TPST1

Summary

TPST1 (tyrosylprotein sulfotransferase 1, HGNC:12020) is a protein-coding gene on chromosome 7q11.21, encoding Protein-tyrosine sulfotransferase 1 (O60507). Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3’-phosphoadenylyl sulfate (PAPS) as cosubstrate.

Enables protein homodimerization activity and protein-tyrosine sulfotransferase activity. Involved in post-translational protein modification. Located in Golgi membrane. Implicated in colorectal adenocarcinoma.

Source: NCBI Gene 8460 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 48 total
• MANE Select transcript: NM_003596

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:12020
Approved symbol	TPST1
Name	tyrosylprotein sulfotransferase 1
Location	7q11.21
Locus type	gene with protein product
Status	Approved
Aliases	TANGO13A
Ensembl gene	ENSG00000169902
Ensembl biotype	protein_coding
OMIM	603125
Entrez	8460

Gene structure

Transcript identifiers

Ensembl transcripts: 30 — 28 protein_coding, 2 protein_coding_CDS_not_defined

ENST00000304842, ENST00000442120, ENST00000451388, ENST00000480281, ENST00000490159, ENST00000649664, ENST00000904436, ENST00000904437, ENST00000904438, ENST00000904439, ENST00000904440, ENST00000904441, ENST00000904442, ENST00000904443, ENST00000904444, ENST00000904445, ENST00000904446, ENST00000904447, ENST00000904448, ENST00000904449, ENST00000935281, ENST00000935282, ENST00000935283, ENST00000935284, ENST00000935285, ENST00000967658, ENST00000967659, ENST00000967660, ENST00000967661, ENST00000967662

RefSeq mRNA: 1 — MANE Select: NM_003596 NM_003596

CCDS: CCDS5533

Canonical transcript exons

ENST00000304842 — 6 exons

Exon	Start	End
ENSE00001131417	66240325	66241270
ENSE00001167449	66359895	66360443
ENSE00001945148	66205334	66205522
ENSE00003546755	66356825	66356871
ENSE00003673981	66286511	66286709
ENSE00003691193	66352505	66352555

Expression profiles

Bgee: expression breadth ubiquitous, 254 present calls, max score 96.38.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 38.9728 / max 325.6449, expressed in 1722 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
78858	34.8235	1708
78857	4.0171	1456
78859	0.0767	26
78860	0.0554	22

Top tissues by expression

292 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stromal cell of endometrium	CL:0002255	96.38	gold quality
gall bladder	UBERON:0002110	94.46	gold quality
endocervix	UBERON:0000458	93.22	gold quality
ectocervix	UBERON:0012249	92.44	gold quality
tibia	UBERON:0000979	92.42	gold quality
periodontal ligament	UBERON:0008266	90.97	gold quality
right lobe of liver	UBERON:0001114	90.92	gold quality
islet of Langerhans	UBERON:0000006	90.37	gold quality
adenohypophysis	UBERON:0002196	89.68	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	89.44	gold quality
colonic epithelium	UBERON:0000397	89.37	gold quality
right testis	UBERON:0004534	88.98	gold quality
decidua	UBERON:0002450	88.92	gold quality
pituitary gland	UBERON:0000007	88.76	gold quality
left testis	UBERON:0004533	88.46	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	88.36	gold quality
urinary bladder	UBERON:0001255	87.98	gold quality
left adrenal gland	UBERON:0001234	87.91	gold quality
hypothalamus	UBERON:0001898	87.82	gold quality
left adrenal gland cortex	UBERON:0035825	87.55	gold quality
liver	UBERON:0002107	87.46	gold quality
testis	UBERON:0000473	87.27	gold quality
mucosa of stomach	UBERON:0001199	87.27	gold quality
right ovary	UBERON:0002118	87.27	gold quality
spinal cord	UBERON:0002240	87.27	gold quality
right adrenal gland	UBERON:0001233	87.08	gold quality
metanephros cortex	UBERON:0010533	87.03	gold quality
vagina	UBERON:0000996	87.02	gold quality
endometrium	UBERON:0001295	86.99	gold quality
lower esophagus mucosa	UBERON:0035834	86.85	gold quality

Single-cell (SCXA)

Detected in 5 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-GEOD-180759	yes	2104.17
E-MTAB-10287	yes	100.45
E-GEOD-84465	yes	23.31
E-CURD-112	no	2.95
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

29 targeting TPST1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-23A-3P	99.95	74.24	3163
HSA-MIR-23B-3P	99.95	74.24	3163
HSA-MIR-23C	99.95	73.92	3192
HSA-MIR-10523-5P	99.91	69.22	2038
HSA-MIR-3934-3P	99.76	65.51	1351
HSA-MIR-4755-5P	99.71	70.34	2716
HSA-MIR-5006-3P	99.71	70.26	2728
HSA-MIR-3714	99.71	70.74	2671
HSA-MIR-1283	99.69	72.42	3009
HSA-MIR-6892-3P	99.68	66.40	1178
HSA-MIR-651-5P	99.64	68.49	1104
HSA-MIR-510-3P	99.54	70.06	2965
HSA-MIR-7106-5P	99.53	67.47	3574
HSA-MIR-208A-5P	99.42	70.83	1913
HSA-MIR-208B-5P	99.42	70.83	1952
HSA-MIR-183-3P	99.41	69.41	1598
HSA-MIR-4311	99.31	70.47	3041
HSA-MIR-3925-5P	99.21	67.90	1466
HSA-MIR-6071	99.16	67.77	1780
HSA-MIR-670-3P	99.03	68.88	2404
HSA-MIR-3124-3P	98.87	68.95	2123
HSA-MIR-1237-3P	98.55	67.65	1423
HSA-MIR-5088-3P	98.29	66.63	1310
HSA-MIR-93-3P	98.15	66.65	1309
HSA-MIR-335-5P	97.10	68.12	1022
HSA-MIR-598-3P	89.25	67.61	112

Literature-anchored findings (GeneRIF, showing 9)

• results exclude TPST1 as the causative gene for Shwachman-Diamond syndrome (PMID:12032733)
• Shear stress-dependent downregulation of TPST1 in human endothelium involves protein kinase C (PMID:12056800)
• Tyrosine sulfation of CCR5 N-terminal peptide follows a discrete pattern and temporal sequence (PMID:12169668)
• Affinity purified salivary TPST showed a single band of 50-54 kDa and is the first report characterizing a tyrosylprotein sulfotransferase in secretory fluid from the parotid gland (PMID:16244708)
• Human tyrosylprotein sulfotransferase may be functional as homodimer/oligomer in the trans-Golgi compartment. (PMID:16859706)
• The kinetic parameters of tyrosylprotein sulfotransferase-1 and -2, catalyzing tyrosine sulfation of CCR8 peptides, were determined using liquid chromatography electrospray ionisation mass spectrometry. (PMID:18672380)
• up-regulation of TPST-1 and tyrosine sulfation of CXCR4 by LMP1 might be a potential mechanism contributing to nasopharyngeal carcinoma metastasis (PMID:23472069)
• TPST1 rs3757417T>G polymorphisms are associated with colorectal cancer. (PMID:25079514)
• TPST1 was significantly negatively correlated with the expression of cMet in lung cancer and may be a negative prognostic biomarker of lung cancer. (PMID:26238632)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	tpst1	ENSDARG00000073872
mus_musculus	Tpst1	ENSMUSG00000034118
rattus_norvegicus	Tpst1	ENSRNOG00000000900
drosophila_melanogaster	Tpst	FBGN0086674
caenorhabditis_elegans		WBGENE00013737
caenorhabditis_elegans		WBGENE00018365

Paralogs (1): TPST2 (ENSG00000128294)

Protein

Protein identifiers

Protein-tyrosine sulfotransferase 1 — O60507 (reviewed: O60507)

Alternative names: Tyrosylprotein sulfotransferase 1

All UniProt accessions (3): O60507, C9J3I4, C9K0F3

UniProt curated annotations — full annotation on UniProt →

Function. Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3’-phosphoadenylyl sulfate (PAPS) as cosubstrate.

Subunit / interactions. Homodimer. Can also form heterodimers with TPST2.

Subcellular location. Golgi apparatus membrane.

Tissue specificity. Ubiquitous. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Post-translational modifications. N-glycosylated.

Similarity. Belongs to the protein sulfotransferase family.

RefSeq proteins (1): NP_003587* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR026634	TPST-like	Family
IPR027417	P-loop_NTPase	Homologous_superfamily

Pfam: PF13469

Enzyme classification (BRENDA):

• EC 2.8.2.20 — protein-tyrosine sulfotransferase (BRENDA: 19 organisms, 159 substrates, 69 inhibitors, 77 Km, 8 kcat entries)

Substrate kinetics (BRENDA)

36 substrates with measured Km, best-characterized 15. Km ranges are aggregated across organisms/conditions.

Substrate	Km (mM)	Measurements
3’-PHOSPHOADENYLYL SULFATE	0.0021–0.59	9
EAY	—	7
3’-PHOSPHOADENYLYLSULFATE	0.0003–0.02	4
VTDYYYPDI	0.0193–120	4
BENZYL-GLU-TYR	1.223–1.297	2
EEFHTDYIYTQDVK	0.071–0.457	2
P-SELECTIN GLYCOPROTEIN LIGAND-1	0.011–0.053	2
PEPTIDE HIR-(57-65)	0.24–0.41	2
PEPTIDE Y+1 TYROSINE	0.002–0.0044	2
PSGL-1	0.0097–0.0269	2
STATHERIN	0.04	2
TYR-TYR-TYR	0.0175–0.022	2
VTDSYYSYPDI	17–21	2
[Y+3 PEPTIDE]-L-TYROSINE	0.0018–0.0019	2
ATEFEFLDYDFL	0.0315	1

Catalyzed reactions (Rhea), 1 shown:

• L-tyrosyl-[protein] + 3’-phosphoadenylyl sulfate = O-sulfo-L-tyrosine-[protein] + adenosine 3’,5’-bisphosphate + H(+) (RHEA:16801)

UniProt features (44 total): helix 15, binding site 7, strand 6, topological domain 2, site 2, glycosylation site 2, disulfide bond 2, mutagenesis site 2, turn 2, chain 1, transmembrane region 1, region of interest 1, active site 1

Structure

Experimental structures (PDB)

3 structures.

PDB	Method	Resolution (Å)
5WRI	X-RAY DIFFRACTION	1.6
5WRJ	X-RAY DIFFRACTION	2.31
9WP1	X-RAY DIFFRACTION	3.2

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O60507-F1	91.62	0.78

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (3): 159 (transition state stabilizer); 286 (transition state stabilizer); 100 (proton donor/acceptor)

Ligand- & substrate-binding residues (7): 239; 286–295; 301; 79–83; 184; 192; 196

Disulfide bonds (2): 97–157, 226–234

Glycosylation sites (2): 60, 262

Mutagenesis-validated functional residues (2):

Position	Phenotype
60	loss of one glycosylation site. loss of n-glycosylation; when associated with a-262.
262	loss of one glycosylation site. loss of n-glycosylation; when associated with a-60.

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-156584	Cytosolic sulfonation of small molecules
R-HSA-163841	Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
R-HSA-9674519	Defective F8 sulfation at Y1699

MSigDB gene sets: 251 (showing top): GSE18804_SPLEEN_MACROPHAGE_VS_BRAIN_TUMORAL_MACROPHAGE_UP, REACTOME_BIOLOGICAL_OXIDATIONS, TTTGTAG_MIR520D, GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS, GOBP_SULFATION, GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS, GOBP_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS, GOCC_TRANS_GOLGI_NETWORK, LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_UP, RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP, FOSTER_TOLERANT_MACROPHAGE_UP, CHIARADONNA_NEOPLASTIC_TRANSFORMATION_CDC25_UP, GENTILE_UV_HIGH_DOSE_DN, GOBP_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, GOBP_ORGANIC_ACID_METABOLIC_PROCESS

GO Biological Process (3): post-translational protein modification (GO:0043687), 3’-phosphoadenosine 5’-phosphosulfate metabolic process (GO:0050427), peptidyl-tyrosine sulfation (GO:0006478)

GO Molecular Function (3): protein-tyrosine sulfotransferase activity (GO:0008476), protein homodimerization activity (GO:0042803), transferase activity (GO:0016740)

GO Cellular Component (5): Golgi membrane (GO:0000139), Golgi apparatus (GO:0005794), Golgi lumen (GO:0005796), trans-Golgi network (GO:0005802), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Phase II - Conjugation of compounds	1
Post-translational protein modification	1
Defective factor VIII causes hemophilia A	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
Golgi apparatus	2
protein modification process	1
sulfur compound metabolic process	1
purine ribonucleotide metabolic process	1
purine ribonucleoside bisphosphate metabolic process	1
oxoacid metabolic process	1
protein sulfation	1
peptidyl-tyrosine modification	1
sulfotransferase activity	1
catalytic activity, acting on a protein	1
identical protein binding	1
protein dimerization activity	1
catalytic activity	1
bounding membrane of organelle	1
cytoplasm	1
endomembrane system	1
intracellular membrane-bounded organelle	1
intracellular organelle lumen	1
Golgi apparatus subcompartment	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1799 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TPST1	SBDS	Q9Y3A5	806
TPST1	SELPLG	Q14242	594
TPST1	ELANE	P08246	543
TPST1	CCR2	P41597	522
TPST1	SLC35B2	Q8TB61	517
TPST1	PUSL1	Q8N0Z8	500
TPST1	SELP	P16109	480
TPST1	PSG2	P11465	480
TPST1	PAPSS1	O43252	461
TPST1	MTMR11	A4FU01	402
TPST1	WDR33	Q9C0J8	401
TPST1	CTNS	O60931	394
TPST1	SLC35B3	Q9H1N7	391
TPST1	PSD3	Q9NYI0	387
TPST1	HS2ST1	Q7LGA3	383

IntAct

30 interactions, top by confidence:

A	B	Type	Score
STX7	SNAP23	psi-mi:“MI:0914”(association)	0.640
TRDN	TMEM223	psi-mi:“MI:0914”(association)	0.640
B2M	KPNA3	psi-mi:“MI:0914”(association)	0.530
CSGALNACT2	TPST1	psi-mi:“MI:0914”(association)	0.530
KCNE3	RIOK3	psi-mi:“MI:0914”(association)	0.530
TPST1	TPST2	psi-mi:“MI:0914”(association)	0.530
TPST1	ACTB	psi-mi:“MI:0915”(physical association)	0.400
TPST1	HSPA5	psi-mi:“MI:0915”(physical association)	0.400
ADGRE5	TMEM223	psi-mi:“MI:0914”(association)	0.350
SCGB2A2	GXYLT2	psi-mi:“MI:0914”(association)	0.350
GINM1	TNFRSF10B	psi-mi:“MI:0914”(association)	0.350
PDGFRA	GXYLT2	psi-mi:“MI:0914”(association)	0.350
CLEC12B	GXYLT2	psi-mi:“MI:0914”(association)	0.350
SCGB2A2	RTL8C	psi-mi:“MI:0914”(association)	0.350
TPST2	NDC80	psi-mi:“MI:0914”(association)	0.350
PMCH	B4GALT5	psi-mi:“MI:0914”(association)	0.350
C1orf54	QSOX1	psi-mi:“MI:0914”(association)	0.350
GDPD5	TMEM120B	psi-mi:“MI:0914”(association)	0.350
SDC1	TCAF2	psi-mi:“MI:0914”(association)	0.350
SLC30A10	GOLIM4	psi-mi:“MI:0914”(association)	0.350
SLC39A4	ESYT2	psi-mi:“MI:0914”(association)	0.350
SLC7A11	PSMD9	psi-mi:“MI:0914”(association)	0.350
SLC7A14	ESYT2	psi-mi:“MI:0914”(association)	0.350
SLC7A8	SPTLC1	psi-mi:“MI:0914”(association)	0.350

BioGRID (35): ACTB (Affinity Capture-MS), TPST1 (Affinity Capture-MS), TPST1 (Affinity Capture-MS), TPST1 (Affinity Capture-MS), TPST1 (Affinity Capture-MS), ACTB (Affinity Capture-MS), TPST1 (Affinity Capture-MS), TPST1 (Affinity Capture-RNA), TPST1 (Affinity Capture-MS), TPST1 (Affinity Capture-MS), TPST1 (Affinity Capture-MS), TPST1 (Affinity Capture-MS), TPST1 (Affinity Capture-MS), TPST1 (Affinity Capture-MS), TPST1 (Affinity Capture-MS)

ESM2 similar proteins: A5GFW8, A5Z2X3, E9Q649, F1QWZ4, L7YAI7, O15466, O35696, O43173, O43529, O54702, O60507, O70281, O93403, P54751, P61643, P61644, P61645, P61646, P70126, Q02745, Q07977, Q09272, Q11200, Q11201, Q16WU7, Q18078, Q18079, Q29G54, Q3KR92, Q5RBZ6, Q5ZIE4, Q64689, Q64690, Q64692, Q6AXM1, Q6GNS1, Q6KB59, Q6PGK7, Q6ZNI0, Q6ZXC8

Diamond homologs: A8XLL3, O60507, O60704, O70281, O77081, O88856, Q20351, Q3KR92, Q3SYY2, Q4R863, Q5RJS8, Q5ZJI0, Q9PTE6, Q9VYB7, P55472

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

48 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	45
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1407 predictions. Top by Δscore:

Variant	Effect	Δscore
7:66286509:A:AG	acceptor_gain	1.0000
7:66286509:AGAGT:A	acceptor_gain	1.0000
7:66286510:G:GA	acceptor_gain	1.0000
7:66286510:GA:G	acceptor_gain	1.0000
7:66286510:GAGT:G	acceptor_gain	1.0000
7:66286510:GAGTG:G	acceptor_gain	1.0000
7:66286705:GAAGG:G	donor_gain	1.0000
7:66286706:AAGG:A	donor_gain	1.0000
7:66286707:AGG:A	donor_gain	1.0000
7:66286708:GG:G	donor_gain	1.0000
7:66286708:GGG:G	donor_gain	1.0000
7:66286708:GGGTA:G	donor_loss	1.0000
7:66286709:GG:G	donor_gain	1.0000
7:66286710:G:GG	donor_gain	1.0000
7:66286711:T:G	donor_loss	1.0000
7:66224423:C:T	donor_gain	0.9900
7:66286507:TCAG:T	acceptor_gain	0.9900
7:66286508:CAG:C	acceptor_gain	0.9900
7:66286509:AGA:A	acceptor_gain	0.9900
7:66286510:G:T	acceptor_gain	0.9900
7:66205523:GT:G	donor_loss	0.9800
7:66205524:T:A	donor_loss	0.9800
7:66205919:GTT:G	donor_gain	0.9800
7:66228416:T:G	donor_gain	0.9800
7:66240324:GAT:G	acceptor_gain	0.9800
7:66241271:G:GG	donor_gain	0.9800
7:66286499:T:TA	acceptor_gain	0.9800
7:66326288:AATTC:A	donor_gain	0.9800
7:66326289:ATTCA:A	donor_gain	0.9800
7:66356823:A:AG	acceptor_gain	0.9800

AlphaMissense

2415 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:66240666:G:A	G81R	1.000
7:66240666:G:C	G81R	1.000
7:66240667:G:A	G81E	1.000
7:66240667:G:T	G81V	1.000
7:66240676:T:C	L84P	1.000
7:66240682:G:T	R86M	1.000
7:66240714:T:C	C97R	1.000
7:66240715:G:A	C97Y	1.000
7:66240716:T:G	C97W	1.000
7:66240723:G:A	E100K	1.000
7:66240724:A:T	E100V	1.000
7:66240733:T:A	V103D	1.000
7:66240796:T:C	L124P	1.000
7:66240811:T:A	V129D	1.000
7:66240835:C:A	A137D	1.000
7:66240894:T:C	C157R	1.000
7:66240895:G:A	C157Y	1.000
7:66240896:T:G	C157W	1.000
7:66240900:A:C	K159Q	1.000
7:66240900:A:G	K159E	1.000
7:66240901:A:T	K159I	1.000
7:66240902:A:C	K159N	1.000
7:66240902:A:T	K159N	1.000
7:66240903:G:C	D160H	1.000
7:66240904:A:G	D160G	1.000
7:66240979:A:T	D185V	1.000
7:66240999:T:C	S192P	1.000
7:66241068:T:A	W215R	1.000
7:66241068:T:C	W215R	1.000
7:66241070:G:C	W215C	1.000

dbSNP variants (sampled 300 via entrez): RS1000007360 (7:66341149 G>A), RS1000047648 (7:66293737 T>C), RS1000055980 (7:66254191 T>TG), RS1000079758 (7:66323021 T>C), RS1000127791 (7:66254459 A>G), RS1000144849 (7:66236487 T>C), RS1000147905 (7:66281347 T>A,G), RS1000196965 (7:66203776 C>T), RS1000201224 (7:66281683 G>C), RS1000205422 (7:66296249 C>T), RS1000238458 (7:66199433 T>C), RS1000251899 (7:66354411 GT>G), RS1000268995 (7:66327265 A>C), RS1000310027 (7:66307410 G>A), RS1000313697 (7:66321646 G>A)

Disease associations

OMIM: gene MIM:603125 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST001356_6	Gout	1.000000e-07
GCST001356_7	Gout	1.000000e-07
GCST006585_2642	Blood protein levels	1.000000e-31

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

36 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases expression	2
Dexamethasone	decreases expression, affects cotreatment, increases expression	2
Estradiol	affects cotreatment, increases expression	2
Cadmium Chloride	increases expression	2
Particulate Matter	decreases expression, increases abundance, affects expression, increases reaction	2
bisphenol F	affects cotreatment, increases expression	1
triphenyl phosphate	affects expression	1
glycidyl methacrylate	increases expression	1
lead acetate	increases expression	1
trichostatin A	affects expression	1
potassium chromate(VI)	decreases expression, affects cotreatment	1
tibolone	increases expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
di-n-butylphosphoric acid	affects expression	1
oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	affects expression, increases reaction	1
(+)-JQ1 compound	increases expression	1
Sunitinib	decreases expression	1
Norethindrone Acetate	affects cotreatment, increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Atrazine	decreases expression	1
Vehicle Emissions	affects expression, increases reaction	1
Benzo(a)pyrene	increases methylation	1
Calcitriol	increases expression	1
Carcinogens	decreases expression	1
Cytarabine	decreases expression	1
Indomethacin	affects cotreatment, increases expression	1
Mutagens	decreases expression	1
Silicon Dioxide	decreases expression	1
Thiram	increases expression	1
Tretinoin	increases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D8CV	Ubigene A-549 TPST1 KO	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.