TPT1-AS1

Summary

TPT1-AS1 (TPT1 antisense RNA 1, HGNC:43686) is a long non-coding RNA gene on chromosome 13q14.13.

Biomarker of malignant astrocytoma.

Source: NCBI Gene 100190939 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43686
Approved symbol	TPT1-AS1
Name	TPT1 antisense RNA 1
Location	13q14.13
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000170919
Ensembl biotype	lncRNA
Entrez	100190939
RNAcentral	URS0000759A07 — lncRNA, 1581 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 60 — 53 lncRNA, 7 retained_intron

ENST00000330825, ENST00000379050, ENST00000412946, ENST00000434849, ENST00000517509, ENST00000519454, ENST00000520310, ENST00000520432, ENST00000520585, ENST00000520590, ENST00000520622, ENST00000520924, ENST00000521336, ENST00000521507, ENST00000522673, ENST00000522845, ENST00000522859, ENST00000523445, ENST00000523506, ENST00000524062, ENST00000618947, ENST00000619457, ENST00000652823, ENST00000653307, ENST00000654229, ENST00000654626, ENST00000655124, ENST00000655385, ENST00000655666, ENST00000655984, ENST00000657761, ENST00000658500, ENST00000658870, ENST00000659577, ENST00000660680, ENST00000661180, ENST00000661291, ENST00000662212, ENST00000662614, ENST00000663584, ENST00000664881, ENST00000665079, ENST00000665586, ENST00000665962, ENST00000667948, ENST00000668209, ENST00000668256, ENST00000669281, ENST00000669627, ENST00000670765, ENST00000822143, ENST00000822144, ENST00000822145, ENST00000822146, ENST00000822147, ENST00000822148, ENST00000822149, ENST00000822150, ENST00000822151, ENST00000822152

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000330825 — 3 exons

Exon	Start	End
ENSE00001760321	45390714	45390902
ENSE00002113792	45387585	45389820
ENSE00003867540	45391032	45391676

Expression profiles

Bgee: expression breadth ubiquitous, 230 present calls, max score 95.75.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 12.0502 / max 100.8628, expressed in 1772 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
134968	4.5193	1632
134966	3.1352	1263
134965	2.5144	817
134967	1.8812	1056

Top tissues by expression

249 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	95.75	gold quality
right testis	UBERON:0004534	95.30	gold quality
mucosa of stomach	UBERON:0001199	95.15	gold quality
left ovary	UBERON:0002119	94.29	gold quality
oviduct epithelium	UBERON:0004804	93.68	gold quality
body of uterus	UBERON:0009853	93.44	gold quality
testis	UBERON:0000473	93.41	gold quality
right ovary	UBERON:0002118	93.08	gold quality
tibial nerve	UBERON:0001323	92.84	gold quality
right hemisphere of cerebellum	UBERON:0014890	92.62	gold quality
right uterine tube	UBERON:0001302	92.60	gold quality
endocervix	UBERON:0000458	92.42	gold quality
cerebellar hemisphere	UBERON:0002245	92.27	gold quality
cerebellar cortex	UBERON:0002129	92.22	gold quality
sural nerve	UBERON:0015488	91.93	gold quality
right coronary artery	UBERON:0001625	91.75	gold quality
popliteal artery	UBERON:0002250	91.75	gold quality
tibial artery	UBERON:0007610	91.75	gold quality
ovary	UBERON:0000992	91.68	gold quality
left uterine tube	UBERON:0001303	91.68	gold quality
ectocervix	UBERON:0012249	91.55	gold quality
aorta	UBERON:0000947	91.20	gold quality
ascending aorta	UBERON:0001496	90.96	gold quality
ventricular zone	UBERON:0003053	90.93	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	90.82	gold quality
cerebellum	UBERON:0002037	90.78	gold quality
thoracic aorta	UBERON:0001515	90.77	gold quality
lower esophagus muscularis layer	UBERON:0035833	90.59	gold quality
lower esophagus	UBERON:0013473	90.57	gold quality
descending thoracic aorta	UBERON:0002345	90.56	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-9543	yes	17.82
E-ANND-3	yes	9.92

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 12)

• Study found TPT1-AS1 expression significantly higher in epithelial ovarian cancer (EOC) metastatic tissue and cell lines. LncRNA TPT1-AS1 facilitates EOC tumor growth and metastasis, and inhibits cell adhesion by inducing TPT1 expression and phosphorylation of PI3K/AKT signaling pathway in vitro and in vivo. These findings suggest that TPT1-AS1 may function as a tumor oncogene. (PMID:30941821)
• Long noncoding RNA TPT1-AS1 downregulates the microRNA-770-5p expression to inhibit glioma cell autophagy and promote proliferation through STMN1 upregulation. (PMID:31637705)
• Knockdown of TPT1-AS1 inhibits cell proliferation, cell cycle G1/S transition, and epithelial-mesenchymal transition in gastric cancer. (PMID:32156253)
• LncRNA TPT1-AS1 Sponges miR-23a-5p in Glioblastoma to Promote Cancer Cell Proliferation. (PMID:32783743)
• Long noncoding RNA TPT1-AS1 promotes the progression and metastasis of colorectal cancer by upregulating the TPT1-mediated FAK and JAK-STAT3 signalling pathways. (PMID:33428595)
• lncRNA TPT1AS1 knockdown inhibits liver cancer cell proliferation, migration and invasion. (PMID:34498708)
• [Effects of tumor protein translation control antisense RNA1 on radiosensitivity, proliferation, migration and invasion of hepatocellular carcinoma cells by targeting miR-30c-5p]. (PMID:34695895)
• Long Non-coding RNA TPT1-AS1 Suppresses APC Transcription in a STAT1-Dependent Manner to Increase the Stemness of Colorectal Cancer Stem Cells. (PMID:35022996)
• Overexpression of IncRNA TPT1-AS1 Suppresses Hepatocellular Carcinoma Cell Proliferation by Downregulating CDK2. (PMID:35377976)
• Positive feedback regulation of lncRNA TPT1-AS1 and ITGB3 promotes cell growth and metastasis in pancreatic cancer. (PMID:35534983)
• A review of literature: role of long noncoding RNA TPT1-AS1 in human diseases. (PMID:36112261)
• Clinicopathological and prognostic value of lncRNA TPT1-AS1 in cancer: A systematic review study and meta-analysis. (PMID:37004278)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.