TRAPPC8

Summary

TRAPPC8 (trafficking protein particle complex subunit 8, HGNC:29169) is a protein-coding gene on chromosome 18q12.1, encoding Trafficking protein particle complex subunit 8 (Q9Y2L5). Plays a role in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage. It is a common-essential gene (DepMap: required in 98.7% of cancer cell lines).

Involved in Golgi organization and collagen biosynthetic process. Part of TRAPP complex.

Source: NCBI Gene 22878 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 234 total
• Cancer dependency (DepMap): dependent in 98.7% of screened cell lines (common-essential)
• MANE Select transcript: NM_014939

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29169
Approved symbol	TRAPPC8
Name	trafficking protein particle complex subunit 8
Location	18q12.1
Locus type	gene with protein product
Status	Approved
Aliases	HsT2706, TRS85, GSG1
Ensembl gene	ENSG00000153339
Ensembl biotype	protein_coding
OMIM	614136
Entrez	22878

Gene structure

Transcript identifiers

Ensembl transcripts: 19 — 11 protein_coding, 4 retained_intron, 3 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

ENST00000283351, ENST00000577426, ENST00000577474, ENST00000578252, ENST00000578658, ENST00000578886, ENST00000580104, ENST00000581057, ENST00000582509, ENST00000582513, ENST00000582539, ENST00000584604, ENST00000584876, ENST00000865827, ENST00000865828, ENST00000865829, ENST00000865830, ENST00000923366, ENST00000923367

RefSeq mRNA: 1 — MANE Select: NM_014939 NM_014939

CCDS: CCDS11901

Canonical transcript exons

ENST00000283351 — 29 exons

Exon	Start	End
ENSE00001010236	31907460	31907610
ENSE00001010242	31913369	31913522
ENSE00001010245	31908303	31908418
ENSE00001108131	31917578	31917667
ENSE00001108134	31900925	31901025
ENSE00001108136	31870372	31870502
ENSE00001108137	31890735	31890866
ENSE00001108141	31870926	31871120
ENSE00001108142	31908754	31909010
ENSE00001108143	31857540	31857982
ENSE00001108146	31897786	31897891
ENSE00001108149	31909667	31909760
ENSE00001108154	31916272	31916446
ENSE00001108156	31867402	31867476
ENSE00001108158	31866849	31866975
ENSE00001108162	31864627	31864781
ENSE00001834739	31942608	31943128
ENSE00001860632	31829197	31830989
ENSE00003500604	31839312	31839457
ENSE00003506125	31849566	31849739
ENSE00003515212	31855660	31855807
ENSE00003573473	31931329	31931523
ENSE00003595905	31852446	31852504
ENSE00003599252	31853849	31853945
ENSE00003621235	31846716	31846817
ENSE00003647124	31852595	31852663
ENSE00003668210	31832084	31832173
ENSE00003725280	31874480	31874704
ENSE00003749622	31873430	31873538

Expression profiles

Bgee: expression breadth ubiquitous, 300 present calls, max score 98.42.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 24.4013 / max 158.4253, expressed in 1814 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
171593	22.0818	1812
171594	1.9189	1042
171595	0.4005	168

Top tissues by expression

301 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
hair follicle	UBERON:0002073	98.42	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	97.48	gold quality
tongue squamous epithelium	UBERON:0006919	97.34	gold quality
jejunal mucosa	UBERON:0000399	97.32	gold quality
caput epididymis	UBERON:0004358	97.24	gold quality
sperm	CL:0000019	97.08	gold quality
superior surface of tongue	UBERON:0007371	97.04	gold quality
renal medulla	UBERON:0000362	96.71	gold quality
male germ cell	CL:0000015	96.68	gold quality
cardia of stomach	UBERON:0001162	96.68	gold quality
bronchial epithelial cell	CL:0002328	96.65	gold quality
corpus epididymis	UBERON:0004359	96.62	gold quality
pylorus	UBERON:0001166	96.54	gold quality
cauda epididymis	UBERON:0004360	96.54	gold quality
mammary duct	UBERON:0001765	96.48	gold quality
tongue	UBERON:0001723	96.43	gold quality
superficial temporal artery	UBERON:0001614	96.34	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	96.32	gold quality
oral cavity	UBERON:0000167	96.22	gold quality
pharyngeal mucosa	UBERON:0000355	96.21	gold quality
jejunum	UBERON:0002115	96.09	gold quality
body of tongue	UBERON:0011876	95.91	gold quality
mucosa of paranasal sinus	UBERON:0005030	95.88	gold quality
epithelium of mammary gland	UBERON:0003244	95.82	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	95.81	gold quality
pericardium	UBERON:0002407	95.74	gold quality
biceps brachii	UBERON:0001507	95.65	gold quality
trigeminal ganglion	UBERON:0001675	95.60	gold quality
pons	UBERON:0000988	95.58	gold quality
upper leg skin	UBERON:0004262	95.45	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-100618	yes	718.37
E-ANND-3	yes	6.52
E-MTAB-6386	no	390.39

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

139 targeting TRAPPC8, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-5193	100.00	67.26	1744
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-371A-3P	99.99	66.77	91
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-1185-1-3P	99.98	71.04	2593
HSA-MIR-1185-2-3P	99.98	71.04	2593
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-507	99.97	70.11	1915
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-3148	99.97	75.06	6478

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 98.7% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 2)

• Data show that a disease-causing mutation of TRAPPC2, D47Y, failed to interact with either TRAPPC9 or TRAPPC8, suggesting that aspartate 47 in TRAPPC2 is at or near the site of interaction with TRAPPC9 or TRAPPC8. (PMID:21858081)
• TRAPPC8 modulates autophagy and secretory trafficking and is required for TBC1D14 to bind TRAPPIII. (PMID:26711178)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	trappc8	ENSDARG00000038866
mus_musculus	Trappc8	ENSMUSG00000033382
rattus_norvegicus	Trappc8	ENSRNOG00000022202
drosophila_melanogaster	l(3)76BDm	FBGN0260655
caenorhabditis_elegans	trpp-8	WBGENE00018512

Protein

Protein identifiers

Trafficking protein particle complex subunit 8 — Q9Y2L5 (reviewed: Q9Y2L5)

Alternative names: Protein TRS85 homolog

All UniProt accessions (6): Q9Y2L5, J3KSL8, J3QQJ5, J3QQS5, J3QR00, J3QSA1

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage. Maintains together with TBC1D14 the cycling pool of ATG9 required for initiation of autophagy. Involved in collagen secretion.

Subunit / interactions. Component of the multisubunit TRAPP (transport protein particle) complex, which includes TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Interacts with TBC1D14. Interacts (via C-terminus) with TMEM131 (via C-terminus); the interaction is direct and is involved in collagen secretion.

Subcellular location. Golgi apparatus. cis-Golgi network.

Miscellaneous. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Similarity. Belongs to the TRS85 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9Y2L5-1	1	yes
Q9Y2L5-2	2

RefSeq proteins (1): NP_055754* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR011990	TPR-like_helical_dom_sf	Homologous_superfamily
IPR024420	TRAPP_III_complex_Trs85	Family
IPR057651	Ig_TPPC8_C	Domain
IPR058538	Ig_TPPC8_2nd	Domain
IPR058540	Ig_TPPC8_3rd	Domain
IPR058541	Ig_TPPC8_1st	Domain

Pfam: PF12739, PF24542, PF24544, PF24545, PF24546

UniProt features (21 total): sequence variant 9, sequence conflict 3, modified residue 3, splice variant 2, chain 1, region of interest 1, mutagenesis site 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y2L5-F1	79.53	0.44

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 273, 279, 309

Mutagenesis-validated functional residues (1):

Position	Phenotype
1035–1040	attenuates interaction with tmem131.

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-8876198	RAB GEFs exchange GTP for GDP on RABs

MSigDB gene sets: 254 (showing top): LI_CISPLATIN_RESISTANCE_DN, FAELT_B_CLL_WITH_VH_REARRANGEMENTS_DN, GOBP_VESICLE_LOCALIZATION, GNF2_BNIP2, GOBP_VESICLE_ORGANIZATION, AAGCCAT_MIR135A_MIR135B, KORKOLA_CHORIOCARCINOMA_DN, GOBP_VESICLE_TARGETING, TATTATA_MIR374, GENTILE_RESPONSE_CLUSTER_D3, GOBP_VESICLE_MEDIATED_TRANSPORT, REACTOME_MEMBRANE_TRAFFICKING, SENESE_HDAC1_AND_HDAC2_TARGETS_DN, chr18q12, GOBP_ENDOPLASMIC_RETICULUM_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT

GO Biological Process (6): endoplasmic reticulum to Golgi vesicle-mediated transport (GO:0006888), Golgi organization (GO:0007030), collagen biosynthetic process (GO:0032964), COPII vesicle coat assembly (GO:0048208), obsolete vesicle tethering (GO:0099022), vesicle-mediated transport (GO:0016192)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (5): cytoplasm (GO:0005737), cytosol (GO:0005829), TRAPP complex (GO:0030008), TRAPPIII protein complex (GO:1990072), Golgi apparatus (GO:0005794)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Rab regulation of trafficking	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	3
cellular anatomical structure	2
intercellular transport	1
intracellular transport	1
Golgi vesicle transport	1
organelle organization	1
endomembrane system organization	1
biosynthetic process	1
collagen metabolic process	1
vesicle coat assembly	1
protein-containing complex assembly	1
COPII-coated vesicle budding	1
transport	1
cellular process	1
binding	1
intracellular anatomical structure	1
vesicle tethering complex	1
intracellular protein-containing complex	1
Golgi apparatus	1
TRAPP complex	1
endomembrane system	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

1770 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TRAPPC8	TRAPPC2	P0DI81	993
TRAPPC8	TRAPPC4	Q9Y296	989
TRAPPC8	TRAPPC5	Q8IUR0	980
TRAPPC8	TRAPPC13	A5PLN9	973
TRAPPC8	TRAPPC11	Q7Z392	971
TRAPPC8	TRAPPC12	Q8WVT3	970
TRAPPC8	TRAPPC6A	O75865	966
TRAPPC8	TRAPPC1	Q9Y5R8	966
TRAPPC8	TRAPPC10	P48553	947
TRAPPC8	TRAPPC9	Q96Q05	932
TRAPPC8	TRAPPC3	O43617	916
TRAPPC8	TRAPPC2L	Q9UL33	845
TRAPPC8	TRAPPC6B	Q86SZ2	805
TRAPPC8	RAB1A	P11476	796
TRAPPC8	TBC1D14	Q9P2M4	754

IntAct

57 interactions, top by confidence:

A	B	Type	Score
TRAPPC2L	TRAPPC13	psi-mi:“MI:0914”(association)	0.560
TRAPPC2L	TRAPPC8	psi-mi:“MI:0915”(physical association)	0.560
MIS12	SPC24	psi-mi:“MI:0914”(association)	0.530
TRAPPC1	TRAPPC13	psi-mi:“MI:0914”(association)	0.530
TKT	POTEF	psi-mi:“MI:0914”(association)	0.530
TPCN2	AP3B1	psi-mi:“MI:0914”(association)	0.530
TRAPPC12	TRAPPC3	psi-mi:“MI:0914”(association)	0.530
MYL6	MYL6B	psi-mi:“MI:0914”(association)	0.530
TRAPPC8	TRAPPC3	psi-mi:“MI:0915”(physical association)	0.400
TRAPPC13	TRAPPC8	psi-mi:“MI:0915”(physical association)	0.400
TRAPPC8	TRAPPC13	psi-mi:“MI:0915”(physical association)	0.400
TRAPPC8		psi-mi:“MI:0915”(physical association)	0.370
Trappc11	TRAPPC3	psi-mi:“MI:0914”(association)	0.350
TRAPPC9	TRAPPC8	psi-mi:“MI:0914”(association)	0.350
BMI1	HMGB1P1	psi-mi:“MI:0914”(association)	0.350
BMI1	MEIS3P1	psi-mi:“MI:0914”(association)	0.350
TECPR1	PLOD3	psi-mi:“MI:0914”(association)	0.350
MAPT	SHTN1	psi-mi:“MI:0914”(association)	0.350
DYRK1A	TEX13D	psi-mi:“MI:0914”(association)	0.350
ACTR2		psi-mi:“MI:0914”(association)	0.350
ARL3	TRAPPC13	psi-mi:“MI:0914”(association)	0.350
ARL8B	ARPC2	psi-mi:“MI:0914”(association)	0.350
KRAS	ARPC1B	psi-mi:“MI:0914”(association)	0.350
TRAPPC11	TRAPPC13	psi-mi:“MI:0914”(association)	0.350

BioGRID (126): TRAPPC8 (Affinity Capture-MS), TRAPPC8 (Affinity Capture-MS), TRAPPC8 (Affinity Capture-RNA), TRAPPC8 (Affinity Capture-MS), TRAPPC8 (Affinity Capture-MS), TRAPPC8 (Affinity Capture-MS), TRAPPC8 (Affinity Capture-MS), TRAPPC8 (Affinity Capture-MS), TRAPPC8 (Affinity Capture-MS), TRAPPC8 (Affinity Capture-MS), TRAPPC8 (Affinity Capture-MS), TRAPPC8 (Affinity Capture-MS), TRAPPC8 (Affinity Capture-MS), TRAPPC8 (Proximity Label-MS), TRAPPC8 (Proximity Label-MS)

ESM2 similar proteins: A0A0R4IES7, A0JN62, A0JNW5, A2AAE1, A2AGL3, A2RSJ4, A2RT67, A2RUS2, A2RV80, B0LPN4, B1H2P5, E7F240, E9Q401, O00507, O94967, P30957, P48553, P51593, Q14161, Q2LD37, Q3TLI0, Q3UHE1, Q3UVG3, Q3UX43, Q5F361, Q5M7Q1, Q5RAQ5, Q5ZJK1, Q658Y4, Q68CL5, Q6BDS2, Q6P6Y1, Q6TEP1, Q6VNB8, Q7TMY8, Q7TSG1, Q7Z6Z7, Q8BHY8, Q8CB44, Q8CGF6

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
TRAPPC8	“form complex”	“TRAPP III complex, TRAPPC2 variant”	binding
TRAPPC8	“form complex”	“TRAPP III complex, TRAPPC2B variant”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 57 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
COPII-mediated vesicle transport	8	27.8×	6e-08
RAB GEFs exchange GTP for GDP on RABs	10	26.4×	1e-09
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	5	10.3×	4e-03
RHO GTPase Effectors	7	10.1×	6e-04
PIP3 activates AKT signaling	6	8.5×	4e-03
RAF/MAP kinase cascade	6	7.8×	4e-03
Signaling by Rho GTPases	8	5.8×	4e-03
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	8	5.7×	4e-03

GO biological processes:

GO term	Partners	Fold	FDR
obsolete vesicle tethering	10	198.3×	2e-19
COPII vesicle coat assembly	7	98.3×	6e-11
peptidyl-tyrosine phosphorylation	5	42.1×	1e-05
endoplasmic reticulum to Golgi vesicle-mediated transport	12	32.6×	3e-13
protein autophosphorylation	6	17.4×	1e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

234 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	182
Likely benign	7
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

4917 predictions. Top by Δscore:

Variant	Effect	Δscore
18:31846816:GCCTA:G	acceptor_loss	1.0000
18:31846818:C:A	acceptor_loss	1.0000
18:31846819:T:C	acceptor_loss	1.0000
18:31849599:A:AC	donor_gain	1.0000
18:31849600:C:CC	donor_gain	1.0000
18:31852436:A:AC	donor_gain	1.0000
18:31852437:C:CC	donor_gain	1.0000
18:31852502:CCG:C	acceptor_gain	1.0000
18:31852503:CG:C	acceptor_gain	1.0000
18:31852503:CGC:C	acceptor_gain	1.0000
18:31852505:C:CC	acceptor_gain	1.0000
18:31852590:TTTA:T	donor_loss	1.0000
18:31852591:TTA:T	donor_loss	1.0000
18:31852592:TACCT:T	donor_loss	1.0000
18:31852593:A:AG	donor_loss	1.0000
18:31852664:C:CC	acceptor_gain	1.0000
18:31853845:AAAC:A	donor_loss	1.0000
18:31853846:AAC:A	donor_loss	1.0000
18:31853848:C:A	donor_loss	1.0000
18:31853885:T:TA	donor_gain	1.0000
18:31853899:C:CT	donor_gain	1.0000
18:31853900:T:TT	donor_gain	1.0000
18:31853903:TTGA:T	donor_gain	1.0000
18:31853904:TGAT:T	donor_gain	1.0000
18:31853942:CACT:C	acceptor_gain	1.0000
18:31853944:CT:C	acceptor_gain	1.0000
18:31853946:C:CC	acceptor_gain	1.0000
18:31853946:CTGTC:C	acceptor_loss	1.0000
18:31853947:T:A	acceptor_loss	1.0000
18:31855654:A:AC	donor_gain	1.0000

AlphaMissense

9452 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
18:31874574:G:T	A620D	1.000
18:31874602:A:G	S611P	1.000
18:31874607:C:G	R609P	1.000
18:31874610:C:T	G608E	1.000
18:31874611:C:A	G608W	1.000
18:31874611:C:G	G608R	1.000
18:31874611:C:T	G608R	1.000
18:31874627:G:C	H602Q	1.000
18:31874627:G:T	H602Q	1.000
18:31874628:T:G	H602P	1.000
18:31874629:G:C	H602D	1.000
18:31874645:C:A	W596C	1.000
18:31874645:C:G	W596C	1.000
18:31874647:A:G	W596R	1.000
18:31874647:A:T	W596R	1.000
18:31874688:C:G	R582P	1.000
18:31874695:C:G	A580P	1.000
18:31890754:C:G	R570P	1.000
18:31890760:C:A	G568V	1.000
18:31890760:C:T	G568D	1.000
18:31890761:C:G	G568R	1.000
18:31890764:C:G	A567P	1.000
18:31890766:A:G	L566S	1.000
18:31890769:A:C	I565R	1.000
18:31890769:A:T	I565K	1.000
18:31890776:G:C	H563D	1.000
18:31890777:A:C	F562L	1.000
18:31890777:A:T	F562L	1.000
18:31890778:A:G	F562S	1.000
18:31890779:A:G	F562L	1.000

dbSNP variants (sampled 300 via entrez): RS1000001596 (18:31834921 T>C), RS1000002891 (18:31910586 T>C), RS1000029841 (18:31920503 TATAAA>T), RS1000039731 (18:31928294 T>C), RS1000068587 (18:31836317 T>C,G), RS1000082757 (18:31889335 C>G), RS1000102158 (18:31848258 G>A), RS1000135549 (18:31864245 T>C), RS1000157752 (18:31840567 A>G), RS1000178256 (18:31942038 T>C), RS1000234168 (18:31873372 A>C,G), RS1000272813 (18:31901281 G>C), RS1000296736 (18:31906468 C>T), RS1000310050 (18:31847277 A>G), RS1000355743 (18:31930878 T>A)

Disease associations

OMIM: gene MIM:614136 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

26 total (human), top 26 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
aristolochic acid I	decreases expression	1
FR900359	affects phosphorylation	1
ginger extract	decreases expression, increases abundance	1
dicrotophos	decreases expression	1
bisphenol A	decreases expression	1
arsenite	affects binding, decreases reaction	1
sodium arsenite	increases expression	1
cobaltous chloride	increases expression	1
butyraldehyde	decreases expression	1
perfluorooctane sulfonic acid	decreases expression	1
K 7174	increases expression	1
jinfukang	decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Temozolomide	decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Benzo(a)pyrene	affects methylation	1
Cadmium	increases abundance, increases expression	1
Coumestrol	decreases expression	1
Ivermectin	decreases expression	1
Oils, Volatile	decreases expression, increases abundance	1
Plant Extracts	affects cotreatment, increases expression	1
Potassium Dichromate	decreases expression	1
Selenium	decreases expression	1
Vitamin E	decreases expression	1
Cadmium Chloride	increases expression, increases abundance	1
Particulate Matter	decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.