TP73-AS2

Summary

TP73-AS2 (TP73 antisense RNA 2, HGNC:40591) is a long non-coding RNA gene on chromosome 1p36.32.

At a glance

• Gene type: non-coding (lncRNA) — no protein product.
• Sense gene: antisense to TP73 — the sense gene carries 6 GWAS associations, 137 ClinVar variants (the sense gene’s biology, not this transcript’s)

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40591
Approved symbol	TP73-AS2
Name	TP73 antisense RNA 2
Location	1p36.32
Locus type	RNA, long non-coding
Status	Approved
Aliases	RP5-1092A11.2
Ensembl gene	ENSG00000235131
Ensembl biotype	lncRNA
Entrez	117134600
RNAcentral	URS00000D9E9B — lncRNA, 351 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

Transcript support level (Ensembl TSL; 1 = fully mRNA-supported): TSL 2: 1

ENST00000416554

RefSeq mRNA: 0

Canonical transcript exons

ENST00000416554 — 2 exons

Exon	Start	End
ENSE00001679378	3712200	3712438
ENSE00001735702	3714187	3714298

Expression profiles

Bgee: expression breadth broad, 89 present calls, max score 71.10.

Highest expression (Bgee): corpus callosum, lymph node, skeletal muscle tissue, islet of Langerhans, monocyte.

Genetic regulation across tissues (GTEx eQTL / sQTL)

TP73-AS2 is not an eGene in any GTEx v10 tissue: no tissue shows a variant significantly associated with its expression or splicing (q < 0.05).

Top tissues by expression

89 tissues by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	71.10	gold quality
lymph node	UBERON:0000029	65.77	gold quality
skeletal muscle tissue	UBERON:0001134	64.05	gold quality
islet of Langerhans	UBERON:0000006	62.54	gold quality
monocyte	CL:0000576	60.18	gold quality
prefrontal cortex	UBERON:0000451	58.86	gold quality
bone marrow	UBERON:0002371	58.64	gold quality
tonsil	UBERON:0002372	58.08	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	58.05	gold quality
muscle of leg	UBERON:0001383	56.62	gold quality
right lung	UBERON:0002167	56.51	gold quality
left adrenal gland cortex	UBERON:0035825	55.60	gold quality
blood	UBERON:0000178	55.33	gold quality
gastrocnemius	UBERON:0001388	55.07	gold quality
right lobe of liver	UBERON:0001114	54.30	gold quality
fallopian tube	UBERON:0003889	53.22	gold quality
right uterine tube	UBERON:0001302	52.99	gold quality
uterine cervix	UBERON:0000002	52.25	gold quality
endometrium	UBERON:0001295	51.24	gold quality
esophagus mucosa	UBERON:0002469	50.67	gold quality
heart left ventricle	UBERON:0002084	50.16	gold quality
esophagus	UBERON:0001043	50.03	gold quality
left adrenal gland	UBERON:0001234	49.55	gold quality
body of uterus	UBERON:0009853	49.47	gold quality
endocervix	UBERON:0000458	49.46	gold quality
amygdala	UBERON:0001876	49.13	gold quality
cerebellum	UBERON:0002037	48.90	silver quality
cerebellar hemisphere	UBERON:0002245	48.81	silver quality
frontal cortex	UBERON:0001870	48.67	gold quality
ascending aorta	UBERON:0001496	48.46	gold quality
stomach	UBERON:0000945	48.36	gold quality
body of pancreas	UBERON:0001150	48.27	gold quality
right adrenal gland	UBERON:0001233	48.20	gold quality
Ammon’s horn	UBERON:0001954	48.14	gold quality
substantia nigra	UBERON:0002038	47.90	gold quality
tibial artery	UBERON:0007610	47.77	gold quality
right coronary artery	UBERON:0001625	47.76	gold quality
rectum	UBERON:0001052	47.63	gold quality
putamen	UBERON:0001874	47.43	gold quality
brain	UBERON:0000955	47.34	gold quality
Brodmann (1909) area 9	UBERON:0013540	47.26	gold quality
body of stomach	UBERON:0001161	47.17	gold quality
adenohypophysis	UBERON:0002196	47.09	gold quality
adrenal tissue	UBERON:0018303	47.08	silver quality
right hemisphere of cerebellum	UBERON:0014890	47.02	silver quality
anterior cingulate cortex	UBERON:0009835	46.72	gold quality
ovary	UBERON:0000992	46.68	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	46.57	gold quality
caudate nucleus	UBERON:0001873	46.55	gold quality
prostate gland	UBERON:0002367	46.53	gold quality
ectocervix	UBERON:0012249	46.49	gold quality
left ovary	UBERON:0002119	46.43	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	46.42	gold quality
skin of abdomen	UBERON:0001416	46.33	gold quality
zone of skin	UBERON:0000014	46.27	gold quality
vagina	UBERON:0000996	46.24	gold quality
saliva-secreting gland	UBERON:0001044	46.20	gold quality
fundus of stomach	UBERON:0001160	46.09	gold quality
right lobe of thyroid gland	UBERON:0001119	45.96	gold quality
spleen	UBERON:0002106	45.62	gold quality
thyroid gland	UBERON:0002046	45.59	gold quality
minor salivary gland	UBERON:0001830	44.93	gold quality
right frontal lobe	UBERON:0002810	44.91	gold quality
nucleus accumbens	UBERON:0001882	44.84	gold quality
skin of leg	UBERON:0001511	44.80	gold quality
right atrium auricular region	UBERON:0006631	44.64	gold quality
left lobe of thyroid gland	UBERON:0001120	44.44	gold quality
subcutaneous adipose tissue	UBERON:0002190	44.37	gold quality
hypothalamus	UBERON:0001898	44.32	gold quality
right adrenal gland cortex	UBERON:0035827	44.27	gold quality
transverse colon	UBERON:0001157	43.83	gold quality
lower esophagus muscularis layer	UBERON:0035833	43.81	gold quality
lung	UBERON:0002048	43.40	gold quality
left uterine tube	UBERON:0001303	43.37	silver quality
colon	UBERON:0001155	42.94	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	42.85	silver quality
intestine	UBERON:0000160	42.68	gold quality
pituitary gland	UBERON:0000007	41.84	gold quality
tibial nerve	UBERON:0001323	41.67	gold quality
upper lobe of left lung	UBERON:0008952	41.55	gold quality
myometrium	UBERON:0001296	41.31	silver quality
thoracic mammary gland	UBERON:0005200	41.27	silver quality
small intestine	UBERON:0002108	40.96	gold quality
omental fat pad	UBERON:0010414	40.22	silver quality
small intestine Peyer’s patch	UBERON:0003454	40.00	silver quality
muscle layer of sigmoid colon	UBERON:0035805	39.99	silver quality
right testis	UBERON:0004534	37.45	gold quality
testis	UBERON:0000473	31.89	silver quality
left testis	UBERON:0004533	31.12	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Genomic neighbors (locus context)

Genes flanking this one on the chromosome (NCBI/Entrez gene neighborhood). Positional context only — some neighbors share regulatory elements (bidirectional promoters, antisense/overlapping transcripts), but chromosomal adjacency is not itself a functional relationship (see Interactions for that).

Symbol	Type	Entrez
TPRG1L	protein-coding	127262
WRAP73	protein-coding	49856
TP73	protein-coding	7161
TP73-AS3	ncRNA	105378610
MEGF6	protein-coding	1953
MIR551A	ncRNA	693135
CCDC27	protein-coding	148870
SMIM1	protein-coding	388588
LRRC47	protein-coding	57470

Protein

Non-coding RNA — no protein product.

Function

Gene-set membership (MSigDB)

This non-coding RNA is a member of 1 curated MSigDB gene set — regulatory-target and signature collections that include it (it has no protein-based pathway / GO / interaction data).

chr1p36

ncRNA interactions

Experimentally supported non-coding-RNA interaction partners (NPInter).

showing 1 of 7 interaction partners:

Partner	Partner type	Level	Source
RP5-1092A11.2	lncRNA	RNA-Protein	High-throughput data

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No curated drug or pharmacology associations for this gene.