TPRG1-AS1

Summary

TPRG1-AS1 (TPRG1 antisense RNA 1, HGNC:42391) is a long non-coding RNA gene on chromosome 3q28.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:42391
Approved symbol	TPRG1-AS1
Name	TPRG1 antisense RNA 1
Location	3q28
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000234076
Ensembl biotype	lncRNA
Entrez	100874043
RNAcentral	URS00003B76FC — lncRNA, 697 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000444488, ENST00000733894

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000444488 — 2 exons

Exon	Start	End
ENSE00003986564	188941196	188942050
ENSE00004065537	188947279	188947829

Expression profiles

Bgee: expression breadth ubiquitous, 121 present calls, max score 80.80.

FANTOM5 (CAGE): breadth broad, TPM avg 0.6489 / max 39.8615, expressed in 262 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
46052	0.6034	245
46053	0.0455	16

Top tissues by expression

121 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	80.80	gold quality
right lobe of liver	UBERON:0001114	80.27	gold quality
monocyte	CL:0000576	76.50	gold quality
leukocyte	CL:0000738	75.98	gold quality
right adrenal gland	UBERON:0001233	71.81	gold quality
left adrenal gland	UBERON:0001234	70.51	gold quality
bone marrow cell	CL:0002092	69.82	silver quality
right adrenal gland cortex	UBERON:0035827	69.80	gold quality
left adrenal gland cortex	UBERON:0035825	69.78	gold quality
adrenal gland	UBERON:0002369	69.53	gold quality
omental fat pad	UBERON:0010414	66.68	gold quality
colonic epithelium	UBERON:0000397	66.60	silver quality
adipose tissue	UBERON:0001013	66.43	gold quality
granulocyte	CL:0000094	66.09	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.82	gold quality
thoracic mammary gland	UBERON:0005200	65.75	gold quality
fallopian tube	UBERON:0003889	63.36	gold quality
calcaneal tendon	UBERON:0003701	63.14	gold quality
saliva-secreting gland	UBERON:0001044	62.78	gold quality
minor salivary gland	UBERON:0001830	62.73	gold quality
skeletal muscle tissue	UBERON:0001134	62.55	gold quality
left coronary artery	UBERON:0001626	62.38	gold quality
vermiform appendix	UBERON:0001154	62.01	gold quality
heart left ventricle	UBERON:0002084	61.22	gold quality
stromal cell of endometrium	CL:0002255	60.60	gold quality
blood	UBERON:0000178	60.48	gold quality
heart	UBERON:0000948	60.28	gold quality
ganglionic eminence	UBERON:0004023	60.25	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	60.11	gold quality
esophagus mucosa	UBERON:0002469	59.46	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.12

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• TPRG1-AS1 induces RBM24 expression and inhibits liver cancer progression by sponging miR-4691-5p and miR-3659. (PMID:34328265)
• Long Noncoding RNA TPRG1-AS1 Suppresses Migration of Vascular Smooth Muscle Cells and Attenuates Atherogenesis via Interacting With MYH9 Protein. (PMID:36172865)
• The oncogenic role of TFAP2A in bladder urothelial carcinoma via a novel long noncoding RNA TPRG1-AS1/DNMT3A/CRTAC1 axis. (PMID:36410635)
• CCND1-associated ceRNA network reveal the critical pathway of TPRG1-AS1-hsa-miR-363-3p-MYO1B as a prognostic marker for head and neck squamous cell carcinoma. (PMID:37481637)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.