TRERNA1

Summary

TRERNA1 (translation regulatory long non-coding RNA 1, HGNC:44307) is a long non-coding RNA gene on chromosome 20q13.13.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44307
Approved symbol	TRERNA1
Name	translation regulatory long non-coding RNA 1
Location	20q13.13
Locus type	RNA, long non-coding
Status	Approved
Aliases	MEF, treRNA, ncRNA-a7
Ensembl gene	ENSG00000231265
Ensembl biotype	lncRNA
Entrez	100887755
RNAcentral	URS000075EDE5 — lncRNA, 615 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000431460

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000431460 — 2 exons

Exon	Start	End
ENSE00001699927	50040707	50041049
ENSE00001714278	50041377	50041504

Expression profiles

Bgee: expression breadth broad, 75 present calls, max score 65.67.

Top tissues by expression

75 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	65.67	silver quality
lymph node	UBERON:0000029	62.83	gold quality
adult mammalian kidney	UBERON:0000082	61.22	gold quality
bone marrow	UBERON:0002371	60.03	gold quality
amygdala	UBERON:0001876	57.09	gold quality
leukocyte	CL:0000738	55.04	gold quality
monocyte	CL:0000576	54.41	gold quality
blood	UBERON:0000178	54.17	gold quality
islet of Langerhans	UBERON:0000006	53.99	gold quality
placenta	UBERON:0001987	53.04	gold quality
vermiform appendix	UBERON:0001154	52.62	gold quality
tonsil	UBERON:0002372	52.57	gold quality
caudate nucleus	UBERON:0001873	51.67	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	51.54	gold quality
ovary	UBERON:0000992	50.99	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	49.88	gold quality
putamen	UBERON:0001874	48.44	gold quality
heart left ventricle	UBERON:0002084	47.83	gold quality
anterior cingulate cortex	UBERON:0009835	47.66	gold quality
body of pancreas	UBERON:0001150	47.24	silver quality
right lobe of liver	UBERON:0001114	47.16	silver quality
right frontal lobe	UBERON:0002810	46.89	gold quality
brain	UBERON:0000955	46.77	gold quality
spleen	UBERON:0002106	46.66	gold quality
tibial artery	UBERON:0007610	45.65	gold quality
myometrium	UBERON:0001296	45.63	silver quality
gastrocnemius	UBERON:0001388	45.63	gold quality
pituitary gland	UBERON:0000007	45.41	gold quality
right adrenal gland	UBERON:0001233	45.34	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	45.04	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.57

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 10)

• Data suggest that suppression of treRNA (translation regulatory long non-coding RNA) by microRNA-190a leads to down-regulation of mesenchymal-epithelial transition and of cell migration/neoplastic invasiveness of hepatoma cells. (PMID:26608035)
• we suggest that treRNA is a novel biomarker in CLL associated with aggressive disease and poor response to chemotherapy through enhanced protection against cytotoxic mediated DNA damage. (PMID:28412730)
• TFAP4 can directly modulate the expression of TRERNA1. (PMID:29845218)
• TRERNA1 promotes cell metastasis and the invasion of HCC via the recruitment of EHMT2 and/or the EHMT2/SNAI1 complex to suppress CDH1. (PMID:31012192)
• Expression and Clinical Significance of Translation Regulatory Long Non-Coding RNA 1 (TRERNA1) in Ependymomas. (PMID:31489574)
• LncRNA TRERNA1 promotes malignant progression of NSCLC through targeting FOXL1. (PMID:32096153)
• Elevated LncRNA TRERNA1 correlated with activation of HIF-1alpha predicts poor prognosis in hepatocellular carcinoma. (PMID:34560417)
• Translation regulatory long non-coding RNA 1 (TRERNA1) sponges microRNA-23a to suppress granulosa cell apoptosis in premature ovarian failure. (PMID:35034562)
• SBF2-AS1 and TreRNA: novel lncRNA players in triple-negative breast cancer pathogenesis. (PMID:37286777)
• Translation regulatory long non-coding RNA 1 negatively regulates cell radiosensitivity via the miR-22-3p/SP1 axis in non-small cell lung cancer. (PMID:38286742)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.