TRAF3IP3

Summary

TRAF3IP3 (TRAF3 interacting protein 3, HGNC:30766) is a protein-coding gene on chromosome 1q32.2, encoding TRAF3-interacting JNK-activating modulator (Q9Y228). Adapter protein that plays essential roles in both innate and adaptive immunity.

The gene encodes a protein that mediates cell growth by modulating the c-Jun N-terminal kinase signal transduction pathway. The encoded protein may also interact with a large multi-protein assembly containing the phosphatase 2A catalytic subunit. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 80342 — RefSeq curated summary.

At a glance

• GWAS associations: 11
• Clinical variants (ClinVar): 67 total
• MANE Select transcript: NM_025228

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30766
Approved symbol	TRAF3IP3
Name	TRAF3 interacting protein 3
Location	1q32.2
Locus type	gene with protein product
Status	Approved
Aliases	T3JAM
Ensembl gene	ENSG00000009790
Ensembl biotype	protein_coding
OMIM	608255
Entrez	80342

Gene structure

Transcript identifiers

Ensembl transcripts: 22 — 14 protein_coding, 3 retained_intron, 3 protein_coding_CDS_not_defined, 2 nonsense_mediated_decay

ENST00000367023, ENST00000367024, ENST00000367025, ENST00000367026, ENST00000400959, ENST00000460314, ENST00000467830, ENST00000468672, ENST00000471368, ENST00000474496, ENST00000476050, ENST00000477431, ENST00000478359, ENST00000479796, ENST00000487271, ENST00000488702, ENST00000884880, ENST00000884881, ENST00000884882, ENST00000884883, ENST00000884884, ENST00000957589

RefSeq mRNA: 4 — MANE Select: NM_025228 NM_001287754, NM_001320143, NM_001320144, NM_025228

CCDS: CCDS1490, CCDS73023, CCDS81422

Canonical transcript exons

ENST00000367025 — 17 exons

Exon	Start	End
ENSE00000792126	209780470	209780606
ENSE00001248122	209779315	209779374
ENSE00001443283	209759034	209759134
ENSE00001900931	209756053	209756309
ENSE00001913729	209782056	209782310
ENSE00002213174	209762813	209762870
ENSE00002221582	209775599	209775736
ENSE00002262885	209763363	209763392
ENSE00002267091	209762515	209762662
ENSE00002284279	209763492	209763587
ENSE00002302242	209759982	209760384
ENSE00002320911	209763068	209763092
ENSE00003479474	209777352	209777487
ENSE00003500170	209781345	209781458
ENSE00003516467	209772948	209773019
ENSE00003679353	209778111	209778173
ENSE00003694681	209775349	209775489

Expression profiles

Bgee: expression breadth ubiquitous, 205 present calls, max score 99.12.

FANTOM5 (CAGE): breadth broad, TPM avg 18.0491 / max 706.3126, expressed in 490 samples.

FANTOM5 promoters (10 alternative TSS)

Promoter ID	TPM avg	Samples expressed
8356	4.4034	355
8366	3.7747	316
8355	3.4173	314
8367	2.7284	218
8357	2.5598	260
8365	0.5581	209
8368	0.3317	98
8363	0.1526	51
8364	0.0831	46
8354	0.0400	19

Top tissues by expression

281 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	99.12	gold quality
leukocyte	CL:0000738	97.98	gold quality
monocyte	CL:0000576	97.94	gold quality
mononuclear cell	CL:0000842	97.91	gold quality
blood	UBERON:0000178	97.40	gold quality
spleen	UBERON:0002106	96.53	gold quality
lymph node	UBERON:0000029	96.39	gold quality
vermiform appendix	UBERON:0001154	95.23	gold quality
bone marrow cell	CL:0002092	94.24	gold quality
thymus	UBERON:0002370	94.03	gold quality
bone marrow	UBERON:0002371	92.79	gold quality
epithelium of nasopharynx	UBERON:0001951	90.33	gold quality
caecum	UBERON:0001153	89.99	gold quality
trabecular bone tissue	UBERON:0002483	88.96	gold quality
tonsil	UBERON:0002372	88.87	gold quality
small intestine Peyer’s patch	UBERON:0003454	88.85	gold quality
gall bladder	UBERON:0002110	86.19	gold quality
rectum	UBERON:0001052	86.16	gold quality
small intestine	UBERON:0002108	86.14	gold quality
mucosa of transverse colon	UBERON:0004991	83.37	gold quality
superficial temporal artery	UBERON:0001614	82.71	gold quality
upper lobe of left lung	UBERON:0008952	82.68	gold quality
right lung	UBERON:0002167	82.48	gold quality
buccal mucosa cell	CL:0002336	82.46	gold quality
amniotic fluid	UBERON:0000173	82.07	gold quality
upper lobe of lung	UBERON:0008948	81.26	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	80.56	gold quality
colonic epithelium	UBERON:0000397	79.51	gold quality
right coronary artery	UBERON:0001625	79.06	gold quality
body of stomach	UBERON:0001161	77.13	gold quality

Single-cell (SCXA)

Detected in 11 experiment(s), a significant marker in 9.

Experiment	Marker?	Max mean expression
E-MTAB-6701	yes	74.77
E-CURD-122	yes	37.32
E-MTAB-10287	yes	31.34
E-MTAB-8410	yes	21.86
E-HCAD-10	yes	21.47
E-HCAD-1	yes	18.13
E-CURD-112	yes	7.93
E-GEOD-130148	yes	3.69
E-MTAB-7606	no	1224.07
E-MTAB-6379	no	1046.64
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

18 targeting TRAF3IP3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-636	99.80	69.58	1500
HSA-MIR-3942-3P	99.57	69.03	2854
HSA-MIR-7159-5P	99.53	72.12	2472
HSA-MIR-6832-3P	99.52	70.44	1726
HSA-MIR-203A-3P	99.49	70.56	2806
HSA-MIR-940	99.37	66.14	2064
HSA-MIR-6808-5P	99.31	66.23	2150
HSA-MIR-6893-5P	99.31	66.25	2119
HSA-MIR-4777-3P	99.15	68.92	626
HSA-MIR-421	98.90	67.04	1883
HSA-MIR-3144-3P	98.15	67.34	677
HSA-MIR-4736	97.96	65.89	1287
HSA-MIR-1910-5P	97.42	66.36	844
HSA-MIR-875-5P	96.74	66.48	579
HSA-MIR-3059-3P	96.71	67.08	606

Literature-anchored findings (GeneRIF, showing 8)

• This paper provides an alignment of the mouse and human proteins. (PMID:14572659)
• TRAF3IP3 stimulated cell growth by modulating the c-Jun N-terminal kinase (JNK) pathway (PMID:17868742)
• Tumor microarray analysis on 23 primary melanoma and nine positive lymph nodes revealed that 70% of human primary melanoma and 66% of lymph node metastases were positive for TRAF3IP3. Immunohistochemistry analysis of the tumors revealed that TRAF3IP3-shRNA tumors had increased apoptosis and reduced microvascular density. (PMID:29553967)
• Findings uncover TRAF3IP3 as an important regulator for RIG-I-MAVS signaling, which bridges MAVS and TRAF3 for an effective antiviral innate immune response. (PMID:31390091)
• Secondary Genome-Wide Association Study Using Novel Analytical Strategies Disentangle Genetic Components of Cleft Lip and/or Cleft Palate in 1q32.2. (PMID:33137956)
• High TRAF3IP3 Level Predicts Poor Prognosis of Patients with Gliomas. (PMID:33444836)
• Novel germline TRAF3IP3 mutation in a dyad with familial acute B lymphoblastic leukemia. (PMID:33503336)
• The variants in PTPRB, TRAF3IP3, and DISC1 genes were associated with Graves’ disease in the Chinese population. (PMID:36397361)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Traf3ip3	ENSMUSG00000037318
rattus_norvegicus	Traf3ip3	ENSRNOG00000005565
drosophila_melanogaster	Slmap	FBGN0040011
caenorhabditis_elegans		WBGENE00019766

Paralogs (2): CCDC136 (ENSG00000128596), SLMAP (ENSG00000163681)

Protein

Protein identifiers

TRAF3-interacting JNK-activating modulator — Q9Y228 (reviewed: Q9Y228)

Alternative names: TRAF3-interacting protein 3

All UniProt accessions (7): Q9Y228, B1AJU2, C9J0C0, C9JBA0, C9JXB3, E2QRE5, H0YF09

UniProt curated annotations — full annotation on UniProt →

Function. Adapter protein that plays essential roles in both innate and adaptive immunity. Plays a crucial role in the regulation of thymocyte development. Mechanistically, mediates TCR-stimulated activation through recruiting MAP2K1/MEK1 to the Golgi and, thereby, facilitating the interaction of MAP2K1/MEK1 with its activator BRAF. Also plays an essential role in regulatory T-cell stability and function by recruiting the serine-threonine phosphatase catalytic subunit (PPP2CA) to the lysosome, thereby facilitating the interaction of PP2Ac with the mTORC1 component RPTOR and restricting glycolytic metabolism. Positively regulates TLR4 signaling activity in macrophage-mediated inflammation by acting as a molecular clamp to facilitate LPS-induced translocation of TLR4 to lipid rafts. In response to viral infection, facilitates the recruitment of TRAF3 to MAVS within mitochondria leading to IRF3 activation and interferon production. However, participates in the maintenance of immune homeostasis and the prevention of overzealous innate immunity by promoting ‘Lys-48’-dependent ubiquitination of TBK1.

Subunit / interactions. Interacts (via its coiled-coil domain) with TRAF3 (via isoleucine zipper). Interacts with MAP2K1. Interacts with PPP2CA; this interaction targets PPP2CA to the lysosomes. Interacts with TLR4. Interacts with MAVS. Interacts with TBK1.

Subcellular location. Cell membrane. Golgi apparatus membrane. Lysosome membrane. Mitochondrion outer membrane.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9Y228-1	1	yes
Q9Y228-2	2
Q9Y228-3	3

RefSeq proteins (4): NP_001274683, NP_001307072, NP_001307073, NP_079504* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR051176	Cent_Immune-Sig_Mod	Family

UniProt features (13 total): splice variant 3, topological domain 2, sequence variant 2, region of interest 2, coiled-coil region 2, chain 1, transmembrane region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y228-F1	74.77	0.43

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 215 (showing top): BROWNE_HCMV_INFECTION_30MIN_DN, MULLIGHAN_NPM1_SIGNATURE_3_UP, GNF2_CASP8, GOBP_POSITIVE_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION, GOBP_RESPONSE_TO_PEPTIDE, GOCC_VACUOLAR_MEMBRANE, GOBP_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION, GOBP_RESPONSE_TO_INTERFERON_BETA, GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS, BROWNE_HCMV_INFECTION_48HR_DN, GOBP_REGULATION_OF_IMMUNE_RESPONSE, GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM, DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN, GOBP_POSITIVE_REGULATION_OF_INTERFERON_BETA_PRODUCTION, SU_THYMUS

GO Biological Process (5): cytoplasmic pattern recognition receptor signaling pathway (GO:0002753), positive regulation of type I interferon production (GO:0032481), positive regulation of interferon-beta production (GO:0032728), cellular response to interferon-beta (GO:0035458), antiviral innate immune response (GO:0140374)

GO Molecular Function (4): protein-macromolecule adaptor activity (GO:0030674), zf-TRAF domain binding (GO:0044198), molecular adaptor activity (GO:0060090), protein binding (GO:0005515)

GO Cellular Component (10): Golgi membrane (GO:0000139), mitochondrion (GO:0005739), mitochondrial outer membrane (GO:0005741), lysosomal membrane (GO:0005765), endoplasmic reticulum membrane (GO:0005789), plasma membrane (GO:0005886), mitochondrial membrane (GO:0031966), lysosome (GO:0005764), Golgi apparatus (GO:0005794), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
positive regulation of cytokine production	2
binding	2
cytoplasm	2
intracellular membrane-bounded organelle	2
organelle membrane	2
pattern recognition receptor signaling pathway	1
intracellular receptor signaling pathway	1
regulation of type I interferon production	1
type I interferon production	1
positive regulation of type I interferon production	1
interferon-beta production	1
regulation of interferon-beta production	1
response to interferon-beta	1
cellular response to cytokine stimulus	1
innate immune response	1
defense response to virus	1
protein binding	1
molecular adaptor activity	1
protein domain specific binding	1
molecular_function	1
Golgi apparatus	1
bounding membrane of organelle	1
mitochondrial membrane	1
organelle outer membrane	1
lysosome	1
lytic vacuole membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
membrane	1
cell periphery	1
mitochondrion	1
mitochondrial envelope	1
lytic vacuole	1
endomembrane system	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1566 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TRAF3IP3	TRAF3	Q13114	974
TRAF3IP3	FGFR1OP2	Q9NVK5	572
TRAF3IP3	OTUD5	Q96G74	549
TRAF3IP3	C1orf74	Q96LT6	544
TRAF3IP3	TBK1	Q9UHD2	497
TRAF3IP3	IKBKE	Q14164	496
TRAF3IP3	RDX	P35241	469
TRAF3IP3	ATG16L1	Q676U5	458
TRAF3IP3	TRAF1	Q13077	450
TRAF3IP3	LTBR	P36941	445
TRAF3IP3	CRNKL1	Q9BZJ0	430
TRAF3IP3	MSN	P26038	429
TRAF3IP3	SLC7A6	Q92536	426
TRAF3IP3	TRIL	Q7L0X0	422
TRAF3IP3	FAM170A	A1A519	416

IntAct

198 interactions, top by confidence:

A	B	Type	Score
EMD	TRAF3IP3	psi-mi:“MI:0915”(physical association)	0.810
TRAF3IP3	EMD	psi-mi:“MI:0915”(physical association)	0.810
KASH5	TRAF3IP3	psi-mi:“MI:0915”(physical association)	0.720
FATE1	TRAF3IP3	psi-mi:“MI:0915”(physical association)	0.720
TRAF3IP3	NDEL1	psi-mi:“MI:0915”(physical association)	0.720
NDEL1	TRAF3IP3	psi-mi:“MI:0915”(physical association)	0.720
TRAF3IP3	FATE1	psi-mi:“MI:0915”(physical association)	0.720
TRAF3IP3	SP100	psi-mi:“MI:0915”(physical association)	0.670
TFIP11	TRAF3IP3	psi-mi:“MI:0915”(physical association)	0.670
SP100	TRAF3IP3	psi-mi:“MI:0915”(physical association)	0.670
TRAF3IP3	TFIP11	psi-mi:“MI:0915”(physical association)	0.670
TRAF3IP3	STRN	psi-mi:“MI:0915”(physical association)	0.620
STRIP1	TRAF3IP3	psi-mi:“MI:0915”(physical association)	0.620
TRAF3IP3	STRN3	psi-mi:“MI:0915”(physical association)	0.620

BioGRID (128): TRAF3IP3 (Two-hybrid), TRAF3IP3 (Two-hybrid), TRAF3IP3 (Two-hybrid), TRAF3IP3 (Two-hybrid), TRAF3IP3 (Two-hybrid), TRAF3IP3 (Two-hybrid), TRAF3IP3 (Two-hybrid), TRAF3IP3 (Two-hybrid), NDEL1 (Two-hybrid), FATE1 (Two-hybrid), CCDC155 (Two-hybrid), TRAF3IP3 (Two-hybrid), FGFR1OP2 (Affinity Capture-MS), SIKE1 (Affinity Capture-MS), STRIP2 (Affinity Capture-MS)

ESM2 similar proteins: A1L443, A2IDD5, A4IFI1, A6NJZ7, A6NNL0, A6NNM3, A8MT33, B1AL46, D3Z5T1, O95153, Q2M3G4, Q2T9R2, Q3TVI4, Q3TYX8, Q49AM3, Q4KLY2, Q569K6, Q5JTD0, Q5JXC2, Q5SSQ6, Q5SW24, Q5VT03, Q5VZR2, Q6ZNE9, Q7TN08, Q7TNF8, Q7Z591, Q80VJ8, Q810H6, Q811T9, Q86SX3, Q8C963, Q8CB62, Q8CII8, Q8IVF1, Q8IXR5, Q8N0S2, Q8N137, Q8N205, Q8N6L0

Diamond homologs: A6ZRW7, O74388, P0C219, P38823, P53924, Q03944, Q06001, Q10322, Q14BN4, Q28623, Q3URD3, Q8C0G2, Q9Y228, Q3TVA9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

67 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	57
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2517 predictions. Top by Δscore:

Variant	Effect	Δscore
1:209756307:G:GT	donor_gain	1.0000
1:209759033:GCA:G	acceptor_gain	1.0000
1:209759969:T:A	acceptor_gain	1.0000
1:209760240:G:GT	donor_gain	1.0000
1:209763393:G:GG	donor_gain	1.0000
1:209775336:A:AG	acceptor_gain	1.0000
1:209775337:T:G	acceptor_gain	1.0000
1:209775347:A:AG	acceptor_gain	1.0000
1:209775348:G:GG	acceptor_gain	1.0000
1:209775348:GAA:G	acceptor_gain	1.0000
1:209775488:AGGT:A	donor_loss	1.0000
1:209775489:GGTA:G	donor_loss	1.0000
1:209775490:GTATG:G	donor_loss	1.0000
1:209775491:T:G	donor_loss	1.0000
1:209775594:CTCA:C	acceptor_loss	1.0000
1:209775595:TCA:T	acceptor_loss	1.0000
1:209775596:CAG:C	acceptor_loss	1.0000
1:209775597:A:AG	acceptor_gain	1.0000
1:209775597:AGC:A	acceptor_gain	1.0000
1:209775598:G:GG	acceptor_gain	1.0000
1:209775598:G:GT	acceptor_loss	1.0000
1:209775598:GC:G	acceptor_gain	1.0000
1:209775598:GCG:G	acceptor_gain	1.0000
1:209775598:GCGAT:G	acceptor_gain	1.0000
1:209775736:GGTA:G	donor_loss	1.0000
1:209777347:TACA:T	acceptor_loss	1.0000
1:209777348:ACAG:A	acceptor_gain	1.0000
1:209777350:AG:A	acceptor_gain	1.0000
1:209777351:GG:G	acceptor_gain	1.0000
1:209777351:GGGA:G	acceptor_gain	1.0000

AlphaMissense

3606 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:209763388:T:C	L201P	0.996
1:209763495:G:C	A204P	0.995
1:209775421:G:C	A283P	0.994
1:209763376:T:C	L197P	0.993
1:209763517:T:C	L211P	0.992
1:209763547:T:C	L221P	0.991
1:209763506:G:C	R207S	0.990
1:209763506:G:T	R207S	0.990
1:209763538:T:C	L218P	0.990
1:209763499:T:C	L205P	0.989
1:209763526:A:T	K214I	0.989
1:209773003:T:C	L253P	0.988
1:209775434:T:C	L287P	0.988
1:209763559:T:C	L225P	0.987
1:209772982:T:C	L246P	0.986
1:209772970:T:C	L242P	0.985
1:209775476:T:C	L301P	0.985
1:209763508:A:T	E208V	0.984
1:209763567:G:C	A228P	0.982
1:209775614:G:C	A311P	0.981
1:209763388:T:A	L201H	0.979
1:209775711:T:C	L343P	0.979
1:209763378:T:C	S198P	0.978
1:209763508:A:C	E208A	0.977
1:209775720:T:C	L346P	0.977
1:209763376:T:A	L197H	0.976
1:209773000:A:C	Q252P	0.976
1:209775430:T:C	S286P	0.976
1:209775732:T:C	L350P	0.976
1:209763527:A:C	K214N	0.975

dbSNP variants (sampled 300 via entrez): RS1000231099 (1:209758833 C>T), RS1000330841 (1:209755875 A>G), RS1000846417 (1:209772021 G>A,C), RS1000940950 (1:209770491 G>A), RS1000990256 (1:209757062 A>G), RS1001172374 (1:209766470 T>C), RS1001192790 (1:209778792 T>C), RS1001317061 (1:209776958 G>A), RS1001478446 (1:209759520 G>A), RS1001598924 (1:209778258 G>A), RS1001637753 (1:209770533 G>A,C), RS1001687214 (1:209766247 G>A), RS1001773527 (1:209771332 T>C), RS1001866391 (1:209779629 A>C), RS1001944322 (1:209758379 A>T)

Disease associations

OMIM: gene MIM:608255 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

11 associations (top):

Study	Trait	p-value
GCST004601_10	Red blood cell count	6.000000e-10
GCST004602_25	Mean corpuscular volume	9.000000e-10
GCST004630_19	Mean corpuscular hemoglobin	5.000000e-09
GCST004866_6	Alopecia areata	2.000000e-06
GCST006946_20	Worry too long after an embarrassing experience	4.000000e-08
GCST011088_2	Orofacial clefts	5.000000e-09
GCST90002390_336	Mean corpuscular hemoglobin	2.000000e-18
GCST90002392_250	Mean corpuscular volume	6.000000e-23
GCST90002396_161	Mean reticulocyte volume	3.000000e-17
GCST90002397_744	Mean spheric corpuscular volume	3.000000e-16
GCST90002403_60	Red blood cell count	8.000000e-18

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0004305	erythrocyte count
EFO:0004527	mean corpuscular hemoglobin
EFO:0009589	worry measurement
EFO:0010701	mean reticulocyte volume

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

27 total (human), top 27 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Tobacco Smoke Pollution	affects expression, decreases expression	3
sodium arsenite	increases expression, decreases expression	2
Benzo(a)pyrene	decreases expression, increases methylation	2
Nickel	decreases expression, increases expression	2
Cadmium Chloride	decreases expression, increases abundance, increases expression	2
GSK-J4	decreases expression	1
triphenyl phosphate	affects expression	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression	1
CGP 52608	affects binding, increases reaction	1
Grape Seed Proanthocyanidins	decreases expression, affects cotreatment	1
Acetaminophen	increases expression	1
Air Pollutants, Occupational	decreases expression	1
Arsenic	affects methylation	1
Cadmium	decreases expression, increases abundance	1
Catechin	affects cotreatment, decreases expression	1
Diuron	decreases expression	1
Lipopolysaccharides	decreases expression, affects response to substance, increases expression	1
Methyl Methanesulfonate	decreases expression	1
Silicon Dioxide	increases expression	1
Smoke	decreases expression	1
Thiram	increases expression	1
Vincristine	decreases expression	1
Isotretinoin	increases expression	1
Aflatoxin B1	increases methylation	1
Asbestos, Crocidolite	increases expression	1
Antirheumatic Agents	decreases expression	1
Okadaic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.