TREM1

Summary

TREM1 (triggering receptor expressed on myeloid cells 1, HGNC:17760) is a protein-coding gene on chromosome 6p21.1, encoding Triggering receptor expressed on myeloid cells 1 (Q9NP99). Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses.

This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Source: NCBI Gene 54210 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 47 total
• Druggable target: yes
• MANE Select transcript: NM_018643

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17760
Approved symbol	TREM1
Name	triggering receptor expressed on myeloid cells 1
Location	6p21.1
Locus type	gene with protein product
Status	Approved
Aliases	TREM-1, CD354
Ensembl gene	ENSG00000124731
Ensembl biotype	protein_coding
OMIM	605085
Entrez	54210

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 4 protein_coding, 3 retained_intron, 1 nonsense_mediated_decay

ENST00000244709, ENST00000334475, ENST00000586287, ENST00000589614, ENST00000589695, ENST00000589882, ENST00000591620, ENST00000718270

RefSeq mRNA: 3 — MANE Select: NM_018643 NM_001242589, NM_001242590, NM_018643

CCDS: CCDS4854, CCDS56427, CCDS59499

Canonical transcript exons

ENST00000244709 — 4 exons

Exon	Start	End
ENSE00000750662	41280961	41281153
ENSE00000849881	41282395	41282751
ENSE00004034583	41286607	41286682
ENSE00004034584	41273605	41276230

Expression profiles

Bgee: expression breadth ubiquitous, 181 present calls, max score 98.30.

FANTOM5 (CAGE): breadth broad, TPM avg 38.0909 / max 10336.6508, expressed in 471 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
73543	37.8621	468
73541	0.1588	33
73540	0.0699	35

Top tissues by expression

280 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	98.30	gold quality
mononuclear cell	CL:0000842	97.87	gold quality
leukocyte	CL:0000738	97.75	gold quality
periodontal ligament	UBERON:0008266	97.75	gold quality
blood	UBERON:0000178	97.73	gold quality
right lung	UBERON:0002167	96.95	gold quality
upper lobe of left lung	UBERON:0008952	94.18	gold quality
upper lobe of lung	UBERON:0008948	93.87	gold quality
granulocyte	CL:0000094	93.44	gold quality
lower lobe of lung	UBERON:0008949	92.07	gold quality
decidua	UBERON:0002450	90.85	gold quality
bone marrow	UBERON:0002371	89.78	gold quality
lung	UBERON:0002048	89.09	gold quality
bone marrow cell	CL:0002092	88.36	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.70	gold quality
spleen	UBERON:0002106	82.98	gold quality
vermiform appendix	UBERON:0001154	81.16	gold quality
tendon of biceps brachii	UBERON:0008188	79.87	gold quality
gall bladder	UBERON:0002110	79.32	gold quality
placenta	UBERON:0001987	77.98	gold quality
left uterine tube	UBERON:0001303	76.82	gold quality
omental fat pad	UBERON:0010414	76.78	gold quality
peritoneum	UBERON:0002358	76.69	gold quality
amniotic fluid	UBERON:0000173	76.32	gold quality
adipose tissue of abdominal region	UBERON:0007808	75.98	gold quality
trabecular bone tissue	UBERON:0002483	75.72	gold quality
descending thoracic aorta	UBERON:0002345	75.17	gold quality
pancreatic ductal cell	CL:0002079	74.94	silver quality
layer of synovial tissue	UBERON:0007616	74.91	gold quality
caecum	UBERON:0001153	74.41	gold quality

Single-cell (SCXA)

Detected in 5 experiment(s), a significant marker in 5.

Experiment	Marker?	Max mean expression
E-CURD-122	yes	69.92
E-ANND-3	yes	19.35
E-HCAD-10	yes	17.87
E-MTAB-9221	yes	17.53
E-MTAB-9801	yes	6.82

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): ATF3, EGR3, FOXC1, IRF6, NFKB1, NFKB, RELA, SPI1

miRNA regulators (miRDB)

100 targeting TREM1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-3692-3P	99.98	70.27	2139
HSA-MIR-1229-3P	99.97	66.49	906
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-6845-3P	99.94	66.88	1439
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-4760-3P	99.93	70.50	2385
HSA-MIR-7107-3P	99.93	66.73	627
HSA-MIR-205-3P	99.92	69.92	3165
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-301B-3P	99.90	73.19	1836
HSA-MIR-4671-3P	99.88	72.46	1045
HSA-MIR-6124	99.87	69.78	3551
HSA-MIR-30E-3P	99.87	69.68	2942
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-6752-3P	99.72	66.71	1587
HSA-MIR-4422	99.72	72.07	2908
HSA-MIR-4755-5P	99.71	70.34	2716
HSA-MIR-5006-3P	99.71	70.26	2728
HSA-MIR-519A-3P	99.67	71.67	1868
HSA-MIR-519B-3P	99.67	71.67	1868
HSA-MIR-519C-3P	99.67	71.67	1870
HSA-MIR-7157-5P	99.66	69.33	1829
HSA-MIR-26A-1-3P	99.64	66.81	788
HSA-MIR-26A-2-3P	99.64	66.82	786
HSA-MIR-4310	99.59	68.84	2527
HSA-MIR-4261	99.59	70.30	3415
HSA-MIR-4649-3P	99.56	66.90	1783
HSA-MIR-4437	99.52	65.29	1266

Literature-anchored findings (GeneRIF, showing 40)

• The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes TREM1. (PMID:12645956)
• Activation of TREM-1 on monocytes participates during the early-induced and adaptive immune responses involved in host defense against microbial challenges. (PMID:12646648)
• Crystal structure of the human myeloid cell activating receptor TREM-1 (PMID:14656437)
• A new regulatory role is described for TREM-1-mediated signals in the resolution of acute inflammation and the control of neutrophil activity. (PMID:15067076)
• TREM-1 may play an important role in the occurrence and development of acute pancreatitis (PMID:15309732)
• monomeric state of this extracellular ectodomain in solution and, presumably, of the TREM family in general (PMID:15351648)
• TREM-1 is upregulated on monocytes during human endotoxemia together with an increase in soluble TREM-1. (PMID:15585833)
• TREM-1 may play an important role in establishing and amplifying the systemic inflammatory response (PMID:16437719)
• Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) seems to behave as a novel mediator in inflammatory bowel disease (IBD) in correlation with the degree of the inflammatory reaction of the intestinal mucosa. (PMID:16733861)
• Monocytes contribute to the production of sTREM-1 in the event of septic syndrome. (PMID:17008237)
• Regulation of TREM-1 and the soluble form of TREM-1 expression by prostaglandin E2 may modulate the inflammatory response to microbial pathogens (PMID:17202378)
• NTAL acts as a negative regulator of TNF-alpha and IL-8 production after stimulation via TREM-1 (PMID:17277102)
• the effects of aging on TREM-1 engagement in human PMN; respiratory burst, PMN survival, recruitment of TREM-1 in the lipid-rafts, phosphorylation (PMID:17336301)
• sTREM-1 is detectable in exhaled ventilator condensate and may be useful in establishing or excluding the diagnosis of ventilator-associated pneumonia. (PMID:17505044)
• Results show that sTREM-1 and procalcitonin are not specific for infection and can increase markedly in acute inflammation without infection. (PMID:17558349)
• We examined the transcriptional regulation of TREM-1 in macrophages. NF-kappaB and PU.1 are involved in the expression of TREM-1 (PMID:17634956)
• prognostic value of serum sTREM-1 levels in patients hospitalized with community acquired pneumonia (PMID:17659879)
• Soluble TREM-1 secreted by the gastric mucosa is an independent mechanism connected to the pathogenesis of peptic ulcer. (PMID:17729416)
• Conclusive evidence favors proteolytic cleavage over alternative splicing as the mechanism responsible for the release of soluble TREM-1 from lipopolysaccharide-stimulated monocytes. (PMID:17785845)
• During melioidosis, TREM-1 expression is differentially regulated on granulocytes and monocytes; measurement of TREM-1 expression on blood granulocytes may not provide adequate information on granulocyte TREM-1 expression at the infection site. (PMID:18008257)
• serum concentrations of sTREM-1 are increased in patients with COPD. Prospective studies are warranted to evaluate the relevance of sTREM-1 as a potential marker of the disease in patients with COPD. (PMID:18317529)
• The present findings suggest that the three studied polymorphisms within the TREM-1 gene may not play a major role in the predisposition to severe sepsis in a Chinese Han cohort (PMID:18396215)
• down-regulation of TREM-1 expression in cystic fibrosis patients is at least partly responsible for the endotoxin tolerance state in which their monocytes are locked (PMID:18628981)
• sTREM-1 seems to be a new mediator involved in patients with AS, particularly in the early stages of disease. (PMID:18634145)
• Increased TREM-1 expression on monocytes is associated with both infectious and noninfectious inflammatory processes. (PMID:18656898)
• Results suggest that TREM-1 and sTREM-1 contribute to the development of shock in patients suffering from sepsis. (PMID:19109693)
• upregulation of expression on lamina propria macrophages in patients with inflammatory bowel disease; plasma levels is a prognostic factor for sepsis (PMID:19230638)
• sTREM-1 may not have a role in infection in patients with secondary peritonitis (PMID:19251433)
• TREM-1 protein expression levels were up-regulated in sepsis patients with acute cholangitis (PMID:19396532)
• TREM-1 ligation contributes to the pathology of autoimmune arthritis. (PMID:19479878)
• Serum sTREM-1 correlates closely with injury severity score, TNF-alpha and onset of sepsis. (PMID:19484952)
• propose that triggering receptor expressed on myeloid cells 1(sTREM-1) play a role in the innate immune response against intra-amniotic infection (PMID:19591072)
• TREM-1 was up-regulation in infected lungs and human plasma together with augmented alveolar macrophage responsiveness toward Streptococcus pneumoniae (PMID:19596984)
• Serum sTREM-1 (triggering receptor expressed on myeloid cells 1 ) levels were significantly higher in the infection group than in the flare group of febrile systemic lupus erythematosus patients (PMID:19917159)
• The expression of human TREM-1 in peripheral blood mononuclear cells is up-regulated in the early stage of acute obstructive suppurative cholangitis. (PMID:19923060)
• Serum sTREM-1 levels were elevated in diffuse systemic sclerosis patients and correlated with severity of pulmonary fibrosis, suggesting that serum sTREM-1 is a novel serological marker for the disease severity of systemic sclerosis. (PMID:20156945)
• we provide new insights into the mechanisms how TREM-1 and TLR interact creating synergistic activation in polymorphonuclear neutrophils (PMID:20375613)
• Trem1 expression is increased in the inner zone of amyloid plaques using a transgenic animal model of Alzheimer’s disease. (PMID:20640189)
• TREM-1 is expressed on mature dendritic cells infiltrating the inflamed hypoxic joints of children affected by juvenile idiopathic arthritis. (PMID:21148811)
• sTREM-1 concentrations in bronchoalveolar lavage fluid fluid are of potential prognostic value in patients with ventilator-associated pneumonia. (PMID:21306476)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Trem1	ENSMUSG00000042265
rattus_norvegicus	Trem1	ENSRNOG00000022859

Protein

Protein identifiers

Triggering receptor expressed on myeloid cells 1 — Q9NP99 (reviewed: Q9NP99)

Alternative names: Triggering receptor expressed on monocytes 1

All UniProt accessions (3): Q9NP99, K7EKM5, Q38L15

UniProt curated annotations — full annotation on UniProt →

Function. Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses. Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12. In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma. This cascade promotes the neutrophil- and macrophage-mediated release of pro-inflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections. By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis. Acts as a decoy receptor, counterbalancing TREM1 pro-inflammatory activity through the neutralization of its ligand.

Subunit / interactions. Monomer. Homomultimer; when activated. Interacts with TYROBP/DAP12. Interacts with TLR4.

Subcellular location. Cell membrane Secreted.

Tissue specificity. Mostly expressed by immune cells of the myeloid lineage, such as monocytes, macrophages, neutrophils and dendritic cells. Expression is associated with a mature stage of myeloid development. Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Isoform 2 was detected in the lung, liver and mature monocytes.

Post-translational modifications. Glycosylated.

Induction. Up-regulated by bacteria, fungi and bacterial lipopolysaccharides (LPS).

Isoforms (3)

UniProt ID	Names	Canonical?
Q9NP99-1	1	yes
Q9NP99-2	2, TREM-1sv, sTREM1
Q9NP99-3	3

RefSeq proteins (3): NP_001229518, NP_001229519, NP_061113* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003599	Ig_sub	Domain
IPR013106	Ig_V-set	Domain
IPR013783	Ig-like_fold	Homologous_superfamily
IPR036179	Ig-like_dom_sf	Homologous_superfamily

Pfam: PF07686

UniProt features (32 total): strand 10, sequence variant 4, splice variant 3, glycosylation site 3, topological domain 2, helix 2, turn 2, signal peptide 1, chain 1, sequence conflict 1, transmembrane region 1, domain 1, disulfide bond 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
1SMO	X-RAY DIFFRACTION	1.47
1Q8M	X-RAY DIFFRACTION	2.6

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NP99-F1	72.30	0.37

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 41–113

Glycosylation sites (3): 146, 191, 194

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-202733	Cell surface interactions at the vascular wall
R-HSA-2172127	DAP12 interactions

MSigDB gene sets: 219 (showing top): GSE45365_NK_CELL_VS_CD11B_DC_DN, TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_MONOCYTE_UP, REACTOME_INNATE_IMMUNE_SYSTEM, MCLACHLAN_DENTAL_CARIES_UP, GOBP_MYELOID_LEUKOCYTE_MIGRATION, GOBP_CELL_CHEMOTAXIS, REACTOME_ADAPTIVE_IMMUNE_SYSTEM, GOCC_CELL_SURFACE, GOBP_LEUKOCYTE_MEDIATED_CYTOTOXICITY, GOBP_LEUKOCYTE_MEDIATED_IMMUNITY, GOBP_LEUKOCYTE_CHEMOTAXIS, TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_ERYTHROCYTE_UP, GOBP_TAXIS, GOBP_LEUKOCYTE_MIGRATION, OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP

GO Biological Process (8): adaptive immune response (GO:0002250), immune response (GO:0006955), humoral immune response (GO:0006959), neutrophil chemotaxis (GO:0030593), intracellular signal transduction (GO:0035556), innate immune response (GO:0045087), neutrophil-mediated killing of gram-negative bacterium (GO:0070945), immune system process (GO:0002376)

GO Molecular Function (4): transmembrane signaling receptor activity (GO:0004888), signaling receptor activity (GO:0038023), scaffold protein binding (GO:0097110), receptor decoy activity (GO:0140319)

GO Cellular Component (5): extracellular region (GO:0005576), obsolete extracellular space (GO:0005615), plasma membrane (GO:0005886), cell surface (GO:0009986), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Adaptive Immune System	1
Hemostasis	1
Innate Immune System	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
immune response	3
cellular anatomical structure	3
immune system process	1
response to stimulus	1
granulocyte chemotaxis	1
neutrophil migration	1
intracellular anatomical structure	1
signal transduction	1
defense response to symbiont	1
defense response to Gram-negative bacterium	1
neutrophil-mediated killing of bacterium	1
biological_process	1
signaling receptor activity	1
molecular transducer activity	1
protein binding	1
molecular sequestering activity	1
membrane	1
cell periphery	1

Protein interactions and networks

STRING

1692 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
TREM1	TYROBP	O43914	996
TREM1	TREM2	Q9NZC2	979
TREM1	HMGB1	P09429	959
TREM1	TREML1	Q86YW5	939
TREM1	PGLYRP1	O75594	915
TREM1	TREML2	Q5T2D2	909
TREM1	FPR1	P21462	784
TREM1	CIRBP	Q14011	726
TREM1	CCL2	P13500	669
TREM1	CLEC5A	Q9NY25	668
TREM1	FCGR1A	P12314	638
TREM1	MYD88	P78397	631
TREM1	CXCL1	P09341	629
TREM1	TLR4	O00206	617
TREM1	IL1A	P01583	615

IntAct

6 interactions, top by confidence:

A	B	Type	Score
TREM1	TYROBP	psi-mi:“MI:0915”(physical association)	0.400
TREM1	APOE	psi-mi:“MI:0915”(physical association)	0.400
HSCB	RBP5	psi-mi:“MI:0914”(association)	0.350
TREM1	RTL8C	psi-mi:“MI:0914”(association)	0.350
TREM1	SEC11A	psi-mi:“MI:0914”(association)	0.350

BioGRID (17): TREM1 (Co-crystal Structure), TREM1 (Affinity Capture-MS), TREM1 (Affinity Capture-RNA), TTK (Affinity Capture-MS), TUBGCP2 (Affinity Capture-MS), SPCS2 (Affinity Capture-MS), MZT2B (Affinity Capture-MS), FAM127A (Affinity Capture-MS), ATP12A (Affinity Capture-MS), NR2F2 (Affinity Capture-MS), SPCS1 (Affinity Capture-MS), SEL1L3 (Affinity Capture-MS), TYROBP (Affinity Capture-Western), ASB9 (Affinity Capture-MS), SEC11A (Affinity Capture-MS)

ESM2 similar proteins: A6NJW9, O02757, P01730, P01731, P01732, P05541, P07725, P09793, P0DSE1, P10300, P10747, P10966, P15530, P16003, P16004, P16410, P30433, P30434, P31041, P31042, P31043, P31783, P33705, P33706, P40259, P41688, P42069, P42072, P50283, P79184, P79336, Q08338, Q08340, Q28071, Q2YFS1, Q2YFS2, Q2YFS3, Q3LRV9, Q495A1, Q5JXA9

Diamond homologs: O95944, Q5RDA5, Q6QUN5, Q6TYI6, Q9JKE1, Q9JKE2, Q9NP99, Q9NZC2, A8K4G0, P81265, Q86YW5, Q8K558, Q5T2D2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

47 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	32
Likely benign	8
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

516 predictions. Top by Δscore:

Variant	Effect	Δscore
6:41282389:ACTCA:A	donor_loss	1.0000
6:41282391:TCA:T	donor_loss	1.0000
6:41282392:CA:C	donor_loss	1.0000
6:41282393:A:AC	donor_gain	1.0000
6:41282393:AC:A	donor_gain	1.0000
6:41282393:ACC:A	donor_gain	1.0000
6:41282394:C:CC	donor_gain	1.0000
6:41282394:CC:C	donor_gain	1.0000
6:41282394:CCC:C	donor_gain	1.0000
6:41286601:TCTTA:T	donor_loss	1.0000
6:41286602:CTTA:C	donor_loss	1.0000
6:41286603:TTA:T	donor_loss	1.0000
6:41286604:TA:T	donor_loss	1.0000
6:41286605:ACC:A	donor_loss	1.0000
6:41286606:C:G	donor_loss	1.0000
6:41282394:CCCT:C	donor_gain	0.9900
6:41282394:CCCTT:C	donor_gain	0.9900
6:41282404:C:CT	donor_gain	0.9900
6:41282405:C:CT	donor_gain	0.9900
6:41282748:AGTT:A	acceptor_gain	0.9900
6:41282749:GTT:G	acceptor_gain	0.9900
6:41282750:TT:T	acceptor_gain	0.9900
6:41282752:C:CC	acceptor_gain	0.9900
6:41282754:A:C	acceptor_gain	0.9900
6:41282759:C:CT	acceptor_gain	0.9900
6:41282760:A:T	acceptor_gain	0.9900
6:41286649:T:TA	donor_gain	0.9900
6:41281152:ACCTG:A	acceptor_gain	0.9800
6:41281153:CCTGC:C	acceptor_gain	0.9800
6:41282747:GAGTT:G	acceptor_gain	0.9800

AlphaMissense

1511 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
6:41282636:C:A	W55C	0.982
6:41282636:C:G	W55C	0.982
6:41282638:A:G	W55R	0.982
6:41282638:A:T	W55R	0.982
6:41282642:T:A	K53N	0.982
6:41282642:T:G	K53N	0.982
6:41282409:A:G	L131S	0.976
6:41282470:A:C	Y111D	0.976
6:41282641:C:G	A54P	0.970
6:41282481:T:G	D107A	0.966
6:41282481:T:A	D107V	0.965
6:41282493:A:T	L103H	0.962
6:41282481:T:C	D107G	0.960
6:41276176:G:C	S218R	0.957
6:41276176:G:T	S218R	0.957
6:41276178:T:G	S218R	0.957
6:41282637:C:G	W55S	0.957
6:41282482:C:G	D107H	0.956
6:41282634:T:G	Q56P	0.956
6:41282463:C:G	C113S	0.955
6:41282464:A:T	C113S	0.955
6:41282643:T:A	K53I	0.950
6:41282480:A:C	D107E	0.948
6:41282480:A:T	D107E	0.948
6:41282657:A:C	F48L	0.944
6:41282657:A:T	F48L	0.944
6:41282659:A:G	F48L	0.944
6:41282464:A:G	C113R	0.943
6:41282469:T:C	Y111C	0.942
6:41282479:A:G	S108P	0.941

dbSNP variants (sampled 300 via entrez): RS1000080955 (6:41267114 A>C), RS1000212977 (6:41282960 G>T), RS1000343052 (6:41288280 C>T), RS1000450081 (6:41275770 G>A), RS1000501160 (6:41283935 G>C), RS1000536240 (6:41267349 G>T), RS1000553561 (6:41284165 C>T), RS1000670699 (6:41281279 G>A), RS1000673838 (6:41288675 T>C), RS1000766089 (6:41269580 A>G), RS1000808998 (6:41272779 C>A,T), RS1001037004 (6:41278269 C>T), RS1001342616 (6:41278679 GA>G,GAA), RS1001512609 (6:41284132 G>A), RS1001551295 (6:41278046 C>T)

Disease associations

OMIM: gene MIM:605085 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST006585_2078	Blood protein levels	1.000000e-54
GCST012490_567	Femur bone mineral density x serum urate levels interaction	2.000000e-11
GCST012490_86	Femur bone mineral density x serum urate levels interaction	2.000000e-10

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004531	urate measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL1697674 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

44 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases expression	2
Benzo(a)pyrene	decreases expression, increases methylation	2
Ozone	affects expression, increases abundance, increases expression	2
Cyclosporine	decreases expression, increases expression	2
GSK-J4	increases expression	1
triphenyl phosphate	affects expression	1
kojic acid	decreases expression	1
sulforaphane	increases expression	1
tetrabromobisphenol A	increases expression	1
nickel chloride	affects expression, increases expression	1
perfluorooctanoic acid	affects cotreatment, decreases expression	1
zinc chromate	increases abundance, increases expression	1
tobacco tar	decreases reaction, increases expression	1
diallyl disulfide	decreases reaction, increases expression	1
zinc sulfide	affects cotreatment, increases expression	1
di-n-butylphosphoric acid	affects expression	1
chromium hexavalent ion	increases abundance, increases expression	1
perfluorooctane sulfonic acid	affects cotreatment, decreases expression	1
paricalcitol	affects cotreatment, increases expression	1
CGP 52608	affects binding, increases reaction	1
perfluorohexanesulfonic acid	affects cotreatment, decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Air Pollutants	affects expression, increases abundance	1
Allergens	decreases expression	1
Amphotericin B	decreases expression	1
Cadmium	affects cotreatment, increases expression	1
Calcitriol	increases expression	1
Copper	affects cotreatment, increases expression	1
Curcumin	decreases expression	1
Dinitrochlorobenzene	affects expression, increases expression	1

ChEMBL screening assays

13 unique, capped per target: 13 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL1693803	Binding	Induction of TREM-1-mediated activation of IL-6 signaling pathway in human PBMC at 20 ug/ml	Structure-activity relationships in nucleotide oligomerization domain 1 (Nod1) agonistic γ-glutamyldiaminopimelic acid derivatives. — J Med Chem

Cellosaurus cell lines

6 cell lines: 3 cancer cell line, 2 transformed cell line, 1 spontaneously immortalized cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D1ZF	Abcam A-549 TREM1 KO	Cancer cell line	Male
CVCL_D9WY	Ubigene HTR-8/SVneo TREM1 KO	Transformed cell line	Sex unspecified
CVCL_E0V7	Ubigene Hep G2 TREM1 KO	Cancer cell line	Male
CVCL_E0VZ	Ubigene Huh-7 TREM1 KO	Cancer cell line	Male
CVCL_E6SB	Genomeditech CHO-K1 H_TREM1+TYROBP	Spontaneously immortalized cell line	Female
CVCL_E6V9	Genomeditech HEK-293 H_TREM1+TYROBP	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.