TRAF3IP2-AS1

Summary

TRAF3IP2-AS1 (TRAF3IP2 antisense RNA 1, HGNC:40005) is a long non-coding RNA gene on chromosome 6q21.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40005
Approved symbol	TRAF3IP2-AS1
Name	TRAF3IP2 antisense RNA 1
Location	6q21
Locus type	RNA, long non-coding
Status	Approved
Aliases	C6UAS, BetaFAAR
Ensembl gene	ENSG00000231889
Ensembl biotype	lncRNA
Entrez	643749
RNAcentral	URS000075A5FA — lncRNA, 4943 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 32 — 32 lncRNA

ENST00000420651, ENST00000438298, ENST00000440001, ENST00000440395, ENST00000442928, ENST00000449449, ENST00000456352, ENST00000525151, ENST00000532226, ENST00000532353, ENST00000606892, ENST00000607066, ENST00000685477, ENST00000687951, ENST00000691364, ENST00000702563, ENST00000833698, ENST00000833699, ENST00000833700, ENST00000833701, ENST00000833702, ENST00000833703, ENST00000833704, ENST00000833705, ENST00000833706, ENST00000833707, ENST00000833708, ENST00000833709, ENST00000833710, ENST00000833711, ENST00000833712, ENST00000833713

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000420651 — 2 exons

Exon	Start	End
ENSE00002193412	111503296	111503608
ENSE00004250545	111483499	111483665

Expression profiles

Bgee: expression breadth ubiquitous, 191 present calls, max score 92.35.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.9668 / max 296.9287, expressed in 1414 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
69295	1.6814	722
69297	1.4256	510
69294	0.9722	552
69296	0.8877	445

Top tissues by expression

242 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	92.35	gold quality
ventricular zone	UBERON:0003053	92.21	gold quality
ganglionic eminence	UBERON:0004023	91.70	gold quality
right uterine tube	UBERON:0001302	89.91	gold quality
oviduct epithelium	UBERON:0004804	89.29	gold quality
body of uterus	UBERON:0009853	88.76	gold quality
sural nerve	UBERON:0015488	87.86	gold quality
right hemisphere of cerebellum	UBERON:0014890	87.49	gold quality
cerebellar hemisphere	UBERON:0002245	87.47	gold quality
calcaneal tendon	UBERON:0003701	87.36	gold quality
cerebellar cortex	UBERON:0002129	87.29	gold quality
endocervix	UBERON:0000458	86.96	gold quality
anterior cingulate cortex	UBERON:0009835	86.64	gold quality
colonic epithelium	UBERON:0000397	86.63	gold quality
nucleus accumbens	UBERON:0001882	86.59	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	86.27	gold quality
hypothalamus	UBERON:0001898	86.20	gold quality
Brodmann (1909) area 9	UBERON:0013540	85.84	gold quality
amygdala	UBERON:0001876	85.61	gold quality
caudate nucleus	UBERON:0001873	85.58	gold quality
adenohypophysis	UBERON:0002196	85.53	gold quality
ectocervix	UBERON:0012249	85.43	gold quality
cerebellum	UBERON:0002037	85.36	gold quality
right frontal lobe	UBERON:0002810	85.33	gold quality
putamen	UBERON:0001874	84.82	gold quality
tibial artery	UBERON:0007610	84.74	gold quality
popliteal artery	UBERON:0002250	84.73	gold quality
right ovary	UBERON:0002118	84.36	gold quality
left ovary	UBERON:0002119	84.23	gold quality
spinal cord	UBERON:0002240	83.83	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.67

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Low expression of TRAF3IP2-AS1 promotes progression of NONO-TFE3 translocation renal cell carcinoma by stimulating N(6)-methyladenosine of PARP1 mRNA and downregulating PTEN. (PMID:33741027)
• Identification of a Long Noncoding RNA TRAF3IP2-AS1 as Key Regulator of IL-17 Signaling through the SRSF10-IRF1-Act1 Axis in Autoimmune Diseases. (PMID:33941656)
• IncRNA TRAF3IP2-AS1 Restrains Cervical Cancer Progression by Sponging miR-3677-3p and Acts As a Diagnostic Marker in Cervical Cancer. (PMID:36374810)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.