TRAK2

Summary

TRAK2 (trafficking kinesin protein 2, HGNC:13206) is a protein-coding gene on chromosome 2q33.1, encoding Trafficking kinesin-binding protein 2 (O60296). May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR.

Predicted to enable GABA receptor binding activity and myosin binding activity. Predicted to be involved in several processes, including mitochondrion distribution; protein O-linked glycosylation; and vesicle transport along microtubule. Predicted to be located in cytoplasm; nucleus; and plasma membrane. Predicted to be active in cytoplasmic vesicle; dendrite; and mitochondrion.

Source: NCBI Gene 66008 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 140 total
• MANE Select transcript: NM_015049

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:13206
Approved symbol	TRAK2
Name	trafficking kinesin protein 2
Location	2q33.1
Locus type	gene with protein product
Status	Approved
Aliases	CALS-C, KIAA0549, GRIF-1, OIP98, MILT2
Ensembl gene	ENSG00000115993
Ensembl biotype	protein_coding
OMIM	607334
Entrez	66008

Gene structure

Transcript identifiers

Ensembl transcripts: 17 — 15 protein_coding, 1 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000332624, ENST00000430254, ENST00000440597, ENST00000451703, ENST00000486291, ENST00000861746, ENST00000861747, ENST00000861748, ENST00000861749, ENST00000861750, ENST00000861751, ENST00000861752, ENST00000861753, ENST00000972035, ENST00000972036, ENST00000972037, ENST00000972038

RefSeq mRNA: 1 — MANE Select: NM_015049 NM_015049

CCDS: CCDS2347

Canonical transcript exons

ENST00000332624 — 16 exons

Exon	Start	End
ENSE00000784650	201384111	201384216
ENSE00000784651	201386218	201386484
ENSE00000784652	201387703	201388001
ENSE00000784653	201389300	201389503
ENSE00000784654	201392909	201393046
ENSE00000784655	201394798	201394872
ENSE00000784656	201395314	201395444
ENSE00000784657	201397502	201397580
ENSE00000934587	201401018	201401094
ENSE00000934588	201399377	201399493
ENSE00000934589	201398145	201398354
ENSE00000934590	201389801	201389880
ENSE00001315209	201377207	201381218
ENSE00001662139	201451350	201451458
ENSE00002435966	201407403	201407597
ENSE00003686006	201420417	201420706

Expression profiles

Bgee: expression breadth ubiquitous, 290 present calls, max score 99.08.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 32.5582 / max 1305.9128, expressed in 1804 samples.

FANTOM5 promoters (10 alternative TSS)

Promoter ID	TPM avg	Samples expressed
33231	21.7231	1790
33232	9.6010	1664
33225	0.3776	100
33233	0.2723	120
33229	0.2013	17
33226	0.1326	41
33234	0.1201	45
33227	0.0583	12
33228	0.0376	9
33230	0.0342	9

Top tissues by expression

294 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
dorsal motor nucleus of vagus nerve	UBERON:0002870	99.08	gold quality
cranial nerve II	UBERON:0000941	98.95	gold quality
trabecular bone tissue	UBERON:0002483	98.87	gold quality
tendon of biceps brachii	UBERON:0008188	98.72	gold quality
choroid plexus epithelium	UBERON:0003911	98.71	gold quality
inferior olivary complex	UBERON:0002127	98.53	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	98.50	gold quality
spinal cord	UBERON:0002240	98.34	gold quality
inferior vagus X ganglion	UBERON:0005363	98.34	gold quality
medulla oblongata	UBERON:0001896	97.84	gold quality
heart right ventricle	UBERON:0002080	97.67	gold quality
subthalamic nucleus	UBERON:0001906	97.58	gold quality
corpus callosum	UBERON:0002336	97.57	gold quality
medial globus pallidus	UBERON:0002477	97.08	gold quality
pons	UBERON:0000988	96.91	gold quality
secondary oocyte	CL:0000655	96.87	gold quality
superior vestibular nucleus	UBERON:0007227	96.79	gold quality
globus pallidus	UBERON:0001875	96.74	gold quality
myocardium	UBERON:0002349	96.37	gold quality
left ventricle myocardium	UBERON:0006566	96.12	gold quality
periodontal ligament	UBERON:0008266	95.90	gold quality
midbrain	UBERON:0001891	95.86	gold quality
substantia nigra	UBERON:0002038	95.79	gold quality
blood vessel layer	UBERON:0004797	95.78	gold quality
dorsal plus ventral thalamus	UBERON:0001897	95.71	gold quality
corpus epididymis	UBERON:0004359	95.68	gold quality
ventral tegmental area	UBERON:0002691	95.64	gold quality
saphenous vein	UBERON:0007318	95.55	gold quality
substantia nigra pars reticulata	UBERON:0001966	95.11	gold quality
tendon	UBERON:0000043	94.99	gold quality

Single-cell (SCXA)

Detected in 5 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-CURD-112	yes	49.33
E-MTAB-10042	yes	23.13
E-MTAB-9221	yes	10.93
E-ANND-3	yes	7.43
E-MTAB-9467	no	0.93

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

178 targeting TRAK2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-3134	100.00	66.43	777
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-518D-5P	100.00	67.51	979
HSA-MIR-518E-5P	100.00	67.66	954
HSA-MIR-518F-5P	100.00	67.51	979
HSA-MIR-519A-5P	100.00	67.66	954
HSA-MIR-519B-5P	100.00	67.66	954
HSA-MIR-519C-5P	100.00	67.66	954
HSA-MIR-520C-5P	100.00	67.51	979
HSA-MIR-522-5P	100.00	67.66	954
HSA-MIR-523-5P	100.00	67.66	954
HSA-MIR-526A-5P	100.00	67.51	979
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-513B-5P	99.99	69.96	2150
HSA-MIR-12136	99.98	72.81	5713

Literature-anchored findings (GeneRIF, showing 11)

• identification, molecular cloning and characterization (PMID:12034717)
• GRIF-1 and OIP106 have roles in protein and/or organelle transport in excitable cells in a manner analogous to glutamate receptor-interacting-protein 1 (PMID:15644324)
• analysis of the GRIF-1 binding domain of the kinesin, KIF5C, which substantiates a role for GRIF-1 as an adaptor protein in the anterograde trafficking of cargoes (PMID:16835241)
• Binds to Kir2.1 and facilitates trafficking of this channel to the cell surface. (PMID:16895905)
• These data suggest that Miro1 and the kinesin adaptor Grif-1 play an important role in regulating mitochondrial transport in neurons. (PMID:19103291)
• The results of this study established a key role for mammalian TRAK2 proteins in axonal and dendritic targeting of mitochondria. (PMID:23395375)
• This study showed that the TRAK2 was more prevalent in dendrites of hippocampal neurons. In cortical neurons, TRAK2 was equally distributed between axons and dendrites. (PMID:25653102)
• Full-length APC promotes assembly of the Miro-1/Milton-2 complex. (PMID:26658612)
• TRAK2 is a novel regulator of LXR-mediated ABCA1 expression, cholesterol efflux, and HDL biogenesis. TRAK2 may therefore be an important target in the development of anti-atherosclerotic therapies. (PMID:28655204)
• miR-487b and TRAK2 that form an axis to regulate the aggressiveness of osteosarcoma, are potential therapeutic targets and prognostic biomarkers. (PMID:32267991)
• Mitochondrial adaptor TRAK2 activates and functionally links opposing kinesin and dynein motors. (PMID:34321481)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	trak2	ENSDARG00000102471
mus_musculus	Trak2	ENSMUSG00000026028
rattus_norvegicus	Trak2	ENSRNOG00000010881
drosophila_melanogaster	milt	FBGN0262872
caenorhabditis_elegans	trak-1	WBGENE00020838

Paralogs (2): HAP1 (ENSG00000173805), TRAK1 (ENSG00000182606)

Protein

Protein identifiers

Trafficking kinesin-binding protein 2 — O60296 (reviewed: O60296)

Alternative names: Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein

All UniProt accessions (2): O60296, Q53RS6

UniProt curated annotations — full annotation on UniProt →

Function. May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR.

Subunit / interactions. Interacts with GABA-A receptor and O-GlcNAc transferase. Interacts with HGS. Interacts with RHOT1/Miro-1 and RHOT2/Miro-2.

Subcellular location. Cytoplasm. Early endosome. Mitochondrion.

Tissue specificity. Widely expressed, with highest expression in heart.

Post-translational modifications. O-glycosylated.

Similarity. Belongs to the milton family.

Isoforms (2)

UniProt ID	Names	Canonical?
O60296-1	1	yes
O60296-2	2

RefSeq proteins (1): NP_055864* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR006933	HAP1_N	Domain
IPR022154	TRAK1/2_C	Domain
IPR051946	Intracell_Traff-Reg	Family

Pfam: PF04849, PF12448

UniProt features (16 total): region of interest 4, sequence variant 3, compositionally biased region 3, splice variant 2, chain 1, domain 1, modified residue 1, coiled-coil region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O60296-F1	61.18	0.24

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 420

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-9013419	RHOT2 GTPase cycle
R-HSA-9013425	RHOT1 GTPase cycle

MSigDB gene sets: 293 (showing top): GOBP_DENDRITE_DEVELOPMENT, GOBP_NEGATIVE_REGULATION_OF_CELL_DEVELOPMENT, GOBP_AXO_DENDRITIC_TRANSPORT, GOBP_LYSOSOMAL_TRANSPORT, GOBP_VESICLE_LOCALIZATION, AREB6_03, GOBP_ENDOSOME_TO_LYSOSOME_TRANSPORT, GOBP_PROTEIN_TARGETING, IVANOVA_HEMATOPOIESIS_MATURE_CELL, GOBP_VACUOLAR_TRANSPORT, GOBP_NEUROGENESIS, TGACCTY_ERR1_Q2, GOBP_VESICLE_MEDIATED_TRANSPORT, GOBP_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT, GOBP_ORGANELLE_TRANSPORT_ALONG_MICROTUBULE

GO Biological Process (10): regulation of transcription by RNA polymerase II (GO:0006357), protein O-linked glycosylation (GO:0006493), protein targeting (GO:0006605), endosome to lysosome transport (GO:0008333), neurogenesis (GO:0022008), vesicle transport along microtubule (GO:0047496), mitochondrion distribution (GO:0048311), dendrite morphogenesis (GO:0048813), negative regulation of axonogenesis (GO:0050771), dendritic transport of mitochondrion (GO:0098939)

GO Molecular Function (7): signaling receptor binding (GO:0005102), myosin binding (GO:0017022), kinesin binding (GO:0019894), enzyme binding (GO:0019899), TPR domain binding (GO:0030911), GABA receptor binding (GO:0050811), protein binding (GO:0005515)

GO Cellular Component (12): nucleus (GO:0005634), cytoplasm (GO:0005737), mitochondrion (GO:0005739), early endosome (GO:0005769), cytosol (GO:0005829), plasma membrane (GO:0005886), dendrite (GO:0030425), cytoplasmic vesicle (GO:0031410), dendrite cytoplasm (GO:0032839), neuronal cell body (GO:0043025), axonal growth cone (GO:0044295), endosome (GO:0005768)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Miro GTPase Cycle	2

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	3
protein binding	2
cytoskeletal protein binding	2
intracellular membrane-bounded organelle	2
cellular anatomical structure	2
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
glycoprotein biosynthetic process	1
establishment of protein localization	1
lysosomal transport	1
intercellular transport	1
vesicle-mediated transport	1
nervous system development	1
cell differentiation	1
organelle transport along microtubule	1
vesicle cytoskeletal trafficking	1
mitochondrion localization	1
dendrite development	1
cell morphogenesis involved in neuron differentiation	1
neuron projection morphogenesis	1
axonogenesis	1
negative regulation of neuron projection development	1
negative regulation of neurogenesis	1
regulation of axonogenesis	1
dendrite cytoplasm	1
mitochondrion transport along microtubule	1
dendritic transport	1
protein domain specific binding	1
signaling receptor binding	1
binding	1
intracellular anatomical structure	1
endosome	1
membrane	1
cell periphery	1
neuron projection	1
dendritic tree	1
intracellular vesicle	1
dendrite	1
neuron projection cytoplasm	1
somatodendritic compartment	1

Protein interactions and networks

STRING

808 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TRAK2	RHOT1	Q8IXI2	995
TRAK2	RHOT2	Q8IXI1	988
TRAK2	STRADB	Q9C0K7	908
TRAK2	TRAK1	Q9UPV9	858
TRAK2	ARMCX3	Q9UH62	845
TRAK2	MYO19	Q96H55	796
TRAK2	MFN2	O95140	792
TRAK2	KIF5C	O60282	789
TRAK2	OGT	O15294	782
TRAK2	KIF5A	Q12840	715
TRAK2	SNPH	O15079	708
TRAK2	MYO10	Q9HD67	701
TRAK2	ALS2	Q96Q42	690
TRAK2	KIF5B	P33176	675
TRAK2	MFN1	Q8IWA4	653

IntAct

13 interactions, top by confidence:

A	B	Type	Score
TRAK2	OGT	psi-mi:“MI:0914”(association)	0.530
KXD1	HIP1	psi-mi:“MI:0914”(association)	0.530
KXD1	TRAK2	psi-mi:“MI:0914”(association)	0.530
GSK3B	SEC16A	psi-mi:“MI:2364”(proximity)	0.420
Xpo1	IFT56	psi-mi:“MI:0914”(association)	0.350
NEK4	E2F8	psi-mi:“MI:0914”(association)	0.350
M		psi-mi:“MI:0914”(association)	0.350
TOMM22	DNM1L	psi-mi:“MI:2364”(proximity)	0.270
TRAK2		psi-mi:“MI:0915”(physical association)	0.000

BioGRID (122): ACAD11 (Affinity Capture-MS), OGT (Affinity Capture-MS), KLC1 (Affinity Capture-MS), KLC2 (Affinity Capture-MS), KLC4 (Affinity Capture-MS), PRKAG1 (Affinity Capture-MS), PLK1 (Affinity Capture-MS), CKAP2 (Affinity Capture-MS), KIF1B (Affinity Capture-MS), KIF5C (Affinity Capture-MS), KIF5B (Affinity Capture-MS), KIF5A (Affinity Capture-MS), RHOT1 (Affinity Capture-MS), GSK3B (Affinity Capture-MS), GSK3A (Affinity Capture-MS)

ESM2 similar proteins: A0A1L8GUX5, A0A1L8GXY6, A0A1W2P884, A2CE83, B8A5S6, E7F5E1, F7DP49, H2MTR9, O08970, O35711, O60296, P27628, P53564, P60853, Q0VF96, Q28GJ0, Q2KJD6, Q3UIJ9, Q4V7D3, Q5BIX7, Q5R923, Q5SXA9, Q5SZL2, Q5U2Y9, Q5U4W1, Q5ZLT3, Q6AW69, Q6DIS8, Q6DJR2, Q6NRW2, Q6NXJ0, Q6P402, Q6PCQ0, Q6PD31, Q7TQE6, Q80ST9, Q86W92, Q8BMK0, Q8C8U0, Q8CFC9

Diamond homologs: O35668, O60296, P54256, P54257, Q6PD31, Q9UPV9, Q6GLX3, Q8R2H7, Q960V3

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
KIF5C	“up-regulates activity”	TRAK2	binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

140 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	114
Likely benign	4
Benign	4

Top pathogenic / likely-pathogenic (0)

SpliceAI

2901 predictions. Top by Δscore:

Variant	Effect	Δscore
2:201384230:T:C	acceptor_gain	1.0000
2:201386215:CA:C	donor_loss	1.0000
2:201386216:A:T	donor_loss	1.0000
2:201386225:TGGTC:T	donor_gain	1.0000
2:201386485:C:CC	acceptor_gain	1.0000
2:201386491:A:AC	acceptor_gain	1.0000
2:201386491:A:C	acceptor_gain	1.0000
2:201387690:A:AC	donor_gain	1.0000
2:201387691:C:CC	donor_gain	1.0000
2:201387837:ACT:A	donor_gain	1.0000
2:201387838:CTC:C	donor_gain	1.0000
2:201387843:T:A	donor_gain	1.0000
2:201389309:T:TA	donor_gain	1.0000
2:201389324:C:A	donor_gain	1.0000
2:201389799:A:AC	donor_gain	1.0000
2:201389800:C:CT	donor_gain	1.0000
2:201389800:CT:C	donor_gain	1.0000
2:201389800:CTT:C	donor_gain	1.0000
2:201389800:CTTTT:C	donor_gain	1.0000
2:201392903:GCTT:G	donor_loss	1.0000
2:201392904:CTTA:C	donor_loss	1.0000
2:201392906:TACCC:T	donor_loss	1.0000
2:201392907:A:AC	donor_gain	1.0000
2:201392907:AC:A	donor_gain	1.0000
2:201392907:ACC:A	donor_gain	1.0000
2:201392907:ACCC:A	donor_gain	1.0000
2:201392908:C:A	donor_loss	1.0000
2:201392908:C:CC	donor_gain	1.0000
2:201392908:CC:C	donor_gain	1.0000
2:201392908:CCC:C	donor_gain	1.0000

AlphaMissense

5959 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:201398344:A:G	L164P	0.999
2:201399450:A:G	L136P	0.999
2:201399465:C:G	R131P	0.999
2:201399474:A:G	L128P	0.999
2:201386462:C:A	W573C	0.998
2:201386462:C:G	W573C	0.998
2:201386464:A:G	W573R	0.998
2:201386464:A:T	W573R	0.998
2:201398332:A:G	L168P	0.998
2:201399454:C:G	A135P	0.998
2:201399459:C:T	G133E	0.998
2:201399469:C:G	A130P	0.998
2:201399472:C:G	A129P	0.998
2:201399480:A:G	L126P	0.998
2:201401028:A:G	L118P	0.998
2:201387726:A:G	L558S	0.997
2:201397528:A:G	L248P	0.997
2:201398152:C:G	R228P	0.997
2:201398311:A:G	L175P	0.997
2:201399441:C:G	R139P	0.997
2:201399486:C:G	R124P	0.997
2:201387717:A:T	V561D	0.996
2:201394808:A:G	L322P	0.996
2:201394838:A:G	L312P	0.996
2:201394850:A:G	L308P	0.996
2:201395333:A:G	L294P	0.996
2:201397536:T:A	E245D	0.996
2:201397536:T:G	E245D	0.996
2:201398155:A:G	L227P	0.996
2:201398185:A:G	L217P	0.996

dbSNP variants (sampled 300 via entrez): RS1000025372 (2:201450448 C>T), RS1000050642 (2:201435238 T>C), RS1000114899 (2:201395077 T>C), RS1000195905 (2:201431760 T>A), RS1000206895 (2:201406710 C>A,T), RS1000209473 (2:201422529 T>C), RS1000261998 (2:201422813 C>T), RS1000299005 (2:201392108 A>G), RS1000353319 (2:201379686 C>T), RS1000384460 (2:201380009 C>A), RS1000409513 (2:201399756 G>A), RS1000415428 (2:201433964 T>C), RS1000470393 (2:201391878 C>T), RS1000486148 (2:201442360 C>T), RS1000593834 (2:201405415 C>T)

Disease associations

OMIM: gene MIM:607334 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST009387_2	Cocaine use disorder x change in residence interaction	3.000000e-08
GCST009665_1	Breast cancer	2.000000e-08

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0010445	cocaine use disorder
EFO:0010552	social environment measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

38 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	increases expression, affects cotreatment	6
Phenylmercuric Acetate	affects cotreatment, increases expression	2
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression, increases expression	2
FR900359	decreases phosphorylation	1
triphenyl phosphate	affects expression	1
uranyl acetate	affects expression	1
afimoxifene	decreases expression	1
sodium arsenite	increases expression	1
cobaltous chloride	increases expression	1
ochratoxin A	decreases acetylation, decreases expression	1
ferrous chloride	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	increases expression, affects cotreatment	1
14-deoxy-11,12-didehydroandrographolide	decreases expression	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, increases expression	1
jinfukang	affects cotreatment, increases expression	1
Temozolomide	decreases expression	1
Sunitinib	increases expression	1
Fulvestrant	decreases expression	1
Acetaminophen	increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Atrazine	decreases expression	1
Cadmium	increases abundance, increases expression	1
Cannabidiol	decreases expression	1
Cisplatin	affects cotreatment, increases expression	1
Doxorubicin	decreases expression	1
Estradiol	increases expression	1
Lead	affects splicing	1
Methyl Methanesulfonate	increases expression	1
Silicon Dioxide	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_E0S5	Ubigene HeLa TRAK2 KO	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.