TPM1-AS

Summary

TPM1-AS (TPM1 antisense RNA, HGNC:53635) is a long non-coding RNA gene on chromosome 15q22.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53635
Approved symbol	TPM1-AS
Name	TPM1 antisense RNA
Location	15q22.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	TPM1-AS1
Ensembl gene	ENSG00000259498
Ensembl biotype	lncRNA
Entrez	111064646
RNAcentral	URS0000BC45F2 — lncRNA, 3209 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000560903, ENST00000561241, ENST00000804116, ENST00000804117

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000560903 — 2 exons

Exon	Start	End
ENSE00002546618	63047694	63048695
ENSE00002563339	63048841	63049248

Expression profiles

Bgee: expression breadth ubiquitous, 130 present calls, max score 78.80.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2187 / max 20.8486, expressed in 80 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
150390	0.2187	80

Top tissues by expression

130 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	78.80	gold quality
sural nerve	UBERON:0015488	76.72	gold quality
apex of heart	UBERON:0002098	76.68	gold quality
heart left ventricle	UBERON:0002084	76.26	gold quality
right atrium auricular region	UBERON:0006631	75.40	gold quality
lower esophagus muscularis layer	UBERON:0035833	74.88	gold quality
lower esophagus	UBERON:0013473	74.75	gold quality
heart	UBERON:0000948	74.51	gold quality
calcaneal tendon	UBERON:0003701	74.20	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	73.66	gold quality
body of uterus	UBERON:0009853	72.30	gold quality
urinary bladder	UBERON:0001255	71.78	gold quality
myometrium	UBERON:0001296	71.73	gold quality
small intestine	UBERON:0002108	71.60	gold quality
prostate gland	UBERON:0002367	70.71	gold quality
small intestine Peyer’s patch	UBERON:0003454	70.68	gold quality
popliteal artery	UBERON:0002250	70.47	gold quality
tibial artery	UBERON:0007610	70.39	gold quality
muscle layer of sigmoid colon	UBERON:0035805	70.25	gold quality
bone marrow cell	CL:0002092	70.17	silver quality
intestine	UBERON:0000160	69.70	gold quality
duodenum	UBERON:0002114	69.68	gold quality
colon	UBERON:0001155	69.33	gold quality
transverse colon	UBERON:0001157	69.25	gold quality
skeletal muscle tissue	UBERON:0001134	69.02	gold quality
ascending aorta	UBERON:0001496	68.92	gold quality
thoracic aorta	UBERON:0001515	68.80	gold quality
mucosa of transverse colon	UBERON:0004991	68.47	gold quality
descending thoracic aorta	UBERON:0002345	68.19	gold quality
mucosa of stomach	UBERON:0001199	68.09	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-9543	yes	1582.03
E-ANND-3	no	3.08

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.