
16:33459924:G:C	C82S	0.883
16:33459900:G:A	G74E	0.881
16:33459870:T:C	I64T	0.876
16:33459964:T:G	C95W	0.864
16:33459974:A:C	S99R	0.863
16:33459976:T:A	S99R	0.863
16:33459976:T:G	S99R	0.863
16:33459962:T:C	C95R	0.862
16:33459824:A:C	S49R	0.859
16:33459826:C:A	S49R	0.859
16:33459826:C:G	S49R	0.859
16:33459860:T:C	C61R	0.854
16:33460009:G:C	W110C	0.851
16:33460009:G:T	W110C	0.851
16:33459862:T:G	C61W	0.846

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
S-Nitrosoglutathione	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.