TPBGL

Summary

TPBGL (trophoblast glycoprotein like, HGNC:44159) is a protein-coding gene on chromosome 11q13.4, encoding Trophoblast glycoprotein-like (P0DKB5).

Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane.

Source: NCBI Gene 100507050 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 51 total
• MANE Select transcript: NM_001195528

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44159
Approved symbol	TPBGL
Name	trophoblast glycoprotein like
Location	11q13.4
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000261594
Ensembl biotype	protein_coding
Entrez	100507050

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000562197

RefSeq mRNA: 1 — MANE Select: NM_001195528 NM_001195528

CCDS: CCDS60895

Canonical transcript exons

ENST00000562197 — 1 exons

Exon	Start	End
ENSE00002609763	75240774	75243704

Expression profiles

Bgee: expression breadth ubiquitous, 133 present calls, max score 93.34.

FANTOM5 (CAGE): breadth broad, TPM avg 0.5520 / max 145.0921, expressed in 199 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
115888	0.2798	122
115889	0.1888	66
115890	0.0377	8
115893	0.0264	8
115887	0.0194	4

Top tissues by expression

236 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cardiac muscle of right atrium	UBERON:0003379	93.34	gold quality
left ventricle myocardium	UBERON:0006566	92.92	gold quality
kidney epithelium	UBERON:0004819	92.48	gold quality
upper arm skin	UBERON:0004263	89.56	gold quality
dorsal root ganglion	UBERON:0000044	83.87	gold quality
trigeminal ganglion	UBERON:0001675	83.68	gold quality
superficial temporal artery	UBERON:0001614	79.16	gold quality
epithelial cell of pancreas	CL:0000083	77.48	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.23	gold quality
myocardium	UBERON:0002349	76.21	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	75.93	gold quality
epithelium of nasopharynx	UBERON:0001951	74.29	gold quality
nasal cavity epithelium	UBERON:0005384	72.80	gold quality
medulla oblongata	UBERON:0001896	72.04	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	71.66	gold quality
cartilage tissue	UBERON:0002418	71.35	silver quality
prefrontal cortex	UBERON:0000451	71.31	gold quality
layer of synovial tissue	UBERON:0007616	71.13	gold quality
subthalamic nucleus	UBERON:0001906	69.99	gold quality
putamen	UBERON:0001874	69.95	gold quality
quadriceps femoris	UBERON:0001377	69.82	gold quality
dorsal plus ventral thalamus	UBERON:0001897	69.38	gold quality
vastus lateralis	UBERON:0001379	69.33	gold quality
cardia of stomach	UBERON:0001162	69.28	gold quality
tibialis anterior	UBERON:0001385	69.27	silver quality
vena cava	UBERON:0004087	69.18	gold quality
inferior vagus X ganglion	UBERON:0005363	68.96	gold quality
pons	UBERON:0000988	68.91	gold quality
substantia nigra pars reticulata	UBERON:0001966	68.74	gold quality
lateral nuclear group of thalamus	UBERON:0002736	68.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.97

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

100 targeting TPBGL, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4713-3P	100.00	65.92	505
HSA-MIR-520G-5P	99.99	66.76	658
HSA-MIR-32-5P	99.98	75.21	1964
HSA-MIR-92A-3P	99.98	75.21	1960
HSA-MIR-92B-3P	99.98	75.25	1955
HSA-MIR-25-3P	99.98	74.60	1817
HSA-MIR-363-3P	99.98	74.72	1821
HSA-MIR-367-3P	99.98	74.83	1819
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-218-5P	99.93	72.22	2103
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-137-3P	99.87	74.74	2401
HSA-MIR-4779	99.86	66.50	1583
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-130B-5P	99.83	68.50	1888
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-6756-5P	99.82	67.97	2466
HSA-MIR-6842-5P	99.80	67.54	1587
HSA-MIR-7110-5P	99.80	67.84	1712
HSA-MIR-636	99.80	69.58	1500
HSA-MIR-6764-5P	99.75	67.89	2304
HSA-MIR-148A-3P	99.74	73.77	1700
HSA-MIR-148B-3P	99.74	73.75	1700
HSA-MIR-152-3P	99.74	73.75	1703
HSA-MIR-149-3P	99.72	68.22	3963
HSA-MIR-6883-5P	99.69	68.05	3785
HSA-MIR-6766-5P	99.68	67.70	2325
HSA-MIR-3202	99.66	67.70	2737
HSA-MIR-1251-3P	99.64	67.21	1408
HSA-MIR-4516	99.61	67.78	3390

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Tpbgl	ENSMUSG00000096606
rattus_norvegicus	Tpbgl	ENSRNOG00000090397

Paralogs (25): SLITRK3 (ENSG00000121871), LRFN3 (ENSG00000126243), LRFN1 (ENSG00000128011), SLIT2 (ENSG00000145147), LRFN2 (ENSG00000156564), LRRC38 (ENSG00000162494), SLITRK5 (ENSG00000165300), LRFN5 (ENSG00000165379), LRTM2 (ENSG00000166159), LINGO1 (ENSG00000169783), LRRN2 (ENSG00000170382), LRRN3 (ENSG00000173114), LRFN4 (ENSG00000173621), LINGO2 (ENSG00000174482), LRRN1 (ENSG00000175928), SLITRK1 (ENSG00000178235), GP5 (ENSG00000178732), SLITRK4 (ENSG00000179542), LRRC55 (ENSG00000183908), SLIT3 (ENSG00000184347), SLITRK6 (ENSG00000184564), SLITRK2 (ENSG00000185985), LRRC70 (ENSG00000186105), SLIT1 (ENSG00000187122), TLR9 (ENSG00000239732)

Protein

Protein identifiers

Trophoblast glycoprotein-like — P0DKB5 (reviewed: P0DKB5)

All UniProt accessions (1): P0DKB5

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

RefSeq proteins (1): NP_001182457* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000483	Cys-rich_flank_reg_C	Domain
IPR001611	Leu-rich_rpt	Repeat
IPR003591	Leu-rich_rpt_typical-subtyp	Repeat
IPR032675	LRR_dom_sf	Homologous_superfamily
IPR052286	Wnt_signaling_inhibitor	Family

Pfam: PF13855

UniProt features (17 total): repeat 5, disulfide bond 4, topological domain 2, signal peptide 1, chain 1, region of interest 1, compositionally biased region 1, glycosylation site 1, transmembrane region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0DKB5-F1	81.45	0.52

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (4): 27–33, 31–43, 238–264, 240–285

Glycosylation sites (1): 62

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 37 (showing top): GOBP_REGULATION_OF_WNT_SIGNALING_PATHWAY, chr11q13, GOBP_CANONICAL_WNT_SIGNALING_PATHWAY, GOBP_NEGATIVE_REGULATION_OF_WNT_SIGNALING_PATHWAY, GOBP_NEGATIVE_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY, ZNF30_TARGET_GENES, MIR4728_5P, MIR6785_5P, MIR218_5P, MIR3202, MIR6764_5P, MIR7110_5P, MIR1915_3P, MIR6842_5P, MIR330_5P

GO Biological Process (1): negative regulation of canonical Wnt signaling pathway (GO:0090090)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
negative regulation of Wnt signaling pathway	1
canonical Wnt signaling pathway	1
regulation of canonical Wnt signaling pathway	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

562 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TPBGL	KIAA1614	Q5VZ46	400
TPBGL	PPP2R2C	Q9Y2T4	375
TPBGL	RUFY3	Q7L099	373
TPBGL	CHST9	Q7L1S5	373
TPBGL	KCNA10	Q16322	367
TPBGL	FSCN3	Q9NQT6	365
TPBGL	FOXD4L1	Q9NU39	350
TPBGL	C1QL1	O75973	349
TPBGL	LBHD2	A0A0U1RRK4	349
TPBGL	SERTM1	A2A2V5	348
TPBGL	A0A0B4J1T7	A0A0B4J1T7	348
TPBGL	ATP10B	O94823	344
TPBGL	METTL27	Q8N6F8	343
TPBGL	CRELD1	Q96HD1	343
TPBGL	DRC10	Q96DY2	324

IntAct

2 interactions, top by confidence:

A	B	Type	Score
DLG1	TPBGL	psi-mi:“MI:0407”(direct interaction)	0.440

ESM2 similar proteins: A2A9Q0, A5PKD8, B0BNK7, D2HFT7, D4ABX8, E9Q7T7, O75325, O94819, P0C7J6, P0DKB5, Q04785, Q13641, Q1RMS4, Q24JP5, Q28730, Q2I0M4, Q2WF71, Q460M5, Q4R8Y9, Q50LG9, Q5PQV5, Q6NUI6, Q6PJG9, Q6UKI2, Q7M6Z0, Q80TG9, Q80W15, Q80WD1, Q80XU8, Q86UN3, Q86WK7, Q8BHA1, Q8BLY3, Q8BNW9, Q8C013, Q8WX77, Q96PE1, Q9BE71, Q9BTN0, Q9BY71

Diamond homologs: A2ARI4, A3KNN3, A4IFA6, A6H789, A6H793, A6NJW4, A8WHP9, D4AC13, E5DHB5, E7FE13, F1MLX5, F1MT22, F7D3V9, G5EFX6, O00206, O02833, O14498, O35367, O35930, O46378, O46379, O46542, O62702, O75093, O75473, O88279, O88280, O94769, O94898, P07359, P07585, P0DKB5, P0DM44, P21793, P23515, P24014, P28675, P51885, P51886, P51890

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

51 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	47
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

57 predictions. Top by Δscore:

Variant	Effect	Δscore
11:75242020:T:TA	acceptor_gain	0.8200
11:75242019:AT:A	acceptor_gain	0.7000
11:75241118:CGCGG:C	acceptor_gain	0.4100
11:75241012:G:GT	donor_gain	0.3700
11:75241138:A:AG	acceptor_gain	0.3700
11:75241139:G:GG	acceptor_gain	0.3700
11:75240958:TC:T	donor_gain	0.3600
11:75242020:T:G	acceptor_gain	0.3600
11:75242323:C:A	acceptor_gain	0.3600
11:75241006:T:A	donor_gain	0.3300
11:75241013:C:T	donor_gain	0.3300
11:75241110:AGC:A	acceptor_gain	0.3300
11:75241120:CGGCA:C	acceptor_gain	0.3300
11:75242332:G:C	acceptor_gain	0.3300
11:75241004:ACT:A	donor_gain	0.3200
11:75242019:ATG:A	acceptor_gain	0.3100
11:75242021:G:A	acceptor_gain	0.3100
11:75242042:C:CA	acceptor_gain	0.3100
11:75242121:G:GT	donor_gain	0.3100
11:75241010:G:A	donor_gain	0.3000
11:75241044:GCCGC:G	donor_gain	0.3000
11:75241373:G:GA	donor_gain	0.3000
11:75242019:ATGGT:A	acceptor_gain	0.3000
11:75242330:G:GC	acceptor_gain	0.2900
11:75241028:GCT:G	donor_gain	0.2600
11:75241128:TGC:T	acceptor_gain	0.2600
11:75241130:C:T	acceptor_gain	0.2600
11:75242249:A:G	donor_gain	0.2600
11:75242329:CGAG:C	acceptor_gain	0.2600
11:75241032:GATGC:G	donor_gain	0.2500

AlphaMissense

2378 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:75241282:T:G	F78C	0.999
11:75241431:A:T	N128Y	0.999
11:75241433:C:A	N128K	0.999
11:75241433:C:G	N128K	0.999
11:75241984:G:A	G312E	0.999
11:75242004:G:C	G319R	0.999
11:75242005:G:A	G319D	0.999
11:75241243:T:A	I65N	0.998
11:75241361:C:A	N104K	0.998
11:75241361:C:G	N104K	0.998
11:75241417:T:A	L123H	0.998
11:75241423:T:A	L125H	0.998
11:75241996:C:A	A316E	0.998
11:75242035:A:T	N329I	0.998
11:75241237:T:C	L63P	0.997
11:75241360:A:T	N104I	0.997
11:75241390:T:C	F114S	0.997
11:75241390:T:G	F114C	0.997
11:75241432:A:T	N128I	0.997
11:75241983:G:A	G312R	0.997
11:75241983:G:C	G312R	0.997
11:75241351:T:A	L101H	0.996
11:75241423:T:C	L125P	0.996
11:75241426:G:T	S126I	0.996
11:75241462:T:C	F138S	0.996
11:75241462:T:G	F138C	0.996
11:75242002:T:A	I318N	0.996
11:75242026:T:A	L326H	0.996
11:75242032:T:C	L328P	0.996
11:75242047:T:C	I333T	0.996

dbSNP variants (sampled 300 via entrez): RS1001493714 (11:75239611 T>C), RS1001608285 (11:75239373 T>C), RS1002155109 (11:75244133 G>T), RS1002610135 (11:75238835 C>T), RS1003132026 (11:75243237 G>T), RS1003162386 (11:75240371 C>T), RS1003725741 (11:75242136 C>G,T), RS1004243224 (11:75241881 C>G,T), RS1004698974 (11:75241354 C>A,T), RS1005050806 (11:75239890 C>A), RS1005166891 (11:75239614 C>A,T), RS1006055266 (11:75242440 C>A), RS1006108925 (11:75240255 AG>A), RS1006699983 (11:75238909 CAG>C), RS1007619986 (11:75242723 T>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
aristolochic acid I	decreases expression	1
bisphenol A	decreases expression	1
tebuconazole	decreases expression	1
Triclosan	increases expression	1
Cadmium Chloride	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.