TP73-AS3

Summary

TP73-AS3 (TP73 antisense RNA 3, HGNC:40590) is a long non-coding RNA gene on chromosome 1p36.32.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40590
Approved symbol	TP73-AS3
Name	TP73 antisense RNA 3
Location	1p36.32
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000227589
Ensembl biotype	lncRNA
Entrez	105378610
RNAcentral	URS00026A280A — lncRNA, 1222 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000443034

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000443034 — 3 exons

Exon	Start	End
ENSE00001593080	3668625	3668772
ENSE00001613786	3662153	3662265
ENSE00001715920	3658938	3659430

Expression profiles

Bgee: expression breadth ubiquitous, 104 present calls, max score 86.00.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1534 / max 147.7572, expressed in 23 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
9953	0.0871	6
9957	0.0248	11
9956	0.0221	7
9954	0.0133	1
9955	0.0061	1

Top tissues by expression

104 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.00	gold quality
bone marrow cell	CL:0002092	67.79	silver quality
tonsil	UBERON:0002372	65.50	gold quality
lymph node	UBERON:0000029	61.58	gold quality
cortex of kidney	UBERON:0001225	59.68	gold quality
pituitary gland	UBERON:0000007	58.61	gold quality
bone marrow	UBERON:0002371	57.03	silver quality
adenohypophysis	UBERON:0002196	56.84	gold quality
urinary bladder	UBERON:0001255	56.57	gold quality
leukocyte	CL:0000738	56.04	gold quality
liver	UBERON:0002107	55.93	gold quality
monocyte	CL:0000576	55.73	gold quality
vermiform appendix	UBERON:0001154	55.24	gold quality
placenta	UBERON:0001987	55.05	gold quality
right lobe of liver	UBERON:0001114	54.71	gold quality
blood	UBERON:0000178	54.02	gold quality
duodenum	UBERON:0002114	52.56	gold quality
islet of Langerhans	UBERON:0000006	51.56	gold quality
descending thoracic aorta	UBERON:0002345	50.40	gold quality
kidney	UBERON:0002113	50.10	gold quality
fallopian tube	UBERON:0003889	50.09	gold quality
muscle tissue	UBERON:0002385	49.91	silver quality
right uterine tube	UBERON:0001302	49.90	gold quality
rectum	UBERON:0001052	49.62	gold quality
brain	UBERON:0000955	48.36	gold quality
thoracic aorta	UBERON:0001515	47.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	47.97	gold quality
fundus of stomach	UBERON:0001160	47.91	gold quality
ascending aorta	UBERON:0001496	47.89	gold quality
muscle of leg	UBERON:0001383	47.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.30

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.